KEGG   Balaenoptera musculus (blue whale): 118894592
Entry
118894592         CDS       T09887                                 
Symbol
PIK3CA
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
bmus  Balaenoptera musculus (blue whale)
Pathway
bmus00562  Inositol phosphate metabolism
bmus01100  Metabolic pathways
bmus01521  EGFR tyrosine kinase inhibitor resistance
bmus01522  Endocrine resistance
bmus01524  Platinum drug resistance
bmus04012  ErbB signaling pathway
bmus04014  Ras signaling pathway
bmus04015  Rap1 signaling pathway
bmus04024  cAMP signaling pathway
bmus04062  Chemokine signaling pathway
bmus04066  HIF-1 signaling pathway
bmus04068  FoxO signaling pathway
bmus04070  Phosphatidylinositol signaling system
bmus04071  Sphingolipid signaling pathway
bmus04072  Phospholipase D signaling pathway
bmus04081  Hormone signaling
bmus04140  Autophagy - animal
bmus04150  mTOR signaling pathway
bmus04151  PI3K-Akt signaling pathway
bmus04152  AMPK signaling pathway
bmus04210  Apoptosis
bmus04211  Longevity regulating pathway
bmus04213  Longevity regulating pathway - multiple species
bmus04218  Cellular senescence
bmus04360  Axon guidance
bmus04370  VEGF signaling pathway
bmus04380  Osteoclast differentiation
bmus04510  Focal adhesion
bmus04550  Signaling pathways regulating pluripotency of stem cells
bmus04611  Platelet activation
bmus04613  Neutrophil extracellular trap formation
bmus04620  Toll-like receptor signaling pathway
bmus04625  C-type lectin receptor signaling pathway
bmus04630  JAK-STAT signaling pathway
bmus04650  Natural killer cell mediated cytotoxicity
bmus04660  T cell receptor signaling pathway
bmus04662  B cell receptor signaling pathway
bmus04664  Fc epsilon RI signaling pathway
bmus04666  Fc gamma R-mediated phagocytosis
bmus04668  TNF signaling pathway
bmus04670  Leukocyte transendothelial migration
bmus04722  Neurotrophin signaling pathway
bmus04725  Cholinergic synapse
bmus04750  Inflammatory mediator regulation of TRP channels
bmus04810  Regulation of actin cytoskeleton
bmus04910  Insulin signaling pathway
bmus04914  Progesterone-mediated oocyte maturation
bmus04915  Estrogen signaling pathway
bmus04917  Prolactin signaling pathway
bmus04919  Thyroid hormone signaling pathway
bmus04923  Regulation of lipolysis in adipocytes
bmus04926  Relaxin signaling pathway
bmus04929  GnRH secretion
bmus04930  Type II diabetes mellitus
bmus04931  Insulin resistance
bmus04932  Non-alcoholic fatty liver disease
bmus04933  AGE-RAGE signaling pathway in diabetic complications
bmus04935  Growth hormone synthesis, secretion and action
bmus04960  Aldosterone-regulated sodium reabsorption
bmus04973  Carbohydrate digestion and absorption
bmus05010  Alzheimer disease
bmus05017  Spinocerebellar ataxia
bmus05020  Prion disease
bmus05100  Bacterial invasion of epithelial cells
bmus05132  Salmonella infection
bmus05135  Yersinia infection
bmus05142  Chagas disease
bmus05146  Amoebiasis
bmus05160  Hepatitis C
bmus05161  Hepatitis B
bmus05162  Measles
bmus05163  Human cytomegalovirus infection
bmus05164  Influenza A
bmus05165  Human papillomavirus infection
bmus05166  Human T-cell leukemia virus 1 infection
bmus05167  Kaposi sarcoma-associated herpesvirus infection
bmus05168  Herpes simplex virus 1 infection
bmus05169  Epstein-Barr virus infection
bmus05170  Human immunodeficiency virus 1 infection
bmus05171  Coronavirus disease - COVID-19
bmus05200  Pathways in cancer
bmus05203  Viral carcinogenesis
bmus05205  Proteoglycans in cancer
bmus05206  MicroRNAs in cancer
bmus05207  Chemical carcinogenesis - receptor activation
bmus05208  Chemical carcinogenesis - reactive oxygen species
bmus05210  Colorectal cancer
bmus05211  Renal cell carcinoma
bmus05212  Pancreatic cancer
bmus05213  Endometrial cancer
bmus05214  Glioma
bmus05215  Prostate cancer
bmus05218  Melanoma
bmus05220  Chronic myeloid leukemia
bmus05221  Acute myeloid leukemia
bmus05222  Small cell lung cancer
bmus05223  Non-small cell lung cancer
bmus05224  Breast cancer
bmus05225  Hepatocellular carcinoma
bmus05226  Gastric cancer
bmus05230  Central carbon metabolism in cancer
bmus05231  Choline metabolism in cancer
bmus05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bmus05415  Diabetic cardiomyopathy
bmus05417  Lipid and atherosclerosis
bmus05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bmus00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118894592 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118894592 (PIK3CA)
   04014 Ras signaling pathway
    118894592 (PIK3CA)
