KEGG   PATHWAY: bng02030
Entry
bng02030                    Pathway                                
Name
Bacterial chemotaxis - Brenneria nigrifluens
Description
Chemotaxis is the process by which cells sense chemical gradients in their environment and then move towards more favorable conditions. In chemotaxis, events at the receptors control autophosphorylation of the CheA histidine kinase, and the phosphohistidine is the substrate for the response regulator CheY, which catalyzes the transfer of the phosphoryl group to a conserved aspartate. The resulting CheY-P can interact with the switch mechanism in the motor. This interaction causes a change in behavior, such as in direction or speed of rotation of flagella.
Class
Cellular Processes; Cell motility
Pathway map
bng02030  Bacterial chemotaxis
bng02030

Other DBs
GO: 0006935
Organism
Brenneria nigrifluens [GN:bng]
Gene
EH206_03840  HAMP domain-containing protein [KO:K03406]
EH206_08255  HAMP domain-containing protein [KO:K03406]
EH206_17090  methyl-accepting chemotaxis protein [KO:K03406]
EH206_13250  methyl-accepting chemotaxis protein [KO:K03406]
EH206_13670  methyl-accepting chemotaxis protein [KO:K03406]
EH206_14590  methyl-accepting chemotaxis protein [KO:K03406]
EH206_15630  methyl-accepting chemotaxis protein [KO:K03406]
EH206_20075  hypothetical protein [KO:K03406]
EH206_07515  HAMP domain-containing protein [KO:K03406]
EH206_03710  methyl-accepting chemotaxis protein [KO:K03406]
EH206_21635  methyl-accepting chemotaxis protein [KO:K03406]
EH206_13625  HAMP domain-containing protein [KO:K05874]
EH206_11205  HAMP domain-containing protein [KO:K05874]
EH206_04045  HAMP domain-containing protein [KO:K05874]
EH206_00530  HAMP domain-containing protein [KO:K05875]
EH206_12895  HAMP domain-containing protein [KO:K05875]
EH206_13620  HAMP domain-containing protein [KO:K05877]
EH206_04310  PAS domain-containing methyl-accepting chemotaxis protein [KO:K03776]
EH206_22410  rbsB; ribose ABC transporter substrate-binding protein RbsB [KO:K10439]
EH206_07220  sugar ABC transporter substrate-binding protein [KO:K10439]
EH206_07500  ABC transporter substrate-binding protein [KO:K10439]
EH206_16035  hypothetical protein [KO:K10439]
EH206_00290  ABC transporter substrate-binding protein [KO:K12368]
EH206_13635  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
EH206_13630  cheW; chemotaxis protein CheW [KO:K03408]
EH206_13605  cheY; chemotaxis protein CheY [KO:K03413]
EH206_13600  cheZ; protein phosphatase CheZ [KO:K03414]
EH206_13610  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
EH206_07430  chemotaxis signal transduction protein CheV [KO:K03415]
EH206_13615  cheR; protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
EH206_13455  fliG; flagellar motor switch protein FliG [KO:K02410]
EH206_13485  fliM; flagellar motor switch protein FliM [KO:K02416]
EH206_13490  fliN; flagellar motor switch protein FliN [KO:K02417]
EH206_13645  motA; flagellar motor stator protein MotA [KO:K02556]
EH206_13640  motB; motility protein MotB [KO:K02557]
Compound
C00049  L-Aspartate
C00107  Dipeptide
C00121  D-Ribose
C00124  D-Galactose
C00208  Maltose
C00716  Serine
Reference
PMID:12011078
  Authors
Kristich CJ, Ordal GW.
  Title
Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis.
  Journal
J Biol Chem 277:25356-62 (2002)
DOI:10.1074/jbc.M201334200
Reference
PMID:11722727
  Authors
Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW.
  Title
CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 42:573-85 (2001)
DOI:10.1046/j.1365-2958.2001.02581.x
Reference
PMID:12920116
  Authors
Szurmant H, Bunn MW, Cannistraro VJ, Ordal GW.
  Title
Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch.
  Journal
J Biol Chem 278:48611-6 (2003)
DOI:10.1074/jbc.M306180200
Reference
PMID:14749334
  Authors
Szurmant H, Muff TJ, Ordal GW.
  Title
Bacillus subtilis CheC and FliY are members of a novel class of CheY-P-hydrolyzing proteins in the chemotactic signal transduction cascade.
  Journal
J Biol Chem 279:21787-92 (2004)
DOI:10.1074/jbc.M311497200
Reference
PMID:11158445
  Authors
Yoshihara S, Geng X, Okamoto S, Yura K, Murata T, Go M, Ohmori M, Ikeuchi M.
  Title
Mutational analysis of genes involved in pilus structure, motility and transformation competency in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Plant Cell Physiol 42:63-73 (2001)
DOI:10.1093/pcp/pce007
Reference
PMID:8104179
  Authors
Darzins A.
  Title
The pilG gene product, required for Pseudomonas aeruginosa pilus production and twitching motility, is homologous to the enteric, single-domain response regulator CheY.
  Journal
J Bacteriol 175:5934-44 (1993)
DOI:10.1128/JB.175.18.5934-5944.1993
Reference
PMID:15187186
  Authors
Szurmant H, Ordal GW
  Title
Diversity in chemotaxis mechanisms among the bacteria and archaea.
  Journal
Microbiol Mol Biol Rev 68:301-19 (2004)
DOI:10.1128/MMBR.68.2.301-319.2004
Reference
PMID:18774298
  Authors
Rao CV, Glekas GD, Ordal GW
  Title
The three adaptation systems of Bacillus subtilis chemotaxis.
  Journal
Trends Microbiol 16:480-7 (2008)
DOI:10.1016/j.tim.2008.07.003
Reference
PMID:18990184
  Authors
Muff TJ, Ordal GW
  Title
The diverse CheC-type phosphatases: chemotaxis and beyond.
  Journal
Mol Microbiol 70:1054-61 (2008)
DOI:10.1111/j.1365-2958.2008.06482.x
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Related
pathway
bng02040  Flagellar assembly
KO pathway
ko02030   
LinkDB

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