Bacillus subtilis subsp. spizizenii W23: BSUW23_08850 Help Entry BSUW23_08850      CDS       T01302                                  Symbol pksN Name (GenBank) polyketide synthase of type I   KO K13614   bacillaene biosynthesis, polyketide synthase / nonribosomal peptide synthetase PksN/BaeN Organism bss  Bacillus subtilis subsp. spizizenii W23 Brite KEGG Orthology (KO) [BR:bss00001]  09180 Brite Hierarchies   09181 Protein families: metabolism    01004 Lipid biosynthesis proteins [BR:bss01004]     BSUW23_08850 (pksN)    01008 Polyketide biosynthesis proteins [BR:bss01008]     BSUW23_08850 (pksN) Lipid biosynthesis proteins [BR:bss01004]  Polyketide synthase   Modular PKS    BSUW23_08850 (pksN) Polyketide biosynthesis proteins [BR:bss01008]  Polyketide synthase (PKS)   Modular type I PKS    trans-AT PKS     Bacillanene hybrid PKS-NRPS      BSUW23_08850 (pksN) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt KR Ketoacyl-synt_C Condensation PS-DH AMP-binding PKS_DH_N RhiE-like_linker PP-binding CurL-like_PKS_C KAsynt_C_assoc adh_short adh_short_C2 Thiolase_N DUF7080 Beta-ketacyl_N Epimerase AMP-binding_C GDP_Man_Dehyd NAD_binding_4 SpnB_Rossmann Motif Other DBs NCBI-ProteinID:  ADM37816 UniProt:  E0TV45 LinkDB All DBs Position 1791801..1808345 Genome browser AA seq 5514 aa AA seqDB search MNHKEILDAFRSGELTISEVEEHLQGKKRQLKSPLSEGQKGLWMLQKMSPDMSAYNIPLC FRISKRIHAETFKKALLFVQRQYPVLTSVIQEENGIPFQTVQSSEVLYFEEEDISAIKSA EVLSLLKEKAKEPFHLEAGPLLRIHLFHRSKEECIVLITIHHIIFDGVSMLTLISELFKA YQELVNGIEPVPQPLTADYYDFVDWETRMLNSREGEEHLAYWKEQLSGNLPVLDLQADRL RSSARKFKGQAYKSLLPHHLRNQIKSFARTNHVNESVVFLSIYKVLLHHYTKQKDIIVGV PTMGRHEDSFETLIGYFINMMAVRSKNIGSQPFTAFIRDLQLTMADGLDHAAYPFPALVR ELNVDRSAAHSPVFQTAFLYQNFFQTTGLQKVLEPYQTLGIEYIEDIRQEGEFELALEIY EQENDTVLHLLYNPDLYELSFIESMMENYMKLAQHMMEDPSLPLETYSLQLHQEQSSLLE QWNATSTNTPSDKCIHEVFEEKAKQTPDAVAVIFEDRSLTYKEVDEKSTSLAIYLQHQGV GPEHPVGICTERSFDMIIGILGILKAGGAYVPLDPSFPQERLEYMLKDSQASIVLTQPNV HHTISGLIDSHVKAINIELACRNGYTDQQSSGLKREVKPEHLAYIIYTSGSTGQPKGVMV EHRSIMNTLNFLESHYPVTAEDAYLLKTNYVFDVSISELFGWFIGNGRLVILPPNGEKSP QKCMDYIEKYKVSHINFVPAMLHVFLETAKDNKQLTEDGPLKYMMVAGEAFPKELVKKAV SIFKNCRVENIYGPTEASIYAAYFGCGKGDIASHHTPIGKPVSNMKIYIVDQHLKPVSIG KPGELCIAGDGLARGYYNKPGLTAEKFIDNPFEPGTKLYKSGDSARWLPDGNIEYLGRID SQVKIRGFRVELGAIETKLSEYPGILDQAVVVKQLEGHQQLAAYYTEESGHSPADPKEMR RHLKFSLPEYMIPSHFIRLDELPLSPSGKVNRKELEKREIVFNKKKPNRLQLTDIEDQVL RIWEETLKVSGFGPEDGFFDAGGDSLLAVAVAERIKKELDCEFSVTELFEYSTIRAASQY VLEMKNSEKAMTRNEDDDDLKRDGKYQQQTIPPYFDDSVAIVGISCQFPGAKHHHDFWNH IKEGKESIQFFSEEELRENGVPEELIQHPDYVPVQSAIEGKDLFDPGFFQISPKDAEYMD PQLRLLLLHSWKAIEDAGYVTKEIPGTSVYMSASNNAYRTLLPKEATEGHESPDGYVSWV LAQSGTIPTMISHKLGLKGPSYFVHSNCSSSLVGLYQAYKSLTSGESQYALVGGATLHAQ SAIGYVHQNGLNFSSDGHVKAFDASADGMAGGEGVAVILLKKAVDAVKDGDHIYAIMRGI GINNDGADKAGFYAPSVKGQTEVIQHVLDQTNVHPETVSYIEAHGTGTKLGDPIELSALN KVYKQYTDKTQFCGIGSVKTNIGHLDTAAGLAGCIKVAMSLYHNELAPTINCTEPNPNIN FESSPFYVVRERKPLEKRAGVHRAALSSFGLGGTNAHAVFEQYENLSAWAGNEGDQPYII PVSAKNSERLQVYVKELLTYISQNEQTHISLRDFAYTFQVGREAMDSRVVFIANDLEEWK