Bos taurus (cow): 281972
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Entry
281972 CDS
T01008
Symbol
PDE5A
Name
(RefSeq) cGMP-specific 3',5'-cyclic phosphodiesterase
KO
K13762
cGMP-specific 3',5'-cyclic phosphodiesterase [EC:
3.1.4.35
]
Organism
bta
Bos taurus (cow)
Pathway
bta00230
Purine metabolism
bta01100
Metabolic pathways
bta04022
cGMP-PKG signaling pathway
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
281972 (PDE5A)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
281972 (PDE5A)
Enzymes [BR:
bta01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
281972 (PDE5A)
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Motif
Pfam:
PDEase_I
GAF
GAF_2
HD-CE
DUF6970
Motif
Other DBs
NCBI-GeneID:
281972
NCBI-ProteinID:
NP_776842
BGD-bta:
BT10779
Ensembl:
ENSBTAG00000024888
VGNC:
32678
UniProt:
Q28156
Structure
PDB
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Position
6:5745681..5894235
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AA seq
865 aa
AA seq
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MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
NT seq
2598 nt
NT seq
+upstream
nt +downstream
nt
atggagagggccggccccggctccgcgcggccgcaacagcaatgggaccaggactcggtc
gaagcgtggctggacgatcactgggactttaccttctcttactttgttaggaaaggcacc
agagaaatggtcaacgcatggtttgctgagagagttcacaccattcctgtgtgcaaggaa
ggaatcaagggccacacggaatcctgctcttgccccttgcagccaagtccccgtgcagag
agcagtgtccctggaacaccaaccaggaagatctctgcctctgaattcgatcggccgctt
agacccatcgttatcaaggattctgagggaactgtgagcttcctctctgactcagacaag
aaggaacagatgcctctaacctccccacggtttgataatgatgaaggggaccagtgctcg
agactcttggaattagtgaaagatatttctagtcacttggatgtcacagccttatgtcac
aaaattttcttgcacatccatggactcatctccgccgaccgctactccttattcctcgtc
tgtgaggacagctccaacgacaagtttcttatcagccgcctctttgatgttgcagaaggt
tcaacactggaagaagcttcaaacaactgcatccgcttagagtggaacaaaggcatcgtg
ggacacgtggccgcttttggcgagcccttgaacatcaaagacgcctatgaggatcctcga
ttcaatgcagaagttgaccaaattacaggctacaagacacaaagtattctttgtatgcca
attaagaatcatagggaagaggttgttggtgtagcccaggccatcaacaagaaatcagga
aatggtgggacattcactgaaaaagacgaaaaggactttgctgcttacttggcattttgt
ggaattgttcttcataatgctcaactctatgagacttcactgctggagaacaagagaaat
caggtgctgcttgaccttgctagcttaatttttgaagaacaacaatcattagaagtaatt
ctaaagaaaatagctgccactattatctctttcatgcaggtgcagaaatgcaccattttc
atagtggatgaagattgctccgattctttttctagtgtgtttcacatggagtgtgaggaa
ttagaaaaatcgtcagatactttaacacgggaacgtgatgcaaacagaatcaattacatg
tatgctcagtatgtcaaaaataccatggaaccacttaatatcccagacgtcagtaaggac
aaaagatttccctggacaaatgaaaacatgggaaatataaaccagcagtgcattagaagt
ttgctttgtacacctataaaaaatggaaagaagaacaaagtgataggggtttgccaactt
gttaataagatggaggaaaccactggcaaagttaaggctttcaaccgcaacgatgaacag
tttctggaagctttcgtcatcttttgtggcttggggatccagaacacacagatgtacgaa
gcagtggagagagccatggccaagcaaatggtcacgttagaggttctgtcttatcatgct
tcagctgcagaggaagaaaccagagagctgcagtccttagcggctgctgtggtaccatct
gcccagacccttaaaatcactgacttcagcttcagcgactttgagctgtctgacctggaa
acagcactgtgcacaatccggatgttcactgacctcaaccttgtgcagaacttccagatg
aaacatgaggtcctttgcaagtggattttaagtgtgaagaagaactatcggaagaacgtc
gcctatcataattggagacatgcctttaatacagctcagtgcatgtttgcggcactaaaa
gcaggcaaaattcagaagaggctgacggacctggagatacttgcactgctgattgctgcc
ttaagccatgatctggatcaccgtggtgtcaataactcatacatacagcgaagtgaacac
ccacttgctcagctctactgccattcaatcatggagcatcatcattttgatcagtgcctg
atgatccttaatagtcctggcaatcagattctcagtggcctctccattgaagagtataag
accaccctgaagatcatcaagcaagctattttagccacagacctagcactgtacataaag
agacgaggagaattttttgaacttataatgaaaaatcaattcaatttggaagatcctcat
caaaaggagttgtttttagcgatgctgatgacagcttgtgatctttctgcaattacaaaa
ccctggcctattcaacaacggatagcagaacttgttgccactgaattttttgaccaagga
gatagagagaggaaagaactcaacatagagcccgctgatctaatgaaccgggagaagaaa
aacaaaatcccaagtatgcaagttggattcatagatgccatctgcttgcaactgtatgag
gccttgacccatgtgtcggaggactgtttccctttgctggacggctgcagaaagaacagg
cagaaatggcaggctcttgcagaacagcaggagaagacactgatcaatggtgaaagcagc
cagaccaagcggaactga
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