Betta splendens (Siamese fighting fish): 114870717 Help Entry 114870717         CDS       T08231                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism bspl  Betta splendens (Siamese fighting fish) Pathway bspl04020   Calcium signaling pathway bspl04260   Cardiac muscle contraction bspl04261   Adrenergic signaling in cardiomyocytes bspl04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:bspl00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     114870717 (ryr2b)    04020 Calcium signaling pathway     114870717 (ryr2b)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     114870717 (ryr2b)    04261 Adrenergic signaling in cardiomyocytes     114870717 (ryr2b)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bspl04040]     114870717 (ryr2b)    04990 Domain-containing proteins not elsewhere classified [BR:bspl04990]     114870717 (ryr2b) Ion channels [BR:bspl04040]  Voltage-gated cation channels   Ryanodine receptor    114870717 (ryr2b) Domain-containing proteins not elsewhere classified [BR:bspl04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    114870717 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  114870717 NCBI-ProteinID:  XP_029031554 UniProt:  A0A6P7Q4X4 LinkDB All DBs Position 15:complement(14506704..14553386) Genome browser AA seq 4953 aa AA seqDB search MTDAAEGDEEYQFLRKGDEVVLQSTFTSQAEHAKLCLAAEGFGSRLCRLEATSNCQNVPP DLSVCGFVLAQCLSVRALQEMVTHSHHPEAEVDAGGSHRTLLYGQAVLFLHSFSGMYLSC LSSSQSSTDKLAFDVGLQEDKAGEACWWTIHPASRQRSEGEKVRVGDDLILVNVSSERYL HLSFGAVTDNRSLSDKVIVNAAFQQTLWSVAPICSRGGVAQGYLKGGDTLRILHSHSDAC LTIPSTEQGEDLQRIMHYEIGSASGYARSLWRLEILRVAWSGRHTCWGQPFRLCHITTGR YLGLTADRGLHLVDRDKADINTTSFCFQPSKEKLDAGTKSNADGMGIPEIKYGDSVCYVH HVASGLWLTYQSTDATSPRTGGVQRTAILHNEGHMDDGLTLSRSHKEESQTACLIRSAFF LLNHFIREQGNLSSVSSPVEKLRCSLQDLIRHFQPPLDGLDHEAKQNSMTALKNRQNMFR EEGVIDLVLDCIDRLHQYSNASHVPEVAQSEMGEEWETILNLLYELLAALIRGNRVNCAH FSGSLDWLISRLDRLEASSGVMDVLHCVLVESPEALNVIKEGHIHSIISFLHKHRHNHKV LEVLCSLCVCHGVAVRSNQNLICDNLLPERDLLLQTRLVNQVTSMRPNIFLTMGEESAQN RRWYYELVVDQVDPFLTPEPTHLRVGWACTEGYHPRPTGGEGWGSNGVGDCLRSYGFDGL YLWSGCVGRRVSSPFPHLLKNDDVVSCCLDLTAPSISFRVNGLPVQGMLENFNAVGFLYP VVSFSAGVKVRFLFGGRHGEFRFLPPLGFAPCTEALLPKTKLTLEPCHKYISDYGDGKHE LTGPLVPVSPVTFTPTPVDISKVVLPPQLQDIKEKMAQNSHELWAMDKIDLGWTYAPVRD ESKKNEPCLVGFSRLPEQERNQNLQMAEDILRTLLALGFHIGLTDVSAEERVKYMRLSNK YEQPSGFRPAPIDMSQVTVSPANDEVINLLAENDHNAWAKERVKQGWTYGAQQDVKWKRS PYLVPYNLLDERNRRSGRESVREAVCVLLLYGYSLEPLSQELTTLSKTSLFSAEKCRVFR ADKSYAVTQGKWYFEFEALTAGNIRVGWARPGCTADKELGSDDQAYVFDGSEAQWYHQGG EPLGRLWQRGDVVGCLVDMDEQTMMVTLNGEVLFNDRGSELAAKDFENKDGLLPVVSVGV NQMGRLNLGRQVATLQYYTVCGQQEGYEPFAVNMARDPALWMSWKQPQFTCIKPDDHNVQ VVKVSGSVDSLSHLRVSQRLFGHHNGAADIGFYRISMSVQCASTLTSPAGVVLPVTSNVV SPGRKEQEEVDSEFEVLMKSAHSFAGSRDELCNKDHSQDKTSRLKQRFMLKKTKPGLVSS