Bos taurus (cow): 281536 Help Entry 281536            CDS       T01008                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 precursor   KO K10160   toll-like receptor 4 Organism bta  Bos taurus (cow) Pathway bta04064   NF-kappa B signaling pathway bta04066   HIF-1 signaling pathway bta04145   Phagosome bta04151   PI3K-Akt signaling pathway bta04217   Necroptosis bta04613   Neutrophil extracellular trap formation bta04620   Toll-like receptor signaling pathway bta04621   NOD-like receptor signaling pathway bta04936   Alcoholic liver disease bta05132   Salmonella infection bta05133   Pertussis bta05134   Legionellosis bta05135   Yersinia infection bta05140   Leishmaniasis bta05142   Chagas disease bta05144   Malaria bta05145   Toxoplasmosis bta05146   Amoebiasis bta05152   Tuberculosis bta05161   Hepatitis B bta05162   Measles bta05164   Influenza A bta05170   Human immunodeficiency virus 1 infection bta05171   Coronavirus disease - COVID-19 bta05205   Proteoglycans in cancer bta05235   PD-L1 expression and PD-1 checkpoint pathway in cancer bta05321   Inflammatory bowel disease bta05323   Rheumatoid arthritis bta05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     281536 (TLR4)    04066 HIF-1 signaling pathway     281536 (TLR4)    04151 PI3K-Akt signaling pathway     281536 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     281536 (TLR4)   09143 Cell growth and death    04217 Necroptosis     281536 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     281536 (TLR4)    04620 Toll-like receptor signaling pathway     281536 (TLR4)    04621 NOD-like receptor signaling pathway     281536 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     281536 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     281536 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     281536 (TLR4)    05161 Hepatitis B     281536 (TLR4)    05171 Coronavirus disease - COVID-19     281536 (TLR4)    05164 Influenza A     281536 (TLR4)    05162 Measles     281536 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     281536 (TLR4)    05135 Yersinia infection     281536 (TLR4)    05133 Pertussis     281536 (TLR4)    05134 Legionellosis     281536 (TLR4)    05152 Tuberculosis     281536 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     281536 (TLR4)    05144 Malaria     281536 (TLR4)    05145 Toxoplasmosis     281536 (TLR4)    05140 Leishmaniasis     281536 (TLR4)    05142 Chagas disease     281536 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     281536 (TLR4)    05321 Inflammatory bowel disease     281536 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     281536 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     281536 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bta04131]     281536 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:bta04054]     281536 (TLR4)    04090 CD molecules [BR:bta04090]     281536 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:bta00536]     281536 (TLR4) Membrane trafficking [BR:bta04131]  Endocytosis   Phagocytosis    Toll-like receptors     281536 (TLR4) Pattern recognition receptors [BR:bta04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    281536 (TLR4) CD molecules [BR:bta04090]  Proteins   281536 (TLR4) Glycosaminoglycan binding proteins [BR:bta00536]  Hyaluronan   Cell surface receptors    281536 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 LRR_14 TIR_2 LRR_9 LRR_Zer-1 LRR_EndoS LRR_NXF1-5 LRR_6 LRR_R13L1-DRL21 ThsB_TIR Motif Other DBs NCBI-GeneID:  281536 NCBI-ProteinID:  NP_776623 BGD-bta:  BT12122 Ensembl:  ENSBTAG00000006240 VGNC:  52834 