QQLDAFVNGKPLAEGYIQGKKTRMISAEQLLGNAEAEELAASRISKEELKKLADMWAKGF HVEWRRLYQNTTPRRISLPTYPFAEERYWPESSTGDNTTIEPSHLHPLVHHNTSILSEQR FSSTFTGQEYFIAEHIIKGMAILPAAVTLEMARAAIEQGIGGLEDHETGIRLKNVVWVRP VVAGDEPVHVNIGLYDEDGGHILYRMYGEPESDDAELVVYNQGIAELMQVKQEKALDLSE IKTRCDQSRVDAALFYEGMIGADYGPGYKSVETVYKGDGQLLAKLSLPESVMHTSGDYVL HPSVMDGALQAAEYLQNVVRAELSDSVDFKAALPFALEELEVFHPCVTDMWVYVQFNAKN KPGDLIQKVDIDLCDEHGTIYMRIKGFSTRVMAADIQTEPSKINAETLLLQPVWQEQQAA EGAAAKKYAEHLVFLCEHDNETRKQIEAAIEDVHVYSLETRPSSVDERFHSYAEQVFKKV QEITRTKPKGDILIQIVTFAEGEQQLFSGLTGLLKTAEQENAKLTGQMIEVSSEEGGESI AGKLIENQMSSDSYIKYHNGTRYIADWRDIKTANHDISKPWKDDGVYLITGGTGGLGLIF AKEITEQTKNATVILTGRSPLSESRRKKLKELHGKGAEVTYQQTDVTDKIEVYQLIDGIQ KTYGRLDGILHSAGIIKDSYMVNKSADDLHDVLAPKVKGLVYLDEATKDLPLDFFILFSS LSGSLGSIGQSDYAAANVFMDMYAGYRNRLAALSQRHGKMLSVNWPLWSEGGMKVDQETE KRLVQMAGIVPMRAKKGIQALYQAFHSEANQVMVIEGDVQKIKQNILAKSASAPMEKKET ERMTEQVKNIDTDSLLDKVKAMLKREVAKLLKVKLETIDDHAEMTVYGLDSISMTEFTNH INRAYKLELTPTVFFDYPTIHAFGKHLSEAYQSVFAKTFAVRAASAQVQVQPAAKQEQAL HVKAKRRRKPHVTMQNAAQSDVGREPIAIVGISGIFPMAKDVEAYWKILKEGKDCMTEIP KDRWDWREYEGNPAKEVNKTNVKWGGFIDGIADFDPLFFGISPREAEQMEPQQRLLLTYA WKAIEDAGYSAKRLSGTKTGVFIGTGNTGYSSLLSKANSAIEGSAAANTSPSVGPNRVSY ILNLHGPSEPIDTACSSSLVAIHHAISSIEEGTCDMALAGGVNTIILPEVYISFDKAGAL SKEGKCKTFSNQADGFAHGEGAGILFLKKLKAAEEAGDHIYGVIKGSAINHGGRAASLTT PNPKAQSDVIQSAYEKAGIDPKTVTYIEAHGTGTELGDPVEINGLKSAFKALGVNEGDPS ANPYCGLGSVKTNIGHLSLAAGAAGIIKILLQLKHKTLVKSLHCETVNPYIQLKGSPFYI VRETEEWKALKNERGEELPRRAGVSSFGIGGVNAHVIIEEYIPEAADEIIPSITPEHPGI FNLSAKNEARLREYAQQLADALDKETYRDVNLTRIAYTLQAGRDAMEERLGIISGSIEDL QQKLKDFAAGKSGVEDLFRGRIDKGTLQMLTEDEEIQEAVEKWMERGKYAKLLELWVKGL DVDWTKLYGENLPKRISLPTYPFAKERYWISDHIQKSGRPEANKAASRLGGAILHPLMHQ NTSNLSEQRFSSIYTGEEFFLAEHVVKGQRILPGVAHLELARAAVEQAAGVQDVPCTMKL KNAVWMRPIVVEDRPQQVHIRLLPGENGEISYEIYGNPDAAGEQSIVYSQGSAVLSPAEN LPVVDLQSLREQCQESHFSVNEVYDTYQMIGFEYGPAYCGMKKIYTAEHFVLARLSLHPS ALDTLSQYNMHPGLMDSALQASSILTGAGDNQLTLPFAVQELEVFGACSSEMWVYARYSQ GSKATDKVQKRDIDMLDENGNVCVRMKGLSFRAAEGGSGSAEPVQTLETLMFEEQWVPKA CEKENPEPHYERHIVMLCDMNGLSKDSIESRMVGAECIVLESFGEGLAERFQDYAEQALE AVQSLLKSKPQGNILIQLLTSARRKKYSFSGLSALLKTASLENKKLIGQTIEIDSNENIE NMIEKLKENKRHAGDQHVKYETGKRYINELREMQMANQDIGLPWRDKGVYLITGGAGGLG FIFAKEVARQAEQPVLILTGRSALNADQQAQLKELQRLGARAEYRRIDVTQAEEASGLVT SITSDYGDLNGVIHSAGLIKDNYLMNKTNEELIQVLSPKVKGLVNVDEATEHIALDFFIL FSSISSVAGSAGQADYAMANAFMDSYAAYRNALVTAMYRHGQTLSINWPLWKEGGMRANK EIENMTLKNTGVTPMQTETGIQALYKGLAFGKDHVIVMEGIRDMIREKLAQKPSSDDVPM KTVQVPVKSEARMDQDSLFDHIQEALKLAISQLLKIKPEEIDPDMEFNQYGFDSITLTEF ANTLNEQYKLDLTPTVFFEYATVYAFAAYLSEEYPNAFTVQTPVKAEQPLQPVEKNIKNM TFSAENRFPKPSVTPVQKEADHGPEPIAIVGMSGVFPKAKDIEEYWKNLKAGVDCITEVP KDRWDWQEYYGDPLKEANKTNVKWGGFIDEVADFDPLFFGISPLEAEQMEPQQRLLMTYA WKAIEEAGYSARSLSGSKTGIFIGTGNTGYSSLLSNVDIEGSAAANMSPSAGPNRVSYFL NIHGPSEPIDTACSSSLVAVHHAVCAIENGNCEMAIAGGVNTVVTPQGHIAYDKAGALSK EGRCKTFSDRADGFAVSEGAGILFLKKLTAAERDGDHIYGVIKGSAVNHGGRANSLTTPN PKAQADVVKTAYEKAGIDPRTVTYIEAHGTGTELGDPVEINGLKAAFKELYEKTGDPAVH GSHCGLGSAKTNIGHLSLAAGVAGVIKVLLQLKHKTLVKSLYSETINSYIRLEDSPFYIV QESREWQALRDEAGRELPRRAGISSFGIGGVNAHVVIEEYIPKETTHPAQAQAMTAQHPG