Bombyx mandarina (wild silkworm): 114250644 Help Entry 114250644         CDS       T05882                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism bman  Bombyx mandarina (wild silkworm) Brite KEGG Orthology (KO) [BR:bman00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bman04040]     114250644    04990 Domain-containing proteins not elsewhere classified [BR:bman04990]     114250644 Ion channels [BR:bman04040]  Voltage-gated cation channels   Ryanodine receptor    114250644 Domain-containing proteins not elsewhere classified [BR:bman04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    114250644 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  114250644 NCBI-ProteinID:  XP_028040404 UniProt:  A0A6J2KJN8 LinkDB All DBs Position Unknown AA seq 5161 aa AA seqDB search MAEAEGGASEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGSETGKENLGKGTGSGHRTLLYGNAILLRHLNSDMYL ACLSTSSSQDKLAFDVGLQEHSQGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATERY LHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPST WTRDGGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVND QNELHLVSREEATTASCAFCLRQEKDDQKQVLEDKDLEVIGAPIIKYGDSTVIVQHSETG LWLSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTK FINGLETLQENRRHSMFFASVNLGEMVMCLEDLINYFAQPDEDMEHEEKQNKFRALRNRQ DLFQEEGILNLILEAIDKINVITSQGFLAGFLAGDESGQSWEMISGYLYQLLAAIIKGNH TNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLL EKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVSSVRPNIFV GRVEGSAVYRKWYFEVTMDHIEKTTHMMPHLRIGWANTSGYVPYPGGGEKWGGNGVGDDL YSFGFDGAYLWSGGRKTPVNRTHHEEPYIRKGDVIGCALDLNVPLINFMFNGVRVTGSFT NFNLEGMFFPAISCSSKLSCRFLFGGEHGRLRYAAPEGYSPLVESLLPQQILSLEPCFYF GNLNKRALAGPSLVQDDTAFVPTPVDTMTISLPTYVEQIRDKLAENIHEMWAMNKIEAGW MYGDQRDDIHKIHPCLVPFERLPPAEKRYDIQLAVQTLKTILALGYYITLDKPPARIRNV RLPNEPFLQSNGYKPAPLDLGAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNED PEMHRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASKQK QADFRTYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAHADMAPGMMLGQDENSWAFDGYN EEKVYSSSTEAFGKQWAVGDVVGVFLDLIDKTISFSLNGELLMDALGGETTFADVQGDNF VPACTLGVGQKARLTYGQDVNTLKYFTTCGLQEGYEPFCVNMKRDVTHWYTKDQPIYENT DEMADTRIDVTRIPAGSETPPCLKISHNTFETMEKANWEFLRLSLPVICHSQFIDESEKA RRWVEIKERQQILMKEATEAQMPAHIDQIMRSGFTMNDIKGLHYEDNQEEIQSSKVKRQP SRPPRKGSVTRGVTIQNYNSPSGQQVNGIHRSTSEAEMAKYELGAQTLAPDEKKDKRGRS PFKFFKSKRAESSDRAKIRKSKTPDPFSDTELSPDRGTKRPNPQIKVSQPNQRYNNGTQP RASRPNLYGSQSGLNMATPTQERKQLMTTTNLSAAATETVGNEIFDSECLKLINEYFYGV RIFPGQDPTHVYIGWVTTQYHLHSKDFNQNKVMKSSVIITDDYDRVIESVNRQSCYMVRA DELYNEVMAEATAKGASQGMFIGCSVDTSTGTVAFTCEGKSTSIKFKMEPETKLFPAIFV EATSKEILQIELGRSPTSLPLSAAVLPTSDKHVTPQFPPRLKVQCLKPHQWARVPNSSLQ VHALKLSDIRGWSMLCEDAVSMLALHIPEEDRCIDILELIEMDKLLSFHSHTLTLYAALC YQSNYRAAHALCQHVDQKQLLYAIKSQYMSGPLRQGFYDLLIALHLESHATTMETCKNEF VIPLGPELKVLYDEPDMGHSLRSLQTESVRPQLEMTDITEKSIMDISNLYSPKFPLEVVR