Bos taurus (cow): 407217 Help Entry 407217            CDS       T01008                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism bta  Bos taurus (cow) Pathway bta01521   EGFR tyrosine kinase inhibitor resistance bta01522   Endocrine resistance bta03272   Virion - Hepatitis viruses bta04010   MAPK signaling pathway bta04012   ErbB signaling pathway bta04014   Ras signaling pathway bta04015   Rap1 signaling pathway bta04020   Calcium signaling pathway bta04066   HIF-1 signaling pathway bta04068   FoxO signaling pathway bta04072   Phospholipase D signaling pathway bta04144   Endocytosis bta04151   PI3K-Akt signaling pathway bta04510   Focal adhesion bta04520   Adherens junction bta04540   Gap junction bta04630   JAK-STAT signaling pathway bta04810   Regulation of actin cytoskeleton bta04912   GnRH signaling pathway bta04915   Estrogen signaling pathway bta04921   Oxytocin signaling pathway bta04926   Relaxin signaling pathway bta04928   Parathyroid hormone synthesis, secretion and action bta04934   Cushing syndrome bta05160   Hepatitis C bta05163   Human cytomegalovirus infection bta05165   Human papillomavirus infection bta05171   Coronavirus disease - COVID-19 bta05200   Pathways in cancer bta05205   Proteoglycans in cancer bta05206   MicroRNAs in cancer bta05207   Chemical carcinogenesis - receptor activation bta05208   Chemical carcinogenesis - reactive oxygen species bta05210   Colorectal cancer bta05212   Pancreatic cancer bta05213   Endometrial cancer bta05214   Glioma bta05215   Prostate cancer bta05218   Melanoma bta05219   Bladder cancer bta05223   Non-small cell lung cancer bta05224   Breast cancer bta05225   Hepatocellular carcinoma bta05226   Gastric cancer bta05230   Central carbon metabolism in cancer bta05231   Choline metabolism in cancer bta05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bta00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     407217 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     407217 (EGFR)    04012 ErbB signaling pathway     407217 (EGFR)    04014 Ras signaling pathway     407217 (EGFR)    04015 Rap1 signaling pathway     407217 (EGFR)    04630 JAK-STAT signaling pathway     407217 (EGFR)    04066 HIF-1 signaling pathway     407217 (EGFR)    04068 FoxO signaling pathway     407217 (EGFR)    04020 Calcium signaling pathway     407217 (EGFR)    04072 Phospholipase D signaling pathway     407217 (EGFR)    04151 PI3K-Akt signaling pathway     407217 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     407217 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     407217 (EGFR)    04520 Adherens junction     407217 (EGFR)    04540 Gap junction     407217 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     407217 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     407217 (EGFR)    04915 Estrogen signaling pathway     407217 (EGFR)    04921 Oxytocin signaling pathway     407217 (EGFR)    04926 Relaxin signaling pathway     407217 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     407217 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     407217 (EGFR)    05206 MicroRNAs in cancer     407217 (EGFR)    05205 Proteoglycans in cancer     407217 (EGFR)    05207 Chemical carcinogenesis - receptor activation     407217 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     407217 (EGFR)    05230 Central carbon metabolism in cancer     407217 (EGFR)    05231 Choline