Bos taurus (cow): 107131177 Help Entry 107131177         CDS       T01008                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X12   KO K19326   nesprin-1 Organism bta  Bos taurus (cow) Pathway bta04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:bta00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     107131177 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:bta03036]     107131177 (SYNE1) Chromosome and associated proteins [BR:bta03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     107131177 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH PBP_N Motif Other DBs NCBI-GeneID:  107131177 NCBI-ProteinID:  XP_024852834 Ensembl:  ENSBTAG00000009362 VGNC:  57362 LinkDB All DBs Position 9:complement(89115400..89618705) Genome browser AA seq 8834 aa AA seqDB search MAASRAASRAPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS IVLGLMWTIILYFQIEELTSNLPQLQALSSSTSSVDSMVSSETASPPSKRKVATKIQGNA KKALLNWVQYIVTKQSGIEVKDFGRSWRSGVAFHSVIHAIRPELVDLEKVKGRPNRENLE EAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKQYPDIHSTGSDGQENDEILP SFPSFTNSIQILKREDRLILKEMKVWIEQFERDLTRAQMTDSSLQDKYQSFKHFRVQYEM KRKQIEHLLQPLHRDGKLSLDQALVKQAWDRVSSRLFDWHMQLDKSLPAPLGTIGAWLYR AEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGGRDSVELLL QNYISFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE VRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHWIQQHTAM NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADELDRMKKEYNDCVTIL SDFATEAHRKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKMITKTAHLITKEISQE EANEMFATMSGLKEQLTKVKDCYSPLLSESQQLLVPLEELEKQMTAFYDSLGKIDEIMTV LEHEAQSSPLFKQKHQELLACQESCKKAMTQIEKGSQSVQKFVTLSNVLKHFDQTKLQRK IADTHVAFQNMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRVAQEGLEEKGDPEDLL KRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQRGLQEAVRKLHKQWKDLQAEAPYHLL HLKIEVEKNRFLASVEECRAELDRETKLVPQEGSEKIIKEHRIFFSDKGPHHLCEKRLQL IEELCLKLPVRDAVRNTPETCHVTLKELRAAIDRTYVKLVGDPDKWKDYTSRISEFSSWI SAKETQLKGIKNETIDTANQGEVKCALEEIRSGITKKGETLSWLKSRLKILIEVSSEDEA QKQGDELAKLSSSFKALGTLLSEVEKMLSNFGDCVQYKEIVKSSLEELITGSKEVQEEAE KILDTENLFEAQQLLLHHQQKTKRINAKKKDVQQQITQAQKGEGGLPGRVQEELQKLEST LDSVEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE QTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDTLEEDIKT MEMVKNKWDHFGTNFETLSVWITEKEKELNALETSSSAMDTQINQIKVMIKEIESEISSI TGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQSLQGIILGHLSQQQKFEEN LKKIQQSVSEFEDKLADPVKICSSATETYKVLQEHMDLCQALESLTSTVAALSASARKVS NRDASIQEAATVQRSFEGLLGRAKERQTELEKLLARWQRLEKELSTFLTWLERCEAIASS PEADISADRVKVESELQSIQVLQNEVVSQASIYSNLLQLKESLFSVASKDDVKMMKLQLD QLDERWRDLPQIISKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ AALTRHKDHAAEVESKKGELQSLQGHLAKLGALGRAEDLHLLQGKAEDCLQLFEEASQVV ERRQHALSQLAEFLQSHASLSESLHQLRQTVESTHSMNKKQSDLLERDLNDAIRNVKTLE SAAISLDGLLTKAQYHLKSGGSEQRTSCRATSDHLSVELERIQNLLGTKQSEADALAVLK KAFRDQKEELLKSIEDIEERTDKERLKDLTRQALQQRLRVFNQLEDELNSHEHELCWLKD KAKQIAQKDVAFAPEVDKEINRLEVTWNDTKKLIHENQGQCCGLIDLMREYQNLKSAITK VLENASNVIATRTTVKDQEDLKWALSKHEAAKNEMCNKQKDLDNFTSKGKQLLSELKKIH SGDFIVVKTDMESTVDKWLDISEKIEENMDRLRVSLSIWDDILTSKDEIDGWSNHSVPQL