Bombus pyrosoma: 122577462 Help Entry 122577462         CDS       T07776                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism bpyo  Bombus pyrosoma Brite KEGG Orthology (KO) [BR:bpyo00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bpyo04040]     122577462    04990 Domain-containing proteins not elsewhere classified [BR:bpyo04990]     122577462 Ion channels [BR:bpyo04040]  Voltage-gated cation channels   Ryanodine receptor    122577462 Domain-containing proteins not elsewhere classified [BR:bpyo04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    122577462 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 CFAP143 Serglycin DASH_Spc34 Motif Other DBs NCBI-GeneID:  122577462 NCBI-ProteinID:  XP_043604726 LinkDB All DBs Position LG2:complement(11125108..11165927) Genome browser AA seq 5158 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQENLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW GTTPSQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEATTETSTFWLRQEKDDQKIILEDKDLEVIGTPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VENSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTAGYMPYPGGGEKWGGNGVGDDLYS FGFDGAHLWTGGRKTQVVQNVTEPYIRKSDVIGCALDLTVPIITFTFNGAPIMGSFRNFN LDGMFFPAISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPAPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWIYG EHRDDMRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTVLALGYYITMDKPPSRIKTLRLP NEPFLQSSGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEANRLRQLY FRTYRVEKHYAVSSGKWYFEFEVLTAGPMRVGWAKADCSPGNMLGSDESTWAFDGYNEEK VYSGTAETFGKQWQVGDVVGVFLDLIDRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTYWYTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFISESEKLRRW QEIKMRQNRLLSEQVEQAQQAAPSAQIEQIMRSGFSMSDIKGLQRNYSEDAVEADEMMKE SPLPMQRNKPLRPPRKGSLYGSRVGNMDNAISEVDMNGYGDMNGDIKDDKKKRGRSPFRK LSKEMEDAPFFSRKAKSPDAKSKTPEPPVRSDVSDKSTKTQSMNKASNRPPQIRISNTDL KVVPPQIPERNAPKAMSMSALSGSGVEAIGNEIFDAECLKLMNEYFYGVRIFPGQDPTHV YVGWVTSQYHLHTKDFNLSRVRKGSVVITDDYDRPVEQVDRQSCYMVRADELYNEVTQDA SGKGASQGMFVGCFVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIE LGRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRG WSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHAL CQHVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQELKDL YENEEMKHSLRYLETESVRPQMKMTDIRDIPSSDQTIENIRSLYSPYFPLDVVRDYVMTA LNEAVEVNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDVMKLLIMIHPETWDPT FDKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDLQSDQ LRRYIEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKNMEFVDDPENSPCGEDLINRM NEFHNSLMSYVSLHALQEAADAVEEAEDAVQKPGAIKKLFNFINAVKELEEEPKPEPEPE RKTPEEVFRKVLIKTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVTNS KTKDDVALMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHEN VMAIMMNTLGRRAQAQSDAQTQPQTTEGEPVSKEKDTSHEMVVACCRFLCYFCRTSRQNQ KAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSR CGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECL GPALRGEGEGLLRAIIDANKMSERIADRRKVHDEAEGTTALMQFEHPLPESDDDEDYIDT GAAILNFYCTLVDLLGRCAPDSSVIEQEASTESVGKNESLRARAILRSLVPLDDLQGVLS LRFTLLNPAAGEEKPKSDMPSGLIPGHKQSIVLFLERVYGIETRELFFKILEEAFLPDLR AATMLDRNDGYESDMALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSK NRMLTKGQREAVSDFLVALTRDVHELNVSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRL LTLHYDRCAKYYGSTGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCL TAIGCALPPDYSLSKNYDDEWYGSKSAAAQSPDGPYNPQPINTSSVVLNNDLNQIVQKFS EHYHDAWASRKLENGWTYGEQWSEVNKTHPRLKPYNMLNDYERERYKEPVRESLKALLAI GWSVEHAEVDVPSTNRSSMRRSSKSQADSASPFNYNPHPVDMTNLTLSREMQNMAERLAD NAHDIWAKKKKEELITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKP NRGGESEVATAGASVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDI KFFSKVVLPLMEKYFSTHKNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAA FGPDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYS HLRGTHLKTSTSLSYINSVVLPVLTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLG VDASLTHDRKYLKTEIERHKPSLGSCLGAFSSCFPVAFLEPHLNKHNQYSLLNRIADHSL EAQDIMMKMESSMPTLETILTEVDQFVESEKTYNDLPHVVDIILPLLCSYLPFWWSQGPD NVNPTEGTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELL KDPFLPLAERVRKRTDTMFHKEESLRGFIKSSTDDTSQIEAQIQEDWQLLVRDIYSFYPL LIKYVDLQRNHWLRNNIPEAEDLYNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIM PTATRRPTTISDGTAPSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGR EQELVQHCKDRFLKKMPEYEISEFAKTQLTLPDKIDPADEMSWQHYLYSKLGQKKDSMEP VKAQQLEDVVARITDMAKVLYGLHMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQTSLHS LPRHRAINIFARTYYELWLQDENVGQEVMIEDLTQSFEDAELKKMDKDEDEGKPDPLTQL VTTFCRGAMTERSGALQEDPLYMSYAQIISKSCGEEEEEGEDEGGGGGEEEGGASIHKRG YKPLMRPMHKLMEQEMEKQKLLFHQTRLANRGVAEMVLLHISACKGVPSEMVMKTLELGI SILRGGNIEIQRGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEG AAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQE SIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDA VGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTL VESASNVELILKYFDMFLKLKDLVSSPSFLEVDLNSDGWVYPKDFKEKMEQQKSYTDEEI EFLLACCETNHDGKIDYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAG SVLNYFEPYLGRIEILGGNKKIERVYFEIKESNIEQWEKPQIKESKRTYFYNTVVEAGEK EKLETFINFCEDAIFEMQHASALMAVEESGGIGKARESSYTYMTEDDEERNKDPIRRGIQ TFKDSIYFFFSIFSPSNIKNKIAEMQQMTFLELFIGFFKMIFYAFYYSGFGVGCIIGYFM KLLLALMKGPHVEEPVVEVKEEEEKPIRHLPALPPTPDESNLQVQAFGMDITKEEGGQIK IAPHESATSTPQSSIEETGESTPEEATGEEGARAEGGGDMESPVSLADLLGGEQARAQAA AAAEAAAAQQAAMAAVEAEAKQETIAEPSTSTIDFSEYTHRIVSFLARNFYNLKYVALVL AFCINFMLLFYKVTSLAGEGDEEGSGQMISDILAEMSGEGASGSGSGSGIEIGSGSGEDE