Bos taurus (cow): 505809
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Entry
505809 CDS
T01008
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
bta
Bos taurus (cow)
Pathway
bta00790
Folate biosynthesis
bta01100
Metabolic pathways
bta01240
Biosynthesis of cofactors
bta01523
Antifolate resistance
bta04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
505809 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
505809 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
505809 (FPGS)
Enzymes [BR:
bta01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
505809 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
505809
NCBI-ProteinID:
NP_001019651
Ensembl:
ENSBTAG00000008994
VGNC:
55047
UniProt:
A6H751
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Position
11:98472685..98496940
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AA seq
585 aa
AA seq
DB search
MSRARCHALFLAAVSPRGATTRVAVRRGLSAWPVLQEPDMEYQDAVRTLNTLQTNANYLE
MVKRKRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRSYGL
KTGFFSSPHLVQVRERIRINGQPISSELFTKHFWRLYHRLEETKDDSSCVSMPGYFRFLT
LMAFHVFLQEKVDLAVLEVGIGGAYDCTNIIRKPVVCGITSLGIDHTGLLGDTMEKIAWQ
KGGIFKSGVPAFTVLQPDEPLAVLRDRAQQISCPLYLCPPLQALEEGGPPLTLGLEGEHQ
RSNAALALQVARCWLQQKGYQDAGELKASRPSLPGQLPLAPVFQPTPRMQQGLRHTEWPG
RTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHRCERPDSGSEVRVLLFNSTGDRDSA
ALLKLLQPCQFDYAIFCPNLAEMASTDNADQQNFTVTLDQVLLRCLAHQQHWSRLHEEQV
SPDPWSTPGQEQDGPASLLLAPHPPHTHSASSLVFSCISHALQWITQGRDPLFQPPSPPR
GLLAHPVADSGATVLQEAADIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1758 nt
NT seq
+upstream
nt +downstream
nt
atgtctcgggcacgctgccacgctctcttcctggcagcggtttctccgcgtggtgcaaca
accagggtcgcagtgcggcgagggttgagcgcgtggcctgtgctgcaggagccagacatg
gagtatcaggatgccgtgcgtacactcaacaccctgcagaccaatgctaactacttggag
atggtgaagcgtaagcggggtgacccccagacacagctggaagccatgaagctgtacttg
gcacggagtgggctgcaggtggaggacttggaccagctgaacattatccacatcactgga
accaaggggaagggctccacgtgtgccttcactgaacgtatcctccgaagctatggcctg
aagacggggttctttagctctccccacctggtgcaggtgcgtgagcggatccgcatcaat
gggcagcccataagctccgagctcttcaccaagcacttctggcgcctctaccaccggctg
gaggagaccaaggacgacagcagctgtgtctccatgcccggctacttccgcttcctcacg
ctcatggccttccacgtcttcctccaagagaaggtagacctggcagtgttggaagtaggc
attggcggggcttacgactgcaccaacatcatcaggaagcctgtggtgtgtgggatcacc
tctcttggcatcgaccacactggccttctgggggacacgatggagaagatcgcatggcag
aaagggggcatttttaagagtggcgtccctgccttcaccgtgctccagcctgacgagccg
ctggcggtgctaagggacagggctcagcagatctcatgtcccctctacctgtgcccacca
ctacaagccctggaggaaggggggccaccactgaccctgggcctggagggagagcaccag
cggtccaatgctgccctggccttgcaggtggcccgctgctggctgcagcagaaaggttac
caggatgctggggagctgaaggcatccaggcccagcctcccggggcagctgcccctggca
cctgtgttccagcccacgccccgcatgcagcaggggcttcggcacacggaatggccaggt
cggacgcagttgctgcggcgcgggcctcttacctggtacctggacggcgcgcacaccacc
agcagcatgcaagcctgtgtgcgctggttccgccaggcgctgcaccgctgcgagaggccg
gacagcggttccgaggtgcgcgtcttgctcttcaactccactggggaccgggattccgcg
gccctgctgaagctgctgcagccctgccagtttgactatgccattttctgccctaacctg
gcagagatggcatcaacagacaatgcagaccaacagaacttcacagtgacactggaccag
gtgctgctccgctgcctcgcccaccaacagcactggagtcgcctgcatgaggagcaggtc
agcccggacccctggagcacccccggccaggagcaggatgggcccgcatctctgctgctg
gcgcctcacccaccccacacccacagtgccagctccctcgtcttcagctgcatctcccat
gccttgcagtggatcacccaaggccgggaccctctctttcagccgcccagtcccccacgg
ggcctcctcgcccaccctgtggcagacagtggggccacggtactccaagaggctgctgac
attcacgtgctggtcacaggcagcctgcacctggtgggcggtgtcctgaagctgctggag
ccctccctgtcccagtag
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