IFILSAKGEDRLKDQARQLADFISSQSILSRDLTDIAYTLQEGRDAMEERLGIIAVSAED LLEKLNLFIAGHASAMYMSGRADKGLVKTLRSDDEIQKILNNSWEPQIYERLLELWIKGM EIDWSKLYGGKQPKRISLPTYPFAKERYWITDMKEGAVTHHAATSVETAALHPLVQSNTS DLSEQRFSSIFTGAEFFFTDHKVKGSRVMPGVAYLEMVHAAVTRSVRGIKETQTVVHIKN VVWVQPIVADGQPVQVDISLDPQQDGEIAFNIFTEDAHNGRKIHCQGSAAINEAGDIPVQ DISVLQDQCCLSTLSHDQCYELFKAIGIDYGPGFQGIDRLYIGRNQALAELSLPPGVSHT LDEFVLHPSMADSALQASIGLKLNSGDEQLSLPFALQELEICSPCTDKMWVSITSRPHED RIQRLDIDLCDDQGRVCVRIKGISSRVLEEDIQPQDEPTSPDIKASLDESLLMAPVWDQV KQEKNIIPPADERIVILGGDDNSRKAVQRQFPFAKELHIEPNASNYEIANQLEALGPFDH IVRLSPSRVTEGEVGDDMIEAQDQGVIQMFRLIKAMLSLGYGEKAISWTVVTANTQCVDQ DDVVDPSDAAVHGLIGSMAKEYPNWQTKLIDVKNHEDLPVSEIFSLPADQEGNTWAYRNQ LWYKLRLIPVHNNQPVHTKYKHGGVYVVIGGAGGIGEAWSEYIIRTYQAQVVWIGRRKMD AAIQSKLDRLARLGPAPFYIQADAANREELERAYETMKQKHREINGIIHSAIVLQDRSLM NMDEKCFRNVLSAKVDVSVRMAQVFRHEPLDFVLFFSSVQSFARASGQSNYAAGCSFKDA FAHRLSRVWSCTVAVMNWSYWGSIGVVSSPEYQKRMAQAGIGSIEAPEAMEALELLLGGP LKQLVMMKMANETSDDEAEQIEETIEVYPETHSSAIQKLRSYHSGDSTKIQQLL NT seq 16545 nt NT seq  +upstreamnt  +downstreamnt atgaatcataaagaaattctcgatgccttcagatcaggagaattaaccatttctgaggta gaagaacaccttcaaggcaagaagcggcagttgaaaagcccgctttcagaagggcaaaaa ggactgtggatgcttcagaaaatgtctcctgatatgagtgcatataatattcctttatgc tttcgcatcagcaaacgaatacatgcagagacgttcaagaaagcccttctgtttgtgcag agacaatatcctgttttaaccagtgtgattcaagaggagaatggcattccatttcaaacg gttcaatcatcagaagtgctttattttgaggaagaggatatttcagcgatcaaatcagca gaggtattatctttactaaaagaaaaagcaaaagaaccttttcatttggaagctggtccg ttattgcgcatacatctttttcatcggtcaaaagaagaatgcattgtgctcataacgatt caccatatcatatttgacggtgtgtcgatgctgacattgatatcggaactttttaaggcg tatcaagaattagtgaatgggattgagcccgtgccgcagccgctaacagctgattattac gattttgtcgattgggaaacccggatgctgaatagcagagaaggggaagagcatctcgct tactggaaagaacagctgtctgggaatctgccagttcttgatcttcaagctgaccgcttg cggtcttctgcacgaaaattcaaggggcaagcatataaaagcttgctccctcatcacctg agaaatcaaatcaaatcgtttgcccgcaccaatcatgtaaatgaatcggttgtatttctc tccatttacaaggtcctgctgcatcactatacaaaacaaaaagatatcattgtcggcgtt ccgacaatgggtcggcatgaagatagctttgaaacccttatcggttactttatcaacatg atggctgttcggagcaagaatatcggatctcagccatttacagcatttattcgggacctg cagctgacaatggctgacggtctggaccatgcggcatatccattcccagcattggtaaga gagctgaatgtagaccgctcggccgcgcattcgccggtttttcaaacagcctttttgtac caaaacttctttcaaacaacaggcttgcaaaaagtgcttgaaccatatcaaacgcttggc attgaatatattgaggatattcggcaagagggagaatttgagctggcactcgagatatat gagcaagaaaatgatacagtgcttcatcttttgtacaaccctgatctatatgaattgtcc ttcattgaaagcatgatggagaactatatgaagctcgcgcaacatatgatggaggacccg tctttgccgcttgaaacctactctttgcagttacatcaagaacaaagcagtttactggaa caatggaatgcgacaagcacaaacacgccaagtgacaagtgtatacatgaagtgtttgag gaaaaagcgaaacaaaccccggatgcggttgctgtgattttcgaagacaggtctcttaca tataaagaagtagatgaaaaaagcacatctttggcaatctaccttcaacatcaaggggtt ggacctgaacaccccgttggaatttgtacagagcgttcgtttgatatgatcatcgggatt ttaggaatactgaaagccggcggagcgtatgtgccgttagatccaagcttcccgcaagaa cggttggagtacatgctcaaagacagccaggcatccattgtcctgacccaacctaacgtt catcatacgatcagcggattaattgacagccatgtaaaagcaatcaatatcgagttggct tgccgaaacggttatacagatcagcaaagcagcggtttaaagcgggaagtaaaaccggag