TESISNLNDSLRAEEFLKEFESEVKKKALRLEELHSKVNDLKELTKNPETPPDLQFIEAD LRQKLEHAKEITEEAKGTLKEFTAQSAQVEKFINDTATWLTKLEESLMNCAQTETCEGLK KVKDIQKELQSQQSNISMTQENLNSLCRKYHSVELGSLGSAMTGLIKRHEAVSQSCSKTQ ASLQDSLEKHFNESMQLFQEWFSGIKAAAKESSDRTGDSKVLEAKLRDLQNILDSVSDGQ SKLDAVTREGQTLYAHLSKQIVSSIQEQVTKANEEFQAFLKQCLKDRQALQDCALELGSF EDQHRKLNLWIHEMEERLSTENLGESKQHIPEKKNEVHKIEMFLGELLVARESLDKLSQR GQLLSEEGHGAGKESRLCSQLLTSYQNLLRMTKEKLRSCQVALQEHEALEEALQSMWSWV KDMQDRLASAESTVGSKDALERRLLQVQEILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ KVIQTQLQTLKDVWANIVDSSIHAQSTLESVISQWNDYLEWKNQLEQWMESVDQKVEHPL QPQPGLKEKFSLLDHFQSVVSEAEDHAGALQRLTAKARELYQKTEDEALTDTAQEELKTQ FNDILTVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDSPATQKKL SKIKELMDSREIGASRLSRVESLAPAVKRNTTASGCELLDTEMQALRADWKQWEDSVFQT QTSLENLVSQMALSEQEFSGQVAQLEQALEQFSALLTSWTQQLALLEGKNTDKELVECWQ KGREILDALQKAEPQTENLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN KEQILQQRFLRAFKDFQQWLVNAKITTAKCFDIPQNINEVSTSLQKIQEFFSESENGQHK LNTMLSKGELLCTLLTKEKASGIQAKIATAKEDWKNFHSNLHQKESALENLKIQMKDFEV SAEPVQDWLSKTEKMVHESTNRLYDLPAKRREQQKLQSVLEEINCYEPQLRRLKEKAQQL WEGQAASRSFMHRVSQLSSQYLALSNVTKEKVSRLDRIVAEHNQFSLGIKDLQDWMMDTV HMLDSYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPAIQ QQLASVKDMWASLLSAAIRCKSQLEGALSKWTSYQDDVRQFCSWMDGVEASLNASERQHA ELREKTAALGKAKLLNEEVLSHGSLLETIEVKGAGMTEHYVTQLEFQDLQERYGAIRERT KEAVTKSEKLVRLHQEYQRDLKAFEAWLEKEQDKLDQYSVLEGDAHTHETALRDLQELQV RCAEGQALLNSALHTREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQFNNVVNKL RLVEQKFQQVDEWLKTMEEKVSLRTARQSSRAAKEMQLHQMKKWHEEITAYRDEVEEVGA RAQEILDESHVSSRMGCQATQLTSKYQALLLQVLEQIKFLEEEIQSLEESELSLSSYSDW YSSTHKNFKNVAAKIDKVDKAMMGKKMKMLEGLLKDMEKGQSLLKSAREKGERALKYLED AEAETLRKEIHDHVERLKELTSTVRKEHMTLEKGLHLTKEFSDKYKALTQWIAEYRDILH GPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ SDYQDLCSAAKEHVCSLEAKVRDHEDYNSELQEVEKWLLQMSGRLVAPDLMETSSLETIT QQLARHKAMMEEIAGFEDRLNDLKTKGDNLISQCADHLQAKLKQNVHAHLQGTKDSYSAI CSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLKPGANPPLSRAEAVKQVKHFR ALQEQARTYLDLLCSMCDLSNSSVKTTAKDIQQTEQMIEQRLAQAQNLTQGWEEIKHMKA ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVNTITEKVDELT KKQESPEHKEISHLNDQWLDLCLQSNNLCLQREEDLQRTRDYHDRMNVVEGFLEKFTTEW DNLARSDAESTAVHLEALKKLALALQERKKAIEDLKEQKQKMIEHLNLDDKELVKEQTSH LEQRWFQLEDLVKRKIQVSITNLEELSVVRSRFQELMEWAEEQQPNIAEALKQSPPPDMA QNLLMDHLAICSELEAKQMLLKSLTKDADRVMADLGLKERQIIQKALSDAQRHVSSLSDL VGQRRKYFNKALSEKTQFLMAVFQATSQIQQHEHKIMFREHICLLPDDVSKQVKTCKSAQ ASLKTYQNEVTGLWAQGRELMKGVTEQEKSEILGKLQELQSVYDTVLQKCSHRLQELEKN LVSRKHFKEDFDKACHWLKQADIITFPEINLMNETAELHTQLAKYKHILEQSPEYENLLL SLQRTGQAILPTLNEVDHSYLDEKLHALPLQFNVIVDLAKDKFYKVQEAMLARKEYASLI ELTSQSLRDLEDQFSRMSQIPGHLSVEEAMSLQDGWRALGGEVAGLTKAVDELNQKKESF RSTGQPWQPDKMPQLITLYHRLKRQTEQRVSFLEDTTSVYQEHEKMCLQLEKQLEAVRME QSKVNEETLPAEEKLKVYHSLAGSLQNSGILLKRVTRHLEDLISHLDPAAYEKAKHQLQA WQEELKLLTSAIGATVTECESRMVQSRDLQTELSRSLEWLRSVEAALSGPLCLDPNLRDI QEEIRKVQIHQEEVQSSLRIMNALSNKEKEKFTRAKELISADLQCTLAELSELDGALQEA LRTRQTTLTQIYSQCQRFYQVFQAANDWLEDAHEMLQLTGNGLDVESAEESLKSHMEFFS AEDQFHSNLEELQGLVANLDPLIKPTGKEDLAQKMASLEEKSQTIMQDSHAQLELLQRCA AQWQDYQKAREEVIELMNEAEKKLSEFSLLKTSSSHEAEEKWSEHKALVSVINSFHEKIV