SEEEEDAYALEYVEVSEDFYYMAHVIRLMAILHAIVSLAMLVAYYHLKVPLAIFKREKEI ARRVEFDGLYIAETPEEDDIKAHWDKMVISAKTFPVNYWDKFVKKKVRQKYSETYDFDYI SNLLGMEKTSFSQQEEEGSGLIHFIVNIDWRYQVWKAGVTITDNAFLYSLWYFTFSILGN YNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIVVYIYTVIAFNFFRKFY IQEEDDEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFFV IVILLAIIQGLIIDAFGELRDQLENVKTNMESNCFICGLGKEYFDTVPHGFDTHVQQEHN LANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNEAVEEEAKKK NT seq 15477 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgagggtggctccgagcaggatgacgtatccttcctccgtacggaggac atggtatgtctgtcctgtaccgcaactggtgaaagggtttgcctcgcagctgaggggttt ggtaatcgacactgtttcctcgagaatatcgcagacaagaacataccacctgacctgtcg caatgcgtattcgtaatagaacaagctctgtcggtgagagctctgcaggaattggtaacc gccgccggttccgagacgcagcaagaaaatttaggaaagggcactggatctggacacaga acgttattgtatggcaacgctattctactgaggcatcaaaacagcgacatgtatttggcg tgtttatcgaccagctcgtccaacgacaagttggctttcgacgtaggtctacaacaacat tctcaaggcgaggcgtgttggtggactgtgcatccagcatcgaagcagaggtcagagggt gagaaggttcgagtcggtgatgaccttattctggtatctgtggccactgagagatacttg cacacaacaaaagaaaacgacttatcagtggttaacgcctcgttccacgtaacccactgg tcggtacaaccttacggcactggaatcagccggatgaaatacgttggttacgtatttggc ggtgacgttctacgattttttcacggtggcgacgaatgcctcactataccgtcaacatgg ggcacaacaccgagtcaaaatatagtggtctacgagggaggcagcgtaatgagtcaagct cgatctctatggagactggagctggcaagaactaaatgggccggtggttttatcaactgg ctgcatccgatgaggatcagacacttgacaactggacgttaccttggtgtcaaagaaaac aacgaactgtacctggtcgatagaaacgaggcaacgaccgagacttcaacgttttggtta cggcaagagaaggatgaccagaagatcattctcgaggacaaggacctcgaagttatcggt acaccgatcatcaagtatggtgactcgactgttatcatgcagcacgctactacttgcctc tgggtctcgtacaagtcgtacgagacgaagaaaaagggtgtgggcaaagtggaggagaag caagccgtccttcacgaagaaggaaagatggacgatggtttggacttctctcggtctcaa gaggaagagtcccggacagctcgtgtgatacgaaagtgtagcagtctgttcacccagttc atcacaggcctagagacgctgcaagtagatagaagagcgtctatgttcttccaaaatgtg aatctgaacgaaatggtgatgtgtctggaagacttgattaattattttgctcaacccgaa gacgacatggagcacgaagagaaacaaaacagattccgcgctctgagaaatcgtcaagac ctgtttcaagaggaaggtatattgaacttgatactcgaagccatcgacaagatcaacgtg attacgtcacaaggtttcctcgtggcactttcgggagacgagagtggtcaagcttgggat caaatatcaggatacctgtatcaactattggcagctattatcaaaggaaatcacacaaac tgcgcgcaatttgctaacagcaatcgtttgaactggttgttcagtcgactcggatcgcag gcttccagcgaaggcactggaatgttggacgtgctgcattgcgttcttatcgactcgccc gaagctttaaacatgatgagggacgagcacattaaagtcatcatttccttgttggagaag cacggaagagatccaaaagtcttggacgtactttgctcgctgtgcgtgggtaacggtgtg gctgttcgatcttcgcagaacaatatctgtgacttcttgctgccaggaaaaaatcttctt cttcaaacgcaattggtcgatcacgtggctagcgttagaccgaacatattcgtcggcaga gtggagaactcggcgctttatcagaagtggtacttcgaagtcaccgtcgaccacatcgaa cagaccacgcacatgatgccgcatttgagaataggatgggcgaacactgctgggtacatg ccataccccggtggtggcgagaaatggggtggaaacggtgttggcgacgacctctattca