NSSARLLEDVVADKDNYEHLISSSRFYYSVRVLPGQEPFNVWVGWVTPDFHSCDMAFDSD AVHTVTVTLGDDSGKVQESVKRSDCYMVCAGEATGLSQSRRSSGLEIGCLIDTATGLLTF TSSGVEMATFYQVEPSTKLFPAVFVKSTTSNMFQFELGSIKNVMPLSAGLLRSHRRNTSP QCPPRFQVQHLSTGTWTRVSDQALKVLVDRPDDFNGWRIQCTEPQQVMTLQIPDENRCVD ILELSELDDLLTFHYHTLLLYCSLCAFGNTRVCHALCSHVDQSQMFHAIQNPSLPGSLRS AFYQLLIQIHLNSHMTACVTMSHEYIVPMSDQIRDTAFCPSSSNDWIGESFKPLDGFPNS SCSTTLKPQLGFLAPCFVWNEEVGEDGSPEKAFTDSPEIPLDILKNLTVKMLTSGVWAVG HGVRDPVGGGIDFLLVPLIRLFHTLLVMGAFQDKDLGEALRLIEPEVFSMTSDTYENDET REGEDEEEWTRDKKNKHYPPKQGLLQMKLSEAVKLELCHLLSYLCDCQVRHRVEAVVAFS DIFVQQLQENQRWRYNQVVEALNMSAALTARKTKEFRSPLEEQMKMLLSFRKGEQQENCS CPVEIQQLLQDFHQLLSTHCGIELDTDSDDEENAEMSVRDWLFSLVPKIIGARKTAIEAG KCMLQSAQSLKKLISETMVRWAQESEMEDPELVRAVFNLLHRQYEGLDGQMARPLSRAYC ISQASVDDTMCLLASLGQIRSLLSVRMGKEEERLMIRKLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGEGELKEITFPKMVASCCRFLCYFCRISCHNQGALFDHLSYLLENSRV GLASPSMRGATPLDVAAASVMDNIELALALNESDLEKVVQYLAGCGLHSCPMLVVKGYPD IGWNPVEGERYLDFLRFAVFCNGENVEENAYVVLRLLIRRPECFGPALRGDGGKGLLVAM KEAIRMSEDLSVDGPSSTYQDPVQDNDDDLIHMGHAIMTFYSALIDLLGRCAPEMYLIQQ GKGDAIRIRAILRSLIPIQDLEGVISISFQTPSVSKDGQVHEPDLSTVFCPDHKAAMVLF LDRVYGIEYQSFFLHLLEVGFLPDFQAAVSLDTADLGSTDMALALNRYLCTAVLPLITKC SSLFCGLEDHAVVVDSLIQAIYSLSKALSLTKAQRDTIEDCLLAVCSKLQPSMIQPFFRR LVFDAPDLSNHSMIPLKLLTSLYEQRWKYYYSPTRGQSDHDLASEDELHLSKKLFWGVFK ALAKKPYESQLYRLSVQCLTTVASALPPNHMDNSCLSQQGRKVSIDTDMHFDPQPVDTSN VSVPEKLEFVVNKYAEHTHEKWSLDKFVNGWVHGDQLCENTKVHPLLKPYRALAEKEKEV YRWAIKETIKSMLAFGWSIERTKDWDAFDMHTCTRRISQSGQLSFEGTSTFSPKPVDLSS ITLSWEQCAMAEQLAENYHSAWAKKKKLEFGGKEEAGHSLLVPFDTLTAKEKNKFRERAH DILKFLQLNGYTVRRDRRTLEMDFPAKATCFGYIFLQRMVLHTEDVQEHILELEVMQARG PTSKGEKASNQQPINFFFKVILPLLEQYVKSHRQYFLSSSFCFSDNRCHASKKEKEIIAS LFCKLAALVRHRISLFGNDASSVASTLHVLAQTLDARTLMKSSSASVWGFLHSFFEASAV DLEMTLENLSVTFVSLPQSRNQQSKGVANVLSYTTSILIPTLTSLFQHIGNQSYGVDILV ERIQVSCYRILNSLYSLGTSRSIHMTGQRPAAGACLAALTGAFPVCFLEPELNQNNPYSI YNTMSDTQREDLGLPEQVEDMCPLLPSLEQTLGEVEVLAEAGAGALQTHYLHVTEVTLPM LCSYMSRWWRWGPEGHPAHPNCTAVIPQHASDLLGSILRIIHNHVGNSQGDWMKHLAVFS QSIICKASTELLRSHFIPLMEKLRKRAECVMLEEEQMKAEGCCASEEELQIQEKFTVLVR DLYAFYPIVIPFVDLNRASWLKESNPEAEQLFSMVAEVFIFWAKSHNFKWEEQNYVVTNE INNLAFLVNKDNISKSSHERKKIRRKGDRYSTNTSLIVASIKRLLPVGLHVCFPVDHSLI MLAKTRFSQKNTEDEIREHVLNGLIQLQNQPINGTRQESKSDQRRLIIDIPKSLDQILRV ARVLYYLEQVEHPHRHNKPAWHTVLSKQRKRAVVACLRMTPLYNLPRHRAVNLFLQGYNK SWISAEVHNFEERLVDDLAKGRMMELRGDGRGKEKDAEKGAKPIDPLMQLITFFSRSSLT ERSKLGNDSLYKTYAAIMAKSCHRDDDDADADADDGVNNEHEAESFEEKEMEKQRMLYQQ ARLHCRGASEMVLQMISASKGAMDSMISPTLKLGIAVLNGGNVTVQQKMLHYLQDKRDVG FFQSMAGLMQSCSVLDLNAFERQNKAEGLGMAMDESSGEKAMPDKDLTCDLFRFLQLLCE GHNLDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWNYSGKDVIDAHGQHNFST AIEVAKQVFNTLTEYIQGPCTENQQSLAHSRLWDAVVGFLHVFAHMQMKLSRDSRQIELL