Bombus pascuorum (common carder bee): 132908115 Help Entry 132908115         CDS       T09597                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism bpas  Bombus pascuorum (common carder bee) Brite KEGG Orthology (KO) [BR:bpas00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bpas04040]     132908115    04990 Domain-containing proteins not elsewhere classified [BR:bpas04990]     132908115 Ion channels [BR:bpas04040]  Voltage-gated cation channels   Ryanodine receptor    132908115 Domain-containing proteins not elsewhere classified [BR:bpas04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132908115 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Serglycin DASH_Spc34 Motif Other DBs NCBI-GeneID:  132908115 NCBI-ProteinID:  XP_060817752 LinkDB All DBs Position 6:11366930..11407899 Genome browser AA seq 5159 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQENLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW ATTPSQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEATTETSTFWLRQEKDDQKIILEDKDLEVIGTPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VENSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTAGYMPYPGGGEKWGGNGVGDDLYS FGFDGAHLWTGGRKTQVVQNVTEPYIRKSDVIGCALDLTVPIITFTFNGAPIMGSFRNFN LDGMFFPAISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPAPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWIYG EHRDDMRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTVLALGYYITMDKPPSRIKTLRLP NEPFLQSSGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEANRLRQLY FRTYRVEKHYAVSSGKWYFEFEVLTAGPMRVGWAKADCSPGNMLGSDESTWAFDGYNVTK VHAGIHESFGHRYQVGDVVGCFIDVADRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTYWYTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFISESEKLRRW QEIKMRQNRLLSEQVEQAQQAAPSAQIEQIMRSGFSMSDIKGLQRNYSEDAVEADEMMKE SPLPMQRNKPLRPPRKGSLYGSRVGNMDNAISEVDMNGYGDMNGDIKDDKKKRGRSPFRK LSKEMEDAPFFSRKAKSPDAKSKTPEPPVRSDVSDKSTKTQSMNKASNRPPQIRISNTDL KVVPPQIPERNAPKAMSMSALSGSGVEAIGNEIFDAECLKLMNEYFYGVRIFPGQDPTHV YVGWVTSQYHLHTKDFNLSRVRKGSVVITDDYDRPIEQVDRQSCYMVRADELYNEVTQDA SGKGASQGMFVGCFVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIE LGRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRG WSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHAL CQHVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQELKDL YENEEMKHSLRYLETESVRPQMKMTDIRDIPSSDQTIENIRSLYSPYFPLDVVRDYVMTA LNEAVEVNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDVVKLLIMIHPETWDPT FDKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDLQSDQ LRRYVEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKNMEFVDDPENSPCGEDLINRM NEFHNSLMSYVSLHALQEAADAVEEAEDAVQKPGAIKKLFNFINAVKELEEEPKPEPEPE RKTPEEVFRKVLIKTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVTNS KTKDDVALMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHEN VMAIMMNTLGRRAQAQSDAQTQPQTTEGEPVSKEKDTSHEMVVACCRFLCYFCRTSRQNQ KAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSR CGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECL GPALRGEGEGLLRAIIDANKMSERIADRRKVHDEAEGTTALMQFEHPLPESDDDEDYIDT GAAILNFYCTLVDLLGRCAPDSSVIEQEASTESVGKNESLRARAILRSLVPLDDLQGVLS LRFTLLNPAAGEEKPKSDMPSGLIPGHKQSIVLFLERVYGIETRELFFKILEEAFLPDLR AATMLDRNDGYESDMALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSK NRMLTKGQREAVSDFLVALTRDVHELNVSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRL LTLHYDRCAKYYGSTGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYEPELFGKALPCL TAIGCALPPDYSLSKNYDDEWYGSKSASAQSPDGPYNPQPINTSSVVLNNDLNQIVQKFS EHYHDAWASRKLENGWTYGEQWSEVNKTHPRLKPYNMLNDYERERYKEPVRESLKALLAI GWSVEHAEVDVPSTNRSSMRRSSKSQADSASPFNYNPHPVDMTNLTLSREMQNMAERLAD NAHDIWAKKKKEELITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKP NRGGESEVATAGASVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDI KFFSKVVLPLMEKYFSTHKNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAA FGPDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYS HLRGTHLKTSTSLSYINSVVLPVLTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLG VDASLTHDRKYLKTEIERHKPSLGSCLGAFSSCFPVAFLEPHLNKHNQYSLLNRIADHSL EAQDIMMKMESSMPTLETILTEVDQFVESEKTYNDLPHVVDIILPLLCSYLPFWWSQGPD NVNPTEGTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELL KDPFLPLAERVRKRTDTMFHKEESLRGFIKSSTDDTSQIEAQIQEDWQLLVRDIYSFYPL LIKYVDLQRNHWLRNNIPEAEDLYNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIM PTATRRPTTISDGTAPSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGR EQELVQHCKDRFLKKMPEYEISEFAKTQLTLPDKIDPADEMSWQHYLYSKLGQKKDSMEP VKAQQLEDVVARITDMAKVLYGLHMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQTSLHS LPRHRAINIFARTYYELWLQDENVGQEVMIEDLTQSFEDAELKKMDKDEDEGKPDPLTQL VTTFCRGAMTERSGALQEDPLYMSYAQIISKSCGEEEEEGEDEGGGGGEEEGGASIHKRG YKPLMRPMHKLMEQEMEKQKLLFHQTRLANRGVAEMVLLHISACKGVPSEMVMKTLELGI SILRGGNIEIQRGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEG AAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQE SIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDA VGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTL VESASNVELILKYFDMFLKLKDLVSSPSFLEVDLNSDGWVYPKDFKEKMEQQKSYTDEEI EFLLACCETNHDGKIDYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAG SVLNYFEPYLGRIEILGGNKKIERVYFEIKESNIEQWEKPQIKESKRTYFYNTVVEAGEK EKLETFINFCEDAIFEMQHASALMAVEESGGIGKARESSYTYMTEDDEERNKDPIRRGIQ TFKDSIYFFFSIFSPSNIKNKIAEMQQMTFLELFIGFFKMIFYAFYYSGFGVGCIIGYFM KLLLALMKGPHVEEPVVEVKEEEEKPIRHLPALPPTPDESNLQVQAFGMDITKEEGGQIK IAPHESATSTPQSSIEETGESTPEEATGEEGARAEGGGDNMESPVSLADLLGGEQARAQA AASAEAAAAQQAAMAAVEAEAKQETIAEPSTSTIDFSEYTHRIVSFLARNFYNLKYVALV LAFCINFMLLFYKVTSLAGEGDEEGSGQMINDIMAEMSGEGASGSGSGSGLEIGSGSGED