   04015 Rap1 signaling pathway
    118894592 (PIK3CA)
   04370 VEGF signaling pathway
    118894592 (PIK3CA)
   04630 JAK-STAT signaling pathway
    118894592 (PIK3CA)
   04668 TNF signaling pathway
    118894592 (PIK3CA)
   04066 HIF-1 signaling pathway
    118894592 (PIK3CA)
   04068 FoxO signaling pathway
    118894592 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    118894592 (PIK3CA)
   04072 Phospholipase D signaling pathway
    118894592 (PIK3CA)
   04071 Sphingolipid signaling pathway
    118894592 (PIK3CA)
   04024 cAMP signaling pathway
    118894592 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    118894592 (PIK3CA)
   04152 AMPK signaling pathway
    118894592 (PIK3CA)
   04150 mTOR signaling pathway
    118894592 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118894592 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118894592 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    118894592 (PIK3CA)
   04218 Cellular senescence
    118894592 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118894592 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    118894592 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118894592 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118894592 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    118894592 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    118894592 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    118894592 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    118894592 (PIK3CA)
   04660 T cell receptor signaling pathway
    118894592 (PIK3CA)
   04662 B cell receptor signaling pathway
    118894592 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    118894592 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    118894592 (PIK3CA)
   04670 Leukocyte transendothelial migration
    118894592 (PIK3CA)
   04062 Chemokine signaling pathway
    118894592 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118894592 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    118894592 (PIK3CA)
   04929 GnRH secretion
    118894592 (PIK3CA)
   04915 Estrogen signaling pathway
    118894592 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    118894592 (PIK3CA)
   04917 Prolactin signaling pathway
    118894592 (PIK3CA)
   04926 Relaxin signaling pathway
    118894592 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    118894592 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    118894592 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118894592 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118894592 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    118894592 (PIK3CA)
   04722 Neurotrophin signaling pathway
    118894592 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118894592 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    118894592 (PIK3CA)
   04380 Osteoclast differentiation
    118894592 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    118894592 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    118894592 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118894592 (PIK3CA)
   05206 MicroRNAs in cancer
    118894592 (PIK3CA)
   05205 Proteoglycans in cancer
    118894592 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    118894592 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    118894592 (PIK3CA)
   05203 Viral carcinogenesis
    118894592 (PIK3CA)
   05230 Central carbon metabolism in cancer
    118894592 (PIK3CA)
   05231 Choline metabolism in cancer
    118894592 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118894592 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118894592 (PIK3CA)
   05212 Pancreatic cancer
    118894592 (PIK3CA)
   05225 Hepatocellular carcinoma
    118894592 (PIK3CA)
   05226 Gastric cancer
    118894592 (PIK3CA)
   05214 Glioma
    118894592 (PIK3CA)
   05221 Acute myeloid leukemia
    118894592 (PIK3CA)
   05220 Chronic myeloid leukemia
    118894592 (PIK3CA)
   05218 Melanoma
    118894592 (PIK3CA)
   05211 Renal cell carcinoma
    118894592 (PIK3CA)
   05215 Prostate cancer
    118894592 (PIK3CA)
   05213 Endometrial cancer
    118894592 (PIK3CA)
   05224 Breast cancer
    118894592 (PIK3CA)
   05222 Small cell lung cancer
    118894592 (PIK3CA)
   05223 Non-small cell lung cancer
    118894592 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118894592 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    118894592 (PIK3CA)
   05161 Hepatitis B
    118894592 (PIK3CA)
   05160 Hepatitis C