KQLMDLQKDMVVFLLSMLEGNVVNGTIGKQMVDMLVESSGNVEMILRFFDMFLKLKDLTS SDAFREYDPDHKGCISRKDFQKAMENCKRFSLTEMNFLLSCMDNNESDMVHYEAFVSRFH EPAKDIGFSIAVLLTNLSEHMPTDPRLRTFLELADSVLTYFQPSLGCIEILGSGKRIERV YFEISEASRTQWKKPQVKESKRQFIFDVVNEGGEKEKMEMFVNFCEDTIFEMQLAAQISG SDVGEKHTPEELEEKTKSKEEDPKGLFFINHCWLLLTSLLSVKSLKKLMKMTLKDILMLA LFFIRFIFMTQVQCICVVIRSILYVLYVVFVNGGVIEGAKKMQLSDLVGGIIEPTLDEVM EVPSSVDQRRKYSASFPSQRELMEIGQVGSLTSQREVDILSDIFGLKVKKEGGQYRLITK DLTASLTDLFSTTSRTTSAAEFPEEHQRTQFKTSGASEEKAEDEKIPELDDTKVKDLEAK TGNEKAKAELRARRCSNKSEESKSQHSAFWEMISTHNKSLLNYFARNFYNMRLLALFVAF AINFILLFYKVASLPPMPERQNAISSVHSEDLDSAAVEDNRSGVYFVLEESSGYMEPSLH FLAVVHTIISFCCIIGYYCLKVPLVIFKREKEVARRLEFDGLYVTEQPPEEDIKGQWDRL VINTPSFPSNYWDKFVKRKVLDKYSQFYGCKKISELLGVDQTALDFSAEKKERRLRRESW SSLFNSIDMKYQVWKLGVVFTDNSFLYLAWYMIMSVLGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSDEKNGEDMKCNDMLTCYM FHMYVGVRAGGGIGDEIEDPAGDEFEVERIVFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKKDMETKCFICGIGSEYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEQT GQESYVWKMYQERCWEFFPVGDCFRKQYEDQLG NT seq 14862 nt NT seq  +upstreamnt  +downstreamnt atgacagacgcggcagagggcgacgaggaatatcagtttctacgcaagggggatgaggtg gttttacagagtaccttcacctctcaagcagaacatgcgaagctctgtcttgcagcggag ggatttggcagcagactttgcaggctcgaggccacctctaactgccagaatgtcccacca gacctgtctgtgtgtggctttgtcttagcccaatgtttgtctgtccgggccctgcaggag atggtgacgcatagtcatcacccagaagccgaggtggatgctggaggaagccatcgcacc cttctgtatgggcaggcagtgttgttcctacactcattcagtggcatgtatcttagctgc ttgtcttcatcccaatcttcaactgacaagctggcttttgatgttggcctgcaagaggat aaagcaggtgaggcgtgttggtggaccatccacccagcctccagacagagatcagagggt gagaaagtgcgtgttggagatgatctgatactggttaatgtgtcctcagaaagatatctg cacctgtccttcggtgctgtaacagacaacagaagcttgagtgacaaggtgattgttaat gcagccttccagcagactctctggagtgtcgctcccatctgctctagaggtggagttgct caaggatacctaaaagggggtgacacgttgcggatactccacagccacagtgacgcatgt ctgacaattccctctacagagcagggagaggacctgcaaaggataatgcattatgaaatt ggatcagcctctggctatgctcgctctctctggagactggagattcttcgtgtcgcctgg agtggcagacatacatgctggggccagccattcagactatgccacataactactgggagg tacctaggtcttacagcagaccgaggcctgcatcttgttgatcgggacaaagcagacatc aacacaacctctttctgctttcaaccctcaaaggagaagcttgacgctggcacaaagtct aatgctgatggcatgggcatccccgagatcaagtatggagattctgtttgttatgttcat catgttgcatctggactctggctcacctatcaatccactgatgcaacatctcctcgcaca gggggagttcaacggacggccattttgcacaatgaggggcacatggatgatgggctgaca ctgtcacgttcccacaaggaggaatctcaaaccgcctgtctcatccggagtgcttttttt ctattaaatcactttatcagggaacaaggaaacttgtcttcagtcagttcgccagtggag aagctgaggtgtagtctgcaagatttaataaggcatttccaaccaccactggatgggcta gaccatgaagcgaaacagaatagcatgacagcactaaagaatcggcagaacatgtttcga gaagagggtgtgatagatttggttctggattgtatagaccggctacaccagtatagtaat gcttcacacgttcctgaagtggctcagagtgagatgggagaagaatgggaaaccatatta aaccttttgtatgagctgctagctgctctgatccgagggaaccgtgtaaactgtgcacat