KEGG   Bubalus kerabau (carabao): 129644127
Entry
129644127         CDS       T11435                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
bke  Bubalus kerabau (carabao)
Pathway
bke00562  Inositol phosphate metabolism
bke01100  Metabolic pathways
bke01521  EGFR tyrosine kinase inhibitor resistance
bke01522  Endocrine resistance
bke01524  Platinum drug resistance
bke04012  ErbB signaling pathway
bke04014  Ras signaling pathway
bke04015  Rap1 signaling pathway
bke04024  cAMP signaling pathway
bke04062  Chemokine signaling pathway
bke04066  HIF-1 signaling pathway
bke04068  FoxO signaling pathway
bke04070  Phosphatidylinositol signaling system
bke04071  Sphingolipid signaling pathway
bke04072  Phospholipase D signaling pathway
bke04081  Hormone signaling
bke04140  Autophagy - animal
bke04150  mTOR signaling pathway
bke04151  PI3K-Akt signaling pathway
bke04152  AMPK signaling pathway
bke04210  Apoptosis
bke04211  Longevity regulating pathway
bke04213  Longevity regulating pathway - multiple species
bke04218  Cellular senescence
bke04360  Axon guidance
bke04370  VEGF signaling pathway
bke04380  Osteoclast differentiation
bke04510  Focal adhesion
bke04517  IgSF CAM signaling
bke04518  Integrin signaling
bke04550  Signaling pathways regulating pluripotency of stem cells
bke04611  Platelet activation
bke04613  Neutrophil extracellular trap formation
bke04620  Toll-like receptor signaling pathway
bke04625  C-type lectin receptor signaling pathway
bke04630  JAK-STAT signaling pathway
bke04650  Natural killer cell mediated cytotoxicity
bke04660  T cell receptor signaling pathway
bke04662  B cell receptor signaling pathway
bke04664  Fc epsilon RI signaling pathway
bke04666  Fc gamma R-mediated phagocytosis
bke04668  TNF signaling pathway
bke04670  Leukocyte transendothelial migration
bke04722  Neurotrophin signaling pathway
bke04725  Cholinergic synapse
bke04750  Inflammatory mediator regulation of TRP channels
bke04810  Regulation of actin cytoskeleton
bke04910  Insulin signaling pathway
bke04914  Progesterone-mediated oocyte maturation
bke04915  Estrogen signaling pathway
bke04917  Prolactin signaling pathway
bke04919  Thyroid hormone signaling pathway
bke04923  Regulation of lipolysis in adipocytes
bke04926  Relaxin signaling pathway
bke04929  GnRH secretion
bke04930  Type II diabetes mellitus
bke04931  Insulin resistance
bke04932  Non-alcoholic fatty liver disease
bke04933  AGE-RAGE signaling pathway in diabetic complications
bke04935  Growth hormone synthesis, secretion and action
bke04960  Aldosterone-regulated sodium reabsorption
bke04973  Carbohydrate digestion and absorption
bke05010  Alzheimer disease
bke05017  Spinocerebellar ataxia
bke05020  Prion disease
bke05100  Bacterial invasion of epithelial cells
bke05132  Salmonella infection
bke05135  Yersinia infection
bke05142  Chagas disease
bke05146  Amoebiasis
bke05160  Hepatitis C
bke05161  Hepatitis B
bke05162  Measles
bke05163  Human cytomegalovirus infection
bke05164  Influenza A
bke05165  Human papillomavirus infection
bke05166  Human T-cell leukemia virus 1 infection
bke05167  Kaposi sarcoma-associated herpesvirus infection
bke05168  Herpes simplex virus 1 infection
bke05169  Epstein-Barr virus infection
bke05170  Human immunodeficiency virus 1 infection
bke05171  Coronavirus disease - COVID-19
bke05200  Pathways in cancer
bke05203  Viral carcinogenesis
bke05205  Proteoglycans in cancer
bke05206  MicroRNAs in cancer
bke05207  Chemical carcinogenesis - receptor activation
bke05208  Chemical carcinogenesis - reactive oxygen species
bke05210  Colorectal cancer
bke05211  Renal cell carcinoma
bke05212  Pancreatic cancer
bke05213  Endometrial cancer
bke05214  Glioma
bke05215  Prostate cancer
bke05218  Melanoma
bke05220  Chronic myeloid leukemia
bke05221  Acute myeloid leukemia
bke05222  Small cell lung cancer
bke05223  Non-small cell lung cancer
bke05224  Breast cancer
bke05225  Hepatocellular carcinoma
bke05226  Gastric cancer
bke05230  Central carbon metabolism in cancer
bke05231  Choline metabolism in cancer
bke05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bke05415  Diabetic cardiomyopathy
bke05417  Lipid and atherosclerosis
bke05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bke00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129644127 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129644127 (PIK3CB)
   04014 Ras signaling pathway
    129644127 (PIK3CB)
   04015 Rap1 signaling pathway
    129644127 (PIK3CB)
   04370 VEGF signaling pathway
    129644127 (PIK3CB)
   04630 JAK-STAT signaling pathway
    129644127 (PIK3CB)
   04668 TNF signaling pathway
    129644127 (PIK3CB)
   04066 HIF-1 signaling pathway
    129644127 (PIK3CB)
   04068 FoxO signaling pathway
    129644127 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    129644127 (PIK3CB)