ESEEEEDAYALEYVEVSEDFYYMAHVIRLMAILHAIVSLAMLVAYYHLKVPLAIFKREKE IARRVEFDGLYIAETPEEDDIKAHWDKMVISAKTFPVNYWDKFVKKKVRQKYSETYDFDY ISNLLGMEKTSFSQQEEEGSGLIHFIVNIDWRYQVWKAGVTITDNAFLYSLWYFTFSILG NYNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIVVYIYTVIAFNFFRKF YIQEEDDEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFF VIVILLAIIQGLIIDAFGELRDQLENVKTNMESNCFICGLGKEYFDTVPHGFDTHVQQEH NLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNESVEEEAKKK NT seq 15480 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgagggtggctccgagcaggatgacgtatccttcctccgtacggaggac atggtatgtctgtcctgtaccgcaactggtgaaagggtttgcctcgcagctgaagggttt ggtaatcgacactgtttcctcgagaatatcgcagacaagaacataccacctgacctgtcg caatgcgtattcgtaatagaacaagctctgtcggtgagagctctgcaggaattggtaacc gccgccggttccgagacgcagcaagaaaatttaggaaagggcactggatctggacacaga acgttattgtatggcaacgctattttactgaggcatcaaaacagcgacatgtatttggcg tgtttatcgaccagctcgtccaacgacaagttggctttcgacgtaggtctgcaacagcat tctcaaggcgaggcgtgttggtggactgtgcatccagcatcgaagcagaggtcagagggt gagaaggttcgagtcggtgatgaccttattctggtatctgtggccactgagagatacttg cacacaacaaaagaaaacgacttatcagtggttaacgcctcgttccacgtaacccactgg tcggtacaaccttacggcactggaatcagccggatgaaatacgttggttacgtatttggc ggtgatgttctacgattctttcacggtggcgacgaatgcctcactataccgtcaacatgg gccacaacaccgagtcaaaatatagtggtctacgagggaggcagcgtaatgagtcaagct cgatctctatggagactggagctggcaagaactaaatgggccggtggttttatcaactgg ctgcatccgatgaggatcagacacttgacaactggacgttaccttggtgtaaaagaaaac aacgaactgtatctggtcgatagaaacgaggcaacgaccgagacttcaacgttttggtta cggcaagagaaggatgaccagaagatcattctcgaggataaggatctcgaagttatcggt acaccgatcatcaagtatggtgactcgactgttatcatgcagcacgctactacttgcctc tgggtctcgtacaagtcgtacgagacaaagaaaaagggtgtgggcaaagtggaggagaag caagccgtccttcacgaggaaggaaagatggatgacggtttggacttctctcggtcacaa gaggaggagtcccggacagctcgtgtgatacgaaagtgcagcagtctgttcactcagttc atcacaggcctagagacgctgcaagtagatagaagagcgtctatgttcttccaaaatgtg aatctgaacgaaatggtgatgtgtctggaagacttgattaattattttgctcaacccgaa gacgacatggagcacgaagagaaacaaaacagattccgcgctctgagaaatcgtcaagac ctgtttcaagaggaaggtatattgaacttgatactcgaagccatcgacaagatcaacgtg attacgtcacaaggtttcctcgtggcactttcgggagacgagagtggtcaagcttgggac caaatatcaggatacctgtatcaactattggcagctattatcaaaggaaatcacacaaac tgcgcgcaatttgctaacagcaatcgtttgaactggttgttcagtcgactcggatcgcag gcttccagcgaaggcactggaatgttggacgtgcttcattgcgttcttatcgactcgccc gaagctttaaacatgatgagggacgagcacattaaagtcatcatttccttattggagaag cacggaagagacccaaaagtcttggacgtactttgctcgctgtgcgtgggtaacggcgtg gctgttcgatcttcgcagaacaacatctgtgacttcttgctgccaggaaaaaatcttctt cttcagacgcaactggtcgaccacgtggctagcgttagaccgaacatattcgtcggtaga gtcgagaactcggcgctttatcagaaatggtacttcgaagtcaccgtcgaccacatcgaa cagaccacgcacatgatgccgcatttgagaataggatgggcgaacactgctgggtacatg ccatatcccggtggtggcgagaaatggggtggaaacggtgttggcgacgacctctattca