ttcggtttcgacggtgcacatctatggaccggtggtagaaaaactcaagttgttcagaat gtcacggaaccttacatcagaaagagcgacgtgatcggatgtgcattagatctcacagtg cccataatcactttcaccttcaacggagcacctatcatgggatccttccgaaatttcaac ctcgatggcatgtttttccccgcaatcagctgctcgtcaaaactatcctgtagattcctg ttaggcggtgaccacggccgactcaagtttcaaccaccagaagaattctcacctttggtg gaaagcttattaccacagcaaattctatctttggatccctgtttctactttggaaacatg aacaaggtggtcctagctggtccatggttggtcgaggatgacacagctttcgtcccagct ccagtcgacacatctatgatcaatttaccatcatatgtcgagcaaatcagagataaacta gctgagaatatccacgagatgtgggcaatgaataaaatcgaagctggttggatatatgga gaacatagagacgatatgagaaagattcatccatgtatcgttcagtttgaacgattacca gctgcagaaaaacgttacgacactcagttggcagtgcaaacactgaagactgttctagcc ttgggatattacatcacgatggataaaccaccctctagaataaagaccctgaggcttccg aatgaacccttcctgcaaagcagcggatacaaaccagcaccgcttgatcttagcgccatt acactcacaccaaagatggaagaactggtagaccagcttgcagagaatactcataatttg tgggcaaaggaaaggattagtcagggatggacttatggtctgaacgaggattctgagatg agaaggagcccccatttggtaccctacccgaaggtagacgaagcgatcaagaaagctaat cgtgacaccgccagtgaaactgtgaggacacttttggtttatggatacatgttggaacca cctactggagaacaacacgaagcgctgctgttggaagccaacaggttacgacaactatac tttagaacatatcgcgttgagaaacactacgcagtcagtagcggaaagtggtacttcgag ttcgaggtgctgacagctggccctatgcgagtcggttgggcaaaagctgactgctctccc gggaatatgctggggagcgacgaatctacttgggcttttgacggctataacgaggaaaaa gtatactcgggcacagccgagacatttggcaaacaatggcaggttggagacgttgtcggg gttttcctggatctaattgaccgaacaattagcttttctctaaacggagaactgctgatg gatgcgctcggtggtgaaacgtctttcgctgacgtacagggtgactgtttcgtaccagct ttcacgcttggtgttggacaaaaagcaaaattaactttcggacaggatgtaaatacctta aagttctttacgacctgcggtttgcaagaaggatacgaaccgttctgtgtgaacatgaat cgtccagttacgtattggtacaccaaggatcaaccaattttcgagaacacagacgatatg gctgacacgaggatagatgtagccaggattccagcgggttccgatactccaccatgttta aagatctctcataacacgtttgaaactatggaaaaggcgaactgggagttcctgcgatta tctttaccggttatttgccaatcgacgtttatttcggaaagtgagaaactaaggagatgg caggaaatcaaaatgcgacagaatagactattgtctgaacaagtggagcaggctcaacaa gcagcgccttctgctcaaatagagcagatcatgaggtctggattcagcatgagcgacatt aaaggattacaaaggaactattcggaggatgcagtggaagccgacgaaatgatgaaggag tcaccgcttcccatgcaaagaaacaagccgttgagacctccaagaaagggttccctctat gggtcacgggtcggaaacatggataacgcaattagcgaggttgacatgaatggatacggc gatatgaacggcgatatcaaggacgataagaagaaacgtgggcgttctccgttccgcaaa cttagcaaagaaatggaggatgccccattcttctctcgtaaagcgaagtctccggacgcg aaatcgaaaacgcccgagccaccagtacgttcagacgtttctgataagagcaccaagacc caatcgatgaacaaagcaagtaaccggcctccccaaattcgcatatcaaacacggacttg aaagtagtgccacctcagatcccagaacgcaacgcaccaaaagcaatgtctatgtctgct ctgagtggaagcggcgtcgaggcaatcggaaatgagatattcgatgcagaatgtttgaaa ttgatgaacgaatacttctacggagtgagaatctttcctggacaggatccaacgcacgtt tatgttggctgggttacttcccagtatcatttgcatactaaagactttaatctgtctcgc gtgaggaagggctctgtagttataaccgatgattatgatcgtcctgtagaacaggttgat agacagagctgctatatggtaagagcggatgagctttacaacgaagtaacgcaagacgca