KEGG   Bubalus kerabau (carabao): 129652971
Entry
129652971         CDS       T11435                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
bke  Bubalus kerabau (carabao)
Pathway
bke01521  EGFR tyrosine kinase inhibitor resistance
bke01522  Endocrine resistance
bke01524  Platinum drug resistance
bke04010  MAPK signaling pathway
bke04012  ErbB signaling pathway
bke04014  Ras signaling pathway
bke04015  Rap1 signaling pathway
bke04022  cGMP-PKG signaling pathway
bke04024  cAMP signaling pathway
bke04062  Chemokine signaling pathway
bke04066  HIF-1 signaling pathway
bke04068  FoxO signaling pathway
bke04071  Sphingolipid signaling pathway
bke04072  Phospholipase D signaling pathway
bke04140  Autophagy - animal
bke04150  mTOR signaling pathway
bke04151  PI3K-Akt signaling pathway
bke04152  AMPK signaling pathway
bke04210  Apoptosis
bke04211  Longevity regulating pathway
bke04213  Longevity regulating pathway - multiple species
bke04218  Cellular senescence
bke04261  Adrenergic signaling in cardiomyocytes
bke04370  VEGF signaling pathway
bke04371  Apelin signaling pathway
bke04380  Osteoclast differentiation
bke04510  Focal adhesion
bke04517  IgSF CAM signaling
bke04518  Integrin signaling
bke04550  Signaling pathways regulating pluripotency of stem cells
bke04611  Platelet activation
bke04613  Neutrophil extracellular trap formation
bke04620  Toll-like receptor signaling pathway
bke04625  C-type lectin receptor signaling pathway
bke04630  JAK-STAT signaling pathway
bke04660  T cell receptor signaling pathway
bke04662  B cell receptor signaling pathway
bke04664  Fc epsilon RI signaling pathway
bke04666  Fc gamma R-mediated phagocytosis
bke04668  TNF signaling pathway
bke04722  Neurotrophin signaling pathway
bke04725  Cholinergic synapse
bke04728  Dopaminergic synapse
bke04810  Regulation of actin cytoskeleton
bke04910  Insulin signaling pathway
bke04914  Progesterone-mediated oocyte maturation
bke04915  Estrogen signaling pathway
bke04917  Prolactin signaling pathway
bke04919  Thyroid hormone signaling pathway
bke04920  Adipocytokine signaling pathway
bke04922  Glucagon signaling pathway
bke04923  Regulation of lipolysis in adipocytes
bke04926  Relaxin signaling pathway
bke04929  GnRH secretion
bke04931  Insulin resistance
bke04932  Non-alcoholic fatty liver disease
bke04933  AGE-RAGE signaling pathway in diabetic complications
bke04935  Growth hormone synthesis, secretion and action
bke04936  Alcoholic liver disease
bke04973  Carbohydrate digestion and absorption
bke05010  Alzheimer disease
bke05017  Spinocerebellar ataxia
bke05132  Salmonella infection
bke05135  Yersinia infection
bke05142  Chagas disease
bke05145  Toxoplasmosis
bke05152  Tuberculosis
bke05160  Hepatitis C
bke05161  Hepatitis B
bke05162  Measles
bke05163  Human cytomegalovirus infection
bke05164  Influenza A
bke05165  Human papillomavirus infection
bke05166  Human T-cell leukemia virus 1 infection
bke05167  Kaposi sarcoma-associated herpesvirus infection
bke05168  Herpes simplex virus 1 infection
bke05169  Epstein-Barr virus infection
bke05170  Human immunodeficiency virus 1 infection
bke05200  Pathways in cancer
bke05205  Proteoglycans in cancer
bke05207  Chemical carcinogenesis - receptor activation
bke05208  Chemical carcinogenesis - reactive oxygen species
bke05210  Colorectal cancer
bke05211  Renal cell carcinoma
bke05212  Pancreatic cancer
bke05213  Endometrial cancer
bke05214  Glioma
bke05215  Prostate cancer
bke05218  Melanoma
bke05220  Chronic myeloid leukemia
bke05221  Acute myeloid leukemia
bke05222  Small cell lung cancer
bke05223  Non-small cell lung cancer
bke05224  Breast cancer
bke05225  Hepatocellular carcinoma
bke05226  Gastric cancer
bke05230  Central carbon metabolism in cancer
bke05231  Choline metabolism in cancer
bke05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bke05415  Diabetic cardiomyopathy
bke05417  Lipid and atherosclerosis
bke05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bke00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129652971 (AKT3)
   04012 ErbB signaling pathway
    129652971 (AKT3)
   04014 Ras signaling pathway
    129652971 (AKT3)
   04015 Rap1 signaling pathway
    129652971 (AKT3)
   04370 VEGF signaling pathway
    129652971 (AKT3)
   04371 Apelin signaling pathway
    129652971 (AKT3)
   04630 JAK-STAT signaling pathway
    129652971 (AKT3)
   04668 TNF signaling pathway
    129652971 (AKT3)
   04066 HIF-1 signaling pathway
    129652971 (AKT3)
   04068 FoxO signaling pathway
    129652971 (AKT3)
   04072 Phospholipase D signaling pathway
    129652971 (AKT3)
   04071 Sphingolipid signaling pathway
    129652971 (AKT3)
   04024 cAMP signaling pathway
    129652971 (AKT3)
   04022 cGMP-PKG signaling pathway
    129652971 (AKT3)
   04151 PI3K-Akt signaling pathway
    129652971 (AKT3)
   04152 AMPK signaling pathway
    129652971 (AKT3)
   04150 mTOR signaling pathway
    129652971 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    129652971 (AKT3)
   04518 Integrin signaling
    129652971 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129652971 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    129652971 (AKT3)
   04218 Cellular senescence
    129652971 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129652971 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    129652971 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129652971 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129652971 (AKT3)
   04613 Neutrophil extracellular trap formation
    129652971 (AKT3)
   04620 Toll-like receptor signaling pathway
    129652971 (AKT3)
   04625 C-type lectin receptor signaling pathway
    129652971 (AKT3)
   04660 T cell receptor signaling pathway
    129652971 (AKT3)
   04662 B cell receptor signaling pathway
    129652971 (AKT3)
   04664 Fc epsilon RI signaling pathway