ALEGKASELERTGNDASKAAISRSTTAVWQRWTRLRAVAQDQEKLLEDAVDEWTSFNNKV KKASEVIDQLQDKLPGSSAEKASKAELVTLLEYHDTFILELERQQLALGMLRQQALSMLQ DGVTPSPGGEPPTVQEITAMQDRCLNMQEKVKKNGKIVKQELKEREVVETRISSVKSWVQ ETKEYLGNPTIEIDAQLEELKILLTEAINHQQNVEKMAEEQKNKYLGLYTILPSELSLQL AEVALDLGTTHDQIQDKVKEVEQSKAMSQEFSQQIQKIARDLTTILTKLRAKTDNLVQAK TDQKVLGEELDGCHLKLMELDKAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIRQAENQL SKLNQAASHLEEYNEILELILRWIEKTKILVHGKIAWNSASQLREQYISHQTMLEESEDI HNDLEAMTEKLQYLDSVYHTETMSQQVADLGRETEELRQVIKIRLQSLHDAAKDMKKFEA ELRNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQVRQSALRIP EDVVASLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQELIEGAHR EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT EVEGLAEGTEDLDGELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPAC RSPSPVANTDASVNQDIAYYQALSPERLQTDAAKVPPSTLPPQELYEPGLEPSATAKLDD LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEQGRSPESQ MAEHQSFPQALMDEILMLQEEISELQSALADELVSESPESEPAEQLALQSTLTVLAERMS TIKMKASGKRQLLEEKLNDQLEEQRQEQALNRYRCEADQLDHWLLSTKATLDIALGSPKE PMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAVKLRTLKGS LLELQRALQDRQLHIQQGTAQEKEESDADLAATQSPGVQEWLAQARSAWTHQRQSSLQQQ KELEQELAEQKSLLQSVASLGEEILTQHSAAETSGGVGEKPDVLSQELGMEGEKSPAEDQ MRMKWESLHQEFSTKQKLLQNVLEQEQEQMLYSRPNRLLSGVPLYKGDGQAQDKSAVTSL LDGLNQVFEEVSSQGGGTKKQNIDLEQKLYDGVSATSTWLDDVEERLFVATALLPEETET CIFNQETLAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQ RCHQMKERLQQILNFQNDLKVLVTSLADHKYIILQKLAKMFEQPVAEQIEVFTAAAFSAI QQAEDGLKELDAGIIELKRRADKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLA LKSQYERALQDLADLLETGREKTAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET LFRKIISFAVPRETQFHTDLMAQASAVLKGAHKRGVELEYILETWSQLEKEHWELSRQLE VVESSTPSVGLVEESEDRLIDRIALYQHLKSSLNEYQPKLYQVIDDGKRLLISVSCSDLE SQLNQLGEHWLSDTNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV TVPQELEMVRDHLNGFLEFSKEVDAKSTLKSSVLSTGNQLLRLKKVDTAALRSELSHIDG QWNDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMTWISLMESVIQKDEENIKNSIGYKTI HEYLQKYKGFQIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAERLGAMNKSWQIL QGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAMKDCQD LEDLIKAKEKEVEKIEQNGLALVQNKKEEVSGIVRSTLQELNQTWANLDHMVGQLKILLK SVLDQWSHHKVAFDEINSCLMESRYSLSRFCLLTGSLEAVQVQVDNLQNLQDDLEKQEKS LQKFGSVTNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLRASKALLQLWQRYKD YFKQCAATVQQQEGRTNEFLKAATDKDIGDDEVATWIQDCNDLLKGLGPIQDSLVVLHEL GGQLKQQVDASAASAIQSDWLSLRQQLHALEQALCKQQTVLQAGVLDYETFTKSLEALET WIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMVPDLDRLNELGYRLPLNDKE IKRMQNLNRRWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGN YQHLLEQQRAHELFQAEMFSRQQILHSIIFDGQHLLEQGQVDDRDEFNLKLTLLSNQWQG VIRRAQQRRGVIDSQIHQWQRYREMAEKLRKWLVEVSCLPVSGLGTVQIPLQQARALFDQ VQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEATLQAELAEIQEKWKSASVCLEEQKK KLAGLLQDWEKCENGIADSLEKLRTFKKRLSQPLPDHHEELHAEQMCCKELENTVGSWTD DLAQLTLLKKALCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFS EKNKELCEWLTQMESKVSQNGDILIEEMIEKLRKDYQEEIAIAQENKIQLQQMGERLARA SHESKASEIEYKLGKINDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES ELAKPIVYDSCDSEEIQKKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDFSHFEDWLKISERTAAFPS SSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDAAGSLKQTVHKGN QRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKI KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERY HKKLIRLPLPDDEHDLSDRELELDEAGTLSDLHWRDTSTDGVLSPQPSSNPSLSLAQPLR SERSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEGPEDKDFYLRGAVGLSD VVIPENPEAYVKLTESAIRNSSGDPGALESQIQQLGKALDDSRFQMQQTENIIHSKTPTG PELDSGYRGYMKLLGECSGSIDSVKRLEHKLTEEEDHFPGFVNLNSTETQTAGVIDRWEL IQAEALSKELRMKQKPQRRQQLDSDLNSVLTWLRETEGDLEQLQRLQLSTDIQSIALQIQ KLKELQKAVDQRKAIILSIHLCSSEFTQPGREESQDLQDRLSQMNGRWERVCSLLEEWRG LLQDALMQCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLKQIRHELL ESQLKVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMS SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVNSPHSRSIRGG SDSSLSEPRPARSGRAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARS FHPMLRYTNGPPPL NT seq 26505 nt NT seq  +upstreamnt  +downstreamnt atggccgcctccagggcagcctcgcgggcccctcgggacatcgccaacgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaactctcat ctggccaagcggaaacccccaatggtggtagatgatctttttgaagacatgaaagatggt gtgaagctacttgctctgctggaagtcctgtctgggcagaaactgccatgtgaacaaggg cgccggatgaagagaattcatgccgtggcaaacattggcacagcactgaagttccttgaa ggaaggaagattaaattagtcaacattaactccactgatatagctgatggtcgaccctcc attgttctcggattgatgtggaccattatcctgtatttccagatcgaggagttgaccagc aacctgcctcagctgcaggctctgtccagcagcacgtcctccgtggacagcatggtcagc tctgagaccgccagccccccgagcaaacggaaggtggccaccaagatccaaggaaacgct aagaaggcgctattgaactgggtccagtacatagtcaccaagcagagtggaatagaagta aaagacttcggccggagttggagaagtggagtggcctttcattctgtcatccacgctatt cggccggagctagtggacctggagaaggtgaaaggaaggcctaaccgagaaaacctggag gaggctttcaccattgctgaaacggagctggggatcccacggctcctggaccctgaagat gttgacgtggataaaccagatgagaagtctattatgacctatgtggcccagtttctgaag cagtatcctgacatccacagtacaggctctgatgggcaagagaatgatgaaatacttcca agtttcccatcttttacaaattctatccaaattcttaagagagaagacaggctaattttg aaggagatgaaagtttggatagaacaatttgaaagagatttgacaagggcacagatgaca gactcaagtttgcaggataaatatcagtcatttaagcatttcagagttcaatatgaaatg aagaggaaacagattgaacacttattgcaaccgttacatagagatggtaaattgtcactt gaccaagcattggtaaaacaggcctgggatagagtgtcctccaggctcttcgattggcat atgcaacttgacaagtctcttcctgcacctctgggtaccataggggcctggttatacaga gcagaggtggccctaagagaggaaataaccattcagcaggttcatgaggaaacagccaac acaatacaacggaaacgtgagcaacacaaggatctgcttcaaaacacagatgcccacaaa agagcattccatgaaatctaccggaccaggtctgtgaacgggatcccagtgccgcctgat caattagaggacatggccgagaggtttcattttgtttcctccacatcagagctacactta atgaaaatggaatttctagaattaaagtaccgtctgctctcactgctggttcttgcagag tcaaagctgaagtcttggatcatcaagtatggggggagagattcagtggagctacttctg caaaactacatctcttttatagaaaatagcaagttctttgaacaatatgaagtgacatac cagatcttgaaacagacagcagagatgtatgtcaaagctgatggttcagtggaagaagct gagaatgtgatgaaattcatgaatgaaaccactgcccagtggaggaacctctccgtggaa gtcaggagtgtgcgaagcatgctagaggaagtcatcgccaactgggaccgatatggcaat accgtggctagtcttcaggcttggctcgaggatgctgaaaaaatgctaaatcagtcagaa catgccaaaaaggattttttccgaaatttgcctcattggatacagcagcacacggccatg aatgatgctggcaattttttaatcgaaacgtgtgatgagatggtttcccgtgatctcaaa