EFVMQALAEAVETNQVHNRDPVGGSNENLFLPLIKLVDRLLLVGKMRDEDVEKLLIMINP ETWDPTFNKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDMQLRHRVESIVAFAHDFVG DLQSDQLRRYTEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKHLEDIDKENCPCGEE LIARMNGFHESLMVHVSLNALQEPDPEEPTEPEIKPGAINKLYSLINTVKELEEEPKTLE EPTKKTPEERFRKVLIQTIVNWAEESQIETPKLVREMFSLLVRQYDAVGELIRALEKTYV INAKTKQDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRV HENVMAVMMNTLGRRAQAQSDAAPNQPLAEDTKEKDTSHEMVVACCRFLCYFCRTGRQNQ KAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSR CGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECL GPALRGEGEGLLKAIVDANKMSERIADRRKLREIEQEGDINIGLSGHREKRFSHPLPESD DDEDYIDTGAAILNFYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLEDLQGVL SLRFTLNNPAAGEERPKSDMPSGLIPGHKQSVGLFLERVYGIETQELFYKLLEEAFLPDL RAATMLDRNDGCESDMALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLS KNRMLTKGQREAVSDFLVALTSAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYER CAKYYGSTGGQGIYGASSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCAL PPDYSLSKNYDDEFYGKEQAAVGSDNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAW ASRKIENGWVYGESWSDSQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLALGWSVEHS DVDLPANSRGSVRRQSKSGLRSSELPTDSATPFNYNPHPVDMTNLTLSREMQNMAERLAD NAHDIWAKKKKEELVTNGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRP SKITQSDTEQTSAGVAIELRFAYSLLEKLIQYIDRATINMKLLKPSTTFSRRSSFKTSTR DIKFFSKVVLPLMEKYFSTHRNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRL AAFGPDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNMADDVGHTIINLQDGK YAHLRGTHLKTSTSLGYINGVQLPVLTAMFDHLANCEYGSDLLLDEIQVASYKMLGSLYT LGTDVTLTHDRKYLKTEIERHKPALGSCLGAFSSTFPVAYLEPHLNKHNQFSLLNRIAEH SLEAQDIMAKMEQSMPTLETILNEVDQFVESDKTYNEAPHIIDVVLPLLCSYLPFWWAQG PDNVTPTGGNHVTMVTAEHMNQLLKNVLKLIKKNIGNESAPWMTRIATYTQQIIINSSEE LLRDSFLPLAERVRKRTDNMFHKEESLRGFIKSSTDDTSQVESQIQEDWQLLVRDIYSFY PLLIKYVDLQRNHWLRNNVPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVL IMPTATRRVTAVVDGTSQSGGKVRKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLF AGREQELVQHCKDRFLKKMSEHDVAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKT AITLENAENKAKIIDDTVERIVAMSKVLFGLHMIDHPQQMSKNVYRSVVSIQRKRAVIAC FRQTSLHSLPRHRACNIFARTYYELWLEEENIGQEVMIEDLTQSFEDAELKKSDVVEEDG KPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYAHIIAKSCGEEEEEGGGEEEEGGGEAE GEEEGRASIHKTVEMFMEQEMEKQKLLFHQARLANRGVAEMVLLHISASKGVPSEMVMKT LQLGISILRGGNIDIQMGMLNHLKDKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLG VGLEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYL LRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCTQNQQALAHS RLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQ MVDTLVESASNVELILKYFDMFLKLKDLTSSASFQEIDANNDGWVLPKDFKEKMEQQKSY TPEEIEFLLACCETNHDGKLDYVGFCDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARF LETAGSVLNYFEPFLGRIEIMGGSKRIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVT EGGDKEKLEAFVNFCEDAIFEMTHASGLMAASDDTAGGPKNREASYMYMGDDDDDRAGKD PFRRGIQSVKDGISTAFSSLSPSNIKAKIADLQQMPPAELAVGFFKMFFYMFYYLGYGVL VVVSHWYIFGVLLGLMRGPQVEEPPPEPTEEEKIGQLRHRLLANQSPRHLPALPPADDTG QMQVSAFGLDITKEDNGQIQVKPHESPTTSTPSSGEEADASPDEGLEHSEEQRPPSLIDL LGGEQAKKQALERIEAQAAQQAAMSAIEAESKKRGFQDLYFKKAVQGPASSSALSQVDLS QYTRRAVSFLARNFYNLKYVALVLAFCINFVLLFYKVSTLDGEKAEGSGIGDIIAGSGSG QGSGSGDGSGEEDDALEVVHIDEDFFYMEHVIKVAAVLHSIVSLAILIGYYHLKVPLAIF KREKEIARKLEFDGLYIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRAKYSET YDFDSISNMLGMEKTSFSAQEDEGSKGLLHYIINIDWRYQVWKAGVTITDNSFLYSLWYF AFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAF NFFRKFYVQEEDDEVNRNCHDMLTCFVFNLYKGVRAGGGIGDELEPPDGDDSEVYRIIFD ISFFFFIIVILLAILQGLIIDAFGELRDQLESVKEDMESNCFICGINKDYFDKVPHGFDT HVQREHNLANYMFFLMHLINKPDTEYTGQETYVWNMYTQRCWDFFPVGDCFRKQYEDLMG E NT seq 15486 nt NT seq  +upstreamnt  +downstreamnt atggcggaagctgagggcggggcgagcgagcaagatgacgtttccttcttacgaacggaa gacatggtgtgcctctcgtgtaccgctaccggggaacgcgtgtgcctcgcagctgaaggc tttgggaaccggcactgcttcctggagaacatcgcggacaagaacataccacccgatctg tcgcaatgcgtcttcgtcatagaacaggcgttatcagtgagagctctccaagaattggtg acggcggccggatcggaaaccggcaaagagaatttaggcaagggaactggatccggtcac aggacactgctttacggaaacgcgatccttttgagacatctcaacagtgatatgtacttg gcgtgtctgtcgacatcatcatcgcaagacaaactggctttcgacgttggtctccaagag cactcccagggtgaagcgtgctggtggacattgcatccggccagtaagcaaagatcggag ggtgaaaaagtgcgagtgggagatgatttgattcttgtatctgttgccactgagagatat ttgcacacaactaaagagaatgaagtatcgatcgtcaatgcctcgttccacgtgacacac tggtcggtccagccatacggaaccggcatctcgaggatgaaatacgtcggctacgtcttc ggaggagacgttctacgtttcttccacggaggagacgaatgccttacaatacctagcact tggactcgggatggaggacagaatattgtagtatacgaaggcggatcggtcatgtcacaa gctcgttcgctatggcgtttggaactagctcgtaccaaatgggccggaggctttatcaac tggtaccatccaatgaggattcggcacatcactacgggtcgatacttgggtgttaatgac cagaatgaactccatttggtcagcagagaggaagctacaaccgcttcctgcgccttttgt cttcgtcaagaaaaagatgatcagaaacaagtgcttgaagataaagatttggaagtaatc ggagcaccaattattaaatacggtgactccaccgtaatcgtgcagcattcggaaactggc ttgtggctttcatataagtcttacgaaacaaagaagaaaggcgtcggtaaagtagaagag aaacaagccatactacacgaagaaggtaaaatggacgacggccttgatttctccaggtct caagaagaagagtcgaggacggccagagtcatcaggaagtgttcttctttattcactaag tttatcaatggccttgaaactcttcaagaaaacagaaggcactcgatgttcttcgcgtcc gtaaacttaggagagatggtgatgtgcttggaggatctgataaactatttcgcacagccc gatgaggacatggaacatgaagaaaaacaaaacaagtttcgtgctcttcgaaaccgccaa gatcttttccaagaggagggtatcctgaatttaatcctggaagcaatcgacaagatcaac gtgatcacgtcccagggattcctggctgggttcctagctggagacgaatcgggacagagc tgggaaatgatctctggatacctttatcagcttttagctgctattataaaaggaaaccac acgaactgcgcacagttcgcaaactccaaccgtctgaactggttgttctctagactcggc tcacaggcatctggcgaaggaactgggatgctggacgtgttgcattgcgtgctcatagac tcgcctgaagccttgaatatgatgagggatgagcacataaaagtaatcataagcttatta