tccggcaagggagcttctcaaggaatgttcgttggatgtttcgtggataccgcaaccggt tgggtgtccttcacttgcgagggaaaggaaactagccacaaattcaagatggaacccgat acgaaattattccctgccatcttcgtagaagctaccagcaaggaaatccttcaaattgaa cttggaagaacatccacaacgttaccattatccgctgctgtgttacaaaactcagaacgt catgtgataccacagttcccacctagattgaaggttcaatgtctgaaacctcaccaatgg gcaagagttccaaatcaatcgcttcaggttcatgccttgaaactgtctgatatcagaggt tggtccatgctgtgcgaggatgccatatcaatgttggctttgcatatccctgaagaggat agatgtatcgatatcttggagcttattgagatggataagttacttagcttccatgcacac accctgacactgtacgcagctctatgttatcagtcgaattacagagcagcacacgctcta tgtcagcacgtcgatcaaaaacaattattgtacgcaattcgagcggaatacatgtccggg cccctacgacaaggattctacgacttgctgatcgccttgcatctcgagtcacacgcgact acgatggaagtgtgtaaaaatgaatacataattcctttaggtcaagaactgaaggattta tacgaaaacgaagaaatgaagcacagcctcaggtatctagaaaccgagtcggttcgtcct cagatgaaaatgacagacataagggatattccttccagcgatcaaacgatcgagaacata aggagcctctacagtccgtacttccctctggatgtagtgcgggactacgtgatgactgca ctgaacgaggccgtcgaggtcaatcaagttcacaatcgggaccccattggtggcagcaat gagaatcttttcctgccacttttgaaactagtagacaggttgctcttggtcggaatgctc aggaacgaagacgttatgaagcttctgattatgattcatcctgagacttgggatccgacg tttgacaaagaaggaaaagacgagcacaagaagggactgcttcacatgaagatggccgaa ggtgcgaaactacagatgtgctatcttcttcatcatctaaacgacatccagcttcgacat cgcgtcgagtccattatcgcatttagccacgacttcgtcggtgatcttcagtccgatcaa cttcggcgttacatcgaaatcaaacaatctgacttaccatcggcagtagctgcgaagaag acaagagaatttcgatgtccacctcgtgaacagatgaatgcgatcttaagcttcaagaat atggaattcgtggatgatcctgaaaatagtccttgcggagaagatctgataaatcggatg aatgaattccacaacagtctcatgtcctacgtgtccttgcacgccctgcaggaagcagcg gacgccgtggaggaggcagaagacgcagttcagaaacctggcgccattaaaaagctattc aactttatcaacgcagtgaaagaactcgaagaggaacctaaacctgaacctgaacccgag agaaagactccagaagaggtgttccgtaaagttctgataaaaaccatcgtcagctgggcc gaggaatcccaaatcgagactcctaagttggttcgagaaatgttcagtttactggttcgc cagtacgacacggtgggcgagttaattcgagctctagagaaaacctacgtgaccaacagc aagacaaaggacgacgttgctttgatgtgggtcggtttgagccaaattcgcgccttactg cctgtacaaatgtctcaagaggaagaagagctcgttcgggaacgactctggaaattagtc aacaatcatacgttcttccagcatccagatttaatcagagtgcttagaattcatgaaaac gttatggcgatcatgatgaacacactaggcagacgtgcacaggcgcaatcggacgctcaa actcagccccaaactaccgaaggagaaccagtttccaaggagaaggatacttctcacgaa atggtggtagcatgctgtagattcctgtgctacttttgtcgaacttccagacagaatcag aaggctatgttcgatcactttgacttcttactggagaatagtaatatcttgttatcgaga ccatctttaagaggttccacgccattggacgtagcttattcttcgctcatggaaaacacg gagctggctctggctctcagagaacattatcttgaaaagattgccatatatctatcccgt tgtggtttgcaatcgaattcagaattggttgaaaaaggttatcccgatctgggatgggat ccggtggaaggcgaaagatatttggactttttgaggttctgcgtttgggttaatggtgaa agcgtcgaggaaaatgcaaacttggtgatccgtttgctgatcagaagaccggaatgtctg ggaccagcgcttcgtggcgagggtgaaggtctattaagagctatcatagatgccaacaag atgtccgaacgaatcgctgatcgaaggaaagtacacgacgaagcagaaggtacaacggcg