metabolism in cancer     407217 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     407217 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     407217 (EGFR)    05212 Pancreatic cancer     407217 (EGFR)    05225 Hepatocellular carcinoma     407217 (EGFR)    05226 Gastric cancer     407217 (EGFR)    05214 Glioma     407217 (EGFR)    05218 Melanoma     407217 (EGFR)    05219 Bladder cancer     407217 (EGFR)    05215 Prostate cancer     407217 (EGFR)    05213 Endometrial cancer     407217 (EGFR)    05224 Breast cancer     407217 (EGFR)    05223 Non-small cell lung cancer     407217 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     407217 (EGFR)    05171 Coronavirus disease - COVID-19     407217 (EGFR)    05163 Human cytomegalovirus infection     407217 (EGFR)    05165 Human papillomavirus infection     407217 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     407217 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     407217 (EGFR)    01522 Endocrine resistance     407217 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bta01001]     407217 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:bta04147]     407217 (EGFR) Enzymes [BR:bta01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      407217 (EGFR) Protein kinases [BR:bta01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    407217 (EGFR) Exosome [BR:bta04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    407217 (EGFR)   Exosomal proteins of pancreatic cancer cells    407217 (EGFR)   Exosomal proteins of bladder cancer cells    407217 (EGFR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Borrelia_P83 Kinase-like Haspin_kinase Motif Other DBs NCBI-GeneID:  407217 NCBI-ProteinID:  XP_002696936 BGD-bta:  BT10403 Ensembl:  ENSBTAG00000011628 VGNC:  28366 LinkDB All DBs Position 22:complement(904065..1121545) Genome browser AA seq 1208 aa AA seqDB search MRLSGAGRAALLVLLAAHFQTSLALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYMQSSYNLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALA VLSNYGANKTGLRELPLRNLQEILQGAVRFSNNPVLCNVETIQWRDIVNPDFLSNMTGDF QNQQGNCPKCDPACLNRSCWGAGEENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC TGPRESDCLVCRRFRDEATCKDTCPPLMLYDPTTYEMKVNPLGKYSFGATCVKKCPRNYV VTDHGSCVRACSSDSQEVEEDGVRKCKKCDGPCGKVCNGIGIGEFKDTLSINATNIKHFR NCTSISGDLHILPVAFRGDSFTRTAPLDPKELDILRTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIISGNRNLCYADTIRWKKL FGTSTQKTKILNNRSEKQCKAAGHICHPLCSSEGCWGPGPKYCMSCQNFSRGKECVGKCN ILEGEPREFVENSECVQCHPECLPQAMNVTCTGRGPGNCVKCAHYIDGPHCVKTCPAGVA GENGTLIWKFADANHVCLLCHPNCTYGCEGPGLEGCPQKGPKIPSIATGIVGGLLLVVVL ALSVGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKVKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNVGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISTVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLVPQ QGFFHSPTTSRTPLLSSLSTSSNTPTVTCVDRNGSYPLKEDSFLQRYSSDPTGALIEDSM DDTFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLYPAPGRDPQYQNSLSNAVDNPEYLNTT HPACINGVLDGPALWAQKGSHQFSLDNPDYQQAFFPKEAKSNGIFKGPAAENAEYLRAAP AGSDFTGA NT seq 3627 nt NT seq  +upstreamnt  +downstreamnt atgcgactctccggggcgggccgcgcggcgctcctggtgctgctggcagcgcacttccag acgagtctagcgctggaggagaagaaagtttgccaagggacaagtaacaagctcacccag ttgggcacttttgaagaccactttctgagcctacagaggatgttcaacaactgtgaggtg gtccttgggaatttggaaattacctacatgcagagtagttacaacctttcttttctcaag accatccaggaggttgccggctatgtactcattgccctcaacacagtggagaagattccg