Betta splendens (Siamese fighting fish): 114846318 Help Entry 114846318         CDS       T08231                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X6   KO K04962   ryanodine receptor 2 Organism bspl  Betta splendens (Siamese fighting fish) Pathway bspl04020   Calcium signaling pathway bspl04260   Cardiac muscle contraction bspl04261   Adrenergic signaling in cardiomyocytes bspl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bspl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     114846318 (ryr2a)    04020 Calcium signaling pathway     114846318 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     114846318 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     114846318 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bspl04040]     114846318 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:bspl04990]     114846318 (ryr2a) Ion channels [BR:bspl04040]  Voltage-gated cation channels   Ryanodine receptor    114846318 (ryr2a) Domain-containing proteins not elsewhere classified [BR:bspl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    114846318 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  114846318 NCBI-ProteinID:  XP_028991032 UniProt:  A0A6P7L959 LinkDB All DBs Position 19:8158878..8219149 Genome browser AA seq 4974 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLASSEDKAEGHVDVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRTVHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKSLQLMDKERADVKSTAFCFRSSKEKLDPGVKKEVDGMGVPDIKYGDSVCYIQH VDTCLWLTYQTVDAKCARMSGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFL FNLFIRGLDALRKKGKSSTLELPIDSVSLSLQDLIGYFQPPGEHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEAVGREVGDAWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSD GSAQYRKWYYELIVDQVLPFVTAEATHLRVGWANTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLHLWSGCIARTVSSPNQHLLRAEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSE GLFFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEACQDQTASRD LLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRD DNKRQHPCLVEFSKLPEQERSYNLQMSMETLKTLLALGCHVGLADEHAVEKVKSMKLSPT YELSSGYKPAPLDLSHIKLTPTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRN PRLVPYILLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDISNMSAERFRIFR AEKTYCVNSGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGN EHFGRAWQTGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVGEGFIPVCSLGV CQVGRMNFGKDVSTLKFFTICGLQEGYEPFAVNMNRDITMWLSKRLPQFVPVPPSHQHIQ VTRIDGTVESCPCLKVTQRSFGSQNSSTDLAFYRLSMPIECAESFSRSQHNGSLFSPKRE LEDFETVSDFEVLMKTSHGHNGPSGPERDEFNNHKDYNQEKPSKLKQRFLLKRNKPDNSC PSSARLSEEVMADDRDDYEVLLQASTHYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFEL HKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNSNGLEIGCLVDTTNGLLT FTANGKELSTYYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSEKKNLV PQCPPRLHVQFLTPVLWSRAPDHFLRILASRVNDRHGWLLQCNEPLQFMSLHIPEENRSV DVLELSEQKDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIDNKYMPGLLR VGYYDLLIDIHLSSYATARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRP