Bos taurus (cow): 512468
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Entry
512468 CDS
T01008
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
bta
Bos taurus (cow)
Pathway
bta00270
Cysteine and methionine metabolism
bta00480
Glutathione metabolism
bta01100
Metabolic pathways
bta01240
Biosynthesis of cofactors
bta04216
Ferroptosis
Module
bta_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
512468 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
512468 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
512468 (GCLC)
Enzymes [BR:
bta01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
512468 (GCLC)
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GFIT
Motif
Pfam:
GCS
SANT_DAMP1_like
GCS2
Motif
Other DBs
NCBI-GeneID:
512468
NCBI-ProteinID:
NP_001077143
Ensembl:
ENSBTAG00000015571
VGNC:
29289
UniProt:
Q32S38
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Position
23:6982221..7026848
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AA seq
605 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
EKKKAQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPTPHLPKDHPGPAQVTFQACSISEARYLYDQLATI
CPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNHYRISKSRYDSI
DSYLSECGEKYNDIDLTKDKEIYEQLLQEGLDHLLAQHVAHLFIRDPLTLFEEKIHLDDA
NESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVI
LSYKLDFLIPLSKVDENMKVAQKRDAVLQELFYFRKDICKGGNAVVDGCGKAAGRAEPAA
EEYALMTIDTIINGKEGVFPGLIPVLNSYLESMEVDVDTRCSILNYLKLIKKRASGELMT
VAKWMREFIAKHPDYKQDSVITDQMNYSLLLKCNQIANESCECPELLGPAFRKVRYSGSK
TDSST
NT seq
1818 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagacccagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgatgaggtggagtacatgttggtgtcttttgatcat
gaaaagaaaaaagcccaactggtcctgtctggagaggaacttcttgaaactctgcaagaa
aagggggaaaggacgaacccaaaccatccaaccctttggagaccagaatatgggagctac
atgatcgaggggacacccgggcagccgtacggtgggaccatgtctgaattcaacacagtt
gaggacaacatgaggaaacggcgcaaagaagccacatctctcctgggggaaaaccaggcc
ctctgcacgatcacttcctttcccagattaggctgccctgggttcacgctgcccgagttc
aaacccaacccggtggaaggaggagcttccaagtcccttttctttcctgatgaagccatc
aacaagcacccgcgcttcagcacgctcaccaggaacatccggcaccggaggggcgagaaa
gtggtcatcaacgtgcccactccccacctgcccaaggatcacccgggcccagcccaggta
acgttccaagcctgcagcatatctgaggccagatacctttacgatcagttggctaccatc
tgcccaattgtcatggctttgagtgctgcgtcgcctttttaccgaggctacgtgtcagac
attgattgtcgctggggcgtgatttccgcgtctgtagatgatagaactcgggaggagaga
ggactggagccactgaagaacaaccactataggatcagtaagtcccgatacgattcgata
gacagttacttgtctgagtgtggtgagaaatacaatgacattgacctgacaaaagacaaa
gaaatctacgaacagctgttgcaggaaggcctcgaccacctgctggcccagcacgtggcg
catctcttcatcagagacccgctgactctgtttgaagagaaaatccacctggatgatgcc
aacgagtccgaccactttgagaatattcagtccacaaattggcagacaatgcgattcaag
cctcctcctccaaactctgacattgggtggagagtggaattccggcccatggaggttcag
ctgacagacttcgagaactccgcgtatgtggtgttcgtggtgctgctcaccagggtgatc
ctgtcctacaaactggactttctcatcccgctgtccaaggttgatgagaacatgaaggtc
gcccagaagcgagatgccgtcctgcaggaactgttttatttcaggaaagacatttgcaaa
ggtggcaacgccgtggtggacggctgcggcaaggccgcgggcagggcggagccagcggcg
gaggagtacgcgctcatgaccatcgacaccatcatcaacggcaaggaaggcgtgttcccc
gggctgatccccgtcctgaactcctacctggagagcatggaggtggacgtggacaccagg
tgcagcattctgaactacctgaagctcatcaagaagagggcgtccggagaattaatgaca
gttgccaaatggatgagggagtttatcgcaaagcatcccgactacaagcaggacagtgta
ataactgaccagatgaactatagccttcttctaaagtgtaatcaaatcgcaaacgaatcg
tgtgagtgcccagagttactcggaccagcgtttaggaaagtcaggtacagtggaagtaaa
accgactcttccacttag
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