ttcggtttcgacggtgcacatctatggaccggtggtagaaaaactcaagttgttcagaat gtcacggaaccttacatcagaaagagcgacgtgatcggatgtgcattggatctcacagtg cccataatcactttcaccttcaacggagcacctatcatgggatccttccgaaatttcaac ctcgatggcatgttcttccccgcaatcagctgctcatccaaactatcctgtagattcctg ttaggcggtgaccacggccgactcaagtttcaaccgccagaagaattctcacctttggtg gaaagcttattaccacaacaaattctatctttggatccctgtttctactttggaaacatg aacaaggtggtcctggctggtccatggctggtcgaggacgacacagctttcgtcccagct ccggtcgacacatctatgatcaatttaccatcttacgtcgagcaaatcagagataaacta gctgagaatatccacgagatgtgggcaatgaataaaatcgaagctggttggatatatgga gaacatagagacgatatgagaaagattcatccatgtatcgttcagtttgaacgattacca gctgcagaaaaacgttacgacactcagttggcagtgcaaacgctgaagactgttctagcc ttgggatattatatcacgatggataaaccaccctctagaataaagactctgaggcttccg aatgaacccttcctgcaaagcagtggatataaaccagcaccactcgatcttagtgccatt acactcacgccaaagatggaagaactggtagaccaacttgcagaaaatactcataatttg tgggcaaaggaaaggattagtcagggatggacttatggtctgaacgaggattctgagatg agaaggagcccccatttggtaccctacccgaaggtggatgaagcgatcaagaaggctaat cgtgacacagccagtgaaactgtgaggacacttttggtttatggatacatgttggaacca cctactggagaacaacacgaagcgctgctgttggaagccaacaggttacgacaactatac tttagaacatatcgcgttgagaaacactacgcagtcagtagcggaaagtggtacttcgag ttcgaggtgctgacagctggccctatgcgagtcggttgggcaaaagctgactgctctccc gggaatatgctgggaagcgacgaatctacttgggcttttgacggctataacgtaactaaa gtacacgccggtatccacgagtcatttggtcacagatatcaagtgggcgacgtagttgga tgtttcattgacgtcgcagaccgaacgatcagcttttctctgaacggagaactgctgatg gatgcgctcggtggtgaaacgtcttttgctgacgtacagggagattgtttcgtaccagct ttcacgcttggtgttggacaaaaagcaaaattaacttttggacaggatgtaaatacctta aagttctttacgacctgcggtttgcaagagggatacgaaccgttctgtgtgaacatgaat cgtccagttacgtattggtacaccaaggatcaaccaattttcgagaacacagacgatatg gctgacacgaggatagatgtagccaggattccagcgggttccgatactccaccatgtttg aagatctctcataacacgttcgaaactatggaaaaggcgaactgggagttcctgcgatta tctttaccggttatttgccaatcgacgtttatttcggaaagtgagaaactaaggagatgg caggaaatcaaaatgcgacaaaatagactattgtctgaacaagtggagcaggctcaacaa gcagcgccttctgctcaaatagagcagatcatgaggtctggattcagtatgagcgacatc aaaggattacaaaggaactattcggaggatgcagtggaagccgatgaaatgatgaaggag tcaccgcttcccatgcaaagaaacaagccgttgagacctccaagaaagggttccctctat gggtcacgagtcggaaacatggataacgcaattagcgaagttgacatgaatggatacggc gatatgaacggcgacatcaaggacgataagaagaaacgtgggcgttctccgttccgcaaa cttagcaaagaaatggaggatgccccattcttctctcgtaaagcgaagtctccggacgcg aaatcgaaaacgcccgagccaccagtacgttcagacgtttctgataagagcaccaagacc caatcgatgaacaaagcaagtaaccggcctccccaaattcgcatatcaaacacggacttg aaagtagtgccacctcagatcccagaacgcaacgcaccaaaagcaatgtctatgtctgct ctgagtggaagcggcgtcgaggcaatcggaaatgagatattcgatgcagaatgcttgaaa ttgatgaacgaatacttctacggagtgagaatctttcctggacaggatccaacgcacgtt tatgttggctgggtcacttcccaatatcatttgcatactaaagactttaatctgtctcgc gtgaggaagggctctgtagttattaccgatgactatgatcgtcctatagaacaggttgat agacagagctgctatatggtaagagcggatgagctttacaacgaagtaacgcaagatgca