RMHFSSPSFVCGTRSSYRNNGSNGSGSGDCFQYSPEFPLDILKIKTIEMLTEAVREGSMH VRDPIGGSTEFLFVPLIKLLYTMLIMGVFQNGDLKNILRLIEPSVFSEREDGQESHAELE LMKEVKTEGGVDGGRNMPNEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDD FVACLQENQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPDY IREQLLDFHEDLMRHCGIELDEERGIDGDSDFTIRGRLMSLVEKVAYLKKKMGNLPSEKK DGKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSV SVEDTINLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETV MEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLAS PSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIGWN PVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEEAI KISQDSSRDGPSPTSESSKTLSDMIEEDEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLI HAGKGEAIRIRAILRSLIPIEDLVGVISIPFSMPSLGKDGMVVEPDMSAGFCPDHKAAMV LFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLT KCASLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGTLRPSMMQHLL RRLVFDVPLLNEHTKMPLKLLTNHFERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGIF DALSRKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADTS SVTVPEKLDYFVTRYAEHNHEKWCIERFSSGWSYGDQICEISKSHPLLKPYKGLSEKDKE LYCWSVRESLKTMLSWGWSIERIRDGDPTSLHNKSRRISQASQLSFEGAPAFSPRPIDMS NVTLSRDMQSMAELLAENYHNIWARKKKVELEAKGGGNHPLLVPYDTLTAKEKSNDREKA QDILKFLQINGYTVSRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDVGVRP KGEKIPHEQQIKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLFC KLGVLVRYRISLFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFDNAAEDLE KTQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQVS CYRILNSLYLLGTNKSIYVERQRPALGECLAAFSAAFPVAFLEPHINKFNSFSIYNSKGP KDKAALGLPGQVEEICPLIPILDKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHW WEHGPEGNMDRADHCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISK AKPQLLKTHFLPLMEKLKKKAAVVLMDEEHSKAEGRGEMSETELLIMDQFTILVRDLYAF YPLLIRFVDYNRAKWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMS FLITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQELI TLAKNRFTQKDTEDEVRETIRNNLHLHGKLEDPAIRWQMALYRDLPNHYEDTSDPEKTVE RVLDISHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFL QGYEKSWIEAEEHYFEDKLIEDLAKSGEQEPCEEEEGVKHIDPLHQLIQLFSRTALTEKC KLDEDNLYMAYADIMAKSCHDEEDDDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVL QTISASKGEMGLMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCS VLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQ NYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQ VFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIDLLKELMDLQ KDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEY DPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIG FNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISES SRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSAV KEESEREKPEEETPEMGFFSVTTVCMALVALRYNVMLLIKVLSTKSLKKQMKKLKNMTVK DMVTTLVSFYWSVLLSLLHVAFSVSRGFCRIFYNTFMGGNLVEGAKTIKVSELLANMPDP TQDEVRGEGDDRDKRPEHSSPKEDLADLAVNTSDTELLSDIFGLDLRREGGQYKITPHNP NASLTELLNSPVPSPTTTGAPTELRQRHQSKTSSSEAKEATPEAECEPDKTSEGHIEKQE KPQKPEKVKPKVRKHRTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRMLALFVA FAINFILLFYKVSTSSSVVEEKKVVHPSSQAGGSVQWDALSGEALEAKGGGADAAAQPPK PVMVRFVLEESSGYMEPMLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMD KAALDFSDAHKKRKPRRDGSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14925 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggggaaggcgaggatgaaatccagttcctgcggactgatgatgaggtg gtcttacaatgttcagctacgatccacaaggagcaacagaaactctgtctggctgctgaa ggcttcggaaacagactgtgcttccttgagtctatctccaactccaagaatgtgccgcca gatctgtccatctgcaccttcgtgctggaacagtcgctgtcggtccgagcgctgcaggag atgctggccagctctgaagacaaggccgaggggcatgtagatgtggaaatatggacggcg cagggcggcgggcatcgcaccctgctgtacggacacgccgtcctgctgcgacactcgtac agcggaatgtacctgtgctgtctgtccacatcccgctcatccacggacaaattggctttt gatgtgggactgcaggaggataccacaggcgaggcgtgctggtggaccatccatccagca tcaaagcagcgttcagagggagagaaggttagagtgggagatgatctcatcctggtcagc gtctcatctgagagatatctgcatctgtcctacggtaacggcagcctgcacgtggatgca gccttccagcagactctgtggagcgtggctcccatctgttctggcagcgaagtagcacaa ggcttcctgataggaggggacgtcctgcgcctccttcacggtcacatggacgagtgtctg actgttccatctggcgagcatggggacgagcagaggaggactgtgcactatgagggaggc gccgtgtccagccatgctaggtccctgtggaggctggagacactgcgggttgtgtggagc gggagccacatccgctggggccagcccttcagactgagacatgtcactacggggaagtat ctgagcctgatagaggacaaatccctgcagctgatggataaagagagagcggatgtcaag tctacagccttctgcttcagatcttccaaggaaaagctggaccctggggtgaagaaggag gtggatgggatgggggttcctgacattaaatatggcgactccgtgtgctacatccaacat gttgacacctgcctatggctcacataccagactgtggatgccaagtgtgcacgaatgagt ggagtgcagagaaaggccatcatgcatcacgagggtcacatggatgacgggctcactctg tctcggtcacaacacgaggagagtcgcactgctagagtcatacgcagcaccgtctttctg tttaatctcttcatcaggggcttggacgcgctgaggaaaaaggggaagagctccaccttg gagctaccgatagattcggtcagcttgagtctgcaggatctgattggctacttccagcca cctggagagcacctggaacatgaagacaagcagaacagactcagagccctgaagaaccga cagaacctgttccaggaggaggggatgataagcctggtgctggagtgtattgatcggctg catgtctacagcagtgcagcacattttgctgaagcagtaggaagggaagtaggagacgcc tggagctccatcctcaactccctctatcagctgctggctgcactcatcagaggaaacagg aagaactgtgcccagttttctggttcgctggactggctgattagcagactggagcgactg gaggcctcctctggtattctagaggtccttcactgtgtgctggtggagagtcctgaggcg ctgaacataatcaaagagggacacatcaagtctattatttccctgctggacaaacacgga cgcaaccacaaggttctcgatgtgttgtgttcgctctgtgtgtgccatggcgtcgctgtg cgctccaaccagcacctcatctgtgacaacctgctgcccgggagagatctgctactgcag acccgcttggtcaaccacgtgagcagcatgcgtcccaacatcttccttggtgtcagtgat ggctctgctcagtacaggaagtggtactacgagctgatcgtggatcaggtgttgccattt gtcacagcagaggctactcacctccgggtgggctgggccaacaccagcggctacgccccc taccccagtgggggtgaggggtggggaggcaacggggtgggagatgacctctactcctat ggctttgatggactccacctgtggtcgggttgcattgcacggacagttagctccccaaac cagcacctcctgagggcagaggacgtggtcagctgctgcctggacctcagcgttcccagc atctcgttcaggatcaacggacagccagtgcagggcatgttcgagaacttcaactccgag ggcctcttctttcccgtcgccagcttttctgccggagtcaaggtgcgcttcctactcggg ggtcgtcatggagagtttaagttccttcctcctccaggttatgctccttgttacgaggca gtgttgccaagggagaaactgaagctggaggcctgtcaggaccagacagcatccagagac ctgctgggacccactgtcaccttgagccaggcagcatttacacccacacctgtggacacc agccagattgtgctgcctcctcacttagagaggatcagggagaaactcgcagaaaacatc catgaactgtgggtgatgaacaagatagaactgggctggacttacggagctgttcgagac gacaacaagcggcagcacccctgtttggtggagttctccaagcttcctgagcaggagcgg agctacaacctgcagatgtctatggagactctcaaaaccctcctggctttaggttgccat gttgggctagcagatgaacatgctgtagagaaagtgaagagcatgaaactgtcaccaacc