UniProt:  Q9GL65 LinkDB All DBs Position 8:107057826..107068837 Genome browser AA seq 841 aa AA seqDB search MMARARLAAALIPATAILSCLRTESWDPCVQVVPNISYQCMELNLYKIPDNIPISTKMLD LSFNYLRHLGSHNFSSFPELQVLDLSRCEIKIIEDDTFQGLNHLSTLILTGNPIQSLAWG AFSGLSSLQKLVAVETNLVSLNDFPIGHLKNLKELNVAHNFIHSFKLPEYFSNLPNLEHL DLSNNKIQNIYYEDVKVLHQMPLLNLSLDLSLNPLDFIEPGTFKEIKLNGLTLRSNFNSS HVMKTCIQGLAGLKTNRLVLGEFKNERKLQRFDRSFLEGLCNLTIEQFRIAYLDKFSGDD TDLFNCLANVSVISLLSISLGSLQALLKDFRWQHLEIINCDFDKFPALKLSSLKKFVFTD NKDISTFTEFQLPSLQYLDLKRNHLSFKGCCSHTDFGTTNLKHLDLSFNDVITLGSNFMG LEQLEHLDFQHSTLKQINAFSAFLSLRNLRYLDISYTNIRIVFHGIFTGLVSLQTLKMAG NSFQNNLLPDIFTELTNLTVLDLSKCQLEQVAQTAFHSLSSLQVLNMSHNKLLSLDTFLY EPLHSLRILDCSFNRIMASKEQELQNLPRSLTWLNLTQNAFACVCEHQSFLQWVKDQRQL LVGAEQMMCAEPLDMEDMPVLSFRNATCQLSKTIISVSVVTVLLVSVVGVLVYKFYFHLM LLAGCKKYGRGESXYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKLEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHVFWRRLRKALLAGKPQSPEGTADAETNPQEATTS T NT seq 2526 nt NT seq  +upstreamnt  +downstreamnt atgatggcgcgtgcccgcctggctgcggctctgatcccagccacggccatcctctcctgc ctgagaaccgagagttgggacccttgcgtacaggttgttcctaacattagttaccagtgc atggagctgaatctctacaaaatccccgacaacatccccatatcaaccaagatgctggac ctgagctttaactacctgagacatttaggcagccataacttctccagcttcccagaactg caagtgctggatttatccagatgtgaaattaagattattgaagacgacacatttcagggc ctaaaccacctctccaccttgatactgacgggaaaccctatccagagtttagcctgggga gccttttctgggctatcaagtttacagaagctggtggccgtggagacaaacctagtctct ctaaatgacttccccattggacatctcaaaaacttgaaagagcttaatgtggctcacaat tttatccattccttcaagttacctgaatatttttctaacctgcccaacctggagcacttg gatctttctaacaacaaaatccaaaatatttattatgaagatgtgaaagttctacatcaa atgcccctactcaacctctctttagatttgtccttgaaccctttagactttattgaacca ggtacctttaaagaaattaagctcaatggattgactctgcgaagtaattttaacagttca catgtcatgaaaacctgtattcaaggtctggctggtttaaaaaccaaccggctggttttg ggagaatttaaaaatgaaaggaagttgcaaagatttgacagatctttcctggagggactg tgcaacctgaccattgaacaattccggatagcgtacttggacaaattctcaggggacgat acagacttatttaattgtttggcaaatgtttctgtgatttctctgttgagtatatcttta ggaagtctacaagcccttcttaaagattttagatggcaacacttagaaattattaactgt gactttgacaagtttcctgcattgaagctcagttctctcaaaaagtttgttttcacagac aacaaagatataagcacttttactgagtttcagctaccaagccttcagtatctagatctc aaaagaaatcacttgagtttcaagggttgctgttctcacactgattttgggacaaccaac ctgaagcatttagatctgagcttcaatgatgtcattaccttaggttcaaacttcatgggc ttagagcaactagaacacctggattttcagcattccactctgaaacagatcaatgctttt tcagcattcctatcactcagaaacctccgctaccttgatatttcttataccaacatccgc attgtcttccatggcatctttactggcttagtcagtctgcaaaccttgaaaatggcaggc aactcttttcagaacaacttgctccctgacatcttcacagaactgactaacttaaccgtc ttggacctctctaagtgtcaactggaacaggtagcccagacagcatttcactccctctct agccttcaggtgctgaatatgagtcacaacaaactcttgtcactggatacatttctttat gaaccactccactcgctccggatcctagactgcagyttcaaccgtatcatggcctctaag gagcaagaactacagaatttgccaaggagcctcacttggctaaatcttactcagaatgca tttgcttgtgtttgtgaacatcagagtttcctgcagtgggtcaaggaccagaggcagctc ttggtgggagctgagcaaatgatgtgtgcagagcctttagatatggaggacatgccagtg cttagtttcaggaacgccacttgtcagctgagcaagacgatcatcagtgtgtcggtggtc actgtgctcctggtgtctgtggtaggggtcctagtctacaagttctatttccacctgatg cttcttgctggctgcaaaaagtatggcaggggcgagagcayctatgatgcctttgtcatc tactcgagccaggatgaagactgggtgcggaatgaactggtaaagaacttggaggagggc gtgcccccctttcagctctgccttcactacagggactttattcctggggtggccatcgcc gccaatatcatccaggagggtttccacaaaagccgtaaggttattgtcgtggtgtcccag cacttcatccagagccgatggtgtatcttcgagtatgagattgcccagacctggcagttt ctgagcagccgtgctggcatcatcttcatcgtcctgcagaagctggagaagtctctcctg cggcagcaggtggagctctatcgccttctgagcaggaacacctacctggagtgggaggac agtgtcctggggcggcatgtcttctggagaagactcagaaaagccttgctggctggtaaa ccccagagtccagaaggaacagcagatgcagaaaccaacccgcaagaagcgacaacctcc acctga

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