ctcatgcaattcgaacatccgcttccggaatcagacgacgacgaagactatatcgataca ggagctgcgatcttgaacttctattgtaccttggtggacctattaggccgctgcgctcca gattcttctgttatcgaacaagaggcttctacagaatctgtcgggaagaacgagtctctt cgagcgagggctattcttcgatctctggtgccactcgatgatctacaaggtgtcctgtct ttgaggttcacgttattgaatcccgcggcaggcgaagagaaaccaaaaagcgatatgccg tctggtttgattcctggacataaacagagcatcgttctgtttttggagcgcgtttacgga atcgaaaccagagaattgttctttaagatactcgaggaagcgtttttgcccgatctcaga gccgccactatgttggataggaacgatggatacgaatcagacatggcgctagcgatgaac cgttacattggaaacagtattctacctttgttgatcaagcattcgaaattctacaacgag gcggataactatgccagcttactggatgctacgttgcacaccgtatatcgattgagcaag aacagaatgctcactaagggtcaacgtgaagcagtgtcggatttcctcgtggcattgacc agagacgtccacgagttaaatgtctcccaaatgcaacccagcatgttgctgaagctgctt cgaaagctgaccgtagacgtgtccaagctatcagaatatacgacagttgctctaaggttg ctgactcttcactacgatcgttgcgcgaaatattacggatcgaccggtggacaaggcgca tacggtgcatcaagcgatgaagagaaacgcctgactatggttctcttcagcaacattttc gattcgttatccaagatggactacgatccagaactgtttgggaaagctctaccttgtctc acagctattggttgcgcgttaccacctgattattcgttgtcgaaaaattacgatgacgag tggtatggaagtaaatctgcagctgcacaatcgcctgatggaccttataatcctcaacca atcaatacctctagtgtggtcctcaataacgacctcaatcagatagtccaaaagttctcc gagcattaccacgacgcttgggccagtcggaagttagaaaacggttggacctacggcgaa caatggtctgaagtgaacaaaactcatcctaggctgaagccgtacaacatgttaaacgat tacgagagagaacgatacaaagagccagtcagagagagtttaaaagctttgttggccata ggatggagcgttgaacatgcagaggtggatgtaccatctaccaatcgtagttccatgaga agatcatcgaaaagtcaagctgattcagcgagtccatttaattataatcctcatccagtt gacatgactaatttgactctgagcagagaaatgcaaaacatggcagagcgtctcgcggat aatgcgcacgatatttgggcgaagaagaagaaggaagaactcatcacttgtggaggtggt attcatcctcaactagttccgtatgatcttttgaccgacaaggagaaacgaaaggatcgc gaacgttcccaagaattcctcaagtacctgcagtatcagggttacaagcttcataaacca aatagaggcggagaatcagaagttgcgactgctggagcctcggtggaattacgattcgcc tactcgttacttgaaaagttgatagcctatttggataaggccactatcaacatgaaattg ctgaaaccgtccgacacgttcagtcgtagaaatagctttaaaacgtctacaagagacatc aaattcttcagcaaagttgtactgccactgatggaaaaatattttagcacacacaaaaac tatttcatcgctgtggcaacggctaccaacaatgtcggagctgcgtccttgaaagagaag gagatggtagcagctctattttgtaaattggccagtttattgagatctagattggctgct ttcgggccggatgttaggatcaccgtccgctgtcttcaagtactagtcaaaggcatagac gcgaagagtttagtgaagaattgtcctgagtttatcagaacgtctatgttaacgttcttc aacaacaccgcagatgacttaggacacacgatccttaatcttcaagagggcaaatacagt catctgagaggaacacatttgaaaacttctacatccttgtcgtatatcaatagcgtggtt ttgccagtgctcacagccatgttcgatcatttggccgcctgcgagtatggtagcgatttg ctattggacgaaattcaggtggcatcctacaaaatgctggcgtctttatacactctcggt gtagatgcctctctaacacacgacagaaaatatttgaagacagaaatcgagcgtcacaag cccagcttaggttcctgtctaggtgccttttctagttgtttccctgtggccttcctggag ccacatttaaacaagcacaatcagtattcccttttaaatcgtatagccgaccattccttg gaagcacaagatatcatgatgaagatggaatcgagtatgcctaccctagagacgatcttg acggaagtcgatcaattcgtcgagtctgagaaaacctacaacgatcttccccacgtagtt