gaaaagcacggtcgtgacccgaaagttctcgacgtgctgtgctcgctgtgcgtcggcaac ggagtggccgtgcgctcgtcccagaacaacatctgcgactacttgctgccagggaagaac ttgctactgcagactcagctagtagaccacgtttccagtgtgcgaccgaacattttcgtg ggccgcgtcgaaggatcagcagtgtatcgtaaatggtacttcgaagtgacgatggaccac atcgagaaaaccacgcacatgatgccccatctgcgcataggatgggctaacacttctgga tacgtaccatatcctggtggcggtgaaaagtggggtggtaacggtgtcggtgacgatttg tattcctttggtttcgatggtgcatatttgtggtctggtggtaggaaaaccccggttaat cgcactcaccacgaagagccttatatcagaaaaggcgatgtgattggatgcgcgctggac ttgaacgttcctttaatcaacttcatgttcaacggcgtcagggtgaccggatctttcacc aacttcaacttggaaggcatgttcttccccgccatcagctgctcaagtaaattaagttgt cggtttctattcggcggcgaacatggccgtctacgttacgcggctcccgagggatactct ccgctggttgagtcgctgcttccgcaacagatcctcagtctcgaaccctgcttctatttt ggtaacctcaacaaaagggctctagctggaccatctctagttcaagatgataccgcattt gtgcctacaccggttgatacgatgacgatatctctgccaacatacgtggaacaaatcagg gataaactagccgaaaatattcacgaaatgtgggctatgaataagattgaagccggctgg atgtacggtgatcagcgcgacgacatacataagatacatccttgcttggtgcccttcgaa cgactaccacccgctgagaagagatacgatatccaactagctgtgcaaacactgaaaaca attcttgcgcttggctactacattactttggataagccaccagcacgtatccgcaacgtc cgacttccaaacgaaccatttttgcagtcaaacggctataaaccagcacctttagacctt ggtgctgttactctgacacccaaaatggatgaactggtggaccaattagctgagaatact cacaacctttgggccagggaaagaatacagcaaggttggacttatggtctcaatgaggat ccggagatgcatcgctcccctcacttagtgccgtatcctaaagttgatgatgccatcaaa aaagccaaccgagacaccgcgtctgaaactgtccgaactttattggtttacggatataat ctggatccgcctaccggagaacagcatgaagctttgttagcggaggcttctaagcagaaa caagctgatttcagaacgtatagggcagaaaagaactatgccgttagttctgggaaatgg tatttcgaattcgaaatattaacggctggaccgatgagggttggttgggctcatgctgac atggctccgggcatgatgttgggacaagacgagaattcttgggcgttcgacggatacaac gaggaaaaggtatactccagtagcacagaagccttcggcaagcaatgggcagtcggtgat gtggttggcgtgttccttgatctcatcgataagacgataagtttctctcttaacggagaa cttctgatggatgcccttggcggggagacgacattcgcagatgtccaaggcgataatttc gtgccggcttgcacgcttggggtcgggcagaaggccaggttgacttacggacaagatgtt aacactctaaaatacttcacgacctgcggtcttcaagagggatacgaaccattctgtgtc aacatgaaaagagatgtcactcattggtacacaaaagaccagcccatctatgaaaacaca gatgaaatggccgacacaagaatcgatgtaaccaggataccagctggatcagagactcca ccatgtctgaaaatatctcacaacacattcgaaacgatggaaaaagccaactgggagttt ctgcgtctgtctttaccggtcatttgtcattcgcagtttatagatgaatcagagaaagca cgacgctgggtagagattaaggaacgtcagcagatcctcatgaaagaagctaccgaagct cagatgccagctcacatcgaccaaatcatgaggagtggatttactatgaatgacataaaa ggtctacactacgaagacaatcaagaagagatccagagctccaaagtgaaacgacagccc tccagaccaccacgtaagggttcagtcacacgcggtgtcacgatacagaattacaattca ccatcaggacaacaagtaaatggaattcatcggtccaccagtgaagcagaaatggcgaaa tatgaattaggcgctcaaactttagcgccagatgagaagaaagacaaaagaggacgttct cctttcaaatttttcaagagcaaacgtgccgagagcagtgatcgcgccaaaatccgcaag tccaaaacaccagatcccttcagtgacaccgaactgtctcctgacaggggaacgaagaga cccaaccctcagatcaaggtgtctcagccgaaccaaaggtataataatggcacgcagccc cgagcaagcagacccaacttgtatggaagtcaaagcggtcttaacatggcgactccaact