catctcgcttatatcatttacacatcgggaagcaccggacagcccaaaggggttatggta gaacatcggagcataatgaataccctgaattttcttgaatcccactatcctgtaactgct gaggatgcatatctactgaagacgaactatgtgttcgatgtatcaatctcggaattgttc ggatggtttatcggaaacggccgccttgtgattcttccgcctaatggagagaaatcaccg cagaagtgcatggattatattgaaaaatacaaagtgagccacattaattttgtgccggct atgctgcatgtttttttagaaacggcgaaagacaacaagcagctaacagaggatggaccg ctcaagtatatgatggttgccggtgaagctttccctaaagaattagtgaaaaaggcggta tcgatctttaaaaactgccgtgttgaaaatatttacggacctactgaagcctccatttac gctgcgtatttcggatgcggaaaaggagatattgcaagtcaccatacgccgattggaaag cctgtctccaacatgaaaatttatattgtggaccagcatttgaaacctgtgtcgatcgga aagcctggtgagctttgcatcgcaggcgacggtttggcaagaggatactataataagccg ggtcttacggctgaaaaatttatagacaacccatttgaaccagggacaaagctttataaa tcgggtgattcagcaagatggcttcctgacggcaacatagaatatttaggccggattgac agccaagtcaaaatacgcggttttcgcgtcgaactgggtgcaatagaaacaaagctaagt gaatatccgggcattttagatcaggcggtcgtggtgaagcagctcgaaggccatcaacag ctcgctgcttattatacagaggaaagcggacattcccctgcagacccaaaagagatgcgc cgtcatctaaaattcagtctgccggaatatatgataccttcacactttatccgcttagat gagttgccgttatcgcctagcggaaaagtgaaccgtaaagaactggagaaacgcgagatc gttttcaataaaaagaaaccaaatcgcttgcagttaacggacatagaggatcaggtgctt cgcatttgggaggaaacgctcaaggtcagcggatttgggccggaagacggatttttcgat gcgggcggcgattcacttctggctgtagctgttgctgaacgaattaaaaaagaattggat tgtgagtttagtgttaccgagctgttcgaatattccaccatccgtgcagcaagccaatac gttttggagatgaaaaactcagaaaaagccatgactcgaaatgaagacgatgatgatctc aaaagagacggaaaataccagcagcagacgatccctccttattttgacgacagtgttgcg attgtcgggatatcctgccaatttccgggtgcgaaacatcatcatgatttttggaatcac atcaaagaaggcaaagaaagtattcagttcttctctgaagaagagcttcgtgaaaacgga gttccggaagaattgattcaacatcctgactatgtgcctgtacaatctgcgatcgagggg aaagacttattcgaccctggtttctttcaaatttctccgaaagatgcagagtatatggac cctcagctccgcctcttattgctgcattcctggaaagcgattgaggatgcaggatatgtg acaaaggagattccgggcacaagtgtatatatgtctgcaagcaacaatgcatacagaacg ttattgccgaaggaagcaacagaagggcatgaatcaccggatggctatgtctcatgggtt ttagcccaaagcggaaccatcccgacgatgatctcgcataagctcggattaaaagggcca agctactttgttcattctaactgctcttcatcactagtcggcttgtatcaggcatacaaa agcctgacatcgggtgaatctcaatatgcgcttgtcggaggcgcaacattgcacgcacaa tcagcgatcggatacgtgcaccaaaacgggttgaatttttcaagtgacggacatgttaag gcgtttgatgcttcggctgacggaatggccggaggtgaaggtgtagcggtcatcctgctg aaaaaagctgtggatgccgtaaaagacggagaccatatttatgccattatgcgcggaata ggtatcaataatgatggcgcagataaggccggcttctatgcgccaagtgtaaaaggccaa acagaagtgatacagcatgtattggatcaaaccaacgtccatcctgaaacggtcagttat attgaagcgcacggaacgggaacgaaattaggcgatcctattgaattgtcagctttaaat aaagtgtacaagcaatacaccgacaaaacacaattttgcggaattggttcagtgaaaacg aatatcggccatttagatacggctgctgggttagccggatgcattaaagttgcgatgagc ttataccataatgaacttgcaccgaccattaactgcacggagccgaatccgaatattaat tttgaaagctctcctttttatgtagttcgtgaacgaaagccgttagagaaacgtgcaggt gtccatcgggcggctctgagttcattcgggcttggcggcactaacgcccatgctgtattt gagcaatatgaaaacctttctgcatgggcagggaacgaaggcgatcagccctacatcatt cctgtatcagcaaagaatagcgaacggctccaagtatacgtaaaggaactgctgacctat atcagtcaaaacgagcaaacgcatatctctctaagagattttgcatacaccttccaggtc ggccgggaagcaatggacagcagggtcgtttttatagcgaacgatctggaagaatggaaa