tatgagttatccagtggctataagcctgctcccctggacctgagccacatcaaactcacc cccacacaggaagccatggtggacaaactggctgagaacgcacacaatgtctgggctaga gaccgcatccgtcaaggctggacctacggcatccagcaggatgtgaagaatcgtagaaat ccacgccttgtcccatacattcttctggatgagagaactaaaaagtccaacaaagacagt ctgagagaggccgtgaggactctgctgggatatggatacaacctggaagctcctgaccag gatcatgcagcacagtctgatatcagcaacatgtctgctgagagattccgcattttcaga gcagagaaaacctactgtgtcaattctgggaaatggtactttgagctggaggtactgaca gcaggcgagatgagggtcggctgggccaggccaggatgcctcccagaccaggagctgggt tctgatgaccaggcgtttgtgtttgatggtttcaaggtacaacggtggcatcagggcaac gagcactttggtcgagcttggcagacgggggacgtggtgggctgcatggtcgatctcaat gaacacaccatgatgtttacactcaatggggaggtgctgctggatgattctggctccgaa ctggccttcaaggactttgaagttggcgaaggttttattcctgtgtgcagtttaggcgtg tgccaggtgggccggatgaactttggtaaagacgtcagcacactcaagttcttcaccatc tgtggcctgcaggaaggctacgagccgtttgctgtcaacatgaaccgagacatcaccatg tggctcagcaaaagactgcctcagtttgtacccgtcccccccagccaccagcacattcag gtgacaagaatagacgggaccgttgagtcctgtccctgcctaaaggtcacccagaggtca tttggctcccagaacagttctacggaccttgccttttacagactgagcatgcccatagag tgtgcagaatctttttccagatcccagcataacggcagtctcttttctccaaagagggag ctagaggactttgaaactgtgtcagacttcgaggttctgatgaagacgtctcatgggcac aatggtcccagtggacccgagagagacgaattcaataaccacaaagattataaccaggag aagccatctaagctcaaacagaggttcttgttgaagagaaacaagcccgacaacagctgt ccctcgtcggctcgactgtcagaggaagtgatggctgacgacagagatgactacgaagtt ctcctgcaagcgtctactcactactactcagtgaggatcttccctggacaggagcccagc agtgtgtgggtgggctgggttacctctgacttccatcagtatgacccaggctttgagctg cacaaggtccgaactgtcactgttactctgggagacgagaagggcaaagttcatgagagt ataaagcgcagcaactgctacatggtgtgggccggagaaagcagcagtccagggcagggc aggaacagcaacggcttagagatcgggtgtctggtagacacaaccaacggtctgctgacc ttcactgccaatgggaaagaactcagcacctattaccaggtggagcccagcaccaagttg ttcccggcagtttttgccaaagccaccagccctaatgtctttcaatttgaactggggaga ataaagaatgtgatgcctctctcagctggattgtttaagagtgagaagaagaacctggtg cctcagtgccctccacggcttcacgtccaatttctcacacctgttctctggagtcgggct cccgatcactttctcaggatattagcatcaagagtcaatgacagacatggctggctgctc cagtgtaatgaacctctgcagttcatgtctctgcacatacctgaggagaacaggtctgtg gatgtcctggagctttcagagcagaaggacctattaaagtttcactaccataccctcaga ctgtactctgcaatctgtgctctgggaaacaaccgcgtggcacatgccctctgctcccac gtagatgaggcccagcttctgcaagctattgacaataaatacatgccaggtttgctacgt gtgggctattatgacctcctcattgacatccacctcagcagctacgccacagctcgcctc atgatgaacaacgagtacatcgtccccatgacggacgagacaaagagcatcaccctcttt ccagatgagaagaagaaacatggcctgccgggcattggcctcagcacctccctgaggccc aggatgcacttctcctctccaagttttgtttgtgggaccagatcctcatatcgtaacaac ggcagcaacggctcaggatcaggagactgtttccagtacagccctgagttccccctggat atactgaaaataaaaaccatcgagatgctgacggaggcagtgcgggagggaagcatgcac gtgcgggatcctataggaggcagcacagagtttctttttgtccccctcatcaagctcctg tacactatgctcatcatgggcgtcttccagaacggagatctgaagaacatcctccgactg atcgagccgtcggtgttctctgaaagggaagatgggcaggagagtcacgcggagctggag ctgatgaaggaggtgaagaccgagggaggcgttgatggagggaggaacatgccaaatgaa ggactgttacagatgaagctgccagagcctgtcaaactccagatgtgccatgttctgcag tacctgtgtgactgtcaggtgcgccatcgtatcgaggcagtggtggccttctctgacgac tttgtggcctgtcttcaagaaaaccaaaggttccgctacaacgaggtgatgctggcgctc aacatgtcggctgcgctcactgccaagaagaccaaagagttcagatcacctccccaagaa