caagagagaaagcagttaatgacaaccacgaatctgtcggccgctgcgacggagaccgtc ggcaacgagatattcgactccgagtgcttaaagctcattaatgaatacttctacggggtc agaatattccctggccaagacccaactcacgtgtacattgggtgggtgaccactcagtac cacttgcactcgaaagacttcaaccaaaacaaggtgatgaagtcatcagtcatcatcacc gacgactacgatcgggtcattgaaagcgtaaaccgtcagtcctgctacatggtgcgagct gatgagctttacaacgaagtgatggcggaagctacggccaagggcgcgtcccaaggaatg tttattggatgttcagtggacacttccaccgggactgtagcgttcacatgcgaggggaaa agcactagcattaaatttaagatggagccagagaccaaattattcccggcgatcttcgtc gaagcgacatcgaaagagatcctccagatagagctgggcaggtctccgacaagtctgccg ctaagtgccgcggtgctaccaacgagcgacaagcacgtcacgccgcagttcccgcccagg ctgaaagtgcagtgtctcaaaccgcatcaatgggctagagtaccaaattcatcattgcaa gtgcacgccctaaagctgtctgacatacgaggctggtcgatgctgtgcgaagacgcagtt tctatgctcgcattgcacataccagaggaagaccggtgcatcgacatattggagcttatc gaaatggataagctgttgagcttccactcgcacaccctcacgttatatgcagctttatgc taccaaagcaactacagggctgcccacgctttatgccagcatgtagatcaaaagcaattg ttatacgccatcaagtcccagtacatgtccgggccactgcgccagggtttctacgatcta ctcattgctctacatttagaatcgcacgcaaccacgatggaaacctgcaagaatgaattc gtcatacccctggggccggagctgaaggttctgtacgacgagcccgacatggggcacagc ctccgctcgctgcagacggagagcgtcagaccgcaattggaaatgaccgatatcacggaa aaaagtataatggacataagtaatctgtactctccgaagttcccactggaagttgtccgt gaattcgtgatgcaggcactcgcggaggccgtggaaactaaccaggtccacaacagagat ccggtcggtggaagcaacgagaatctcttcctgccgctaattaagctcgtggaccgtcta ctcctggtcggaaaaatgcgcgacgaagacgttgagaaacttctcatcatgatcaacccc gagacctgggatccaacgttcaataaagaaggcaaagacgaacaccgaaaaggacttctt cacatgaaaatggctgaaggcgctaaactgcaaatgtgttatttgctccaacatctgaac gatatgcagctacgtcacagggttgaatctatagtggcttttgcacatgactttgttggg gacctgcagtccgaccaattgagacgctacactgagatcaagcaatcagatttaccgagt gcggtcgcagccaagaagaccagagaattccgttgtcctcccagggaacagatgaacgca atcctgagtttcaaacacctcgaagatatcgataaggagaactgtccttgtggcgaagaa cttatcgctaggatgaacggcttccacgaaagtctcatggtacatgtatctctgaacgcc ctgcaggaacccgatcctgaggagcccactgaaccagaaataaagccgggggccattaat aaattatatagccttataaataccgtcaaggaactagaagaggaacccaagacattagag gaaccaaccaagaagactccagaggaacgtttccggaaagtacttatccagacgatcgtg aattgggcggaggaatcgcagattgagactccgaagttagtcagggagatgtttagccta ctggttcgccagtatgacgccgtaggagaactgatccgagctctcgaaaagacttacgtc atcaatgcgaagaccaagcaggacgtggccgagatgtgggtgggactcagtcagatcaga gccctgctcccggtgcaaatgagtcaagaagaggaggaactcatgaggaaaaggctttgg aaactggtcaacaaccacacgttcttccagcatccagatctgataagagtattgagggta cacgaaaacgtcatggctgtaatgatgaatactttgggaagaagagcccaagcgcagtct gatgctgcaccgaaccagccgcttgccgaggataccaaggagaaggacacttcgcatgaa atggttgtggcctgttgtcgattcctctgctacttctgtcgcaccggtcgccagaatcaa aaagccatgttcgatcactttgactttttgctggagaactccaatattctactgtcgaga ccttcgttgcgaggttcgactcctttggatgttgcctactccagtttgatggagaacacg gaattggctctggcattgagggagcactatcttgagaaaatagcggtatatctttctcgt tgtgggctacagagcaactctgagttagtggaaaaagggtatccagaccttggatgggat ccggtagaaggcgagagatatttggacttcctgaggttttgtgtttgggtaaatggtgaa