cagcagctggatgcttttgtgaatggaaagccgctcgcagaaggctatattcaaggaaaa aaaacgagaatgatatccgctgaacagttgcttggaaacgctgaagcggaagaactggct gcatcacggatatcaaaagaagaattgaaaaagcttgccgacatgtgggcaaaaggcttt cacgttgaatggcgaaggctttaccaaaatacgacgccgcgccgcatcagcttgccgaca tacccttttgctgaagaacggtactggcctgaaagcagcaccggcgataacacaacaatt gaaccatcgcatttgcatcctttggtgcaccataatacatcgattctgtcagagcagcgg ttcagctccaccttcacgggacaagaatattttattgccgagcatatcattaaaggcatg gcgattttgccggcggcggtcacgcttgaaatggcaagagccgctatagaacaaggaatt ggcggattggaggatcatgaaaccggaatcaggctgaaaaacgtcgtgtgggttcgtccg gttgtagcaggagatgagccggttcacgtcaacatcggactttatgatgaagacggcgga cacattctttatcggatgtatggtgagccggaatctgatgatgcagaactagttgtatat aaccagggtatagcggaattgatgcaggtaaagcaggaaaaagcgctggatctttctgag atcaagacccgatgtgatcaaagcagagtagacgctgccttgttttatgaaggaatgatc ggagccgattacggtcccggttacaagagtgtagagaccgtatataaaggcgacggacag ctgcttgccaaattatcactgccggaatctgtgatgcatacgtcaggcgattatgttctt catccaagtgtaatggatggggcgttacaggcggctgaatatttgcaaaacgtcgttaga gcggagttatcagacagtgtagattttaaggcagcactgccgtttgccctggaggagctt gaggtctttcatccatgcgtcactgacatgtgggtttatgttcaattcaacgcgaaaaat aaaccaggggacctgatacagaaagtcgatattgatctatgcgatgagcatggcacgatt tacatgcggataaaaggattttcgacgagagtgatggcggctgatatacaaaccgaacca tcaaaaataaacgctgaaactttattgcttcagcctgtttggcaagaacaacaggcagct gaaggcgctgctgcaaaaaaatatgcagagcatctcgtgttcctatgtgaacatgacaat gagacgagaaaacagattgaagctgcgatcgaggatgtccatgtatatagcctagaaaca aggccttcttcagtggatgagcgtttccattcttatgcggaacaagtgtttaagaaggtg caagagatcactcgcacgaaaccgaaaggcgacattcttattcagatcgtaacctttgca gaaggagaacagcaattgttttcagggttgactggactgttgaaaacggccgagcaggaa aatgccaaactaaccggccaaatgattgaagtcagcagtgaagaaggcggagaaagcatt gctggcaaactgatagaaaatcaaatgagcagcgattcatatatcaaatatcacaacggt acacgatacattgctgattggcgtgacatcaaaacggcaaaccatgacatcagcaagcct tggaaagatgatggcgtttatctcattacaggaggtaccggaggcttaggtcttattttt gcaaaagaaatcacggaacaaacgaagaatgcgacggtgattctgacgggccgctcgcct cttagcgaaagtagaaggaaaaagcttaaagagcttcacggcaagggggctgaggtcacc tatcagcaaacagatgttaccgataagattgaagtttaccagctcattgacggaatccag aaaacatatggccgactggacggcattcttcacagcgcgggaatcatcaaagacagctat atggtcaataaatcagctgatgacctgcacgacgtactggcgcctaaagtaaaaggactt gtttacctagacgaagcgactaaggatttgccgttggacttctttattctcttttcatca ctttctggaagtttaggaagcattggtcagtctgactatgcggcagccaatgtatttatg gatatgtatgcaggctatcgaaataggcttgccgccctcagccagaggcacggtaagatg ctttctgtaaactggccgttatggagcgagggcggcatgaaggtcgatcaagaaacagag aaaagacttgtgcaaatggccgggattgttcctatgagagcaaaaaaaggaattcaggca ttatatcaagcgtttcattccgaagcaaaccaagtaatggtgatcgaaggcgatgtgcag aagataaaacaaaacatactggcaaaaagcgcctcagcacctatggaaaagaaggaaaca gagcgtatgactgaacaagtaaaaaacatcgatacagacagtttgctggataaagtaaag gcgatgttaaagcgggaggtcgccaagctgttaaaggttaagcttgaaacgattgatgat catgccgagatgacggtatatggacttgattctatctcaatgacggaattcaccaaccat atcaatcgcgcctataaattagagctgacgccaaccgtcttttttgactacccgacgatt catgcgtttggcaagcatttgtcagaagcatatcaatcggtgtttgcgaagacatttgct gtgcgcgcagcatcggctcaggttcaggttcagcctgctgccaaacaggaacaagcctta catgtcaaagctaagagacgccgaaagccgcacgtcacaatgcaaaacgccgcacagagt