cagatcaatatgctgctgaacttcaaggatgagaagcaggagtgtccctgtcccgactac atccgagagcagctgctcgacttccatgaagatctgatgaggcactgtggtatagagttg gacgaggagagagggatagacggcgatagtgacttcaccattcgaggtcgactcatgtca ctggtggaaaaagttgcctacctgaagaaaaagatgggcaacctgccgagcgagaaaaaa gacgggaagcccagcacgttgcagcagctgatctctgataccatggtccgctgggcccag gagtcagtcatcgaggacccagagctggtcagagccatgttcgtcctgctgcaccgccag tatgacggtattggaggccaggtgcgagctcttcctaagacctacaccataaactccgta tcagtggaggatacgatcaacttgttggctgctcttggtcagatcaggtccctgctgagt gtccgaatgggaagagaggaggagaaactaatgatcagagggctgggcgacattatgaac aacaaggtgttttaccagcatcccaacctcatgagagctctggggatgcacgagaccgtc atggaggtcatggtcaatgttctcagcggaggagattcaaaggaaataacctttcctaaa atggtggccaactgttgtcgctttctctgctatttctgtcgaatcagtcgacagaaccag aaagccatgtttgaccatctcagctacctgctggagaacagcagtgttggccttgcgtct ccatccatgcggggctcaactcctcttgatgtggccgcagcatcagtcatggataataat gagctggctctggctttaagagagccagacctggagaaggtggtgcagtaccttgccggc tgcgggctgcagagctgcgtgatgctggtgcgtaaagggtaccctgacatcggctggaac ccggtcgagggcgagcgctaccttgacttcctgcgcttcgctgtcttctgcaacggcgaa agcgtggaggagaacgccaacgttgtggtgaggctgctgatccgccggccggaatgcttt ggcccagccctccgaggggaaggtggcgatgggctgttggcagcgatggaggaagctatt aagatttctcaagactcctccagggatggaccctctcctacatctgagagcagcaagacg ctcagtgacatgatagaagaggatgaagatgacaccatccacatgggaaatgccatcatg accttctatgctgctcttattgacctgctgggtcgctgtgctcctgagatgcatttgatt catgcaggtaaaggcgaggcgatccgcatcagggccattctacggtctctcatcccgatt gaggacctggtcggagtcatcagcattcccttctccatgcccagtttgggaaaagatggg atggtggtggagccagacatgtcagccggcttctgtccggaccacaaagcggccatggtg ctgttcctggaccgtgtctatggcatagaggaccagaatttcctgctccatctgcttgaa gtcggatttttacccgacctgagagcggctgcctctctggacactgctgctctcagtgcc acggacatggcgctggcccttaacaggtacctgtgcacagccgtgttgcctcttctcact aaatgcgcttcgctgtttgcggggacggagccctttgcctccctcatcgactcgcttctc cacacggtttaccgcctgtccaaaggctgctgcctcaccaaggcccaaagggatgccata gaagagtgtctgctggctgtttgtggtacgctgaggccatcaatgatgcagcatctgctg aggagactggtgtttgacgtcccgctgcttaatgaacacaccaaaatgcctctgaagcta ttgaccaaccactttgagcgttgctggaaatattactgcctggctggaggctggggaaac tttggagccgcatcggatgaagaactgcacctttccaggaaattgttttgggggatattc gacgcactctcacgcaagcgctacgaccaggagctctttaagctggcattgccatgtctc agtgctgtggctggagctcttcctccagactacatggagtctaactacatggccatgatg gagaagcagtcttccatggactcagagggaaacttcactccacagcctgcagacacctcc agcgtgactgttcctgagaagctggactatttcgtaaccagatatgcagaacacaaccat gagaaatggtgcattgaaaggttttccagcggctggtcatatggagaccagatatgtgag atcagcaagagccaccctttactgaaaccatacaaaggcctctctgaaaaggataaggag ctgtactgctggtctgtcagggagtctctgaagaccatgctgtcatggggctggagcatt gaaaggatcagagacggagaccccaccagcctccataacaagtctaggaggatatcacaa gcgagccagctgtcttttgagggagctccagctttcagtcctagacccattgatatgagc aatgttacactgtccagagacatgcagtctatggcagagctgcttgcagagaattaccat aatatctgggccaggaaaaagaaagtagagcttgaagccaaaggtggaggaaaccaccct ctcctggttccttatgatacactgaccgccaaagagaaatccaacgacagggagaaagca caagacatcttgaagttccttcagatcaatggctacactgtgtccagaggtgtaaagtca caggagctggacactccagccatagagaagcgatttgcctacaccttcctccagcagctc atcacatatgtagaccaggctcaccaacacatgatggagtttgatgttggagtgagacca aagggggagaagattccgcatgaacagcaaattaagtttttcggaaaggtggtcctgcca ttagtggatcagtacttcaaaaaccacaggctttacttcctgtccacagccatccatcca