KEGG   Balaenoptera musculus (blue whale): 118891063
Entry
118891063         CDS       T09887                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
bmus  Balaenoptera musculus (blue whale)
Pathway
bmus01521  EGFR tyrosine kinase inhibitor resistance
bmus01522  Endocrine resistance
bmus04010  MAPK signaling pathway
bmus04012  ErbB signaling pathway
bmus04014  Ras signaling pathway
bmus04015  Rap1 signaling pathway
bmus04022  cGMP-PKG signaling pathway
bmus04024  cAMP signaling pathway
bmus04062  Chemokine signaling pathway
bmus04066  HIF-1 signaling pathway
bmus04068  FoxO signaling pathway
bmus04071  Sphingolipid signaling pathway
bmus04072  Phospholipase D signaling pathway
bmus04114  Oocyte meiosis
bmus04140  Autophagy - animal
bmus04148  Efferocytosis
bmus04150  mTOR signaling pathway
bmus04151  PI3K-Akt signaling pathway
bmus04210  Apoptosis
bmus04218  Cellular senescence
bmus04270  Vascular smooth muscle contraction
bmus04370  VEGF signaling pathway
bmus04371  Apelin signaling pathway
bmus04380  Osteoclast differentiation
bmus04510  Focal adhesion
bmus04540  Gap junction
bmus04550  Signaling pathways regulating pluripotency of stem cells
bmus04613  Neutrophil extracellular trap formation
bmus04620  Toll-like receptor signaling pathway
bmus04650  Natural killer cell mediated cytotoxicity
bmus04660  T cell receptor signaling pathway
bmus04662  B cell receptor signaling pathway
bmus04664  Fc epsilon RI signaling pathway
bmus04666  Fc gamma R-mediated phagocytosis
bmus04668  TNF signaling pathway
bmus04720  Long-term potentiation
bmus04722  Neurotrophin signaling pathway
bmus04725  Cholinergic synapse
bmus04726  Serotonergic synapse
bmus04730  Long-term depression
bmus04810  Regulation of actin cytoskeleton
bmus04910  Insulin signaling pathway
bmus04912  GnRH signaling pathway
bmus04914  Progesterone-mediated oocyte maturation
bmus04915  Estrogen signaling pathway
bmus04916  Melanogenesis
bmus04917  Prolactin signaling pathway
bmus04919  Thyroid hormone signaling pathway
bmus04921  Oxytocin signaling pathway
bmus04926  Relaxin signaling pathway
bmus04928  Parathyroid hormone synthesis, secretion and action
bmus04929  GnRH secretion
bmus04934  Cushing syndrome
bmus04935  Growth hormone synthesis, secretion and action
bmus05010  Alzheimer disease
bmus05022  Pathways of neurodegeneration - multiple diseases
bmus05034  Alcoholism
bmus05132  Salmonella infection
bmus05135  Yersinia infection
bmus05160  Hepatitis C
bmus05161  Hepatitis B
bmus05163  Human cytomegalovirus infection
bmus05164  Influenza A
bmus05165  Human papillomavirus infection
bmus05166  Human T-cell leukemia virus 1 infection
bmus05167  Kaposi sarcoma-associated herpesvirus infection
bmus05170  Human immunodeficiency virus 1 infection
bmus05200  Pathways in cancer
bmus05205  Proteoglycans in cancer
bmus05206  MicroRNAs in cancer
bmus05207  Chemical carcinogenesis - receptor activation
bmus05208  Chemical carcinogenesis - reactive oxygen species
bmus05210  Colorectal cancer
bmus05211  Renal cell carcinoma
bmus05212  Pancreatic cancer
bmus05213  Endometrial cancer
bmus05214  Glioma
bmus05215  Prostate cancer
bmus05216  Thyroid cancer
bmus05218  Melanoma
bmus05219  Bladder cancer
bmus05220  Chronic myeloid leukemia
bmus05221  Acute myeloid leukemia
bmus05223  Non-small cell lung cancer
bmus05224  Breast cancer
bmus05225  Hepatocellular carcinoma
bmus05226  Gastric cancer
bmus05230  Central carbon metabolism in cancer
bmus05231  Choline metabolism in cancer
bmus05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bmus00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118891063 (MAP2K1)
   04012 ErbB signaling pathway
    118891063 (MAP2K1)
   04014 Ras signaling pathway
    118891063 (MAP2K1)
   04015 Rap1 signaling pathway
    118891063 (MAP2K1)
   04370 VEGF signaling pathway
    118891063 (MAP2K1)
   04371 Apelin signaling pathway
    118891063 (MAP2K1)
   04668 TNF signaling pathway
    118891063 (MAP2K1)
   04066 HIF-1 signaling pathway
    118891063 (MAP2K1)
   04068 FoxO signaling pathway
    118891063 (MAP2K1)
   04072 Phospholipase D signaling pathway
    118891063 (MAP2K1)
   04071 Sphingolipid signaling pathway
    118891063 (MAP2K1)
   04024 cAMP signaling pathway
    118891063 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    118891063 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    118891063 (MAP2K1)
   04150 mTOR signaling pathway
    118891063 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118891063 (MAP2K1)
   04148 Efferocytosis
    118891063 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    118891063 (MAP2K1)
   04210 Apoptosis
    118891063 (MAP2K1)
   04218 Cellular senescence
    118891063 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118891063 (MAP2K1)
   04540 Gap junction