gatgttgggcgagagccaattgccattgtagggataagcgggattttccctatggcgaaa gatgttgaggcatactggaagatcttaaaagagggcaaagactgcatgacggaaattccg aaagaccgctgggattggcgggaatatgaaggtaatccggcgaaggaagtcaataaaacg aacgtaaaatggggcggttttattgacggaattgcagattttgatccattatttttcggc atttccccgcgtgaagctgaacaaatggaacctcagcagcgcttactgttgacttacgcc tggaaggcgatcgaagatgcagggtattcggcgaaacgtctgtctggcacaaaaacaggc gtcttcatcggaacgggaaatacagggtacagctctcttttgtcaaaagccaactcggca atagaaggctcagcggcggccaatacaagcccttcagtcggtccgaaccgggtcagttat atcttgaatctgcatgggccgagcgaaccgattgatacagcatgctccagctcattggtg gctatccaccacgccatctcttcaattgaggaaggcacttgtgacatggcgttagccggc ggcgtgaatacaattatcctacctgaggtgtatatcagctttgataaagcgggggcactg agtaaagaaggaaaatgtaagacgttttcgaatcaagccgatggttttgcccatggagaa ggggccggcatcctgttcttgaaaaaattaaaagcggctgaagaagcgggagaccacatt tacggagtcataaaaggcagcgcaatcaatcacggcggccgtgcagcatctttaacgacg cctaatccgaaggcgcagtcggatgtcattcagtcggcatatgaaaaagcgggaatcgat ccgaaaactgtgacctacattgaagcgcacggaaccgggacggagcttggagacccggtt gaaattaacggattgaaatcagcttttaaagcactgggggtgaatgaaggagatccatca gccaatccttattgcggattggggtctgtgaagacaaacatcggccacttatcgctggca gccggtgcagcagggatcattaaaatattattgcagcttaagcacaaaaccttagtgaaa agtcttcactgcgaaaccgtgaatccgtacattcagctgaaaggcagtccgttctatatc gtccgggaaacagaagaatggaaagcgctgaaaaatgaacggggagaagagctgcctcgc cgagcaggtgtcagttcatttgggatcggcggcgtaaacgcccacgtgattattgaggaa tatattccagaagcagccgatgaaattataccgtccatcacacctgaacatccgggtatc ttcaatttatcagctaaaaacgaagcgcggcttagagaatatgcacagcagctggcagat gcgcttgataaggaaacatatcgtgacgtaaatctcacccgcatcgcttatacactgcaa gccggacgggatgcgatggaagagcgtctcgggattatttccggttccattgaggatctg cagcaaaagttaaaagactttgcagcaggcaaaagcggtgtggaagatttatttagaggc aggattgataagggcacgctgcaaatgctgacagaagacgaagagattcaagaagccgtt gaaaaatggatggaacggggaaagtacgcaaaactgcttgagttatgggtaaaggggctt gatgtagactggacgaaactgtatggcgagaatctaccaaagcgcatcagcttgccgacg tatcctttcgcaaaagaacgttattggatctctgatcatattcaaaaaagcggccgccct gaagcaaacaaagcagcctcccgccttggaggagccatactccatccattaatgcatcaa aacacatcgaacctctcggaacaaagatttagctccatctatacgggagaagagtttttc cttgccgaacatgttgtcaaaggccaacggatcttgccgggagtggcgcatcttgaattg gcgcgggcggccgtcgaacaggcagcaggggtacaagatgttccgtgcaccatgaagcta aagaatgcggtttggatgcggcctattgttgtagaggatcggccgcagcaagtacacatc aggcttttaccgggcgaaaatggtgaaatctcttatgaaatctacggtaatccagacgct gcaggcgaacagtcaatcgtctacagtcaaggcagcgcagtattaagtcctgctgaaaac ctgccggtggttgacttgcaatccttgcgggagcagtgtcaggaaagccatttcagcgtt aatgaagtatatgacacctatcaaatgatcggttttgaatatggtcctgcttattgcggg atgaaaaaaatctatacagccgaacattttgttttagcaagattgtcattgcatccgtct gctttagatacgctcagccaatacaatatgcaccctgggctgatggactctgctttgcaa gcatcaagcattttaacaggagcgggggataaccagctgacactgccttttgcggtccaa gagcttgaagtcttcggagcatgctcttcagaaatgtgggtatatgcaagatacagtcaa ggcagcaaggcgactgataaagtacaaaagcgggatattgatatgttagatgagaacggc aatgtttgcgtacggatgaaaggattgtctttcagggcagctgaaggcggctctggatcg gcagaacccgttcaaacgctggaaaccttgatgtttgaagaacaatgggtgcctaaggct tgtgagaaagaaaatcctgagcctcattacgaacggcacattgtcatgctttgtgacatg aatggtctctcaaaagacagcattgaatcaagaatggtaggagcggaatgcattgttttg