gacattattcttcctctactttgctcctatctgcctttctggtggtctcaaggcccagac aatgtaaacccgacagaaggaacgtacgtcagcatggtcaccagcgatcacatgaatcaa ttgctgaagaacgtattaaagttgattaaaaagaacatcggtaacgaaaatgctccttgg atgactcgtattgctgcttacactcagcagatcattataaattcatcagaagagttgctg aaggatccattcttgccacttgctgaacgtgtcagaaaacgtacggacactatgttccat aaagaagaatctcttcgtggttttattaaatcttccacggatgacacgtcacagatcgaa gcacagattcaagaggactggcaacttctggttcgcgatatttactcgttctatcctctt ttgattaagtacgttgatttgcaaaggaatcattggctgaggaataacattccagaagca gaagatctttataatcatgtagcagcgatatttaatatttggtccaagtctcagtacttc ttgagagaagaacaaaacttcatatcggctaatgagatcgataatatggtgctcattatg ccgacagcgaccagaagacctactactatttcggatggaacagcaccttccggaggaggc aagaaaaagaagaagcaccgtgacaagaaaagagataaagacaaagaagtgcaggcttcc ctaatggtagcctgtttgaagaggttgcttccagttggtctgaacttatttgctggtcgc gaacaagaattagtgcaacactgcaaggacagattcctaaagaagatgccggaatacgag atctcggaattcgcgaagacgcaactcactttgccagacaaaatcgacccagctgacgaa atgtcctggcaacattatctgtactccaaactaggtcagaagaaggattctatggaacca gtgaaagcacaacagctagaggacgtggttgcaaggatcacagacatggccaaagtcctt tacggtttacatatgatagatcatccgcaacagcagagcaagggtcaatatcgatccgtg gtgtcgatacaacgtaaacgagcagtgatcgcttgtttccgtcaaacttccctacattcc ctgcccaggcatcgggctataaatatcttcgcgcgaacatactacgagctctggttgcag gatgagaatgttggccaagaagtgatgattgaagaccttacgcaatctttcgaggacgcg gaactgaagaaaatggacaaagacgaggacgaaggaaaaccagaccctcttacgcaattg gtaacaacattctgtcgtggcgctatgaccgagcgatctggcgcgcttcaagaagatccc ttgtacatgagttatgcgcaaattatatcaaaatcttgtggcgaagaggaagaggaaggt gaagacgaaggtggaggaggaggcgaagaagaaggtggcgcctcgatccataagcggggc tataagccacttatgcgaccgatgcacaaacttatggaacaagaaatggagaagcagaaa ctacttttccaccaaacgcgtcttgccaatcgtggcgtagcagagatggttctgcttcat atctctgcgtgcaagggtgtccctagtgaaatggtaatgaagactttggaattgggaatc tctatcctgcgaggcggtaacatagaaattcaacgaggaatgctgaaccacctgaaggaa aagaaggatgtaggtttcttcacttcgattgctggtctgatgaattcctgtagcgtattg gatttggatgcgttcgagaggaacacgaaagcagaaggtcttggagtcggctctgaagga gctgctggagagaagaatatgcacgatgctgaatttacgtgcgctctatttcgattcatt caattgacttgcgaaggccacaatcttgattggcagaattatctgaggacacaagctggc aacacgacgacggtaaacgtggtcatctgcaccgtcgattatctactacgcctccaggaa tccatcatggacttttactggcattattccagcaaggaactcatcgatcctgctggcaag gctaatttctttaaagctatcggcgttgccagtcaagtattcaatacccttactgaagtg attcaaggaccttgcgctcagaatcaacaggcacttgcccactctcgattgtgggacgct gttggtggattccttttcctcttctctcatatgcaggacaagttatccaaacactcgagt caagtggaccttctgaaggaattgttgaacttacaaaaggatatgatcactatgatgctc tctatgctggaaggtaatgtcgtaaatggaactattggaaagcagatggtggacacactg gtagaatccgcaagcaacgtcgagttgattttgaaatacttcgacatgttcttgaagctc aaagacctcgtgtcgtcgccaagcttcttggaagtggatctcaacagcgatggctgggta tatccgaaagattttaaagagaaaatggaacaacagaagagttacaccgacgaggagatc gaatttttgttggcctgttgcgagacgaaccacgacggtaaaatcgattacgtggctttc