Bos mutus (wild yak): 102286137 Help Entry 102286137         CDS       T02919                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom01521   EGFR tyrosine kinase inhibitor resistance bom04151   PI3K-Akt signaling pathway bom04217   Necroptosis bom04380   Osteoclast differentiation bom04550   Signaling pathways regulating pluripotency of stem cells bom04620   Toll-like receptor signaling pathway bom04621   NOD-like receptor signaling pathway bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom05140   Leishmaniasis bom05145   Toxoplasmosis bom05152   Tuberculosis bom05160   Hepatitis C bom05161   Hepatitis B bom05162   Measles bom05163   Human cytomegalovirus infection bom05164   Influenza A bom05165   Human papillomavirus infection bom05166   Human T-cell leukemia virus 1 infection bom05167   Kaposi sarcoma-associated herpesvirus infection bom05168   Herpes simplex virus 1 infection bom05169   Epstein-Barr virus infection bom05171   Coronavirus disease - COVID-19 bom05200   Pathways in cancer bom05203   Viral carcinogenesis bom05212   Pancreatic cancer bom05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102286137 (JAK1)    04151 PI3K-Akt signaling pathway     102286137 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102286137 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102286137 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102286137 (JAK1)    04621 NOD-like receptor signaling pathway     102286137 (JAK1)    04658 Th1 and Th2 cell differentiation     102286137 (JAK1)    04659 Th17 cell differentiation     102286137 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102286137 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102286137 (JAK1)    05203 Viral carcinogenesis     102286137 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102286137 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102286137 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102286137 (JAK1)    05161 Hepatitis B     102286137 (JAK1)    05160 Hepatitis C     102286137 (JAK1)    05171 Coronavirus disease - COVID-19     102286137 (JAK1)    05164 Influenza A     102286137 (JAK1)    05162 Measles     102286137 (JAK1)    05168 Herpes simplex virus 1 infection     102286137 (JAK1)    05163 Human cytomegalovirus infection     102286137 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102286137 (JAK1)    05169 Epstein-Barr virus infection     102286137 (JAK1)    05165 Human papillomavirus infection     102286137 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102286137 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102286137 (JAK1)    05140 Leishmaniasis     102286137 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102286137 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102286137 (JAK1) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102286137 (JAK1) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102286137 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  102286137 NCBI-ProteinID:  XP_005886754 LinkDB All DBs Position 3:78276390..78415804 Genome browser AA seq 1158 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTVTVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT FQNLIEGFEALLRSMSNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg agctccaagaaggcagagatgaatctggaggcccctgagccgggggtggaggtgctcttc tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg tgcattcgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagaacaccaagctctggtatgctccgaatcgcaccgtcaccgtcgacgacaaa acgtcactccggcttcactaccggatgaggttctatttcaccaactggcatgggaccaac gacaatgaacaatcagtatggcgacattctccaaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgcaacacctctccttgacgccagctcgctggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtcttgggatggccgtgctggccatctcccactac gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggattttctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtccacgcacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag gaggccttgtccttcgtgtccctggtcgatggctacttccggctcacggcagacgcccat cactacctctgcactgacgtggctcccccattgatcgtccacaacatacagaatggctgt catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag gggatgtacgtgctgcggtggagctgcaccgactttgacaacatcctcatgaccgtcacc tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggac ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcacggattacaaggatgacgaagggacttctgaagagaagagaataaaagtcatcctg aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgcgtccgagatgtg gagaatatcatggtggaagagtttgtggaggggggacccctggacctcttcatgcaccgg aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctt ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc atccccatcactgtgctctccaggcaagagtgcatagaacgaatcccctggattgctccc gagtgtgttgaagactccaagaatctgagtgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgattgag aaagagagattctatgaaagccggtgcaggccagtgaccccatcttgtaaggagctagct gacttgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagatggtggaaatggtattaagctcatcatggagtttctgccttca gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatatgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac cgggacttagcagcaagaaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac ttcggtctcaccaaagccatcgaaactgataaggagtactacacagtcaaggacgaccgc gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc tctgatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagat tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta acaagactcgtgaatacattaaaagaaggaaaacgcttgccatgtccaccgaactgtcca gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

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