    118894592 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    118894592 (PIK3CA)
   05164 Influenza A
    118894592 (PIK3CA)
   05162 Measles
    118894592 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    118894592 (PIK3CA)
   05163 Human cytomegalovirus infection
    118894592 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118894592 (PIK3CA)
   05169 Epstein-Barr virus infection
    118894592 (PIK3CA)
   05165 Human papillomavirus infection
    118894592 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118894592 (PIK3CA)
   05135 Yersinia infection
    118894592 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    118894592 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118894592 (PIK3CA)
   05142 Chagas disease
    118894592 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118894592 (PIK3CA)
   05017 Spinocerebellar ataxia
    118894592 (PIK3CA)
   05020 Prion disease
    118894592 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118894592 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    118894592 (PIK3CA)
   05415 Diabetic cardiomyopathy
    118894592 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118894592 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    118894592 (PIK3CA)
   04931 Insulin resistance
    118894592 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118894592 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118894592 (PIK3CA)
   01524 Platinum drug resistance
    118894592 (PIK3CA)
   01522 Endocrine resistance
    118894592 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bmus04131]
    118894592 (PIK3CA)
Enzymes [BR:bmus01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     118894592 (PIK3CA)
Membrane trafficking [BR:bmus04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118894592 (PIK3CA)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 118894592
NCBI-ProteinID: XP_036706829
UniProt: A0A8B8XB89
LinkDB
Position
4:56690568..56797413
AA seq 1067 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRAEVAQMYCLXKIGLNQTEQAMEL
LDCXYPDPMVRGFCFACLEKYLTEDKLSQYLIQLVQVLKYXQYLDNLLVRFLLKKALTNQ
RIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQ
EKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWL
NWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSI
GDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSC
AGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL
IVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAY
IRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3204 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcgagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatctcaattcaccgcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgacgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctaatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcacttagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagat
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagctgaagta
gctcagatgtactgcttgtaaaagattggcctcaatcaaactgaacaggctatggagctt
ctggactgcnaatacccagatcctatggttcgagggttttgcttcgcatgcttagaaaaa
tatttaacagaggacaaactttctcagtacctaattcagctagtacaggtcctaaaatat
ngacagtatttggataacctacttgtgaggtttttactcaaaaaagcattgactaatcaa
aggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagttagt
cagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatttgaagcac
ctgaataggcaggttgaggctatggaaaagctcattaacttaactgacattctcaaacaa
gagaagaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgcggcga
ccagatttcatggatgctctacagggctttctatcgcctctaaaccctgctcatcagctg
ggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtggttg
aattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatcttt
aaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatggaa
aatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtccatt
ggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaattcag
tgtaaaggaggcctgaaaggtgccctgcagttcaacagccacacactacatcagtggctc
aaagacaagaacaagggagaaatatacgatgcagccatcgatctatttacacgttcatgt
gctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaacatc
atggttaaagatgatggacaactgtttcatatagattttggacactttttggatcacaag
aagaaaaaatttggttataaacgagagcgtgtgccatttgttttgacacaagatttctta
atagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggtttcag
gagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaatctt
ttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgcatac
attcgaaagaccctagctttagataaaactgagcaggaggctttggaatatttcatgaaa
caaatgaatgatgcacaccatggtggctggacgacaaaaatggattggatcttccacaca
attaagcagcatgctttgaactga

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