tccggcaagggagcttctcaaggaatgttcgttggatgtttcgtggataccgcaaccggt tgggtgtccttcacctgcgagggaaaggaaactagccacaaattcaagatggaacccgat acgaaattattccctgccatcttcgtagaagctaccagcaaggaaatccttcagattgaa cttggaagaacctccacaacgctaccattatccgctgctgtattacaaaactcagaacgt catgtgataccacagttcccacctagattgaaggttcaatgtctgaaacctcaccaatgg gcaagagttccaaatcaatcgcttcaggttcatgccttgaaactgtctgatatcagaggt tggtccatgctgtgcgaggatgccatatcaatgttggctttgcatatccctgaagaggat agatgtatcgacatcttggagcttattgagatggataagttacttagcttccacgcacac actctgacactgtacgcagctctatgttatcagtcgaattacagagcagcacacgctcta tgccagcacgtcgatcaaaaacaattattgtacgcaattcgagcggaatacatgtccggg cccctacgacaaggattctacgacttgctgatcgccttgcatctcgagtcacacgcgact acgatggaagtgtgtaaaaatgaatacataattcctttaggccaagaactgaaggattta tacgaaaacgaagaaatgaagcacagcctcaggtatctagaaaccgagtcggttcgtcct cagatgaaaatgacagacatcagggatattccttccagcgatcaaacgatcgagaacata aggagtctctacagtccgtacttccctctggatgtagtgcgggactatgtgatgactgca ctgaacgaggccgtcgaggtcaatcaagttcacaatcgggaccccattggtggcagcaat gagaatcttttcctgccacttttgaaactagtagacaggttgctcttggtcggaatgctc aggaacgaagacgttgtgaagcttctgattatgattcatcctgagacttgggatccgacg tttgacaaagaaggaaaagacgagcacaagaagggactgcttcacatgaaaatggccgaa ggtgcgaaactacagatgtgctatcttcttcatcatctaaacgacatccagcttcgacat cgcgtcgagtccattatcgcatttagccacgacttcgtcggtgatcttcagtctgatcaa cttcggcgttacgtcgaaatcaaacaatctgacttaccatcggcagtagcagcgaagaag acaagagaatttcgatgtccacctcgtgaacagatgaatgcaatcttaagtttcaagaat atggaattcgtggatgatcctgagaatagtccttgcggagaagatctgataaatcggatg aatgaattccacaacagtctcatgtcctacgtgtccttgcacgccctgcaggaagcagcg gatgccgtggaggaggctgaagacgcagttcagaaacctggcgccattaagaaactattc aactttatcaacgcagtgaaagaactcgaagaggaacctaaacctgaacctgaacccgag aggaagactccagaagaggtgttccgtaaagttctgataaaaaccatcgtcagctgggcc gaggaatcccaaatcgagactccgaagttggttcgagaaatgttcagtttactggttcgc cagtatgacacggtgggcgagttaattagagctttagaaaaaacctacgtgacgaacagc aagacaaaggacgacgttgctttgatgtgggtcggtttgagccaaattcgcgccttactg cctgtacaaatgtctcaagaggaagaagagctcgttcgggaacgactctggaaattagtc aacaatcatacgttcttccagcatccagatctaatcagagtgcttagaattcacgagaac gtcatggcgatcatgatgaacacactaggcagacgtgcacaggcgcaatcggacgctcaa actcagcctcaaactaccgaaggagaaccagtttccaaggagaaggatacttctcacgaa atggtggtagcatgctgtagattcctgtgctacttttgtcgaacttccagacagaatcag aaggctatgttcgaccactttgactttttactggagaatagtaatatcttgttatcgaga ccatctttaagaggttccactccactggacgtagcttattcttccctcatggaaaacacg gagctggctctggctctcagagaacattatcttgaaaagattgccatatatctatcccgt tgtggtttgcaatcgaattcagaattggttgaaaaaggttatcccgatctgggttgggat cccgtggaaggcgaaagatatttggactttttgaggttctgcgtttgggttaatggtgaa agcgtcgaagaaaatgcaaacttggtgatccgtttgctgatcagaagaccggaatgtctg ggaccagcgcttcgtggcgagggtgagggtctattaagagctatcatagacgccaataag atgtccgaacgaatcgctgatcgaaggaaagtgcacgacgaagcagaaggtacaacggcg