ttctcaggctctcttgactggctgattagtaggcttgaccgactggaggcttcctctggg gtcatggatgttctgcactgtgtcctagtggaaagtcctgaggcactcaatgtcatcaaa gaagggcacattcattctatcatctctttccttcataagcacagacacaaccacaaggtg cttgaggtgctgtgctctctgtgcgtgtgccatggtgtagcagtgcggtccaatcagaac ctcatctgtgacaatctcctgccagaaagagacttgctgctccaaacacgcctggttaat caggtcacaagcatgaggccaaacatcttcttgaccatgggggaagagtcagctcagaac cggaggtggtactatgagctggttgttgatcaagtcgaccccttcctcacacctgagccc actcacctgcgtgttggctgggcttgcaccgagggctatcaccccaggcccactggagga gaaggctggggaagcaatggggtgggagactgcctgcgctcctatggctttgatgggctt tatctttggtcaggctgtgtgggccgaagagtaagttctccctttcctcacctgctgaaa aatgacgacgtggtcagctgctgtcttgacctcactgctccctccatctccttccgggtc aacggtctccctgtgcagggcatgttggagaacttcaacgctgttggatttctttatcct gtggtcagcttttcagccggagtcaaggttcgttttctctttggaggacgtcatggagag tttcgcttcctacccccactgggttttgctccatgcacagaggctttgctcccaaaaacc aaactgacattagagccttgtcataaatatatctcagattacggagatgggaaacatgaa cttactggtcccttggtaccagtctctccagttacttttacacccacacccgtagacata agcaaggtggtactgcccccacaacttcaggacattaaagaaaaaatggcacaaaatagc catgaactgtgggcaatggacaaaattgaccttggatggacatatgcacctgtgagagat gaaagtaagaagaatgaaccttgccttgtggggttctctaggcttccagagcaggagagg aaccagaatcttcagatggctgaggacatcctcaggactctacttgcccttggtttccac attggtttgactgatgtcagtgctgaagagagagtcaaatacatgaggctatcgaacaag tatgagcagcccagtggtttcagacctgccccaatagacatgagccaggttactgtgagc ccagccaatgatgaagtgattaacttgttggcagagaatgatcacaatgcgtgggctaaa gaacgtgtcaagcagggatggacatatggagcccaacaggatgtgaaatggaagcggagc ccataccttgtgccttataacctccttgatgaaaggaataggagatcgggcagggaaagt gtcagagaagctgtctgtgttctgctgctctatggttacagcctcgagcccctcagccag gaactgaccacattatcaaaaacatctctattttctgctgagaagtgcagagtgttcaga gcagataaatcttatgctgtgacccaggggaagtggtattttgaatttgaagcactgaca gcagggaatattagagtgggctgggctcgaccaggctgcactgcagataaggagcttggc tcagatgaccaggcatatgtctttgatggatctgaggctcagtggtaccatcagggtggt gagcccctgggacgtttgtggcagagaggcgatgtggtgggttgcttggtggacatggat gaacagaccatgatggtcacgctcaatggagaggttctgtttaatgacagaggatcagaa ctggctgccaaggattttgaaaacaaagacggccttttacctgtggtcagtgttggggtg aaccagatggggaggctgaacctaggccgtcaagtcgccactctacagtactatactgtg tgtggtcagcaggaaggctatgaaccatttgctgtcaacatggccagagatccagccttg tggatgagttggaaacagcctcagtttacctgcataaaacctgatgatcacaacgtgcag gtggttaaagtcagtggatcagtggattccttatcacacctgagagtttctcagcggttg tttggtcaccacaatggagctgccgacattggcttttaccgaatcagcatgtcagttcaa tgtgcatctaccctcactagtcctgcaggcgttgtgcttccagtgacttccaatgttgtt tcaccaggaaggaaggagcaagaggaggtggactctgagtttgaagtgttgatgaaatca gcccacagttttgctggctcaagggatgagctctgcaataaggatcatagccaagacaaa acatcaagactgaaacaacggttcatgctcaagaagactaaaccaggactagtcagcagc aactcttcggcacgtcttttagaagatgtcgtagctgacaaagataactacgaacacctc atctctagctccagattttattactcagtgagggttcttcccggccaggagccattcaat