Bos mutus (wild yak): 102278692 Help Entry 102278692         CDS       T02919                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom01521   EGFR tyrosine kinase inhibitor resistance bom04062   Chemokine signaling pathway bom04081   Hormone signaling bom04148   Efferocytosis bom04151   PI3K-Akt signaling pathway bom04217   Necroptosis bom04550   Signaling pathways regulating pluripotency of stem cells bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom04725   Cholinergic synapse bom04917   Prolactin signaling pathway bom04920   Adipocytokine signaling pathway bom04933   AGE-RAGE signaling pathway in diabetic complications bom04935   Growth hormone synthesis, secretion and action bom05140   Leishmaniasis bom05145   Toxoplasmosis bom05152   Tuberculosis bom05161   Hepatitis B bom05164   Influenza A bom05167   Kaposi sarcoma-associated herpesvirus infection bom05168   Herpes simplex virus 1 infection bom05200   Pathways in cancer bom05207   Chemical carcinogenesis - receptor activation bom05235   PD-L1 expression and PD-1 checkpoint pathway in cancer bom05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102278692 (JAK2)    04151 PI3K-Akt signaling pathway     102278692 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     102278692 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     102278692 (JAK2)   09143 Cell growth and death    04217 Necroptosis     102278692 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102278692 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102278692 (JAK2)    04659 Th17 cell differentiation     102278692 (JAK2)    04062 Chemokine signaling pathway     102278692 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     102278692 (JAK2)    04917 Prolactin signaling pathway     102278692 (JAK2)    04935 Growth hormone synthesis, secretion and action     102278692 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     102278692 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102278692 (JAK2)    05207 Chemical carcinogenesis - receptor activation     102278692 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102278692 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     102278692 (JAK2)    05164 Influenza A     102278692 (JAK2)    05168 Herpes simplex virus 1 infection     102278692 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102278692 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     102278692 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102278692 (JAK2)    05140 Leishmaniasis     102278692 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102278692 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102278692 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102278692 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102278692 (JAK2) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102278692 (JAK2) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102278692 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  102278692 NCBI-ProteinID:  XP_005891424 UniProt:  L8IT24 LinkDB All DBs Position 8:72743676..72867929 Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGNAEGDYLQFLTG EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIDKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtacat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaacgctgagggggattatctgcagtttctaactgga gagtatgttgctgaagagatctgtattgctgcttctaaagcttgtggaatcacacctgta tatcacagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttc ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaaccccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgagcttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gttgagcgagaaaatgttattgaatataagcactgtttgattaccaaaaatgagaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagaagagaaataggagactatggtcagcttcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggaatttgtaaaatttggatcactagatacgtatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa agaaaactacagttttatgaagataggcaccagcttcctgcgccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttaggccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgctctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgtcggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcaatacacatctcagata tgcaaggggatggaatatcttggtacaaaaagatatatccacagggatctggcaacaagg aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgacaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa ctcctgaagaataacggaagattaccaagaccagatggatgcccagatgagatatatgtg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacaacatgactggatga

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