ctcatgcaattcgaacatccgcttccggaatcagacgacgacgaagactatatcgataca ggagctgcgatcttgaacttctactgtaccttagtggacctattaggccgctgcgctcca gattcttctgttatcgaacaagaggcttctacagaatccgtcgggaagaacgaatctctt cgagcgagggctattcttcgatctctggtgccactcgatgatctacaaggtgtcctgtct ttgaggttcacgttattgaatcccgcggcaggcgaagagaaaccaaaaagcgatatgccg tctggtttgattcctggacataaacagagcatcgttctgtttttggagcgcgtttacgga atcgaaaccagagaattgttctttaagatactcgaggaagcatttttgcccgatctcaga gccgccactatgttggataggaacgatggatatgaatcagacatggcgctagcgatgaac cgttacattggaaacagtattctacctttgttgattaaacattcgaaattctacaacgag gcggataactatgccagtttactagatgctacgttgcacaccgtatatcgattgagcaag aacagaatgctcactaagggtcaacgtgaagcagtgtcggatttcctcgtggcattgacc agagacgtccacgagttaaatgtctcccaaatgcaacccagcatgttgttgaagctgctt cgaaagctgaccgtagacgtgtccaaactatcagaatatacgacagttgctctaaggttg ctgacccttcactacgatcgttgcgcgaaatattacggatcgaccggtggacaaggcgca tacggtgcatcgagcgatgaagagaaacgcctgactatggttctcttcagcaacattttc gattcgttatccaagatggactacgaaccagaactatttggaaaagctctaccttgtctc acagctattggttgcgcgttaccgcctgattattcattgtccaaaaattacgatgacgag tggtacggaagtaaatctgcatctgcacagtcgcctgatggaccttataatcctcagcca atcaatacctctagtgtggttctcaataacgacctcaatcagatagtccaaaagttctcc gagcattaccacgacgcttgggccagtcgaaagttagaaaacggttggacctacggcgaa caatggtctgaagtgaataagactcatcccaggctgaagccgtacaacatgttaaacgat tacgagagagaacgatacaaagagccagtcagggagagcttgaaagctttattggccata ggatggagcgttgaacatgcagaggtggatgtaccatctaccaatcgtagttccatgaga agatcatcgaaaagtcaagctgattcagcgagtccatttaattataatcctcatccagtt gatatgactaatttgactctgagcagagaaatgcaaaacatggcagagcgtctcgcggat aatgcgcacgatatttgggcaaagaagaagaaggaagaactcatcacttgtggaggtggt attcatcctcaactagttccgtatgatcttttgaccgataaggagaaacgaaaggatcgc gaacgttcccaagaattcctcaagtacctgcaatatcagggttacaagcttcataaaccg aatagaggcggagaatcagaagttgcaacggctggagcctcggtggaattacgattcgcc tactcgttacttgaaaagttgatagcctacttggataaggctactatcaacatgaaatta ctgaaaccgtccgacacgttcagtcgtagaaatagctttaaaacgtctacaagagacatc aaattcttcagtaaagttgtcctgccactgatggaaaaatattttagcacacacaaaaac tatttcatcgctgtggcaacggctaccaacaatgtcggagctgcgtccttgaaagagaag gagatggtagcagctctattttgtaaattggccagtttattgagatctagattggctgct ttcggaccggatgttaggatcaccgtccgctgtcttcaagtactagtcaaaggcatagac gcgaagagtttagtgaagaattgtcctgagtttatcagaacgtctatgctaacgtttttc aacaacactgcagacgatttaggacacacgattcttaatcttcaagagggcaaatacagt catctgagaggaacacatttgaaaacttctacatccttgtcgtatatcaatagcgtggtt ttgccagtgctcacagccatgttcgatcatttggctgcctgcgaatatggtagcgatttg ctattggacgaaattcaggtggcatcctacaaaatgctggcgtctttatacactctcggt gtagatgcctccctaacacacgacagaaaatatttgaagacagaaatcgagcgtcacaag cccagcttaggttcctgtctaggtgccttttctagttgtttccctgtggccttcttggag ccacatttaaacaagcacaatcagtattcccttttgaatcgtatagccgaccattccttg gaagcacaagatatcatgatgaagatggaatcgagtatgcctaccctagagacgatcttg acggaagtcgatcaattcgtcgagtctgagaaaacctacaacgatcttccccacgtagtt