gtgtgggtgggatgggtgactcctgactttcattcgtgtgatatggcatttgacagcgat gctgttcacactgtgactgtcacccttggagatgacagtggtaaagtgcaggaaagtgtg aagcggtccgactgttacatggtgtgtgctggagaagcaacaggcctgtctcagagtcgg agaagctcagggctagaaattggctgtttgatagacaccgcgacaggtctgctcacattt acctccagtggagtcgagatggccaccttctaccaagtggaacccagcacaaagcttttt cctgctgtatttgttaaatcaaccaccagcaacatgtttcagtttgaactagggagcatt aagaatgtgatgccattatcagcaggtttactccgcagccatcggagaaatacatctcct cagtgtcccccaaggtttcaggtccagcatctcagcacaggcacctggaccagagtgtca gaccaagcattgaaggtgctggtggatcggccagatgatttcaatggctggagaatccag tgcactgagccccagcaagtcatgaccctacagatccctgatgaaaacaggtgtgttgac attttggagctctccgaacttgacgatctcttgacctttcattaccacacgctcctcctc tactgctctttatgtgcctttggcaacaccagagtttgtcatgccctctgcagtcacgtg gaccagtcacaaatgtttcatgccattcagaatcccagcctacctggctcactccgctct gctttttaccagctacttattcagattcatcttaacagtcacatgacagcatgcgttact atgagccatgagtatattgtcccaatgtcagaccagatcagagacaccgccttttgtccc agttcttcgaatgactggattggtgagagtttcaaacctttggatggatttcccaacagc agttgtagcacaacccttaaaccacagttgggtttcttagcaccttgttttgtctggaac gaggaggttggagaagatggttcacctgaaaaagctttcacggacagcccagaaatccca ctggacattctgaagaatctgactgtgaagatgctgacatcaggagtctgggctgtgggt catggtgtgagggatcctgtaggaggcggcattgattttctgctggttccgctaattagg ctattccataccttattggtaatgggagcatttcaggataaagatctgggtgaagctctg agactaatagagccagaagtcttctctatgacttctgacacctatgagaatgatgaaaca agagagggtgaggatgaagaggaatggacacgggacaagaaaaataaacattaccctcct aaacagggacttcttcaaatgaagctctcagaagctgtaaaacttgagctttgccatttg ctgtcctacctgtgtgattgccaggtgcgccacagggtggaagctgtagttgccttctct gacatctttgtgcagcagcttcaggagaaccagcgctggcgctacaaccaggttgtggaa gctctcaacatgtctgcagctctcactgctcgcaagaccaaggagttccgttcacccctc gaagagcagatgaaaatgctgctgagcttcagaaagggtgagcagcaggagaactgctca tgtccagttgaaattcaacagctcctgcaagactttcatcagctccttagcacacattgt ggcattgaattggacactgactcagatgatgaagagaatgctgagatgtctgtaagagat tggcttttcagcctagtgccaaaaatcattggagcaaggaagacagccatagaagcagga aagtgtatgctgcagagtgcccaatcccttaagaagctgatctctgagacaatggtacgc tgggctcaagagagtgagatggaagaccctgaactggtcagggctgtttttaacttgctg catcgccagtatgagggtcttgatgggcaaatggcacgaccactgtcaagggcctattgc atcagtcaggcttcggttgatgacacaatgtgtctgctagcctccctgggccaaatacgt tctcttctcagtgtccgcatgggtaaagaagaggagagactcatgatcagaaaactagga gatatcatgaacaataaagttttctaccagcaccccaacttaatgagggcattggggatg catgagacagtgatggaggtgatggtgaatgttctaggagaaggagagttgaaggagatt acttttccaaaaatggtggccagctgctgcagattcctgtgttacttttgccgtatcagc tgtcacaatcagggagcattgtttgaccatctcagctacctgctggaaaatagccgtgtt ggattagcttcaccatcaatgcgtggtgccactcccttggatgtggcagctgcctctgta atggataatattgaactagccttagcattaaatgagtccgacttggaaaaggtggtgcag taccttgctggctgtggtctgcacagctgtccaatgctagtggttaaaggctatccagac attggttggaatcctgtggagggagagcgatacctggactttctgcggtttgctgtcttc tgcaatggtgagaatgtagaggagaatgcttatgtagtcctgaggttgctcattcgccgt