Bos taurus (cow): 280877 Help Entry 280877            CDS       T01008                                  Symbol NF1 Name (RefSeq) neurofibromin isoform 1   KO K08052   neurofibromin 1 Organism bta  Bos taurus (cow) Pathway bta01521   EGFR tyrosine kinase inhibitor resistance bta04010   MAPK signaling pathway bta04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     280877 (NF1)    04014 Ras signaling pathway     280877 (NF1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     280877 (NF1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  280877 NCBI-ProteinID:  NP_001116200 Ensembl:  ENSBTAG00000011829 VGNC:  54463 UniProt:  B1PK19 LinkDB All DBs Position 19:complement(18616564..18890185) Genome browser AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSL RKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVS FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIV NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacacataccaaagtcagcactgagcacaacaag gaatgtcttatcaatatttccaaatacaagttttctttggttataagtggcctcaccact atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttgtat ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt cttcatacttgtcgtgaaggaaaccaacatgcagctgaacttcggaattctgcctctggg gtgttattttctcttagctgcaacaacttcaatgcagtctttagtcgaatttctaccagg ttacaggaattgactgtttgttcagaagacaatgtggatgttcatgatatagaactgtta cagtatattaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa tttaaagccctaaagaaagttgcacagttagcagttataaatagcctggaaaaagcattt tggaactgggtagaaaattatccagatgaatttacaaagctgtaccagattccacagact gatatggctgagtgtgctgaaaaactgtttgacttagtggatggttttgctgaaagcacc aaacgtaaagcagcagtttggccactacaaatcattctgcttatcttgtgtccagaaata atccaggatatatctaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg gacagtctgcgaaaagcacttgccggccatggaggaagcaggcagctcactgaaagtgct gcaatcgcctgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagataactct gtcatctttctgctggttcagtccatggtggttgatcttaagaacctgctgtttaatccg agtaagccattctcgaggggcagtcagccggcagatgtggacctaatgatcgactgcctt gtctcttgcttccggataagccctcacaataaccaacacttcaagatctgcctggctcag aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat tctgcattggattggtggcctaagattgatgctgtatattgccactcagttgaacttcga aatatgtttggtgaaacacttcataaagcagtccagggttgtggagcacacccagcaata cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa cctacagacctggagacaagaagctacaagtatcttctcttgtccatggtgaaactaatt catgcagatccgaagctcttgctttgtaatccaagaaaacaggggcctgaaacccaaggc agtactgcagaattaattacagggcttgtccagctggtccctcagtcacacatgccagag attgcccaggaagcgatggaggctctgctggttcttcatcagttagatagcattgatttg tggaatcctgatgctcctgtagaaacattttgggaaattagctcacaaatgcttttttac atttgcaagaaattgactagtcatcaaatgcttagtagcacagaaattctcaaatggttg cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcactttctcttcctttatggagtaggatgtgatgttccttcaagtgggaatacc agtcaaatgtccatggatcatgacgaattactacgcacttgtgctcctggaacctctctc aggaaggggaaaggaaattcatccatggatagtgcagcagggtgcagtggaaccccacca atatgccgacaagcccagaccaaactagaagtggccctgtacatgttcctgtggagcccc gacactgaagcagttctggttgccatgtcctgttttcgtcacctctgtgaggaagcagat atccggtgtggggtggatgaagtgtcagtacacaacttcttgcccaactataacacattc atggaatttgcttctgttagcaatatgatgtcaacaggaagagcagcacttcagaaaaga gtgatggcgctactacggcgaattgagcatcccactgcaggaaacactgaggcttgggaa