atcagcagcggcggccacgcctccaataaggagaaagagatggtgactagtctcttctgc aaactgggagttcttgtcagatataggatatccttatttggtaacaatgccacgtctata gtcaactgtctgcagatacttggccaaagtcttgatgccagaacagtgatgaagactggt ctggagtcggtgaaggcggcgctgcggtcgtactttgacaacgcagcagaggatctggag aagacgcaggagaacctgaagctgggccagttcacgcacagcagggagcagccacgaggc gtcactcagatcatcaactacaccaccttcgccctgctgcccgtgctctcgtccctcttt gaacacattggccagaacatgtttggagaagaccttatattggacgacgtccaggtttct tgctacagaatcctcaacagcctctatcttttgggcaccaataaaagtatctatgtagaa aggcagcgtccagcattaggagagtgtctcgctgccttctctgcagccttccctgtagcc tttctggagcctcacatcaataagttcaacagcttctctatctacaacagcaaaggcccc aaagacaaagcagctctaggtcttccagggcaggtggaggagatttgtcctctgatccca atcttggataagtctctggaggagatcatggagctggcagagtctggcatgagatacact cagatgccgcatgtcatggaggtggtgttgcccatgttatgcagctatatgtcccactgg tgggaacatggaccagagggcaacatggacagagctgaccactgctgcacctctgtcacc tctgaacacatgaacactctgcttggaaacatactcaagatcatctacaacaacctggga atagacgagggagcctggatgaagaggctggccgtgttctcccagccgatcatcagcaag gccaaaccccagctgctcaagacccatttcctacctctgatggagaagctgaagaagaaa gcagcagtcgtgttgatggatgaggagcacagcaaggcagaggggaggggcgagatgtcc gagacggagcttctcatcatggaccagttcaccatactagtccgcgacctgtacgccttc taccccctccttatccgatttgttgactacaacagggccaaatggctcaaagagtccaac ccagaggctgaggaactgttccgcatggtggccgaggttttcatcttctgggccaagtct cataatttcaagagagaagagcagaattttgtggtccagaatgaaatcaacaacatgtcc ttcctcatcacagacacaaagtgtaagatgtcaaagggaatagtttcagaccaggagagg aagaagatgaagaggaagggcgatcgatactcgatgcagacgagcctcatcgttgccact ctgaagcgtctgctgccagttggactcaacatctgtgcccccggagaacaagagctcatc actctggcgaagaaccgcttcacgcagaaagacacagaggatgaagttcgagagaccatc agaaacaatctccatttacatgggaagctggaggacccagcaattcgctggcagatggcg ctgtacagggacctacccaaccactacgaggacacctctgaccctgagaagactgtggag agagtcctggacatttcccatgtcctcttccacctagaccaggtggagcatcctcagcgc agcaagaaagccgtgtggcacaagctgctgtccaagcagaggaagagagcagtggtggcc tgcttcaggatggcaccgctctataacctgcccaggcaccgggccgtcaacttgttcctg cagggctacgagaagtcttggatagaggcagaggagcactactttgaagacaaactgata gaggaccttgcaaaatcaggtgaacaggagccttgtgaggaagaggaaggagtaaaacac atcgaccccctgcaccagctcattcagctgttcagcagaacagcgctcacagagaagtgt aaactggatgaggataatctctacatggcctatgctgacatcatggctaagagctgccac gatgaagaggatgatgacggggaagaggttaaaagctttgaagagaaggagatggagaag cagaagctgctgtatcagcaggcgcgactgcacgaccgaggagctgccgagatggtgctt cagaccatcagtgctagcaaaggagagatgggtctcatggtggcctccacgctgaagctg ggcatagctattctaaacggaggcaactccactgtacagcagaaaatgttggattatctg aaggacaagaaggatgtgggcttttttcagagtctagctggtctgatgcagtcatgcagc gttctggatctgaatgcttttgagaggcagaacaaagcggaaggactggggatggtgact gaggaggggtcagtcatcactcatgagcgtggtgagaaggtcatgcaggatgacgagttc acctgtgaccttttccgcttcctgcagctgctctgtgagggacacaactcagactttcag aactacttgaggactcaaacggggaacaatacgactgtgaacatcattatctccactgtg gactatctcctcagagtccaggaatcaattagtgacttctactggtattattctggcaaa gatgttattgatgaacagggccagaggaatttctccaaggcaataaatgtggccaaacaa gtttttaatacactcaccgaatacatccagggcccgtgcaccggcaaccagcagagtctg gcccatagtcgtctgtgggacgccgtggtgggtttcctccatgtcttcgctcatatgcag atgaaactgtcgcaggactccagtcagatcgacttactgaaggagctgatggatctgcag aaagacatggtggtcatgctgctgtccatgctggagggtaatgtggtgaatgggaccatt