cctgaatgctttggccctgccttgcgaggtgatggggggaaaggtctccttgtggccatg aaggaagccatcaggatgtctgaagatctgtctgttgatggaccttcttccacataccag gatcctgtccaggataacgatgatgacctcattcatatggggcatgccattatgactttc tattcagcccttattgacttgttgggacgctgtgcgccagagatgtatttgatacaacaa ggcaaaggagatgccattcgcatcagggcaattctgaggtcactcatccccattcaggat cttgagggagttattagcatctcctttcaaaccccctcggtctctaaagatggtcaggta catgaacctgacctttctacagtgttttgcccagaccacaaggcagctatggttctgttc ctggaccgggtttatggcattgagtaccagagtttctttcttcatctattagaagttggc tttttgcctgactttcaggcagctgtctcgcttgacactgctgatttaggatccaccgat atggccctagccctgaatagatacttgtgtacagctgtgcttcccctcatcacgaaatgt tcttctctcttctgtggattggaggaccatgccgtggtggttgattctcttatccaagca atctatagcctctccaaggcacttagcttgaccaaggctcaaagagacactattgaagac tgtttattggctgtgtgcagtaagcttcagccctcaatgattcagccattttttagacgt cttgtctttgatgctcccgatctctcaaaccacagcatgataccactgaagctcttaacc agcctctatgagcagagatggaagtactactattcaccaactcgagggcaaagtgaccat gatttggcctcagaagatgagcttcatctgtctaaaaagttgttctggggagtgttcaag gccttggcaaagaagccctatgagtctcagttgtatagactgtctgttcaatgcctgaca acagtggccagcgctctgcctccaaaccacatggacaacagttgtttgtcgcagcagggg agaaaggtgtccattgacacagatatgcactttgatccccagccagtagacacttccaat gtgtcagtcccagagaaactggagtttgtagttaacaaatatgctgaacatacccatgag aagtggtcactggacaagtttgtcaatggctgggttcatggagatcagctatgtgagaac acaaaggttcatcctctgctcaagccgtacagggctctggctgagaaggagaaggaggtg taccgctgggccattaaagaaacaataaagagcatgctggcctttggatggagcatagaa agaactaaagactgggatgcatttgatatgcacacctgcacacgcagaatctctcaatca ggacagctgtcctttgaaggaacctcaaccttcagccccaaacctgtggacttgagcagc atcacattatcatgggagcaatgcgcaatggctgaacagttagctgaaaactaccacagt gcctgggctaagaagaagaaattagagtttggaggtaaagaagaggctggtcattctttg cttgtaccttttgacaccctgactgccaaagagaagaacaaattcagagaaagagctcat gatatcctcaagttccttcagctcaatggctacactgtgcggagggatcggaggacactt gagatggactttccagccaaagctacctgcttcggttacattttccttcagcgaatggtg cttcacactgaggatgtccaagagcacatactggaactggaggtgatgcaagcaagagga ccgacgtctaaaggagagaaagcttcaaaccagcaaccaataaatttctttttcaaggtc atccttcctcttctggaacaatatgtgaaaagccatcgccaatatttcctgtccagttct ttttgcttcagtgataatagatgtcatgcttccaaaaaggaaaaggaaataattgcaagc ctcttttgtaagcttgctgctcttgtaagacacagaatatcactctttggaaatgatgca tcatcagtcgcaagcaccctccatgttttggctcagactctggatgctaggacattgatg aagtccagttcggcgtctgtctggggatttttacattcattctttgaagcatctgcagtt gatcttgagatgacactggaaaacctttctgttaccttcgtctctttgcctcagagcagg aatcagcagtctaaaggagtggccaatgttctcagttacacaacctccatccttattccc accctcacttcactcttccagcatattggcaaccaaagctatggagtggatatcctggtg gagagaattcaggtgtcgtgttacaggatcctaaacagcctatattctcttggcaccagt aggagcatccacatgacagggcaaaggccagcagcaggtgcttgtctggcagctctgact ggggcttttcctgtatgtttcctggagccagaactcaaccaaaataacccctactccatc tacaacacaatgagtgatactcaaagagaagatctgggattgccagagcaggtggaggac