cagcaattactactgctaaatgggcgatggagggagttgtttatggaagtcaagcaatat gctcgagctgatgagttggacagaatgaagaaagaatacaacgattgtgttactatcttg tctgattttgcaactgaagcccataggaaactttcagagcccttagaagtctcttttatg aatgtcaagttattaattcaagacttggaggatattgaacagagggtgcctgtgatggat gctcagtataagatgataacaaagacagcgcacctcattaccaaagagatctctcaagaa gaagctaatgaaatgtttgcaaccatgtctgggctcaaagaacaactaaccaaggtcaaa gactgttactccccactcctttctgagtctcagcagctgttggtaccgttggaggaatta gaaaagcagatgacggccttttatgactcacttgggaaaatcgatgaaattatgacagtt cttgaacatgaggcacagtctagtcctctttttaaacagaaacatcaggaactgttggct tgtcaagaaagctgtaagaaagccatgactcaaattgagaaaggcagtcagagtgttcag aagtttgtgaccttgagcaacgtgttaaagcattttgaccagacgaagctacagagaaag attgcagatacgcatgttgcttttcagaatatggtaaagaaaactggagattggaagaaa catgtggaaaccaacagccgcttgatgaagaagtttgaggagtctcgagctgagttggag aaggtgctcagggtcgctcaggagggcctggaggaaaagggggacccggaagacctgctg aagagacacaccgagtttttcagtcagctggaccagagggtgctcaatgctttcctgaaa gcgtgtgatgagctcactgacattctgcctgagcaggagcagcggggcctgcaggaagcc gtcagaaagctccacaaacagtggaaggatcttcaagcagaagctccatatcatttgctt cacctgaagattgaggtggagaagaacaggttcttagcttctgtggaagagtgcagagct gagctggaccgagagaccaagctggtgccccaggaaggcagcgaaaaaatcatcaaagag cacaggatcttcttcagtgacaagggccctcaccatctctgtgagaaaaggttacagctc attgaagaactgtgtctgaaacttccagtccgggatgcagtccggaacacacctgagacc tgtcacgtgaccctcaaggagctcagagctgctattgaccgcacctacgtgaagctggtg ggagacccagacaagtggaaggattacacgagcagaatttctgagttctcctcttggata tctgcaaaggagacccagttaaaggggattaagaatgagaccattgatactgctaatcaa ggagaagttaaatgtgctctggaggagatcagaagtggtattaccaaaaaaggggagact ctcagctggctgaaatccaggcttaaaattctgattgaagtttcttctgaggatgaagcc caaaagcaaggagatgagctggcaaaattatctagttctttcaaggctctcgggactttg ttgtcagaggttgaaaagatgttaagcaactttggagactgtgtccagtacaaagaaata gtcaaaagttccctggaagagttaatcactggctctaaagaagtccaggaagaagccgag aagatcttggacactgaaaatttgtttgaagcacaacaactactccttcatcaccagcaa aagacaaagagaatcaatgcaaagaagaaggacgtgcaacaacagatcacgcaggctcag aagggagaaggtgggctgcctgggcgagtccaagaggagctgcagaagctggagagcacc ctggacagtgtggagcacagtcgggagaaacaggagcgccgcatccaggtcacattaaga aaatgggagagatttgaaacaaacaaagagacagtggtcagatacctttttcaaacaggt tccagccatgagcgcttcttgagttttagcagtttggaaagcttatcttcagaattggaa cagacaaaggagttttctaaacgaacagaaggtattgcagtccaggctgagaatcttgtg aaggaagcttcagagatcccacttgggcccaagaataagcagctgcttcagcagcaggcc aagtcaatcaaggagcaagttaaaaaattagaagacacccttgaagaagatattaaaacc atggaaatggtgaaaaacaagtgggatcattttggcactaactttgagaccctgtccgtc tggataactgagaaagaaaaagaactcaatgccttggagacgtcatcatctgccatggat acacaaatcaaccaaattaaggtcatgattaaggaaatagaaagtgagatcagcagcatt 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gttggacgtctaagtctcaaggagcaactctctcaccgacagcatttgctgtctgagatg gagtcactcaagccaaaagtccacgcagtgcaggtccgtcagagtgcgctccggatcccc gaggacgtggtcgccagcctgccgctctgccacgcggctctgcacctgcaggaggaggcc agccggctccagcacacggccatccagcagtgcaacatcatgcaggaggctgtggtgcaa tatgaacaatatgagcaagaaatgcagcacctccaggaactcatagaaggagctcacaga gagattgaggataagcctgtggccaccagcaacatccaggaactgcaagcccagatttct cggcatgaggagctggctcagaaaatcaagggctaccaagagcagatcgcctctttgaac tccaagtgcaagatgctgaccatgaaagccaagcacgccaccatgctgctgacggtgacc gaggtggaggggctggcggaggggacggaggacttggacggggagctcctccccgcgacc