   04072 Phospholipase D signaling pathway
    129644127 (PIK3CB)
   04071 Sphingolipid signaling pathway
    129644127 (PIK3CB)
   04024 cAMP signaling pathway
    129644127 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    129644127 (PIK3CB)
   04152 AMPK signaling pathway
    129644127 (PIK3CB)
   04150 mTOR signaling pathway
    129644127 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    129644127 (PIK3CB)
   04517 IgSF CAM signaling
    129644127 (PIK3CB)
   04518 Integrin signaling
    129644127 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129644127 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    129644127 (PIK3CB)
   04218 Cellular senescence
    129644127 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129644127 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    129644127 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129644127 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129644127 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    129644127 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    129644127 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    129644127 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    129644127 (PIK3CB)
   04660 T cell receptor signaling pathway
    129644127 (PIK3CB)
   04662 B cell receptor signaling pathway
    129644127 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    129644127 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    129644127 (PIK3CB)
   04670 Leukocyte transendothelial migration
    129644127 (PIK3CB)
   04062 Chemokine signaling pathway
    129644127 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129644127 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    129644127 (PIK3CB)
   04929 GnRH secretion
    129644127 (PIK3CB)
   04915 Estrogen signaling pathway
    129644127 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    129644127 (PIK3CB)
   04917 Prolactin signaling pathway
    129644127 (PIK3CB)
   04926 Relaxin signaling pathway
    129644127 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    129644127 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    129644127 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129644127 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    129644127 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    129644127 (PIK3CB)
   04722 Neurotrophin signaling pathway
    129644127 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129644127 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    129644127 (PIK3CB)
   04380 Osteoclast differentiation
    129644127 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    129644127 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    129644127 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129644127 (PIK3CB)
   05206 MicroRNAs in cancer
    129644127 (PIK3CB)
   05205 Proteoglycans in cancer
    129644127 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    129644127 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    129644127 (PIK3CB)
   05203 Viral carcinogenesis
    129644127 (PIK3CB)
   05230 Central carbon metabolism in cancer
    129644127 (PIK3CB)
   05231 Choline metabolism in cancer
    129644127 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129644127 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129644127 (PIK3CB)
   05212 Pancreatic cancer
    129644127 (PIK3CB)
   05225 Hepatocellular carcinoma
    129644127 (PIK3CB)
   05226 Gastric cancer
    129644127 (PIK3CB)
   05214 Glioma
    129644127 (PIK3CB)
   05221 Acute myeloid leukemia
    129644127 (PIK3CB)
   05220 Chronic myeloid leukemia
    129644127 (PIK3CB)
   05218 Melanoma
    129644127 (PIK3CB)
   05211 Renal cell carcinoma
    129644127 (PIK3CB)
   05215 Prostate cancer
    129644127 (PIK3CB)
   05213 Endometrial cancer
    129644127 (PIK3CB)
   05224 Breast cancer
    129644127 (PIK3CB)
   05222 Small cell lung cancer
    129644127 (PIK3CB)
   05223 Non-small cell lung cancer
    129644127 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129644127 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    129644127 (PIK3CB)
   05161 Hepatitis B
    129644127 (PIK3CB)
   05160 Hepatitis C
    129644127 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    129644127 (PIK3CB)
   05164 Influenza A
    129644127 (PIK3CB)
   05162 Measles
    129644127 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    129644127 (PIK3CB)
   05163 Human cytomegalovirus infection
    129644127 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129644127 (PIK3CB)
   05169 Epstein-Barr virus infection
    129644127 (PIK3CB)
   05165 Human papillomavirus infection
    129644127 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129644127 (PIK3CB)