agcgtagaagaaaacgccaacttagtgatccggttactgatcaggcggccggagtgtctt ggcccggcacttcggggagaaggcgaaggtctactgaaagctattgtggacgcaaacaag atgagcgagaggatcgcagatagaagaaaactaagagaaatagaacaggaaggggatatt aatatagggctatcaggtcaccgagagaagagattcagccatccactcccggagtcggac gacgacgaggattacatcgatactggagcggccatacttaacttctactgcaccctggtc gatctactggggcgctgtgctccggatgcggcagtaattgctcttggtaagaacgagtcg cttcgggctcgtgccattctgcgctccttggtaccgctggaagatcttcaaggagtgctc agtcttcggttcaccctcaacaatcccgctgctggtgaagaaagacccaagtccgacatg ccatcgggactaatcccgggacacaagcagagcgtcggactgttcttagaacgagtctac ggcatcgagacgcaagagcttttctacaagcttctcgaagaagctttcttgccggacttg agagctgcgactatgctagacaggaacgacggctgcgaatcagatatggcgctgtcaatg aaccggtacatcgggaactcgatccttccgctgctgatcaaacacgccaacttctacaac gaagccgagaactacgccagtctgctggacgccacgctgcacacagtgtacagattatcc aaaaaccgcatgctgacaaaaggccaacgtgaggctgtctccgacttcttggtggctctg acgtcagcgatgcagccctccatgctgttgaagctgctgaggaagctcacggttgacgtc tcgagactgtccgagtacaccaccgtggctctcagactcctgacgctgcactacgaacgt tgcgccaaatactacggtagcactggtgggcagggaatatacggagcatcttctgatgag gagaagcgtctaaccatgatgctcttctctaacatcttcgattcgctcagcaagatggac tacgaacccgagctgtttgggaaagctttaccctgtctcatcgctataggctgtgctcta ccaccagactactctctatcaaagaattacgacgatgaattctatgggaaggagcaagcc gcagtaggctccgacaacccgcagtacgatccccagccgatcaacacctcatcagtcgcc ctgaacaacgacttgaacacgatcgtgcagaagttctccgagcattaccacgacgcctgg gcctccaggaaaatcgagaacggctgggtgtacggcgagtcttggtcagacagccagaag acgcatccgcgactgaagccttacaacatgctcaatgactatgagaaagagcggtacaaa gaaccggtccgcgagtcgctgaaggcactcctggctctgggctggtccgtggagcattcc gacgtagacctgcccgccaacagccgcggctctgtgcggagacagtccaagtccggactg cgttcgtctgaattaccgactgactcagcaactcctttcaactacaaccctcaccccgtg gacatgacgaatctgacgctgtccagagaaatgcagaacatggccgagagactggccgac aacgcacatgacatctgggctaagaaaaaaaaagaagaactagttactaatggaggcgga atccatcctcaactagttccttacgatctcctaactgataaagaaaagaagaaagaccga gaacgctcacaggagttcctcaagtacctccaatatcaaggctacaagctgcacaggcca agcaaaatcacacagagcgacacagaacagacctctgccggagtggcaatagagctgaga ttcgcttactcgttgctagaaaagttgatccagtacatagacagggctacaatcaacatg aaacttctgaagccatcgacgacgttcagtcgtagaagcagcttcaagacaagcaccaga gatataaagttcttctcgaaagtggttctccctctaatggagaagtacttctcgacccat cgcaactacttcatagcggttgcgactgccaccaataatgtgggagccgcgagccttaaa gagaaagaaatggtcgccgctttgttctgtaagctggcgagcctgcttcgatccagacta gcagcttttggccccgacgtccgcatcaccgttcgctgtctccaagtcctcgtcaagggc atcgacgctaaatctctggtcaaaaactgcccggaattcattcggacttcaatgctgacc ttcttcaacaacatggccgacgatgttgggcacaccatcatcaatttgcaggatggcaag tacgcgcacctccgcggtacccatttgaaaacgtctacctctcttggatacattaacgga gtccaattgccggttctgactgctatgttcgatcacctagcgaactgcgaatacggatca gatctgcttttggacgaaattcaagtcgcgtcatacaagatgctcgggtcactctacacg ttgggcactgatgtaacgctgacccacgaccgcaagtacttgaagacggaaattgaaaga cacaagcctgctttgggttcgtgtctgggcgctttcagctcgaccttccccgtggcatat ctggagccgcatctcaacaaacacaaccagttttctctgcttaacaggatcgctgagcat