Bos taurus (cow): 282001 Help Entry 282001            CDS       T01008                                  Symbol PRKCA Name (RefSeq) protein kinase C alpha type   KO K02677   classical protein kinase C alpha type [EC:2.7.11.13] Organism bta  Bos taurus (cow) Pathway bta01521   EGFR tyrosine kinase inhibitor resistance bta04010   MAPK signaling pathway bta04012   ErbB signaling pathway bta04014   Ras signaling pathway bta04015   Rap1 signaling pathway bta04020   Calcium signaling pathway bta04066   HIF-1 signaling pathway bta04070   Phosphatidylinositol signaling system bta04071   Sphingolipid signaling pathway bta04072   Phospholipase D signaling pathway bta04082   Neuroactive ligand signaling bta04150   mTOR signaling pathway bta04151   PI3K-Akt signaling pathway bta04261   Adrenergic signaling in cardiomyocytes bta04270   Vascular smooth muscle contraction bta04310   Wnt signaling pathway bta04360   Axon guidance bta04370   VEGF signaling pathway bta04510   Focal adhesion bta04540   Gap junction bta04613   Neutrophil extracellular trap formation bta04650   Natural killer cell mediated cytotoxicity bta04664   Fc epsilon RI signaling pathway bta04666   Fc gamma R-mediated phagocytosis bta04670   Leukocyte transendothelial migration bta04713   Circadian entrainment bta04720   Long-term potentiation bta04723   Retrograde endocannabinoid signaling bta04724   Glutamatergic synapse bta04725   Cholinergic synapse bta04726   Serotonergic synapse bta04727   GABAergic synapse bta04728   Dopaminergic synapse bta04730   Long-term depression bta04750   Inflammatory mediator regulation of TRP channels bta04911   Insulin secretion bta04912   GnRH signaling pathway bta04916   Melanogenesis bta04918   Thyroid hormone synthesis bta04919   Thyroid hormone signaling pathway bta04921   Oxytocin signaling pathway bta04925   Aldosterone synthesis and secretion bta04926   Relaxin signaling pathway bta04928   Parathyroid hormone synthesis, secretion and action bta04929   GnRH secretion bta04933   AGE-RAGE signaling pathway in diabetic complications bta04935   Growth hormone synthesis, secretion and action bta04960   Aldosterone-regulated sodium reabsorption bta04961   Endocrine and other factor-regulated calcium reabsorption bta04970   Salivary secretion bta04971   Gastric acid secretion bta04972   Pancreatic secretion bta05017   Spinocerebellar ataxia bta05022   Pathways of neurodegeneration - multiple diseases bta05031   Amphetamine addiction bta05032   Morphine addiction bta05143   African trypanosomiasis bta05146   Amoebiasis bta05161   Hepatitis B bta05163   Human cytomegalovirus infection bta05164   Influenza A bta05170   Human immunodeficiency virus 1 infection bta05171   Coronavirus disease - COVID-19 bta05200   Pathways in cancer bta05205   Proteoglycans in cancer bta05206   MicroRNAs in cancer bta05207   Chemical carcinogenesis - receptor activation bta05214   Glioma bta05223   Non-small cell lung cancer bta05225   Hepatocellular carcinoma bta05231   Choline metabolism in cancer bta05415   Diabetic cardiomyopathy bta05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     282001 (PRKCA)    04012 ErbB signaling pathway     282001 (PRKCA)    04014 Ras signaling pathway     282001 (PRKCA)    04015 Rap1 signaling pathway     282001 (PRKCA)    04310 Wnt signaling pathway     282001 (PRKCA)    04370 VEGF signaling pathway     282001 (PRKCA)    04066 HIF-1 signaling pathway     282001 (PRKCA)    04020 Calcium signaling pathway     282001 (PRKCA)    04070 Phosphatidylinositol signaling system     282001 (PRKCA)    