Bos mutus (wild yak): 102270241
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Entry
102270241 CDS
T02919
Symbol
CYP17A1
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase isoform X1
KO
K00512
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:
1.14.14.19
1.14.14.32
]
Organism
bom
Bos mutus (wild yak)
Pathway
bom00140
Steroid hormone biosynthesis
bom01100
Metabolic pathways
bom04913
Ovarian steroidogenesis
bom04917
Prolactin signaling pathway
bom04927
Cortisol synthesis and secretion
bom04934
Cushing syndrome
Module
bom_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
bom_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
bom_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
bom00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
102270241 (CYP17A1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
102270241 (CYP17A1)
04917 Prolactin signaling pathway
102270241 (CYP17A1)
04927 Cortisol synthesis and secretion
102270241 (CYP17A1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102270241 (CYP17A1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
bom00199
]
102270241 (CYP17A1)
Enzymes [BR:
bom01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
102270241 (CYP17A1)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
102270241 (CYP17A1)
Cytochrome P450 [BR:
bom00199
]
Cytochrome P450, animal type
CYP17 family
102270241 (CYP17A1)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
p450
ZSWIM4-8_C
HEPN_MAE_28990
Motif
Other DBs
NCBI-GeneID:
102270241
NCBI-ProteinID:
XP_005888108
UniProt:
L8J3G2
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All DBs
Position
26:28216215..28222444
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AA seq
509 aa
AA seq
DB search
MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN
ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHNEKEWQHPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA
SLVLQIKPFKVKIEVRQAWKEAQAEGSTP
NT seq
1530 nt
NT seq
+upstream
nt +downstream
nt
atgtggctgctcctggctgtctttctgctcaccctcgcctatttattttggcccaagacc
aagcactctggtgccaagtaccccaggagcctcccatccctgcccctggtgggcagcctg
ccgttcctccccagacgtggccagcagcacaagaacttcttcaagctgcaggaaaaatat
ggccccatctattcctttcgtttgggttccaagactactgtgatgattggacaccaccag
ttggccagggaggtgcttctcaagaagggcaaggaattctctgggcgtcccaaagtggcc
actctagacatcctgtcagacaaccaaaagggcattgcctttgccgaccatggtgcccac
tggcagctgcatcggaagctggcactgaatgcctttgccctgttcaaggatggcaacctg
aagttagagaagatcattaatcaggaagccaatgtgctctgtgatttcctggccacccag
catggagaggccatagatctgtccgagcctctctctctggcggtgaccaacataatcagc
tttatctgcttcaacttctccttcaagaatgaggatcctgccctgaaggccatacaaaat
gtcaatgatggcatcctggaggttctgagcaaggaagttctgttagacatattccctgtg
ctgaagattttccccagcaaagccatggaaaagatgaagggttgtgttcaaacgcgaaat
gaattgctgaatgaaatccttgaaaaatgtcaggagaacttcagcagtgattccatcact
aacttgctgcacatactgatccaagccaaggtgaatgcagacaataacaatgctggccca
gaccaggattcaaagctgctttcaaatagacacatgctcgctactataggggacatcttc
ggggctggtgtggagaccaccacgtctgtgataaagtggatcgtggcctacttgctacac
catccttcgttgaagaagaggatccaggatgacattgaccagattataggtttcaatcgc
accccaaccatcagtgaccggaaccgccttgtcctgctggaggcgaccatcagagaagtg
ctccgaatccggcctgtggcccctacgctgatcccccacaaggctgtcattgactccagc
attggcgaccttaccattgacaaaggcacagacgttgtggtcaacctgtgggcactgcat
cacaatgagaaggagtggcagcatcccgacctgttcatgcccgagcgcttcttggacccc
acggggacgcaactcatctcgccatcattaagctacttgccctttggagcaggaccccgc
tcctgcgtaggtgagatgctagcccgccaggagctcttcctcttcatgtcccggctgctg
cagaggttcaacctggagatcccggatgatgggaagctaccctctctggagggccatgcc
agtctcgtcttgcagatcaaacctttcaaggtgaagatcgaggtgcgccaggcctggaag
gaagcccaggctgagggtagcaccccatga
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