tcggcccacccctctgtggtcatgatgactgcaggtcgctgtcacactttgctgtcacct gtcactgaggagtctggggaggagggaaccaacagtgagatctcctctccgcctgcttgc cgctccccttcacctgtggctaatacagatgcctctgttaaccaggacatcgcttattac caagccttatctcctgagaggttacagactgatgctgccaaggttccccccagcacgctg ccaccccaagagctctatgaaccgggactggagccttccgctactgcgaagctggatgat ctgcagcgctcttgggaaaccttaaagaatgtgatcagcgagaagcagcgcacactctat gaagccttggaacgccagcagaagtaccaggactccctccagtccatctccacgaaaatg gaggccatcgagatgaaactcagtgagagtctggagcagggcaggagtcccgagagccag atggccgaacatcagtctttccctcaggctctgatggatgagatcctcatgctccaagag gagatcagcgagctgcagtcggccctcgcagacgagctggtgtctgagtccccggagtcc gagccggcagagcagctggccctgcagtccacgctcaccgtcttggcggagcgaatgtcc accatcaagatgaaggcatccgggaagcggcagcttctggaggagaaactcaacgatcag ctggaggaacagagacaggaacaagccctgaacaggtatcgctgtgaagctgatcagctg gaccactggctcttgagcacgaaggccactctggacattgccctggggtcacccaaggag cccatggacatggaggcccagttagtggactgccagaatatgctggtggaaatagagcag aaggtggtggccttatcagagctctcggtccacaatgaaaacctgctgctggagggcaag gctcacacaaaggacgaggccgagcagctggcggtgaagctgagaaccctcaaggggagc ctcctggagctgcagagggcgctgcaggacaggcaactccacatccagcaggggacagcc caggagaaggaggagagcgatgctgacctggctgccactcagagccccggggttcaggaa tggctggctcaagctcggagcgcatggacccaccagcgacagagcagcctccagcaacaa aaagagttggaacaggaattggcagagcagaagagcctcctccagtcagtagccagcctt ggagaggaaattctaacgcaacactcagctgcagagacctctggtggtgttggcgaaaaa cctgatgtgttatcccaggagttggggatggaaggggagaaatcacctgctgaagaccag atgagaatgaaatgggaaagcctacatcaagaatttagcaccaagcagaaactacttcag aatgttctggagcaggaacaagagcaaatgctctacagcaggcccaatcggctcctgtct ggcgtgccactgtacaaaggcgacgggcaggcccaggataaatctgcggtgacgtctttg ctggatggattgaaccaggtcttcgaggaggtttcatcccagggtggagggacaaagaag cagaacattgacttggagcagaagttgtatgatggggtctcggccacctctacctggctg gatgatgtagaggaacggttatttgttgccacagcccttttaccagaagagacagaaact tgcatctttaaccaagagactcttgccaaagatattaaggaaatgtctgaagaaatggat aagaacaagaacttgttttcccaagcctttccggagaatggtgataaccgagatgttatt gaagacactttgggttgtctcttgggcaggttatctttgctagactcagtagtaaatcag cgatgtcatcagatgaaggaaagacttcagcagatactaaatttccagaatgatctgaag gtgctagttacatcactggctgaccacaaatacatcattctgcagaagctggcgaaaatg tttgaacaacctgtggcagagcaaatagaggtatttacggctgcagctttttccgcaata cagcaggctgaagatgggctaaaggaattagatgcgggaatcattgaattaaaaaggcgt gctgacaagttgcagattgagcagccttccatgcaagaactctccaaactccaggacatg tatgatgaactcatgatgactattggctcccggcggagcgggctgaaccagaatcttgcc ctcaagagtcagtacgaaagagccttgcaggatctggccgacctactggaaacaggacga gagaagacggcaggagaccagaaaattattgtgtcttccaaagaggaaatccaacaacta cttgataaacataaggaatactttcagggtctggaatctcacatgatcttgaccgaaacc ctcttcagaaagatcatcagctttgcagtcccacgggaaactcagttccacacagacctg atggcgcaggcttccgctgtgctcaaaggggctcacaagaggggtgtggaactggagtac atcctcgagacatggtcccaactggagaaggagcactgggagcttagccggcagctggag gtggtggagagcagcaccccaagcgtgggtttggtggaggagagcgaagacaggcttatc gaccggatcgcactctaccagcatttgaaatccagccttaatgaataccagcccaaatta tatcaggtaatagatgatggaaaacgacttctgatatctgttagctgttcagatctggaa agccagctaaatcaacttggagagcactggttaagtgataccaacaaagtgtctaaggaa cttcacagattggaaacaatattgaaacactggaccagatatcaaagtgaatctgcagat ctaatccactggttacagtctgcaaaagacaggctggaattttggactcaacaatctgtg