atggatcgtttccacgaaccggctaaagaaattggtttcaatcttgctgttctgttaaca aatttatcagaacatatgccaaatgaaccgagactggcaagatttctggaaacggcaggc tccgtgttgaactacttcgaaccgtatcttggaagaatcgaaattctcggtggaaataag aagatcgagcgtgtatacttcgagattaaggaatcgaacatcgagcaatgggagaaacca caaattaaagagtcaaagagaacatacttctataataccgtagttgaagctggagaaaaa gaaaaattggagaccttcatcaacttctgtgaggatgctatctttgaaatgcaacacgcc agtgcgctgatggcggtagaagaaagtggaggaatcggaaaggcgagagaatcatcatac acctatatgacggaggatgacgaagaaagaaacaaagatcccatcagaagaggcattcaa acattcaaggacagcatttacttctttttctccatattctcccctagtaacatcaagaac aagatcgcagaaatgcaacagatgacgttcctggaactcttcattggtttcttcaagatg atattctatgcgttctattattctggttttggcgttggctgtataattggatactttatg aagctattgttggccttaatgaaaggaccacatgtggaagaacctgtagtcgaggtgaag gaagaggaagaaaagccgataagacatttgcctgctttgccgccaacaccggatgaatct aatctacaggtacaagcgtttggaatggatataacgaaagaagaaggcgggcagataaag atcgcaccccacgaatcggcaacatcgactcctcaatcgagcatcgaagaaacgggcgaa agcacaccggaagaagctactggcgaagaaggtgcaagagctgaaggtggtggagacatg gaatcgcctgtttcattggctgatttattaggaggtgaacaagccagagcccaagcagca gccgcagcagaagcagcggccgctcaacaagcagccatggctgctgtcgaagcggaagcg aaacaagaaacgatagcagagccttcaacatctactatcgacttctccgaatatacccat cgtatcgtctccttcttggctagaaatttctacaatctaaaatacgtggctctagttctc gctttctgtattaatttcatgttgctgttctacaaggttacatcattggccggcgaaggg gatgaggaaggaagcggacaaatgattagtgacatactggcagaaatgtctggcgagggt gcatctggttctggaagtggcagtggcatagaaataggtagcgggagcggggaagacgag tcggaagaagaggaagatgcgtacgcgttagaatacgtggaggtgtcagaggatttctat tacatggcacacgttataagactcatggctattcttcatgccatcgtctctcttgctatg ctggttgcctactatcacttgaaagtaccgctggctatcttcaaacgggaaaaggaaatt gcgcgacgcgtagagttcgatggtctgtacattgctgagacgccggaagaagatgacatc aaggcgcattgggataagatggtgatatcggcgaaaacgttccccgtgaattattgggac aagttcgtgaagaaaaaagttcgacagaaatacagcgagacttacgacttcgattacata agcaacttgcttggcatggaaaagacttcgttcagccaacaagaggaagagggttctggt ttgatacactttatcgtaaatatcgattggagatatcaagtatggaaagctggagtcacc atcacggataacgcatttttgtatagtttatggtatttcacattttcgatccttggcaat tataacaacttcttctttgctgcgcatttgctggatgtcgcggttggtttcaaaactctg agaacgatcttgcagtccgtcacgcacaatggcaaacaacttgtgttaacagtgatgtta ttaactatcgtcgtctatatatacactgtcatagccttcaacttcttcagaaaattctat attcaagaggaggacgacgaagtcgacaagaaatgtcatgatatgttaacgtgcttcgta tttcatctgtacaaaggtgtcagggctggtggtggtatcggtgatgaaattggcgaacct gatggcgatgactatgaagtctaccgtatcatgtttgatatcactttcttcttcttcgtc attgtcattctattggccattattcaaggtttgatcatcgatgcattcggtgagcttcga gaccagctcgaaaacgtaaaaacgaacatggagagcaactgtttcatttgtggcttagga aaagaatatttcgatacggtaccgcatggtttcgatacacatgttcaacaggagcataat cttgcaaattatatgttcttccttatgcacttaatcaacaaaccagacacggaatacacc ggtcaagaaacgtacgtgtggaatatgtatcaacaaaggtgttgggactttttcccggtc ggtgattgcttccgcaaacagaacgaggcagtggaggaagaggcaaagaagaaataa

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