gagtctttcggcgaaggactggcagagagattccaagattatgctgaacaagcacttgag gcagtacagagccttctcaaaagcaagccgcagggcaatatcctgatccagctgctaact tctgcccgaagaaagaagtactcattttcagggctatcggcgctccttaaaaccgccagc ctggaaaacaaaaaattgatcggccagacgattgagatcgattcaaacgaaaacattgaa aatatgatagaaaaactgaaagagaataaaagacacgcaggagatcagcacgtcaaatat gaaactggcaaacggtacatcaatgaattacgtgaaatgcaaatggctaatcaggacata ggcctgccgtggagagataagggtgtatacctcatcacgggcggtgcaggagggctcggg tttatttttgcaaaagaggttgctcgtcaagccgaacagcctgtgctcattctgacaggc agatctgcgttgaatgcggatcagcaggcgcagcttaaagaacttcagcgcttaggggct cgcgcagaatacagacggattgatgtaacacaagcagaggaagcctccgggcttgtcaca agcatcacgtctgattacggagacttgaatggcgtcattcacagcgcagggctgattaaa gataactatctcatgaacaaaaccaatgaagagctgatacaagttctctctcctaaggta aaaggacttgtgaatgtggatgaggcaaccgagcatatcgcgttagatttctttatcctc ttttcttcaatatcaagtgttgccggcagcgcagggcaagcggattatgcgatggctaac gcctttatggacagttatgcagcttatcgaaatgcgcttgtgactgccatgtacaggcac gggcaaacgttgtcgatcaattggccgctctggaaagaaggcggcatgcgcgcgaataaa gaaattgaaaacatgacgttgaaaaacacaggtgtgactccaatgcagaccgaaaccggc attcaggcgctgtataaaggtttggcatttggcaaagatcacgtcatcgtcatggaaggg atcagagacatgataagggaaaagctggctcaaaaaccgtcttctgatgatgttccaatg aaaacagtgcaggtaccggtgaagtctgaagcaagaatggaccaagacagtttgtttgac cacattcaagaagctttaaagctagcaatctctcaattgctcaaaatcaaacctgaagag attgacccggatatggaatttaatcaatatggatttgattcgataacgttgactgaattt gcaaatacactgaatgagcagtacaagctggatctcacgcctacggtcttcttcgagtac gcaactgtttatgcatttgcagcgtatctgtcagaagagtatccaaatgcctttacagtt caaacgcctgtcaaagctgagcagcctttacaacctgtagaaaaaaatataaaaaacatg acattttcagctgaaaaccgctttccaaaaccatcggtaacgccagtgcaaaaggaagct gatcacgggcctgagccaattgcgattgtggggatgagcggcgtttttccgaaggcaaag gacatcgaggaatactggaagaacctgaaagcgggcgtagattgtattacagaggttcca aaagaccgctgggattggcaggagtattacggagaccctctaaaagaagcgaataaaaca aacgtcaaatggggcggttttattgatgaggtagctgactttgatccattgttcttcggc atatctccgcttgaggcagaacagatggagcctcagcagcgcctgttaatgacctatgcg tggaaggcgatagaagaagcgggatactcagcgagaagcctgtcagggtcgaaaacgggc atcttcatcggaacaggaaacacgggatacagctcgcttctgtcaaatgtcgatatcgaa ggctcagcagctgcaaacatgagtccttctgcaggtccgaatagagtcagttattttctg aacattcatggaccgagcgaaccgatcgacactgcatgctcaagctctttggtcgccgtt catcatgcggtttgcgcaattgaaaacggaaactgtgaaatggcgattgcaggaggtgtc aacacagttgtaacaccgcaaggccatatcgcctatgataaggccggggcgctgagcaaa gaaggaagatgcaaaacattttctgatagagccgatgggttcgcagtcagtgaaggtgcc ggcattctcttcctgaaaaagctgacagctgctgaacgagacggtgatcatatttacggt gtcatcaaaggaagtgcggtcaaccacggaggccgcgcaaattctctgacgactcctaat ccaaaggctcaggcggatgtcgtgaaaactgcatatgaaaaagcgggaatcgatccaaga accgtgacctatattgaagcgcacggaactggaacagaacttggtgatccagtagaaatc aacggcttgaaagcggcatttaaagagctgtatgaaaaaacgggagacccggctgttcat ggcagtcattgcggacttggatctgcaaagacaaacatcggtcacttatcgctggcggcc ggtgtggcgggtgtcattaaagtgttattgcagctgaaacataagacgcttgtaaagagt ttgtacagtgaaacgataaattcgtatatcagactggaggacagcccgttttatattgtg caggaatccagagagtggcaggcgctgcgggatgaagccggccgagagctgcctcgccgc gccggcatcagttcatttggcataggcggcgtcaatgcccatgtggtgatcgaggaatat attccaaaagaaacaactcatcccgcacaagcgcaagctatgacagcacaacacccgggc