ctggaaaacctgcagatcatccgaggaaatgtgctttatgaaaacacccatgccttagcc gtcttatccaactatggagcaaacaaaaccggactgagggagctgcccttgagaaactta caggaaattctgcaaggtgccgtgcgattcagcaacaaccctgtcctctgcaacgtggag accatccagtggcgggacatcgtcaaccctgattttctaagcaacatgacaggagacttt cagaaccagcagggcaactgcccaaagtgtgatccagcctgtctcaacagaagctgctgg ggtgccggggaggagaactgtcagaaattgaccaaaatcatctgtgcccagcagtgttcc gggcgctgccgtggcaggtcccccagtgactgctgccacaaccagtgtgccgctggctgc acagggccacgggagagcgactgcctggtctgccgcaggttccgtgatgaagccacctgc aaggacacgtgtccgccactcatgctctatgaccctaccacctacgaaatgaaggtcaac ccgctggggaagtacagctttggcgccacctgtgtcaagaagtgtccccgtaactacgtg gtgacagaccacggctcctgcgtccgcgcctgcagttctgacagccaggaggtagaggaa gacggtgtccgcaagtgtaaaaagtgtgacgggccttgtggcaaagtttgtaacggaata ggaatcggtgagtttaaagacacactttccataaatgctacaaacattaaacacttcaga aactgcacatccatcagtggagatcttcatatcctgccagtagcatttaggggtgactcc ttcacacgtactgcacctctggacccgaaagaactggacattctaagaactgtaaaagaa ataacagggtttttgctgattcaggcctggcccgaaaacaggactgacctccatgctttt gagaacctggaaatcatacgtggcagaacgaagcagcatggccagttttctcttgcggtt gtcggcctggatataacatctttgggattacgctccctcaaggagataagtgatggtgat gtgataatttcaggaaatcgaaacttgtgctatgcagatacaatacgctggaaaaaactt tttgggacctcaactcagaaaaccaaaattttaaacaacaggagtgaaaaacagtgcaag gccgcaggccacatctgtcacccgctgtgctcatcagagggctgctggggacctggaccc aaatactgcatgtcctgccagaacttcagtcgtggcaaggagtgtgtgggaaagtgcaac attctagagggagagcccagagaattcgtggagaactccgagtgtgtgcagtgccatcca gaatgcctgccccaggccatgaacgtgacctgcactggacgcggaccaggcaactgtgta aagtgcgcccactacattgatggccctcactgcgtcaagacctgccctgctggagtcgcg ggagagaatggcaccctgatctggaagtttgcagatgccaaccacgtgtgtctcctgtgc caccccaactgcacctatggctgtgaagggccaggtctcgaaggctgtccacagaaaggg cccaagatcccgtccattgccacgggcatcgtgggcggcctgctgctggtggtggtgctg gccctgagcgtcggcctcttcatgcgcaggcgccacatcgtgcgcaagcgcacactgcgc cggctgctgcaggagcgtgagctcgtggagcctctgacgcccagcggagaagctcccaac caagctctcttgaggatcctaaaggaaacagaattcaagaaggtcaaggtgctgggctca ggagcattcggcaccgtgtacaagggactctggatcccagaaggcgagaaggttaaaatt cctgtagctatcaaggaattaagagaagccacatctccaaaagccaacaaggaaattctt gatgaggcctacgtgatggccagtgtggacaacccccatgtgtgccgcctcctgggcatc tgcctgacctccaccgtgcagctcatcacacagctcatgcccttcggctgcctgctggac tacgtccgcgagcacaaggacaacgtcggctcccagtacctgctcaactggtgtgtgcag atcgcaaagggcatgaattacctggaagaccggcgcttggtgcatagggacctggcagcc aggaacgtgctggtgaagacgccgcagcacgtgaagatcacagacttcgggctggccaag ctgctgggtgccgaggagaaggagtatcatgcagaaggaggcaaggtccctatcaaatgg atggctttggaatcaattttacaccgaatttatacccatcagagtgatgtctggagctat ggagtcactgtttgggagttgatgacctttggatccaagccttacgatggaatccctgcg agtgagatctcgactgtcctggagaaaggagagcgcctcccacagccacccatctgcacc atcgacgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccaaag ttccgtgagttgatccttgaattctccaagatggcccgagacccccagcgctaccttgtc atccagggggacgagagaatgcatttgccaagccctacggactccaacttctaccgcgcc ctgatggatgaggaggacatggaggatgttgtggatgctgatgagtacctcgtcccccag cagggcttcttccacagccccaccacctcccggacacccctcctcagctcgctgagcacc tccagcaacactcccactgtgacttgcgttgatagaaatgggagctaccctctcaaggaa gacagcttcctgcagcgctacagctcagaccccactggtgccctcatcgaggacagcatg gacgacactttcctcccagtacccgaatatgtaaaccaatctgttcccaaaagacccgca ggctctgtccagaaccctgtctatcacaatcagcctctatatccagctcctggcagagac cctcagtaccaaaattcactcagcaacgccgtggacaaccctgagtatctcaacaccacc catcctgcctgtatcaatggtgtgctcgacggccctgccctctgggctcagaagggcagt caccaatttagcctagacaaccctgactaccagcaggccttctttcccaaggaagccaag tcgaatggcatctttaaggggcctgcagctgaaaatgcagaatacctgcgggcagcacca gcaggcagtgactttactggggcctga

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