acagtcccacaagaactggaaatggtccgtgatcacctgaatggctttctggagttttcc aaagaggtggatgccaagtccacgctaaaatcatctgttctgagcactggaaatcagctt cttcgattaaagaaagtggacacagctgccttgcgttctgagctgtcccacattgatggc cagtggaatgacctgctgacaaatattccagccgtacaggaaaagcttcaccagctccaa atggataaactaccttctcgccacgccatttccgaagtcatgacttggatttctcttatg gaaagtgttattcaaaaggatgaagagaatattaaaaattccatcggttacaagacaatt catgagtaccttcagaaatataagggttttcagatcgacattaactgtaagcagctgact gttgattttgtgaatcagtctgtgctacagatcagcagtcaggatgtggaaagtaaacgc agcgacaagactgattttgctgagcgacttggagcaatgaataaaagctggcaaatcctg cagggtctggtcactgagaagattcagttgttggaaggcttattggaatcttggtcagaa tatgaaaataacgtacaatgtctgaaaacgtggtttgaaacccaggaaaagagactgaaa caacaacatcgcattggagaccaggcttcagttcagaacgcaatgaaagactgtcaggat ctggaagacttgattaaagcaaaagagaaagaggtagagaaaattgagcagaatggactt gctttggttcagaacaagaaagaagaagtctctggcattgtcaggagcacgcttcaggag ctcaaccaaacttgggcaaatttagaccacatggttggccaactcaagatcctgttgaaa tccgtgcttgaccagtggagccaccataaagtggcatttgatgagataaacagttgcctc atggagtcccgatactctctttctcgattctgtctactcactggctctttagaagctgtg caagttcaggtggacaatcttcagaatcttcaagatgatctagaaaaacaggaaaagagc ttgcagaaatttggctctgtgaccaaccaacttctaaaagagtgtcacccacctgtgaca gaaactcttactaatacactaaaagaagtcaacatgagatggaataacttgctggaagag attgccgagcagctgcgtgccagcaaggccctacttcagctttggcagagatacaaggac tacttcaaacagtgtgctgctacagttcaacagcaggagggacgaaccaacgagttcttg aaggcagccaccgacaaggacatcggtgatgacgaagttgccacctggatccaagattgc aatgacctcctcaaaggattggggccgattcaggattctcttgtagttcttcatgagctg ggagggcaactcaagcaacaagtggacgcttcggcagcatcagccattcaatccgattgg ctctctttgaggcaacaattacatgctctcgaacaggctctctgcaaacagcagactgtg ttacaggctggcgttcttgactatgaaacctttaccaagagtttagaagctttggagacc tggatagtagaagctgaagaaatattacaagggcaggaccctagccactcctctgacctc tcgaccatccaggaaaggatggaggagctgaagggacagatgctgaaattcagtagcatg gtcccagatttagaccgtctgaatgagcttggatacaggctgcccctgaacgataaagaa atcaaaaggatgcagaatctcaatcggcgctggtctctgatctcctcccagactacggaa agattcagtaagttacagtcatttttgctacaacatcagactttcttggaaaaatgtgaa acatggatggaattcctagttcaaacggaacaaaagttagcagtagagatttcaggcaat tatcagcatcttttggagcagcagagagcacatgagttgtttcaagcagagatgttcagc cgtcagcagattttgcactcaatcatttttgatggacagcaccttctagaacaaggtcaa gttgatgacagggatgagttcaacctgaaattgaccctcctcagtaatcagtggcagggg gtgatccgccgggcccagcagaggcggggcgtcattgacagccagatccaccagtggcag cgatacagggagatggcggaaaagctccgtaaatggctggtggaggtgtcctgtctgccc gtgagtggtctggggactgtccagataccactgcagcaggcaagggccctctttgatcaa gtgcagttcaaagaaaaagtgttcctgcggcaacaaggcagctacatcctcaccgtggag gctggcaagcagcttctgctttcggccgacagcggggctgaggccaccctgcaggccgaa ctcgctgagatccaagagaaatggaagtcagcaagtgtgtgtctggaggagcagaagaaa aaactggccggcttgctgcaggactgggaaaagtgtgagaacggaatagctgattctctg gagaaactacgaactttcaaaaagaggctttcccagcctctcccagatcatcatgaagag ctccatgcggagcagatgtgctgcaaggaattggaaaacacagttgggagctggacagat gacttggcacagctgacactgctgaagaaggctctctgtgcttacatcagtgcagatgat atctccatccttaacgaacgcatggagcttctgcagaggcagtgggaagaactatgccac cagctctccttaaggcgacagcaagtaagtgagaggctgaacgagtgggccgtcttcagt gaaaagaacaaggagctttgcgaatggctgactcagatggaaagcaaggtctctcagaat ggagacattctcattgaagaaatgattgagaagctcaggaaggattatcaagaggaaatt