gacattattcttcctctactttgctcctatctgcctttctggtggtctcaagggccagac aatgtaaacccgacagaaggaacgtacgtcagcatggttaccagcgatcacatgaatcaa ctgctgaagaacgtattaaagttgattaaaaagaacatcggtaacgaaaatgctccttgg atgactcgtattgctgcttacactcaacagatcattataaattcatcagaagagttactg aaggatccattcttaccacttgctgaacgtgtcagaaaacgaacggatactatgttccat aaagaagaatctcttcgtggttttattaaatcatccacggatgacacgtcacaaatcgaa gcacagattcaagaagactggcaacttctggttcgcgatatctactcattctatcctctt ttgatcaagtacgttgatttgcaaaggaatcattggctgaggaataacattccagaagca gaagatctttataatcacgtagcagcgatatttaatatttggtccaagtctcagtacttc ttgagagaagaacaaaacttcatatcggctaatgagatcgataatatggtgctcattatg ccgacagcgaccagaagacctactactatttcggatggaacagcaccttccggaggaggc aagaaaaagaagaaacaccgtgacaagaaaagagataaggacaaagaagtgcaggcttcc ctaatggtagcctgtttgaagagattgcttccagttggtctgaacttatttgctggtcgc gaacaagaattagtgcaacactgcaaagacagattcctaaagaagatgccggaatacgag atctcggaattcgcgaagacgcaactcactttgccagacaaaatcgacccagctgatgaa atgtcctggcaacattatctgtactccaaactaggtcagaagaaggattccatggaacca gtgaaagcacaacagctagaggacgtggttgcaaggatcacagacatggccaaagttctt tacggtttacatatgatagatcatccgcaacagcagagcaagggtcaatatcgatccgtg gtgtcgatacaacgtaaacgagcagtgatcgcttgtttccgtcaaacttccctacattcc ctgcccaggcatcgggctataaatatcttcgcgcgaacatactacgagctctggttgcag gatgagaatgttggccaagaagtgatgattgaagaccttacgcaatctttcgaggacgcg gaactgaagaaaatggacaaagacgaggacgaaggaaaaccagatccgcttacgcaattg gtaacaacattctgtcgtggcgctatgaccgagcgatctggcgcgctacaagaagatccc ttgtacatgagttacgcgcaaattatatcaaaatcttgtggcgaagaggaagaggaaggc gaagacgagggtggaggaggaggtgaagaagaaggtggcgcctcgatccataagcggggc tataagccacttatgcgaccgatgcacaaacttatggaacaagaaatggagaagcagaaa cttcttttccaccaaacgcgtcttgccaatcgtggcgtagcagagatggttctgcttcat atctcagcatgcaaaggtgtccctagtgaaatggtaatgaagactttggaattgggaatc tctatcttgcgaggtggtaacatagaaattcaacgaggaatgctgaaccacctgaaggaa aagaaggatgtaggcttcttcacttcgattgctggtctgatgaattcctgtagcgtattg gatttggatgcgttcgagaggaacacaaaagcagaaggtcttggagtcggctctgaagga gctgctggagagaagaatatgcacgatgctgaatttacgtgcgctctgtttcgattcatt caactgacttgcgaaggccacaatcttgattggcagaattatctgaggacgcaagctggc aacacgacgacggtgaacgtggtcatctgcaccgtcgattatctactacgcctacaggaa tccatcatggacttttactggcattattccagcaaagaactcatcgatcctgctggcaaa gctaatttctttaaagctatcggcgttgccagtcaagtattcaatacccttactgaagtg attcaaggaccttgcgctcagaatcaacaggcacttgcccactctcgattgtgggacgct gttggtggattccttttcctcttctctcatatgcaggacaagctatctaaacactcgagt caagtggaccttctgaaggaattgttgaacttacaaaaggatatgatcactatgatgctc tctatgctggaaggtaacgtcgtaaatggaaccattggaaagcagatggtggacacgctg gtagaatccgcaagcaacgtcgagttgattctgaaatacttcgacatgttcttgaagctc aaagacctcgtatcgtcgccaagcttcttggaagtagatctcaacagcgatggctgggta tatccgaaagattttaaagagaaaatggaacaacagaagagttacaccgacgaggagatc gaatttttgttggcctgttgcgagacgaaccacgacggtaaaatcgattacgtggctttc