04072 Phospholipase D signaling pathway     282001 (PRKCA)    04071 Sphingolipid signaling pathway     282001 (PRKCA)    04151 PI3K-Akt signaling pathway     282001 (PRKCA)    04150 mTOR signaling pathway     282001 (PRKCA)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     282001 (PRKCA)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     282001 (PRKCA)    04540 Gap junction     282001 (PRKCA)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     282001 (PRKCA)    04650 Natural killer cell mediated cytotoxicity     282001 (PRKCA)    04664 Fc epsilon RI signaling pathway     282001 (PRKCA)    04666 Fc gamma R-mediated phagocytosis     282001 (PRKCA)    04670 Leukocyte transendothelial migration     282001 (PRKCA)   09152 Endocrine system    04911 Insulin secretion     282001 (PRKCA)    04929 GnRH secretion     282001 (PRKCA)    04912 GnRH signaling pathway     282001 (PRKCA)    04921 Oxytocin signaling pathway     282001 (PRKCA)    04926 Relaxin signaling pathway     282001 (PRKCA)    04935 Growth hormone synthesis, secretion and action     282001 (PRKCA)    04918 Thyroid hormone synthesis     282001 (PRKCA)    04919 Thyroid hormone signaling pathway     282001 (PRKCA)    04928 Parathyroid hormone synthesis, secretion and action     282001 (PRKCA)    04916 Melanogenesis     282001 (PRKCA)    04925 Aldosterone synthesis and secretion     282001 (PRKCA)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     282001 (PRKCA)    04270 Vascular smooth muscle contraction     282001 (PRKCA)   09154 Digestive system    04970 Salivary secretion     282001 (PRKCA)    04971 Gastric acid secretion     282001 (PRKCA)    04972 Pancreatic secretion     282001 (PRKCA)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     282001 (PRKCA)    04961 Endocrine and other factor-regulated calcium reabsorption     282001 (PRKCA)   09156 Nervous system    04724 Glutamatergic synapse     282001 (PRKCA)    04727 GABAergic synapse     282001 (PRKCA)    04725 Cholinergic synapse     282001 (PRKCA)    04728 Dopaminergic synapse     282001 (PRKCA)    04726 Serotonergic synapse     282001 (PRKCA)    04720 Long-term potentiation     282001 (PRKCA)    04730 Long-term depression     282001 (PRKCA)    04723 Retrograde endocannabinoid signaling     282001 (PRKCA)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     282001 (PRKCA)   09158 Development and regeneration    04360 Axon guidance     282001 (PRKCA)   09159 Environmental adaptation    04713 Circadian entrainment     282001 (PRKCA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     282001 (PRKCA)    05206 MicroRNAs in cancer     282001 (PRKCA)    05205 Proteoglycans in cancer     282001 (PRKCA)    05207 Chemical carcinogenesis - receptor activation     282001 (PRKCA)    05231 Choline metabolism in cancer     282001 (PRKCA)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     282001 (PRKCA)    05214 Glioma     282001 (PRKCA)    05223 Non-small cell lung cancer     282001 (PRKCA)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     282001 (PRKCA)    05161 Hepatitis B     282001 (PRKCA)    05171 Coronavirus disease - COVID-19     282001 (PRKCA)    05164 Influenza A     282001 (PRKCA)    05163 Human cytomegalovirus infection     282001 (PRKCA)   09174 Infectious disease: parasitic    05146 Amoebiasis     282001 (PRKCA)    05143 African trypanosomiasis     282001 (PRKCA)   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     282001 (PRKCA)    05022 Pathways of neurodegeneration - multiple diseases     282001 (PRKCA)   09165 Substance