gcaattgcccaagagaacaaaatacagctccagcaaatgggagaacggctggctcgagcc agccatgaaagcaaagcgtctgagattgagtacaagcttggcaagatcaatgaccggtgg cagcaccttctggacctcatggcagccagggtaaagaagctgaaggagactctggttgca gtacaacagctggataagaacatgagcagtctgaggacgtggttagcccacatcgagtca gagctggccaaacccattgtctacgattcctgtgactcagaagaaatacagaaaaagctt aacgagcagcaggagcttcagagagacatcgagaaacacagcacaggagtggcctctgtg ctcaacctgtgcgaggtacttctccatgactgtgatgcctgcgctacagacgccgagtgc gattccatccagcaggctacgcgaaacctggaccgccgatggagaaacatctgtgccatg tccatggaaaggagactcaaaattgaagagacatggcgattgtggcagaagtttctggat gacttttctcattttgaagattggctcaagatctcagaaaggacagctgcctttcccagc tcttccggggtgctctatacagttgccaaggaggaactaaagaaatttgaggctttccag cgacaggtccatgagagcctgacccagctggagctgatcaacaagcagtaccgccgcctg gccagagagaaccgcacggacgcggccggcagcctcaaacagacggttcacaaaggcaac cagagatgggacaacctgcagaagcgcgtcacctccatcctgcgcagactcaagcatttc attggccagcgggaggagttcgagacggcacgggacagcattctggtgtggctaacggag atggatctgcagctcaccaacatcgagcacttctctgagtgtgatgttcaagctaaaata aagcagctcaaggccttccagcaggaaatctcattgaaccacaataagattgaacagata atcgcccaaggagaacagctgatagaaaagagtgagcccttggatgcggccgtcattgag gaagagctggatgagctccgacgttactgtcaggaggtctttggacgcgtggaaagatac cataagaaactgattcgcctgcctctcccagatgatgagcacgacctctctgaccgggag ctggaactggatgaggctggaactctgtcagacctccactggcgggacacctccacggac ggcgtgctctccccgcagccttcctccaacccttccctctcactcgcccaacccctccgg agtgagaggtctggacgagacacccccgccagtgtggactccatccccctggaatgggac catgactatgacctcagccgtgacctggagtccgccgtgtccagaactctgccgtctgag gacgaagagggtccggaagataaagatttctacctcaggggagctgttggcttatcagat gtagtgatccctgaaaatcccgaggcctatgttaaactcacagaaagtgcaatcagaaat tcctctggggaccctggtgccttggagtcacagatccaacagctgggcaaagccttggat gacagccgctttcagatgcagcaaacagagaatatcatccacagcaaaacgcccacagga ccagagctagactccggctacaggggctacatgaaactgctgggtgaatgcagtggcagc atagactcagtgaaaagactggagcacaagctgaccgaggaagaggaccattttcctggc tttgttaacttgaatagcactgaaacccaaacagctggcgtgattgaccgctgggaactc atccaggcagaggccctgagcaaggagctgaggatgaaacagaagccccagaggaggcag cagttggactcagatctgaatagcgttctgacctggcttagggagacggagggcgacctg gaacagcttcagcgcctacagctcagcaccgacatccagtccatcgcgctccaaatccag aagctgaaggagctccagaaagctgtggaccagcgcaaagccatcatcctgtccatccat ctgtgcagctccgagttcactcagcctggccgggaggagagccaggatcttcaggaccgc ttgtcccagatgaacgggcggtgggaacgcgtgtgctccctgctggaggagtggcggggt cttctccaggatgcgctcatgcagtgccaggattttcatgaaatgagtcacggtttgctg cttatgctggagaacatcgacagaaggaaaaatgaaattgtccccattgattctaacctt gatgcagaaatacttcaggaccatcacaaacagcttaagcaaataagacatgagctgttg gaatctcaactcaaagtggcctcactgcaagacatgtcttgccaactgttggtgaatgct gaaggcacagactgtttagaagccaaagaaaaagtccacgtgattggaaatcgactcaaa cttctcttgaaggaggtcagtcgtcatatcaaggagctggagaagttattagacatgtca agcagtcagcaggatctgtcttcctggtcttctgctgacgaactggacacctcaggatct gtgagtcctacctcgggaagaagtaccccaaacagacagaaaacgccacgaggcaaatgt agtctctcacagcctggaccctctgtcaacagtccacatagcaggtccataagaggtggc tccgattcctccctttctgagcctcggccagcccggtccggccgagccttcctgttcaga gtcctccgagcggctcttcctcttcagctcctcctgctgcttctcattgggctggcctgc ctagtccccatgtcggaggaagactacagttgtgccctctccaacaattttgcccgatca ttccaccccatgctcagatacaccaacggccctcctcctctctga

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