KEGG   Bos taurus (cow): 100337091
Entry
100337091         CDS       T01008                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
bta00562  Inositol phosphate metabolism
bta01100  Metabolic pathways
bta01521  EGFR tyrosine kinase inhibitor resistance
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04020  Calcium signaling pathway
bta04062  Chemokine signaling pathway
bta04064  NF-kappa B signaling pathway
bta04066  HIF-1 signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04072  Phospholipase D signaling pathway
bta04360  Axon guidance
bta04370  VEGF signaling pathway
bta04380  Osteoclast differentiation
bta04611  Platelet activation
bta04613  Neutrophil extracellular trap formation
bta04625  C-type lectin receptor signaling pathway
bta04650  Natural killer cell mediated cytotoxicity
bta04662  B cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04670  Leukocyte transendothelial migration
bta04722  Neurotrophin signaling pathway
bta04750  Inflammatory mediator regulation of TRP channels
bta04919  Thyroid hormone signaling pathway
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05169  Epstein-Barr virus infection
bta05170  Human immunodeficiency virus 1 infection
bta05171  Coronavirus disease - COVID-19
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05214  Glioma
bta05223  Non-small cell lung cancer
bta05225  Hepatocellular carcinoma
Module
bta_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100337091 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100337091 (PLCG2)
   04064 NF-kappa B signaling pathway
    100337091 (PLCG2)
   04066 HIF-1 signaling pathway
    100337091 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100337091 (PLCG2)
   04072 Phospholipase D signaling pathway
    100337091 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100337091 (PLCG2)
   04613 Neutrophil extracellular trap formation
    100337091 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100337091 (PLCG2)
   04662 B cell receptor signaling pathway
    100337091 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100337091 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100337091 (PLCG2)
   04670 Leukocyte transendothelial migration
    100337091 (PLCG2)
   04062 Chemokine signaling pathway
    100337091 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    100337091 (PLCG2)
   04919 Thyroid hormone signaling pathway
    100337091 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100337091 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100337091 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    100337091 (PLCG2)
   04380 Osteoclast differentiation
    100337091 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100337091 (PLCG2)
   05206 MicroRNAs in cancer
    100337091 (PLCG2)
   05205 Proteoglycans in cancer
    100337091 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100337091 (PLCG2)
   05214 Glioma
    100337091 (PLCG2)
   05223 Non-small cell lung cancer
    100337091 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100337091 (PLCG2)
   05171 Coronavirus disease - COVID-19
    100337091 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100337091 (PLCG2)
   05169 Epstein-Barr virus infection
    100337091 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100337091 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100337091 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    100337091 (PLCG2)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100337091 (PLCG2)
Membrane trafficking [BR:bta04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100337091 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100337091 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like
Other DBs
NCBI-GeneID: 100337091
NCBI-ProteinID: XP_059733647
Ensembl: ENSBTAG00000002103
VGNC: 32989
LinkDB
Position
18:8310872..8467944
AA seq 1372 aa
MNCQFTGITGQRIECMCAWAALGPPRGRGWGGPGRRGRPRRSHVARGRGRRRSSSARVGG
RARQGVPGAWTAGGYARDPEPGPAAEARPASLFTRFLLASPTGQQTTASTMANVDTLPEY
EKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEI
RPGKSSKDFERAKAVRQKEECCFTVLYGSQFILSTLSLAADSKEDAAKWLSGLKILHQEV
MSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSAKFLKDKFLEIGAH
KDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFLLGNTDRPDASAVHLHDFQRFLLHE
QQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDVVDMQD
MNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDCWDGPDGKPIIYHG
WTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARVFKEVFGDLLLTKP
KEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELHMWDPIDQKWTR
HYCAVADAKLSFSDDIEQTVEEELPLDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCAE
TGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNLMFTSIYAL
IQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRIPRDGAFLIRK
REGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMKLRY
PVTPELLERYNTERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYRAKQSDELSFCRG
ALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISPTEGEEVDKQIIEDNPLGSLCRGIL
NLNIYNVVKAPHGKNQKPFVFILEPKKQGDPPVEFATDSVEELFEWFQSIREITWKMDAK
ENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIVRQKPSD
LLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGR
TGYVLQPESMRAEKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRSIACPFVEVEICGAE
YDSNKFKTTVVNDNGLSPVWTPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATY
PIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQ
LFLYDTHQNLRSATRDALVREFNVNENQLQLYQEKCNRRLREKRVSNSKFYS
NT seq 4119 nt   +upstreamnt  +downstreamnt
atgaactgccaattcacggggattacagggcagcgtattgaatgcatgtgtgcatgggcg
gcgctgggcccgcctcggggccgggggtggggcgggccggggcgcagggggcggccccgg
aggagtcacgtggcgcgcggccgcggccgaaggagaagtagcagcgcccgcgtcggaggg
cgtgcgcggcagggagtgcccggagcctggacagcgggtggctacgcgcgggacccggag
cccggacccgcggcggaggcgcggccagcctccttgttcacccgcttcctcctcgcctcc
cccactgggcagcagacgacggcgagcaccatggccaacgtggacaccctcccggagtat
gagaagagtcagatcaagcgggccctggagctgggcaccgtcatgaccgtgttcagcttc
cgcaagtccaccccggagcggaggaccgtccaggtgatcatggagacgcggcaggtggcc
tggagcaagacggccgacaagatcgagggcttcctggacatcatggagataaaggagatc
cggccggggaagagctccaaggatttcgagcgcgcgaaagcggtccgccagaaggaagaa
tgctgcttcaccgtcctgtatggctcccagtttatcctcagcacgctcagcctggcagcc
gactcgaaggaggatgccgctaagtggctgtctggcctgaagatcttacaccaggaagtg
atgagcgcgtccacccccaccatcatcgagagctggctgagaaagcagatttattctgtg
gatcaaaccaggagaaacagcatcagcctccgggaattgaagaccatcttgcccctggtc
aacttcaaagtgagcagtgccaagttcctcaaagataagttcctggaaataggcgcacac
aaagatgaactcagctttgaacagttccatctcttctataaaaaacttatgtttgaacag
caaaaatcgatccttgacgaattcaaaaaggattcttccgtgttcctcttgggcaacacc
gaccggccagacgcctctgctgtccacctgcacgactttcagcggtttctcttgcatgaa
cagcaggagctttgggctcaggatctgaacaaagtccgtgagcggatgacaaagtttatt
gacgacaccatgagggaaactgctgaacccttcctgtttgtggatgagttcctcacgtac
ctgttttcccgggagaacagcatctgggacgagaagtacgacgtggtggacatgcaggac
atgaacaaccccttgtctcattactggatctcctcgtcgcacaacacgtacctcacgggg
gaccagctgcggagtgagtcgtccacggaggcctacatccgctgcctgcggatgggctgc
cgctgcatcgagctggactgctgggacgggcccgatggcaagcccatcatctaccacggc
tggacgcggaccaccaagatcaagttcgacgacgttgtgcaggccatcaaagaccacgcc
tttgtcacctccagcttccccgtgatcctgtccatcgaggagcactgctgtgtggagcag
cagcgccacatggccagggtgttcaaggaagtgtttggagacctgctgctgaccaaaccc
aaggaggccagtgccgaccagctgccgtcgcccagccagctgcgcgggaagatcatcatc
aagcataagaagctgggcccccgcggtgacgtggacgtcaacatggaggacaagaaggac
gagcacaagcagcagggcgaactgcacatgtgggaccccatcgaccagaaatggactcgg
cactactgtgctgttgctgatgccaagctgtccttcagcgatgacattgaacagactgtg
gaagaggagctgcccctggatatacccccaacagagctgcattttggggagaagtggttc
cacaagaaggtggagaagaggacaagtgccgagaagctgctacaggaatactgcgccgag
acagggggcaaggatgggaccttcttggtgcgggagagtgagaccttccccaacgactac
accttgtccttctggcggtcgggccgcgtgcagcactgccggatccgctccaccatggag
ggtgggaccatgaagtactacctgaccgacaacctcatgttcaccagcatctacgccctc
atccagcactaccgagagacacacctgcgctgtgccgagttcgagctccggctgaccgac
cccgtgcccaaccccaacccgcacgagtccaagccgtggtactacgatgggctgagccgt
ggagaagcggaggacatgctgatgcggatcccccgggacggggccttcctgattcggaag
cgggaaggtaccgactcctacgccatcaccttcagggccaggggcaaggtgaagcactgt
cgcatcaaccgagacggccggcacttcgtgctgggcacctccgcctacttcgagagcctc
gtggagctggtcagttactacgagaagcacgcgctctaccggaagatgaagctgcgctac
cccgtgacccccgagctcctggagcgctacaacacggaaagagatataaactccctctac
gatgtcagcaggatgtatgtggatcccagtgaaatcaatccttcaatgcctcagagaacc
gtgaaagctctgtatgactacagggccaagcagagtgacgagctgagcttttgccgcggt
gccctcatccacaacgtctccaaggagcctgggggctggtggaaaggagactatgggacc
agaatccagcagtacttcccgtccaattacgtcgaggacatttcaccaacagaaggggag
gaggtggataagcagattattgaagacaatcccttagggtccctttgcagaggaatcctg
aatctcaacatctataatgttgtaaaagccccacatgggaagaaccagaagcctttcgtc
tttatcttggagcccaagaagcagggcgaccctccggtagagtttgccacggacagcgtg
gaggagctgtttgagtggttccagagcatccgggagatcacctggaagatggacgccaag
gagaacaacatgaagtactgggagaagaaccagtccatcgccatcgagctctcggacctg
gtcgtctactgcaagccaaccagcaagaccaaggacaacctcgaaaaccctgacttccga
gaaatccgctccttcgtggagacgaaggctgacagtatcgtcagacagaagcccagcgat
ctcctgaaatacaatcaaaagggcctgacccgtgtgtaccccaaaggacagcgggtggac
tcgtccaactatgaccccttccgcctctggctgtgcggctcccagatggtggcactcaat
ttccagactccagataagtacatgcagatgaaccacgccctgttctccctcaacgggcgg
acgggctacgtcctgcagcctgagagcatgagggcggagaagtacgaccccatgccaccc
gagtcccagaggaagatccagatgaccctgacggtcaaggtgctgggggcccgtcacctc
cccaagcccggccgcagcatcgcgtgccccttcgtggaggtggagatatgcggagcggag
tacgacagcaacaagtttaagacgacggttgtgaatgacaatggcctcagccctgtttgg
accccaacgcaggagaaggtgacgtttgagatttatgaccccaaccttgcatttctgcgc
tttgtggtttatgaggaagatatgttcagcgatcccaactttctggcccatgccacgtac
cccattaaaggaatcaagtcaggatttagatctgttcctctgaagaacggctacagtgaa
gacattgagctggcgtccctcctggttttctgtgagatgcggccagtcctggagagcgaa
gaggagctgtattcctcctgccgccagctgcggaggcggcaagaagaactgaacaaccag
ctctttctgtacgacacccaccagaacctgcgcagcgccacccgcgatgccctggtcaga
gaattcaacgtcaacgagaaccagctgcagctgtaccaggagaagtgcaaccgcaggtta
agagagaagagagtcagcaacagcaagttttactcatag

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