dependence    05031 Amphetamine addiction     282001 (PRKCA)    05032 Morphine addiction     282001 (PRKCA)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     282001 (PRKCA)    05415 Diabetic cardiomyopathy     282001 (PRKCA)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     282001 (PRKCA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     282001 (PRKCA)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bta01001]     282001 (PRKCA)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bta04131]     282001 (PRKCA) Enzymes [BR:bta01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      282001 (PRKCA) Protein kinases [BR:bta01001]  Serine/threonine kinases: AGC group   PKC family [OT]    282001 (PRKCA) Membrane trafficking [BR:bta04131]  Endocytosis   Lipid raft mediated endocytosis    Caveolin-mediated endocytosis     282001 (PRKCA) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C ABC1 C1_2 Motif Other DBs NCBI-GeneID:  282001 NCBI-ProteinID:  NP_776860 BGD-bta:  BT10523 Ensembl:  ENSBTAG00000001061 VGNC:  33327 UniProt:  P04409 LinkDB All DBs Position 19:62664528..62975086 Genome browser AA seq 672 aa AA seqDB search MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRL SEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE LRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRI DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN PQFVHPILQSAV NT seq 2019 nt NT seq  +upstreamnt  +downstreamnt atggctgacgtcttcccggccgccgagccggcggcgccgcaggacgtggccaaccgcttc gcccgcaaaggggcgctgaggcagaagaacgtgcacgaggtgaagaaccaccgcttcatc gcgcgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt gggaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgaa tttgttactttttcttgtccgggggcggataaaggacccgacacagatgacccgaggagc aagcacaagttcaagatccacacgtatggcagccccaccttctgtgatcactgcggctcc ctgctctacggactcatccaccaggggatgaaatgtgacacctgtgatatgaacgtgcac aagcagtgcgtgatcaacgtgcccagcctctgcgggatggaccacacggagaagaggggc cgcatctacctgaaggccgaggtcacggatgaaaagctgcacgtcacagtacgagacgcg aaaaacctaatccctatggatccaaatgggctttcagatccttacgtgaagctgaagctt attcctgaccccaagaacgagagcaaacagaaaaccaagaccatccgctcgacgctgaac ccccggtgggacgagtccttcacgttcaaattaaaaccttctgataaagaccggcgactg tccgaggaaatctgggactgggatcgaaccacacggaacgacttcatggggtccctttcc tttggggtctcggagctgatgaagatgccggccagcggatggtacaagctgctgaaccaa gaggagggcgagtactacaacgtgccgatccccgaaggcgacgaggaaggcaatgtggag ctcaggcagaaattcgagaaagccaagcttggccctgccggcaacaaagtcatcagtccc tccgaggacaggagacagccttccaacaacctggacagagtgaagctcacggacttcaac ttcctcatggtgctgggcaaaggcagctttgggaaggtgatgctggccgaccggaagggg acagaggagctgtacgccatcaagatcctgaagaaggacgtggtcatccaggacgacgac gtggagtgcaccatggtggagaagcgggtcctggcgctgctcgacaagccgccgttcctg acgcagctgcactcctgcttccagacggtggaccggctgtacttcgtcatggagtacgtc aacggcggggacctcatgtaccacatccagcaggtcgggaagttcaaggagccgcaagca gtgttctatgcagcagagatttccatcgggctgttctttcttcataaaagaggaatcatt tatcgggacctgaagttagacaacgtcatgctggactcggaaggacacattaagatcgcg gacttcgggatgtgcaaggagcacatgatggacggcgtcacgaccaggaccttctgcggg acccccgactacatcgccccagagataatcgcctatcagccgtacgggaagtccgtggac tggtgggcctacggcgtcctgttgtacgagatgttggccgggcagcctccgttcgacggc gaggacgaggacgagctgttccagtccatcatggagcacaacgtctcgtaccccaagtcc ttgtccaaggaggccgtgtccatctgcaaagggctgatgaccaagcaccccgggaagcgg ctgggctgcgggcccgagggcgagcgcgacgtgcgggagcatgccttcttccggaggatc gactgggagaagctggagaaccgtgagatccagccacccttcaagcccaaagtgtgcggc aaaggagcagagaactttgacaagttcttcacgcgagggcagcctgtcttgacgccgccc gaccagctggtcatcgctaacatcgaccagtctgattttgaaggcttctcctacgtcaac ccccagttcgtgcaccccatcctgcagagcgcggtatga

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