atctttatcttgtcggcaaagggtgaagatcgtctgaaagaccaggcccggcaattagca gactttatcagcagccaatctatcctatctcgtgatctcactgatattgcttatacactc caagaagggcgtgacgcaatggaggagagactggggatcatcgctgtctcggcagaggac ttgctggaaaaactgaacctctttatcgctggacatgcaagtgcgatgtacatgtcaggc agagcagacaaagggctcgtaaagacattgagatcagatgatgaaatacagaaaatactc aataacagctgggaaccacaaatatatgaaagacttcttgaattatggataaaaggcatg gaaatagattggagtaaactgtatggcggcaaacagccgaaacgcattagtctcccaacc tatccatttgcaaaagaacgctactggataacggatatgaaagagggagcagtcacacat catgcagcaactagtgtcgaaacagcagctttgcacccattagtacagtccaacacatcc gatttatcagagcagcgtttcagctcgatctttacaggtgctgagttctttttcaccgat cataaggtgaagggaagccgggtcatgccgggtgtagcatatcttgagatggttcatgct gccgttacgagatcagtgagaggaatcaaagagacacaaactgttgttcacatcaaaaat gttgtgtgggtgcagccaatagtggcggatggccagcctgttcaagtcgatatcagtctg gatccccagcaggacggtgaaattgcttttaacatctttacagaggatgcgcacaatggg cggaaaatacactgtcagggcagtgctgcaatcaacgaggcgggagacattccagttcag gatatcagtgtgcttcaagatcaatgctgcctaagcacactctcacacgaccaatgttat gaattatttaaggcgatcggcattgactacggacctggttttcaaggaatagatcggctt tatatcggccgcaatcaggccttggcagaactttcactgcctcctggtgtatcccacacg ctggacgaattcgttctccatccaagtatggcagactctgcgttacaagcgtcgatcggg ctgaagctgaattcaggtgacgagcagctttccctgccttttgcgctgcaagagcttgaa atatgtagtccgtgtacagacaaaatgtgggtgtctatcacatctcgtccacatgaggac agaatacagagactggatattgatctgtgtgatgatcaaggtcgagtgtgtgtacgaatc aagggtatttcctcaagggtgctggaagaagacatacagccgcaagatgagccgacatca ccagatatcaaggcatctcttgatgaatcgcttcttatggcgccggtatgggatcaagtg aaacaggagaagaacatcattcctcctgcagatgagcgtattgtcatcctcggaggggat gacaacagcagaaaagctgttcaaagacagttcccgtttgccaaagagctgcacattgaa ccgaacgcatcgaattatgagattgcaaaccagcttgaagcactcggaccgtttgaccat attgtgcggctgtctccttctcgtgtgacagaaggggaagtcggcgatgacatgattgaa gcccaagatcaaggcgtgattcaaatgttcaggctcattaaggcaatgctctctttaggc tatggtgaaaaagccataagctggacggtcgtgacggcgaacacgcaatgtgttgatcag gatgatgttgtcgacccgtctgatgccgctgtgcacggcctgatcggttcgatggcaaaa gaatatccaaattggcagacaaagctaatcgatgtcaagaatcatgaggacttgccggtg tctgagatcttttccctgcctgctgatcaagaagggaatacttgggcctatcgaaatcag ctctggtataaactgcgcttgattccagtgcacaacaatcaaccagtgcacacgaagtat aagcacggaggcgtttatgtcgtcataggcggcgcaggcggtattggcgaagcttggagt gaatatataatcagaacataccaggcgcaggtcgtttggattggcagaagaaagatggat gctgctattcaaagtaagctggacagacttgcacgtctagggccagccccgttttacatt caagctgatgcggctaaccgcgaggaattagaacgcgcttatgaaacaatgaaacaaaag catcgagaaatcaacggcatcattcattctgccattgtcttgcaagaccgaagcttgatg aatatggatgaaaaatgtttcagaaacgttctttctgcaaaagttgatgtaagtgtgcga atggctcaagttttccggcatgaaccacttgactttgttttgtttttctcttctgtacaa tcttttgcgagagcttccggacaaagcaattacgctgccggctgcagttttaaggatgct tttgcacatcggctttctcgagtatggtcttgtacagtggccgtgatgaattggagttat tggggaagcatcggtgttgtttcctcaccggaatatcagaagagaatggctcaggcaggc attggctctattgaagcccctgaagcgatggaggcattggaattgctgctcgggggaccg ctgaagcagctagtgatgatgaaaatggcaaacgaaacgagtgatgatgaagcggaacag atagaagaaacaattgaagtttacccggaaactcacagttccgccattcaaaagctgcga agctatcactcgggtgacagcacaaagattcaacaactgttatag

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