gggaagcagatggtggacatgttggtggagtcgtccaacaacgtggagatgatcctcaag tttttcgacatgtttctcaaactcaaggacctcacctcctcagacgccttcaaggagtat gaccccgacgggaaaggtgtcatctccaagcgggacttccacaaggccatggagagccac aagcactacacccagtctgagaccgagttcctcctctcctgcgccgagacggatgagaat gaactcttggactatgaagaatttgtagagcgctttcatgagccggccaaggacattggc ttcaacgtggcggttctgctcaccaacctgtcggagcacatgccccacgacacgcggctg cagaccttcctggagctggccgagagcgtgctcaactacttccagccgtacctgggccgg atcgagatcatgggcagcgccaagcgcatcgagagggtctactttgagatcagcgagtcc agccggacgcagtgggagaagccgcaggtcaaagagtccaagcgccagttcatcttcgac gtggtgaacgagggaggcgagaaggagaagatggagctgttcgtcaacttctgcgaggac accatcttcgagatgcagctggcggcgcagatgtccgacgccggcgagcgctcggccgtg aaggaggagagcgagcgggagaagccggaggaagagacccccgagatgggcttcttctcc gtcaccaccgtctgcatggcgctggtggcgctgagatacaacgtcatgctgctcattaag gttctctccacgaaaagcttgaagaagcagatgaagaagctgaagaacatgacagtgaag gacatggtgaccacgctggtgtccttctactggtcagtgctgctgagcctcctgcatgtt gccttcagcgtgtctcggggcttctgccggatcttctacaacacgttcatgggaggcaat ctggtagaaggagccaagaccataaaggtgtcagagttgctggccaacatgccggatccc acccaggatgaggtgcgtggcgaaggggacgacagagacaagaggcccgagcacagctcc cccaaggaggacctggccgacctggctgtcaacaccagcgacaccgagctcctgtcggac atttttggcctggacctgagaagggagggcggccagtacaagatcacccctcacaacccc aacgccagcctcaccgagctgctcaactccccagttccctccccaacgaccacaggagcc cccactgagctcagacagagacatcagtcaaagacgtcttcctcagaggcaaaggaggca acaccagaggctgaatgtgagccagacaaaacatcagaggggcacatagagaaacaggag aaaccgcagaagcctgagaaggtaaagcccaaagtgagaaagcaccgcacctcaaagtct gatgagccggacctgcaggagtctgcgttcctgaagaagatcatcgcataccagaggaag ctgctgaactactttgccaggaacttctacaacatgagaatgctggcgctgtttgtcgcc tttgccatcaacttcatcctcctcttctacaaggtttccacgtcctcgtccgtggtggag gagaagaaggtggtgcatcccagcagccaggcgggcggcagcgtgcagtgggacgcgctg agcggagaagcgctggaggcgaagggggggggcgcggacgcggcggcgcagcccccgaag cccgtgatggttcgctttgtgctggaggagagcagcgggtacatggaacccatgctgcgc atcctggccatcctgcacacggtcatctccttcttctgcatcatcggctactactgtctg aaggtgccgctggtgattttcaagcgtgagaaggaggtggcccggaagctggagttcgac ggtctttatatcacagagcagccgtctgaggacgacatcaagggccagtgggacagacta gtcatcaacacgcagtcgttccccaacaactactgggacaagtttgtgaagaggaaggtg atggataaatacggggagttctacggccacgaccgcatcagcgagctgctggggatggac aaggccgcgctggacttcagcgacgcccacaagaagaggaagcccaggagggacggctcc ctcgctgccgtgctcaactccatcgacgtcaagtaccagatctggaagctcggggttgtg tttacagataactccttcctctacctggcctggtacatgaccatgtccattctaggtcac tataacaacttcttctttgctgcccacctgcttgacatcgctatgggatttaagaccttg cgaacaatcctgtcctcagtcacacacaacggaaagcagctggtgctgacggtcggcctg ctggcggtggtggtgtacctctacaccgtagtggccttcaacttcttcaggaagttctac aacaagagcgaggacggagagctgccggacatgaagtgtgacgacatgctgacatgctac atgttccacatgtacgtcggcgtcagagcgggcggaggcatcggcgaccagatcgaggac ccagcgggcgacgagtacgagatctatcgcatcatctttgacatcaccttcttcttcttc gtcatcgtaatcctgctggctatcatccagggcttgatcattgatgcgtttggagagttg agggatcagcaggaacaggtgaaagaagacatggagaccaaatgcttcatctgcggaata gggaacgattatttcgacacggtgccacatggctttgaaacgcacacgctacaggagcac aacctcgccaactacctattctttgtgatgtatctgatcaacaaagatgaaacagagcac accggccaggagtcttacgtgtggaagatgtaccaggagcgttgctgggagttcttcccc gcaggcgactgcttccggaaacaatacgaggaccagctcaactga

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