   05135 Yersinia infection
    129644127 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    129644127 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129644127 (PIK3CB)
   05142 Chagas disease
    129644127 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129644127 (PIK3CB)
   05017 Spinocerebellar ataxia
    129644127 (PIK3CB)
   05020 Prion disease
    129644127 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129644127 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    129644127 (PIK3CB)
   05415 Diabetic cardiomyopathy
    129644127 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    129644127 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    129644127 (PIK3CB)
   04931 Insulin resistance
    129644127 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129644127 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129644127 (PIK3CB)
   01524 Platinum drug resistance
    129644127 (PIK3CB)
   01522 Endocrine resistance
    129644127 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bke04131]
    129644127 (PIK3CB)
Enzymes [BR:bke01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     129644127 (PIK3CB)
Membrane trafficking [BR:bke04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    129644127 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 LepB_N
Other DBs
NCBI-GeneID: 129644127
NCBI-ProteinID: XP_055425514
LinkDB
Position
2:176533332..176714007
AA seq 1070 aa
MCFYFMMPPAMADVLDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISCIKQMLW
KQVTNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKHTYPPEL
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPIMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHSLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMVAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMTRLCFAVYAVLDKVKTKKSTKTM
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPHALPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKTEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttctacttcatgatgcctcctgctatggcagacgtccttgacatctgggcagtg
gactcacagatagcatctgatggctccatacccgtggattttcttttgcccactgggatt
tatatccagttggaggtgcctcgtgaagctaccatttcctgtattaagcagatgttatgg
aaacaagttaccaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagctcgaagatgaaacaagaagactttgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
cagtcgcttgtgggattatcttggatggattggctaaagcatacctatccacctgagctt
gaaccatccatccctgaaaatttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaggtatctcctattatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtctgactattcatgggaaagaagatgaa
gttagcccttatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cactcactaattcagttccagtatatccggaactgtgtaatgaacagaacattgccccat
tttatacttgtggaatgttgcaagatcaagaagctgtatgaacaggaaatggttgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaagga
aataaacttaacacagaagaaactgtaaaagttcatgtcagggccggcctttttcatggt
accgaactcctgtgtaaaactgttgtaagctcagagatatcagggaagaatgatcatatt
tggaatgaaccactggaatttgatatcaacacttgtgacctgccacgaatgactcgatta
tgttttgctgtttatgcagttttggataaagtgaaaactaagaaatcaactaaaaccatg
aatccctctaagtatcagaccatcaggaaatctggaaaagtgcattatcctgtagcctgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagatataatattacac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatacagaaaatgcaacagctttgcacataaaattcccagagaataaaaaa
caaccgtattactatcctcccttcgataagattattgaaaaagcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactatgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacatgcattgccaaaattgctgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
ctgcccccccgggaggcccttgagcttctagatttcaactatccagatcagtatgtgcga
gaatatgctgtgggctgcctgcaacagatgagtgatgaagaactctctcagtatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccttgtctagattccta
ctcgaaagagcacttgctaatcggaggatagggcagtttttattttggcacctcagatct
gaagtacacattcctgctgtttcagtacaatttggtgttatccttgaagcgtactgccgg
ggaagcgtaggtcacatgaaggcgctttctaagcaggttgaagcactcaataaactaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaatagagccaaagggaaagaa
gcaatgcacacttgtttaaaacagaatgcttatcgtgaagccctctctgacctgcagtca
cctctcaacccatgtgttatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggcttgtgtacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacactccaaatgctg
cgcttgatggatttactctggaaagaagctggtctggaccttcggatgctaccttacggc
tgcttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgttgctgcagcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggag
tttaccctatcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acttatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cggttccgccagtgttgtgaggatgcgtatctgattttacgccggcatgggaatctcttc
atcacgctctttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagactgaagaagaagcactcaagcaa
ttcaagcaaaaatttgatgaggcactcagggaaagttggactactaaagtcaattggatg
gcccacacagttcggaaagactacagatcttaa

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