tcgctcgaggcccaagacataatggcgaaaatggagcaatctatgccgactctagaaacg attttgaacgaagtggaccaattcgttgaatcagacaagacgtacaacgaagcgccgcac attatcgacgtggtcctgccattactgtgctcttacctgccgttctggtgggcgcaggga cccgacaacgtcacccctactggagggaaccacgttaccatggtaacggcggaacacatg aaccaactcctcaagaacgtgctcaaactaattaagaagaacatcggcaatgagagcgct ccgtggatgacgaggatcgcgacgtacacccagcagatcataatcaacagctccgaagag ttgctcagggattccttcctgcctctcgccgagagagtcaggaaacgaacagacaatatg ttccacaaggaagagagcttgaggggcttcataaagtcctcgaccgacgacacttcgcaa gtagaatctcagatacaagaagactggcagttgctggtgcgagacatctactccttctac ccgcttctcatcaagtatgtggacttgcagaggaatcactggttgaggaataatgttcca gaggccgaggagctttacaaccacgtggccgaaatcttcaacatctggtcgaagagtcaa tacttcttgaaggaagaacaaaactttatatcggcaaacgaaatcgataatatggtctta ataatgccaacagccacacgccgagtcacggccgtggtcgacggcacgtcgcaaagtggt gggaaggtgcgaaaaaagaagaagcatcgcgacaagaaacgcgacaaggacaaggaagtt caggcgtctctgatggtcgcctgtctgaagcggctgctaccggtaggactgaatctcttc gctggaagggaacaggaactggtacagcactgcaaggataggttcctgaagaaaatgtcc gagcatgacgttgccgaattcgcgaagactcagctgacgctaccggacaaaatagacccg gccgacgagatgtcgtggcaacactacctctacagcaaattggggtctaaaagcaaaact gccatcactctggagaatgccgagaacaaagcgaaaatcatcgacgacaccgttgagagg atcgtcgcgatgagcaaagtgctcttcggattgcatatgatcgaccatccgcaacaaatg agcaagaacgtttatcgatcagtggtctccatacaaaggaagagggccgtcatagcgtgt ttcagacagacgtccctacattcgctgccgagacatcgtgcttgtaacatcttcgcgagg acttattacgagctgtggctggaggaagaaaacatcggacaagaagtcatgattgaggat ttgacgcaatcgttcgaggatgctgaactcaagaagagtgatgtggtagaggaggacggg aagcctgatccactgacccagctggtcacgaccttctgcaggggagctatgacggaacgg tccggagccttgcaggaagatccactgtacatgtcgtacgcgcatatcattgcgaagtca tgcggagaagaggaggaggaagggggcggagaggaagaggagggaggaggagaagcggaa ggggaagaggaaggtcgggccagtatacacaaaactgtggaaatgtttatggagcaagaa atggagaagcagaagctactcttccaccaggcgaggctcgccaacaggggggtcgcggag atggtgctcctgcacatctctgcatccaagggggtgcctagtgaaatggtcatgaagacc ctacagctcggcatatcgatactgcgcggcggaaacattgacatacaaatgggaatgctg aaccatttgaaagacaagaaagacgtgggcttcttcacgtccatagctgggctcatgaac tcttgctctgtgttggatttggacgccttcgaaaggaacactaaggctgaaggtctcggg gtggggctggagggagccgccggcgaaaagaatatgcacgacgcagagttcacgtgcgcc ctcttcagattcatccagctgacttgcgaagggcacaacttggattggcagaactatctc cggacccaggccgggaatacgaccaccgtgaacgtcgtgatctgcactgtggactacctg ctacgtctccaggagtccatcatggacttctactggcactattcgagcaaggaactaatc gacccggccggtaaagcgaacttcttcaaggcgatcggcgtcgcttcgcaagtcttcaac acgctcactgaagtcatccagggtccttgtactcagaaccagcaagccttggcccactct agactgtgggacgctgtgggagggtttctcttcctgttctcgcacatgcaggacaagctg tcgaagcactcgtcacaagtggacctgctgaaggagctgctcaatctgcagaaggacatg atcaccatgatgctgtccatgctcgaaggaaacgtcgtcaatggtaccatcggtaagcag atggtggacacattagtagagtctgcttcaaacgtggaactgatcctcaagtacttcgac atgttcctgaagctgaaggacttgacctctagcgccagtttccaagaaatcgacgccaat aacgacggctgggtcctgccgaaagatttcaaagagaagatggaacagcagaagagttac