Bos mutus (wild yak): 102267556 Help Entry 102267556         CDS       T02919                                  Symbol NOS3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism bom  Bos mutus (wild yak) Pathway bom00220   Arginine biosynthesis bom00330   Arginine and proline metabolism bom01100   Metabolic pathways bom04020   Calcium signaling pathway bom04022   cGMP-PKG signaling pathway bom04066   HIF-1 signaling pathway bom04071   Sphingolipid signaling pathway bom04151   PI3K-Akt signaling pathway bom04370   VEGF signaling pathway bom04371   Apelin signaling pathway bom04611   Platelet activation bom04915   Estrogen signaling pathway bom04921   Oxytocin signaling pathway bom04926   Relaxin signaling pathway bom04931   Insulin resistance bom04933   AGE-RAGE signaling pathway in diabetic complications bom05415   Diabetic cardiomyopathy bom05417   Lipid and atherosclerosis bom05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:bom00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     102267556 (NOS3)    00330 Arginine and proline metabolism     102267556 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     102267556 (NOS3)    04371 Apelin signaling pathway     102267556 (NOS3)    04066 HIF-1 signaling pathway     102267556 (NOS3)    04020 Calcium signaling pathway     102267556 (NOS3)    04071 Sphingolipid signaling pathway     102267556 (NOS3)    04022 cGMP-PKG signaling pathway     102267556 (NOS3)    04151 PI3K-Akt signaling pathway     102267556 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102267556 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     102267556 (NOS3)    04921 Oxytocin signaling pathway     102267556 (NOS3)    04926 Relaxin signaling pathway     102267556 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102267556 (NOS3)    05418 Fluid shear stress and atherosclerosis     102267556 (NOS3)    05415 Diabetic cardiomyopathy     102267556 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     102267556 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     102267556 (NOS3) Enzymes [BR:bom01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      102267556 (NOS3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  102267556 NCBI-ProteinID:  XP_070224984 LinkDB All DBs Position 4:465460..483906 Genome browser AA seq 1205 aa AA seqDB search MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLPRKLQTRPSPGPP PTEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEVHLTVA VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP DTPGP NT seq 3618 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagtgtgggccaggagcccgggcccccctgcggcctggggctgggg ctgggcctcgggctatgcggcaagcagggcccagcctccccggcacctgagcccagccgg gcccccgcacccgccaccccgcacgcgccagaccacagcccagctcccaacagccccaca ctgacccggcctccggaggggcccaagttccctcgcgtgaagaactgggagctggggagc atcacctacgacactctgtgcgcgcagtcccaacaggacgggccctgcactcccaggcgc tgcctgggctccctggtgttgccccggaaactgcagacccggccctccccgggacctcca cccactgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc aagaggagcggctcccaggctcacgaggagcggcttcaggaggtggaggccgaggtggca tccacgggcacctaccacctccgagagagcgagctggtgttcggggccaagcaggcctgg cgcaacgcaccccgctgcgtgggccgcatccagtgggggaagctgcaggtgtttgatgcc cgggactgcagctcagcacaggagatgttcacctacatctgcaaccacatcaagtacgcc accaaccgtggcaaccttcgctcggccatcacagtgttcccgcagcgcgccccgggccgc ggagacttccggatctggaacagccagctggtgcgctacgcaggctacagacagcaggat ggctctgtgcgtggggacccagccaacgtggagatcacggagctctgcatccagcacggc tggacccccggaaacggccgcttcgacgtgctgcccctgctgctccaggccccagacgag gctccagagctctttgttctgccccccgagctggtccttgaagtgcccctggagcacccc acactggagtggttcgcggccctgggcctgcgatggtatgccctcccggccgtgtccaac atgctgctggaaatcgggggtctggagttctccgcggcccccttcagcggctggtacatg agcacggagattggcacgcggaacctgtgtgaccctcaccgctacaatatcctggaggat gtggccgtctgcatggacctcgacacacggaccacctcgtccctgtggaaggacaaggcg gccgtggagatcaacctggctgtgctgcacagctttcagctcgccaaggtgaccatcgtg gaccaccacgccgccacggtgtccttcatgaagcacctggacaacgagcagaaggccagg gggggctgccccgccgactgggcctggatcgtgccccccatctcaggcagcctcacgccc gtcttccaccaggagatggtcaactacatcctgtcccctgccttccgctaccagccagac ccctggaaagggagcgcgaccaagggcgccggcatcaccaggaagaagacctttaaggaa gtggccaacgcggtgaagatctctgcctcactcatgggcaccctgatggccaagcgagtg aaagcaaccatcctgtacgcctctgagaccggccgggcccagagctacgctcagcagctg gggaggctcttccggaaggccttcgatccccgggtcctgtgcatggatgagtatgacgtg gtgtccctggagcacgaggcgctggtgctggtggtgaccagcacctttgggaatggcgat cccccggagaatggagagagttttgcagctgccctgatggagatgtcggggccctacaac agctccccgcggccggaacagcacaagagttacaagatccgcttcaacagcgtctcctgc tcagacccgctggtgtcctcctggcggcggaagagaaaggagtccagcaacacagacagc gcgggggccctggggaccctcaggttctgtgtgttcggactgggctcccgggcgtacccc cacttctgcgccttcgcgcgagcggtggacacccggctggaagagcttggaggggagcgg ctgctgcagctgggccagggcgatgagctctgcggccaggaagaggccttccgtggttgg gcaaaggcggccttccaggcctcctgtgagacgttctgcgttggggaggaggccaaggcc gccgcccaggacatcttcagccccaaacgaagctggaaacgccagaggtaccggctgagc acccaggccgagggcctccagctgctgccaggcctgatccacgtgcacagacggaagatg tttcaggccacagtcctctcggtggaaaatctgcaaagcagcaagtccacccgggccacc atcctggtgcgcctggacactgcaggccaggaggggctgcagtaccagccgggggaccac ataggcatctgcccgcccaaccggccgggcctcgtggaggcgctgctgagccgcgtggag gacccgccaccgcccaccgagtctgtggctgtggagcagctggagaaaggcagcccaggc ggccctcctcccagctgggtgcgggacccacggctgcccccgtgcacgctgcgccaggct ctcaccttcttcctggacatcacctccccacccagcccccggcttctccgactgctcagc accctggccgaagaacccagcgagcagcaggagctcgagaccctcagtcaggacccccgg cgctacgaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttc ccgtccgtggcgctgcccgccccgctgctcctcacccagctgcccctgctgcagccccgg tactactctgtcagctcggcccccagcgcccaccccggagaggtccacctcacagtggcc gtgctggcgtacaggacccaagatgggctgggccccctacactacggggtctgctccaca tggctgagccagctcaagactggagaccccgtgccctgcttcatcaggggggctccctcc ttccggctgccacctgacccctacgtgccctgcatcctcgtgggccctggcactggcatc gcccccttccggggattttggcaggagaggctgcatgacattgagagcaaagggctgcag cccgcccccatgaccctggtgttcggctgccggtgctcccaactcgaccatctctaccgc gacgaggtgcaggacgcccaggagcgcggggtgtttggccgcgtcctcaccgccttctcc cgggaacctgacagccccaagacctacgtacaggacatcctgagaaccgagctggctgcc gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgacgtcact atggcaaccagcgtcctgcagacggtgcagcgcatcttggcgacagagggcgacatggag ctggacgaggcgggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac attttcggcctcacgctgcgcacccaggaggtgacaagccgtatacgtacccagagcttt tccctgcaggagcggcatctgcggggcgcggtgccctgggccttcgacccgcccggccca gacacccccggcccctga

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