KEGG   Bos taurus (cow): 281985
Entry
281985            CDS       T01008                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
bta  Bos taurus (cow)
Pathway
bta00562  Inositol phosphate metabolism
bta01100  Metabolic pathways
bta04015  Rap1 signaling pathway
bta04020  Calcium signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04062  Chemokine signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04081  Hormone signaling
bta04082  Neuroactive ligand signaling
bta04261  Adrenergic signaling in cardiomyocytes
bta04270  Vascular smooth muscle contraction
bta04310  Wnt signaling pathway
bta04371  Apelin signaling pathway
bta04540  Gap junction
bta04611  Platelet activation
bta04613  Neutrophil extracellular trap formation
bta04621  NOD-like receptor signaling pathway
bta04713  Circadian entrainment
bta04720  Long-term potentiation
bta04723  Retrograde endocannabinoid signaling
bta04724  Glutamatergic synapse
bta04725  Cholinergic synapse
bta04726  Serotonergic synapse
bta04728  Dopaminergic synapse
bta04730  Long-term depression
bta04742  Taste transduction
bta04750  Inflammatory mediator regulation of TRP channels
bta04911  Insulin secretion
bta04912  GnRH signaling pathway
bta04915  Estrogen signaling pathway
bta04916  Melanogenesis
bta04918  Thyroid hormone synthesis
bta04919  Thyroid hormone signaling pathway
bta04921  Oxytocin signaling pathway
bta04922  Glucagon signaling pathway
bta04924  Renin secretion
bta04925  Aldosterone synthesis and secretion
bta04926  Relaxin signaling pathway
bta04927  Cortisol synthesis and secretion
bta04928  Parathyroid hormone synthesis, secretion and action
bta04929  GnRH secretion
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04934  Cushing syndrome
bta04935  Growth hormone synthesis, secretion and action
bta04961  Endocrine and other factor-regulated calcium reabsorption
bta04970  Salivary secretion
bta04971  Gastric acid secretion
bta04972  Pancreatic secretion
bta04973  Carbohydrate digestion and absorption
bta05010  Alzheimer disease
bta05016  Huntington disease
bta05017  Spinocerebellar ataxia
bta05022  Pathways of neurodegeneration - multiple diseases
bta05142  Chagas disease
bta05143  African trypanosomiasis
bta05146  Amoebiasis
bta05163  Human cytomegalovirus infection
bta05200  Pathways in cancer
bta05415  Diabetic cardiomyopathy
bta05417  Lipid and atherosclerosis
Module
bta_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    281985 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    281985 (PLCB4)
   04310 Wnt signaling pathway
    281985 (PLCB4)
   04371 Apelin signaling pathway
    281985 (PLCB4)
   04020 Calcium signaling pathway
    281985 (PLCB4)
   04070 Phosphatidylinositol signaling system
    281985 (PLCB4)
   04072 Phospholipase D signaling pathway
    281985 (PLCB4)
   04071 Sphingolipid signaling pathway
    281985 (PLCB4)
   04022 cGMP-PKG signaling pathway
    281985 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    281985 (PLCB4)
   04081 Hormone signaling
    281985 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    281985 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    281985 (PLCB4)
   04613 Neutrophil extracellular trap formation
    281985 (PLCB4)
   04621 NOD-like receptor signaling pathway
    281985 (PLCB4)
   04062 Chemokine signaling pathway
    281985 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    281985 (PLCB4)
   04922 Glucagon signaling pathway
    281985 (PLCB4)
   04929 GnRH secretion
    281985 (PLCB4)
   04912 GnRH signaling pathway
    281985 (PLCB4)
   04915 Estrogen signaling pathway
    281985 (PLCB4)
   04921 Oxytocin signaling pathway
    281985 (PLCB4)
   04926 Relaxin signaling pathway
    281985 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    281985 (PLCB4)
   04918 Thyroid hormone synthesis
    281985 (PLCB4)
   04919 Thyroid hormone signaling pathway
    281985 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    281985 (PLCB4)
   04916 Melanogenesis
    281985 (PLCB4)
   04924 Renin secretion
    281985 (PLCB4)
   04925 Aldosterone synthesis and secretion
    281985 (PLCB4)
   04927 Cortisol synthesis and secretion
    281985 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    281985 (PLCB4)
   04270 Vascular smooth muscle contraction
    281985 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    281985 (PLCB4)
   04971 Gastric acid secretion
    281985 (PLCB4)
   04972 Pancreatic secretion
    281985 (PLCB4)
   04973 Carbohydrate digestion and absorption
    281985 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    281985 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    281985 (PLCB4)
   04725 Cholinergic synapse
    281985 (PLCB4)
   04728 Dopaminergic synapse
    281985 (PLCB4)
   04726 Serotonergic synapse
    281985 (PLCB4)
   04720 Long-term potentiation
    281985 (PLCB4)
   04730 Long-term depression