acgcccgaagagatagagttcttactcgcttgctgcgagacgaaccacgacggtaaactt gactacgtgggcttctgcgaccgtttccacgaaccggccaaagaaatcggcttcaacctt gccgtactgctgaccaacctctcggagcacatgcccaacgaaccaagattggcccgtttt ctggagacagccggttcggtgctgaactacttcgagccattcctcggccgcatcgagatc atgggcggatcgaagcgcatcgaacgagtctactttgagatcaaggaatctaatattgaa cagtgggagaagccgcagatcaaggaatcgaagcgcgcgtttttctacagcatcgtaacc gaaggcggcgacaaggagaagctggaagcgttcgtaaacttctgcgaggacgccatcttt gagatgacccacgcgtcgggtctgatggccgcttcggacgacaccgccggcggacctaag aacagggaggccagctacatgtacatgggagacgacgatgatgatcgtgccggcaaggat ccgttccgtcgcggcatccaatcagtgaaagacggcatctccacggctttctcgtcttta tcgccgtcgaacataaaggcgaaaattgcagatctacagcaaatgccaccggcagaattg gccgtcggcttcttcaaaatgttcttctatatgttctactacttgggctatggagtgctg gtcgttgtcagtcattggtacatattcggagtgctccttggactaatgcggggcccgcag gtggaggagccaccaccagagccaactgaagaggagaaaatcggtcagttaagacacagg ttgctcgcgaatcaaagtccgagacatctgccagctttaccgccggctgatgacactgga cagatgcaagtctcggccttcggtttggacataactaaagaagacaacgggcagatccag gtgaagccgcacgagtctcctactacatcgacgccgtcttcaggtgaagaggctgacgcg tctccggacgagggactggaacactccgaggagcaacgaccaccgtcactgattgactta ctaggcggggaacaggcaaagaaacaagctctagagcgcattgaggctcaggccgcgcaa caggccgccatgtcggcgatcgaggccgagagcaagaagcgaggatttcaagatttatat ttcaaaaaggccgtccagggtcctgcttcatcgtcagctctgtcccaagtggatctgtcg cagtacacacggcgggccgtttcgtttttggccagaaacttctacaacttgaaatacgtg gccctcgtgctggctttttgcatcaacttcgtgcttttgttttataaggtttcgacccta gatggtgaaaaagccgaaggttcgggcatcggagacatcattgcgggctctggttctggg caaggctcgggcagcggcgacggaagcggcgaagaagacgacgcattagaagtggtacat atcgacgaagacttcttctatatggagcacgtcatcaaagtggcagcggtcctgcattcc atcgtgtccctggctatactgatcgggtattatcatttgaaggtgccgcttgcgatcttc aaacgcgagaaagaaatagctcgtaaactggagtttgacggcctgtatatcgccgagcaa cccgaagatgatgacttcaaaagtcattgggataaactcgtcatatctgctaagtccttc cctgtgaactattgggacaaattcgtgaagaagaaagtacgagctaagtactctgagacc tacgacttcgattcgatatcgaatatgctcgggatggagaagacttcgttctcagctcaa gaagacgaaggcagcaaggggttgctccactacattataaacatcgactggcgttaccaa gtgtggaaggccggcgtcacgataacggacaactccttcttgtactcgctgtggtatttc gctttctcggtcatgggaaacttcaataatttcttcttcgcggcccatctactggacgtc gccgtcggcttcaagactctaaggacgattcttcaatcagttacacataacgggaaacag ctcgtcctaacagtgatgttgcttacgatcatcgtgtacatatacactgtgatcgctttc aatttcttccgcaagttctacgtccaggaggaagatgacgaggtcaaccggaactgtcat gacatgctgacgtgcttcgtgttcaacctgtacaagggagtgcgcgccggcggtggcatc ggggacgagctggagccgcccgacggagacgactccgaggtctacaggatcatattcgac atatccttcttcttcttcatcatcgtcattctgctggccattctgcagggtttgatcatc gatgccttcggtgagctccgtgaccagctcgagtccgtgaaggaggacatggagtccaac tgctttatatgcggcatcaataaagactactttgataaggttccacacgggttcgatacg cacgtgcagcgagaacataatttagcaaattacatgttcttccttatgcatctcatcaac aaaccagacacggaatacaccggtcaagaaacatacgtatggaacatgtacacgcagcgt tgctgggacttcttcccggtcggtgactgcttcaggaagcaatacgaagatcttatggga gaataa

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