    118891063 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    118891063 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118891063 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118891063 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    118891063 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    118891063 (MAP2K1)
   04660 T cell receptor signaling pathway
    118891063 (MAP2K1)
   04662 B cell receptor signaling pathway
    118891063 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    118891063 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    118891063 (MAP2K1)
   04062 Chemokine signaling pathway
    118891063 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118891063 (MAP2K1)
   04929 GnRH secretion
    118891063 (MAP2K1)
   04912 GnRH signaling pathway
    118891063 (MAP2K1)
   04915 Estrogen signaling pathway
    118891063 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    118891063 (MAP2K1)
   04917 Prolactin signaling pathway
    118891063 (MAP2K1)
   04921 Oxytocin signaling pathway
    118891063 (MAP2K1)
   04926 Relaxin signaling pathway
    118891063 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    118891063 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    118891063 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    118891063 (MAP2K1)
   04916 Melanogenesis
    118891063 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    118891063 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    118891063 (MAP2K1)
   04726 Serotonergic synapse
    118891063 (MAP2K1)
   04720 Long-term potentiation
    118891063 (MAP2K1)
   04730 Long-term depression
    118891063 (MAP2K1)
   04722 Neurotrophin signaling pathway
    118891063 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118891063 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118891063 (MAP2K1)
   05206 MicroRNAs in cancer
    118891063 (MAP2K1)
   05205 Proteoglycans in cancer
    118891063 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    118891063 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118891063 (MAP2K1)
   05230 Central carbon metabolism in cancer
    118891063 (MAP2K1)
   05231 Choline metabolism in cancer
    118891063 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118891063 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118891063 (MAP2K1)
   05212 Pancreatic cancer
    118891063 (MAP2K1)
   05225 Hepatocellular carcinoma
    118891063 (MAP2K1)
   05226 Gastric cancer
    118891063 (MAP2K1)
   05214 Glioma
    118891063 (MAP2K1)
   05216 Thyroid cancer
    118891063 (MAP2K1)
   05221 Acute myeloid leukemia
    118891063 (MAP2K1)
   05220 Chronic myeloid leukemia
    118891063 (MAP2K1)
   05218 Melanoma
    118891063 (MAP2K1)
   05211 Renal cell carcinoma
    118891063 (MAP2K1)
   05219 Bladder cancer
    118891063 (MAP2K1)
   05215 Prostate cancer
    118891063 (MAP2K1)
   05213 Endometrial cancer
    118891063 (MAP2K1)
   05224 Breast cancer
    118891063 (MAP2K1)
   05223 Non-small cell lung cancer
    118891063 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118891063 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    118891063 (MAP2K1)
   05161 Hepatitis B
    118891063 (MAP2K1)
   05160 Hepatitis C
    118891063 (MAP2K1)
   05164 Influenza A
    118891063 (MAP2K1)
   05163 Human cytomegalovirus infection
    118891063 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118891063 (MAP2K1)
   05165 Human papillomavirus infection
    118891063 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118891063 (MAP2K1)
   05135 Yersinia infection
    118891063 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118891063 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    118891063 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    118891063 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118891063 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118891063 (MAP2K1)
   01522 Endocrine resistance
    118891063 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bmus01001]
    118891063 (MAP2K1)
Enzymes [BR:bmus01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118891063 (MAP2K1)
Protein kinases [BR:bmus01001]
 Serine/threonine kinases: STE group
  STE7 family
   118891063 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 118891063
NCBI-ProteinID: XP_036700543
UniProt: A0A8C0CFE2
LinkDB
Position
2:complement(67779440..67863331)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aatgggaccagctcggctgagaccaacctggaggccttgcaaaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgccttgaggccttccttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggaggt
gtagtgttcaaggtctcccacaagccgtccggtctggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccttacattgtgggcttctacggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctttgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccgccccggccaaggactcccggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaagttgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacacccacccacgcggctggcatctaa

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