gatacgcatgcaaagtgggaacaagctacaaaactaatcctcaactacccaaaagccaaa atggaagatggccaggctgctgaaagccttcacaagaccattgttaagaggcgaatgtct catgtgagtggaggaggatccatagatttatctgacacggactcactacaagaatggatc aacatgactggcttcctttgtgcccttgggggagtgtgcctgcagcagagaagcaattct ggcttagcaacatatagcccacccatgggccctgtcagtgaacgcaagggttccatgatt tcagtgatgtcttcagagggaaatgcagatacacctgtcagcaaatttatggatcggctg ctgtccttaatggtctgtaaccatgagaaagtgggacttcaaatacggaccaatgttaag gatctggtgggtctagaattgagtcctgctctttatccaatgctttttaacaaactgaag aataccatcagcaagttttttgactcccaaggacaggttttattgactgacaccaatact cagtttgtggagcaaaccatagctataatgaagaacttactagataatcataccgaaggc agttctgaacatctggggcaagccagcattgaaacaatgatgttaaatctggtcagatat gttcgtgtacttggaaatatggttcatgcaattcaaataaaaacaaaactgtgtcagtta gtcgaggtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaattcagg aataagatggtagaatacttgacagattgggttatgggaacatcaaaccaagcggcagat gacgatgtaaaatgtcttacaagagatttggaccaggcaagcatggaagcagtagtttca ctcctggctggtctgccgctgcagcctgaggaaggagatggtgtggagttgatggaagcc aaatcacagttgtttcttaagtatttcacattgtttatgaaccttttgaacgactgcagt gaagtcgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctg gcatcactgaggcactgcacagtcctggcaatgtcaaacttactcaatgctaacgtggac agcggcctcatgcactccataggcttaggttatcacaaagatctccagacaagagctacg tttatggaagttctgacaaaaatccttcaacaaggcacagagtttgacacacttgcagaa acagtattggcagatcgttttgagagactggtggagttggtcacaatgatgggtgatcaa ggagagctccctatagccatggctctggccaatgtggttccctgttctcagtgggatgaa cttgctcgcgttctagtgactctgtttgactctcggcatttgctctaccaactgctctgg aacatgttttctaaggaagtagaattggcagactctatgcagactcttttccgaggcaac agcttggccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacag aaactcctggatcctttattacgggttgtgatcacctcctctgattggcagcacgtcagc tttgaagtggatcctaccaggttagaacagtcagagagccttgaggaaaaccaacgaaat ctccttcaaatgactgaaaagttcttccatgccatcatcagttcgtcctccgaatttccc cctcaactacgaagtgtgtgccactgtttgtaccaggcaacttgccactccctactgaat aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct cagaacagcatcggtgcagtaggaagtgccatgtttctcagatttatcaatcctgccatt gtctcaccatatgaagcagggattttagataaaaagccaccgcctagaatcgaaaggggc ttgaagttaatgtcgaagatacttcagagtattgccaatcatgtccttttcacaaaagaa gagcatatgcggccttttaatgattttgtgaaaagcaactttgatgcagcacgaaggttt ttccttgatatagcatctgattgtcctacaagtgatgctgtaaatcatagtctttccttc atcagcgatggcaatgtgcttgctttacatcgtctactatggaataatcaagagaaaatt ggccagtatctttccagcaacagggatcacaaagctgttggaagacgaccttttgataag atggcaacacttcttgcatacctgggtcctccagagcacaaacctgtggcagatacacac tggtccagccttaaccttaccagttcgaagtttgaggagtttatgactaggcatcaagta catgaaaaagaagagttcaaggctttgaaaacattaagtattttctaccaagctgggact tccaaagctgggaatcctatattttattatgttgcacggaggttcaaaacaggtcaaatc aatggtgatttgctgatataccacgtcttgctgactttaaagccatactatgcaaagcca tatgagattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttt ctctccaagtggtttgtggtttttcctggctttgcttatgataatgtctctgcagtatat atctataactgtaactcctgggtcagggaatataccaagtatcatgagcggctgctgact ggcctcaaaggcagcaaaagactcattttcatagactgtcctgggaaactggctgagcac attgagcatgaacagcagaaactacccgctgccaccttggctttagaagaggacctgaag gttttccacaacgctctcaagctagctcacaaagacaccaaggtgtctattaaagttggt tctactgctgttcaagtaacctctgcagagcgaacaaaagtcctggggcaatcagtcttt ctaaatgatatctattatgcctcagaaattgaagagatctgcctggtggacgagaaccag