atggatcgtttccacgaaccggctaaagaaatcggtttcaatcttgctgttctgttaaca aatttatcagaacatatgccaaatgaaccgagactggcaagatttttggaaacggcaggc tccgtattgaactacttcgaaccgtatcttggaagaatcgaaattctcggtggaaataag aagatcgagcgtgtatacttcgagattaaggaatcgaacatcgagcaatgggagaaacca caaattaaggagtcaaagagaacatacttctataataccgtagttgaagctggagaaaag gaaaaattggaaaccttcatcaacttttgcgaggatgctatctttgaaatgcaacacgcg agtgcgctgatggcggtagaagaaagtggaggaatcggaaaggcgagagaatcatcgtac acctatatgacggaggatgacgaagaaagaaacaaagatcccatcagaagaggcattcaa acattcaaggacagcatttacttctttttctccatattctcccctagtaacatcaagaac aagatcgctgaaatgcaacagatgacgttcctggaactcttcattggtttcttcaagatg atattctatgcgttctattattctggttttggcgttggctgtataattggatactttatg aagctattgttggcattaatgaaaggaccacatgtggaagaacctgtagtcgaggtgaag gaagaggaagaaaagccgataagacatttgcctgctttgccgccaacaccggatgaatct aatttacaggtacaagcgttcggaatggatataaccaaagaggaaggtgggcagataaag atcgcgccccacgaatcggcaacatcgactcctcaatcgagcatcgaagaaactggcgaa agcacacctgaagaagctactggcgaagaaggtgcaagagctgaaggtggtggagataac atggaatcgcctgtttcattggctgatttattaggaggtgaacaagctagagcccaagca gcagcctcagcagaagcagcggccgctcaacaagcagctatggctgctgtcgaagcggaa gcgaaacaagaaacgatagcagagccttcaacatctactatcgacttctccgaatacacc catcgtatcgtctctttcttggctagaaacttctacaatctaaaatacgtggctctagtt ctcgctttctgtatcaatttcatgttgctgttctacaaggttacatcattggccggcgaa ggggatgaggaaggaagcggacaaatgattaatgacataatggcagagatgtccggtgag ggtgcatctggttctggaagtggcagtggcttagaaataggcagcgggagcggagaagac gagtcggaagaagaggaagatgcgtacgcgttagaatacgtggaggtgtcagaagatttc tattacatggcacacgttataagactcatggctatccttcatgctatcgtctctcttgct atgctggttgcctactatcacttgaaagtgccattggctatcttcaaacgggaaaaggaa attgcgcgacgcgtagagttcgatggtctgtatattgccgagacaccggaagaagatgac atcaaagcgcattgggacaagatggtgatatcggcaaaaacgttccccgtgaattattgg gacaagttcgtgaagaaaaaagttcgacagaaatacagcgagacttatgacttcgattac ataagcaacttgcttggcatggaaaagacttcgttcagccaacaagaggaagagggttct ggtttgatacactttatcgtaaatatcgattggagatatcaagtatggaaagctggagtc accatcacggataacgcatttttgtatagtttatggtatttcacattttcgatccttggc aattacaacaacttcttcttcgctgcacatttgctggatgtcgcggttggtttcaaaact ctgagaacgatcttgcagtctgtcacgcacaatggcaaacaacttgtgttaacagtgatg ttattaactatcgtcgtctatatatacactgtcatagccttcaacttcttcagaaaattc tatattcaagaagaggacgacgaagtcgacaagaaatgtcatgatatgttaacgtgcttc gtatttcatctgtacaaaggtgttagggctggtggtggtatcggtgatgaaattggcgaa cctgatggcgacgactatgaagtctaccgtatcatgtttgatatcactttcttcttcttc gtcattgtcattctattggctattattcaaggtttaatcatcgatgcattcggtgagctt cgagaccagctcgaaaacgtaaaaacgaacatggagagcaactgtttcatttgtggctta ggaaaagaatatttcgatacggtaccgcatggtttcgatacacatgttcaacaggagcat aatcttgctaattatatgttcttccttatgcacttaatcaacaaaccagacacggaatac accggtcaagaaacgtacgtgtggaacatgtatcagcaaaggtgttgggactttttcccg gtcggtgattgcttccgcaaacagaacgagtcagtggaggaagaggcaaagaagaaataa

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