atgtgtcctcttctgccttctctggaacagaccctgggtgaagtggaggtgttggcagag gctggtgctggagctctacagacccactatctccatgtcactgaggtcactttgcccatg ctgtgcagctatatgtcccggtggtggcgctggggccctgagggtcatccagcccatcca aactgcaccgctgttattcctcagcatgccagtgacctacttggcagtattctccgtata attcacaaccatgtgggcaacagccagggtgattggatgaaacatctggcagtgttttct cagtcaatcatatgcaaagccagcactgagctgctgagaagccactttataccactgatg gaaaagttaaggaagagagcagaatgtgtgatgctggaggaagagcagatgaaggcagaa ggctgttgtgcctctgaagaggagttacagatccaggaaaagttcactgtgttggttcga gatctctacgccttctatcccatagttatcccatttgtggatttaaatagggccagctgg ctgaaagagtcaaaccccgaggctgagcagctgttcagcatggtggcagaggtctttata ttctgggccaaatctcataattttaaatgggaggaacagaattatgtggttacaaatgaa atcaataacttggcatttttggtcaacaaagacaacatttccaagtcaagccatgagaga aagaagataaggaggaagggggaccggtattccacaaacacatctctaattgtggcttcc attaagaggctactccctgtgggactccatgtttgtttcccagtcgaccatagcctcatc atgctggctaagactagattctctcagaagaacactgaagatgagattcgagagcatgtt cttaatggcctcatacaacttcagaatcagccaataaatggtacaaggcaagaaagtaaa tctgaccagcgaagactgattattgatatcccaaagagtctggaccagattctgagagta gctcgagtcctctattacctagaacaggtggaacatccccatcgacataacaaacctgcg tggcacacggtcctatctaaacagaggaaacgtgcagtggtggcttgcttaaggatgact cccctctacaatctgccaaggcacagagctgtaaacctgttcctccaaggctacaataaa tcttggatttcagctgaagtccacaactttgaggaaaggcttgttgatgacttagctaaa ggaagaatgatggagctgcgtggagatggccgaggcaaagaaaaggatgcggaaaaaggc gccaaaccaatcgatccgctcatgcagctgattacattcttcagtcgaagctccctgaca gaaaggagtaagcttggaaacgacagtctctacaagacctatgctgctataatggccaag agttgccacagagacgatgatgatgctgatgctgatgctgatgatggtgttaataatgaa catgaggctgaaagttttgaagagaaggaaatggagaaacaaaggatgctgtaccagcag gctaggttgcattgtcgtggcgcttcagaaatggttctgcaaatgataagtgccagcaaa ggggcaatggactcaatgatttcacccacactcaagctgggtattgctgttcttaatgga gggaatgtcactgttcagcagaaaatgctccattatctgcaagataagcgagatgttggc ttctttcagagcatggctggtctcatgcagtcatgtagtgttctggatctgaacgcattt gagaggcagaacaaagcagaaggattaggcatggccatggatgagagctcaggagagaag gcgatgcccgataaagacctaacttgtgacctgttccgttttctgcagctactctgtgaa ggacacaacttagatttccagaattacttgagaacgcaaacaggaaacaacaccactgtc aacattattatatccactgtggactatttactaagagtacaggaatcaatcagtgacttc tactggaactactcaggaaaggatgtcattgatgcacacggtcaacacaacttctctacg gctattgaagtagctaaacaggtcttcaataccctcacagagtacatacagggcccatgt actgagaatcaacagagtctagctcacagtcgtctgtgggatgctgtagtgggtttcctc cacgtctttgcccacatgcagatgaagctctctcgggattcaaggcaaattgagcttttg aaacagttgatggacttacaaaaggacatggttgtgtttctgctttccatgttggagggt aatgttgtcaatggaactattggaaagcagatggtggatatgttggtggagtcgtcgggc aatgtggagatgatcctgaggttttttgacatgttcctcaaacttaaagacctcacctcc tctgatgccttcagagagtatgaccctgaccataagggatgcatttccaggaaggacttt cagaaagccatggaaaattgcaaacgtttctcgctaactgagatgaatttcctactttcc tgcatggacaataatgaaagtgatatggtccattatgaggcctttgtcagtcgcttccat