ttcaccttaactattgcaaaccagggcacaccgctcaccttcatgcaccaggagtgtgat gccattgttcagtctatcattcacatccggacacgttgggagctgtcgcaaccagactcc attccccagcacaccaagattcggccaaaagacgtccctgggacactactcaatattgca ttacttaatttaggcagttcagaccctagtttacggtcagctgcctataatcttctgtgt gccttaacttgtacctttaatttaaaaattgagggccagttactagagacgtcaggttta tgtatcccagccaacaacaccctctttattgtctctattagtaagaccctggcagccaat gagccacacctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt attgaattgaaacacctttgtttggagtacatgactccatggctatcaaatctagtacgt ttttgtaagcacaacgatgatgccaagcgacagagagttactgcaattcttgataagctg ataacaatgaccataaacgagaaacagatgtatccatctattcaagcaaaaatatggggg agccttgggcagattacagacctccttgatgttgtactagacagtttcatcaaaaccagt gcaacgggtggcttaggatcaataaaggctgaggtgatggcagatactgctgtagctttg gcttctggaaatgtgaaattggtttcaagcaaggttattggaaggatgtgcaaaataatt gacaagacatgcctatctccaactcctactttagagcaacatcttatgtgggatgacatt gccattctggctcgctacatgctaatgctgtccttcaacaattccctggacgtggcagct catctcccctacctcttccacgttgttactttcttagtagcaacagggccactctccctg agagcttccacacatggattggtcattaacatcattcactctctgtgtacttgttcacag cttcattttagtgaagagaccaagcaagttttgagactcagcttgacagagttctcatta ccgaaattttacctgctatttggcattagcaaagtcaagtcagctgctgtcattgccttc cgctccagctaccgggacaggtcattctctcctggctcctatgagagggagacttttgct ttgacatccttggagacagtcacagaggctttgttggagatcatggaggcatgtatgaga gatattccaacatgcaagtggctggaccaatggacagaactagcacaaagatttgcattc cagtataacccgtccctgcaaccgagagctcttgttgtctttggctgtattagcaaacga gtgtctcatgggcagataaagcagattatccgtatcctcagcaaggctcttgagagttgc ttaaaaggacctgatacttacaacagtcaagttctgatagaagctacagtaatagcacta accaaattacaaccacttcttaataaggactcccctctgcacaaagccctcttttgggtt gctgtagccgtgctacagctcgatgaggtcaacttgtattcagcaggcactgcacttctg gaacaaaacctgcacaccttagacagtctcaggatattcaacgacaagagtccagaggaa gtgttcatggcaatccggaaccctctggaatggcactgcaaacaaatggatcattttgtt ggactcaatttcaactctaactttaacttcgcactggttggacacctcttaaaaggatac aggcatccttcacctgccattgttgcaagaacagtcagaattttgcatacactactagct ctggttaataaacacagaaattgtgacaaatttgaggtgaatacacagagcgtggcttac ttggcagctttacttacagtgtctgaggaagttcgaagtcgctgtagcctaaaacataga aagtctctgcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatt catcatggtgaccctagctataggacactaaaggagcatcagccgtggtcatctcccaaa gcttctgaagggtaccttgcagccagctatccacctgcgggccagaccagtccccgagcc aggaaatctatgagcttggacatggggcagccttctcaggccaacacgaagaaattgctt ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa atggaaacccaaaggatttcctcatcacagcagcacccacatttacgcaaagtttcagtg tctgaatcaaatgttcttttagatgaagaagtacttactgatccgaagatccaagcactt cttcttactgttctggctacactggtgaaatacaccacagatgagtttgatcaacgaatt ctttatgaatacttagcagaagccagtgttgttttccccaaagtttttcctgttgtgcac aatttgttggactctaagatcaacaccctgttgtcattgtgccaagatccaaatttgtta aatccgatccatggaattgtgcaaagtgtggtgtaccatgaagaatccccaccacaatac caaacatcttacctgcaaagttttggttttaatggcttatggaggtttgcaggacccttt tcaaagcaaacacaaatcccagactatgctgagctaattgttaagtttcttgatgccttg attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acatctccttatcctcctgcagtgcagagccagcttagtattactgctaaccttaacctt tctaattccatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaat gttgaactctcccccaccactgggcactgtaacagtggacgaactcgccatggatccgca agccaggtgcagaagcagagaagtgctggcagtttcaaacgtaatagcattaagaagatc gtgtga

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