    129652971 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    129652971 (AKT3)
   04062 Chemokine signaling pathway
    129652971 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129652971 (AKT3)
   04922 Glucagon signaling pathway
    129652971 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    129652971 (AKT3)
   04920 Adipocytokine signaling pathway
    129652971 (AKT3)
   04929 GnRH secretion
    129652971 (AKT3)
   04915 Estrogen signaling pathway
    129652971 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    129652971 (AKT3)
   04917 Prolactin signaling pathway
    129652971 (AKT3)
   04926 Relaxin signaling pathway
    129652971 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    129652971 (AKT3)
   04919 Thyroid hormone signaling pathway
    129652971 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    129652971 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129652971 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    129652971 (AKT3)
   04728 Dopaminergic synapse
    129652971 (AKT3)
   04722 Neurotrophin signaling pathway
    129652971 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    129652971 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    129652971 (AKT3)
   04213 Longevity regulating pathway - multiple species
    129652971 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129652971 (AKT3)
   05205 Proteoglycans in cancer
    129652971 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    129652971 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    129652971 (AKT3)
   05230 Central carbon metabolism in cancer
    129652971 (AKT3)
   05231 Choline metabolism in cancer
    129652971 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129652971 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129652971 (AKT3)
   05212 Pancreatic cancer
    129652971 (AKT3)
   05225 Hepatocellular carcinoma
    129652971 (AKT3)
   05226 Gastric cancer
    129652971 (AKT3)
   05214 Glioma
    129652971 (AKT3)
   05221 Acute myeloid leukemia
    129652971 (AKT3)
   05220 Chronic myeloid leukemia
    129652971 (AKT3)
   05218 Melanoma
    129652971 (AKT3)
   05211 Renal cell carcinoma
    129652971 (AKT3)
   05215 Prostate cancer
    129652971 (AKT3)
   05213 Endometrial cancer
    129652971 (AKT3)
   05224 Breast cancer
    129652971 (AKT3)
   05222 Small cell lung cancer
    129652971 (AKT3)
   05223 Non-small cell lung cancer
    129652971 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129652971 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    129652971 (AKT3)
   05161 Hepatitis B
    129652971 (AKT3)
   05160 Hepatitis C
    129652971 (AKT3)
   05164 Influenza A
    129652971 (AKT3)
   05162 Measles
    129652971 (AKT3)
   05168 Herpes simplex virus 1 infection
    129652971 (AKT3)
   05163 Human cytomegalovirus infection
    129652971 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129652971 (AKT3)
   05169 Epstein-Barr virus infection
    129652971 (AKT3)
   05165 Human papillomavirus infection
    129652971 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129652971 (AKT3)
   05135 Yersinia infection
    129652971 (AKT3)
   05152 Tuberculosis
    129652971 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    129652971 (AKT3)
   05142 Chagas disease
    129652971 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129652971 (AKT3)
   05017 Spinocerebellar ataxia
    129652971 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129652971 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    129652971 (AKT3)
   05415 Diabetic cardiomyopathy
    129652971 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    129652971 (AKT3)
   04932 Non-alcoholic fatty liver disease
    129652971 (AKT3)
   04931 Insulin resistance
    129652971 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129652971 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129652971 (AKT3)
   01524 Platinum drug resistance
    129652971 (AKT3)
   01522 Endocrine resistance
    129652971 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bke01001]
    129652971 (AKT3)
Enzymes [BR:bke01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     129652971 (AKT3)
Protein kinases [BR:bke01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   129652971 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like PH_20 ABC1
Other DBs
NCBI-GeneID: 129652971
NCBI-ProteinID: XP_055438128
LinkDB
Position
5:87978786..88262821
AA seq 496 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKMKM
CVKILVCLAEGLPRWLSGKESACQCRRCRRRGFELWVGKILWRKKWWSMPVFLPGKSHDQ
GSLAGYSPGGHRVRQD
NT seq 1491 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag
aaaccccaagatgtggatttaccttatcccctcaacaacttttcagtagcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc
actgttatagagagaacatttcacgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacaggctccagaggcaagaagaagagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcttctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatattatgctatgaagattctgaag
aaagaagttattattgccaaggatgaagtggcgcatactttaactgaaagcagagtatta
aagaacactagacatccctttttaacatccctgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatttgatgctggat
aaagatggccacataaaaatcacagattttggactttgcaaagaagggatcactgatgca
gccaccatgaagactttctgtggtacaccggagtatctggcaccagaggtgttagaagat
aatgactatggccgagctgtggattggtggggccttggggttgtcatgtatgaaatgatg
tgcgggagattacctttctataaccaggatcatgagaaactttttgaactaattctaatg
gaagatattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcaggcctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttttctggagtaaactggcaagatgtgtatgataaaaagatgaagatg
tgtgtgaagatattggtatgtttagcggaagggcttccgcgatggctcagtggtaaagaa
tccgcctgccaatgcagaagatgcaggagacgcgggtttgagctctgggttgggaagatc
ctctggaggaagaaatggtggtccatgccagtattcttgcctggaaaatcccatgaccag
gggagcctggcaggctacagtccagggggccacagagttagacaggactag

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