    281985 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    281985 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    281985 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    281985 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    281985 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    281985 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    281985 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    281985 (PLCB4)
   05142 Chagas disease
    281985 (PLCB4)
   05143 African trypanosomiasis
    281985 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    281985 (PLCB4)
   05016 Huntington disease
    281985 (PLCB4)
   05017 Spinocerebellar ataxia
    281985 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    281985 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    281985 (PLCB4)
   05415 Diabetic cardiomyopathy
    281985 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    281985 (PLCB4)
   04934 Cushing syndrome
    281985 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    281985 (PLCB4)
Enzymes [BR:bta01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     281985 (PLCB4)
Membrane trafficking [BR:bta04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    281985 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    281985 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 281985
NCBI-ProteinID: NP_001159982
BGD-bta: BT13437
Ensembl: ENSBTAG00000013116
VGNC: 32983
LinkDB
Position
13:2021105..2503504
AA seq 1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEALGKSENDLEGRIVCVCSGADLVNISFTYMVAENPE
ITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGSELSADDLGHKEAIANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
LGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKLTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSDMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCVKLQDTN
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtagatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggccaagtgcta
gaatgctccctcatcaacagtgttcggctgggagccacaccgaaggatcccaaaattttg
gctgctcttgaagctcttggcaaatcagaaaatgatctggaagggcggatagtttgcgtc
tgcagtggtgcagatctggtgaacatcagtttcacgtacatggtggctgaaaatccagaa
ataactaagcaatgggtcgaaggcctgagatccatcattcacaacttcagggccaacaac
gtcagcccgatgacgtgcctcaagaagcactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgag
cctgccgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcccgatgaagat
ttgaagaaacaaggcctcatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aacgcccccgtcttcctagatcgtctagagctgtaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtgggaaa
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaggaaccgataataactcacgggaaagcaatgtgc
acagacatcctttttaaggatgttattcaagccatcaaggaaactgcctttgtcacatcg
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatactgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcagacccttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaacaaacgactgaaacccgaggttgaaaaaaaacagcttgaagctttgaaaagcatg
atggaagccggagaatccgctgccccggtgaacatcttagaggatgataatgaagaggaa
atagaaagtgctgagcaagaggaggaagcccaccctgaatacaaatatggaagtgaactt
tctgcagatgacttgggtcacaaggaagctattgccaatagtgtcaagaagggcctggtt
accgtagaagatgagcaggcgtggatggcatcttataaatatgtgggtgctaccactaat
atccatccgtatttgtccacaatgatcaactatgcacagcctgtaaagtttcaaggtttc
catgtggctgaagaacgcaatattcattataacatgtcttcctttaatgagtcagtcggt
ctaggctacttgaagacacacgccattgaatttgtgaattataataaacggcaaatgagt
cgcatttaccccaagggaggccgagtggactccagtaattacatgcctcagattttctgg
aacgctggctgccagatggtttcgctgaactatcaaaccccagatttagcgatgcagttg
aatcaggggaaatttgagtataatggatcgtgtgggtaccttctcaaaccagatttcatg
agacggcctgatcgaacatttgatcctttctctgaaacgcctgttgatggggttattgca
gccacttgctccgtgcaggtcatatcaggtcagttcttatcagataagaaaattggcaca
tatgtagaagtggatatgtatgggctgcccacggacactatccggaaggagttccgcact
cgcatggtgatgaacaacggactcaatccagtttacaatgaagaatcatttgtgtttcgg
aaggtgatcctccccgacctggctgtcttgaggatcgccgtgtatgacgacaacaacaag
ctgatcggccagaggattctgcccctggatggcctccaagcaggctatcgacacatatcc
ctccggaatgagggaaataaacctttatcactgccaaccattttctgcaatattgtccta
aaaacatatgtgcctgatggattcggagatattgtggatgctttatcagatccaaagaaa
tttctttccattacggaaaagagagcggatcaaatgagagctatgggcattgaaactagt
gacatcgccgatgtgcccagtgacacttcaaagaacgacaagaaagggaaagccaacaca
gccaaagcgaatgtgacccctcagagcagctcggagctcaggccaaccaccacagctgcc
ctgggggctggcctggaggccaagaaaggtattgaactgatccctcaagtgaggatagaa
gatttaaagcagatgaaggcttacttgaagcatttaaagaaacaacagaaagagctcagt
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaaactccattgcactcaa
gttgacaagattgtggcacagtacgacaaggagaaattgactcacgagaaaatcctagag
aaggcaatgaagaagaaagggggaagtaattgtcttgaaatgaagaaagaaacagaaatt
aaaattcagacgctgacatcagatcacaaatctaaggtcaaggagattgtggcacagcac
acaaaggagtggtcagacatgatcaacacccacagtgcggaggagcaggagatccgggac
ctgcacctcagccagcagtgcgagctgctcagaaagctcctgatcagcgcccacgagcag
cagacccagcagctgaaactgtcccatgacagggaaagcaaagagatgcgagcacaccaa
gctaagatttctatggaaaatagcaaagccatcagccaagataaatccatcaagaataaa
gcagaacgggaaaggagagtcagggagttaaacagcagcaacactaaaaagtttctggaa
gaaagaaagcgactcgccatgaagcagtccaaagaaatggatcagttgaaaaaagtccag
cttgagcacctcgaattcctagagaaacagaatgagcagcttttgaaatcctgtcacgca
gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagttgtgtgaaactccaggacacaaactga

DBGET integrated database retrieval system