gaaccagctaaagacattgggttcagcatcgcggttctactcaccaatttgtctgaacac atgcccacagatccgagactaaggacattcctggagctggcagactctgtcctgacttac ttccagccctctctaggatgtattgaaattcttggcagtgggaagcgtattgaacgtgtc tacttcgagatcagtgaagctagccgcacacagtggaagaagccccaggtcaaagagtcc aagaggcagttcatttttgatgtggtcaatgagggaggagagaaggaaaagatggagatg tttgtgaatttttgtgaggacactatatttgagatgcagcttgcagcacaaatatctgga tctgatgttggagaaaagcacacaccagaagaactggaggaaaagacaaagagcaaggag gaagaccccaaaggactgtttttcataaatcactgctggttgttgttgacatcgcttctt tctgttaaaagcctgaagaaactgatgaagatgactctaaaggacatcctaatgctggct cttttcttcattagattcatttttatgactcaagttcagtgcatttgtgttgtcattcgc agcattctgtatgtgctgtatgtagtttttgttaatggtggagtcatagagggagccaaa aaaatgcagctgtctgacttggttggtggtatcattgagccaactcttgatgaggtcatg gaggtgccaagcagtgtggatcagaggagaaagtactcagccagtttcccctcccagaga gaattgatggagattggtcaggtgggatctctgacctcccaaagggaggtggacatactg tcggacatatttggccttaaagtgaagaaggagggaggtcaatacagacttataacaaag gacctcactgccagtctgactgacttgttcagcacaacctccagaacaactagcgcagca gaatttccagaagagcatcagagaacgcagtttaagaccagcggtgcctcggaggaaaaa gcagaagatgagaaaatacctgagttagatgacacaaaagtgaaggacttggaggcgaag actgggaatgagaaagcaaaggcagaattgagagcccggagatgctctaataagtctgag gaatcaaaaagccaacattctgccttctgggagatgataagcactcataacaagagtctg ctgaattactttgcaaggaatttttataatatgcgccttctggctctgttcgtggccttt gcaatcaacttcatccttctcttctacaaggtcgcatccttgcctccgatgccagagagg caaaatgcgatctcatctgttcacagtgaagacctggactctgctgctgtggaggacaat agaagcggagtttattttgtgctagaggagagcagtggatatatggaaccatcgcttcat ttcctggctgtagtgcacacaatcatttccttttgttgtattatcggctactactgcctc aaggtaccactggtgatcttcaaacgtgagaaagaagtggcgcgaaggctggagtttgac gggctgtatgtgacagagcagccccctgaggaagacatcaaagggcagtgggaccgactg gtcattaacacaccatcatttcccagtaattactgggataaattcgtgaaaaggaaggta ctggataaatatagtcagttttatggctgtaagaaaataagtgagctcctgggtgtggac caaactgctttagacttcagcgcagaaaaaaaggaaagaaggcttaggagggaatcctgg agttctctatttaattccattgacatgaaataccaggtctggaaactaggagtcgttttc actgataattcctttttgtacttggcctggtacatgatcatgtcagttctgggtcattat aacaacttcttctttgcggcccaccttttggacattgccatgggctttaagacacttcgt accatcctttcctctgtgacacacaacgggaaacagctggtcctcactgtaggcctcctg gctgttgtggtttacctctacaccgttgtggccttcaatttcttcaggaagttttacaat aagagcgatgaaaagaacggtgaagacatgaaatgcaacgacatgctaacttgttatatg tttcacatgtatgtgggggtgcgagcgggaggaggcattggcgatgagattgaggacccg gctggagatgagtttgaggtggagcgcattgtcttcgatatcacatttttcttctttgtc attgtcatcctcttggccattattcagggcttaataattgatgcctttggagagctccgt gaccagcaggaacaggttaagaaggacatggagaccaagtgttttatctgtggaataggt agtgaatattttgacacggtccctcatggctttgagactcacactctacaggaacacaac ctggccaactatctgttttttctgatgtatcttattaacaaggatgaaactgaacagacg ggacaggaatcgtatgtgtggaaaatgtaccaggaacgctgctgggaattctttcctgtg ggagactgttttcgtaagcaatatgaggatcaactaggataa

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