KEGG   Bos taurus (cow): 517948
Entry
517948            CDS       T01008                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
bta  Bos taurus (cow)
Pathway
bta00562  Inositol phosphate metabolism
bta01100  Metabolic pathways
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta01524  Platinum drug resistance
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04015  Rap1 signaling pathway
bta04024  cAMP signaling pathway
bta04062  Chemokine signaling pathway
bta04066  HIF-1 signaling pathway
bta04068  FoxO signaling pathway
bta04070  Phosphatidylinositol signaling system
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04081  Hormone signaling
bta04140  Autophagy - animal
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04152  AMPK signaling pathway
bta04210  Apoptosis
bta04211  Longevity regulating pathway
bta04213  Longevity regulating pathway - multiple species
bta04218  Cellular senescence
bta04360  Axon guidance
bta04370  VEGF signaling pathway
bta04380  Osteoclast differentiation
bta04510  Focal adhesion
bta04550  Signaling pathways regulating pluripotency of stem cells
bta04611  Platelet activation
bta04613  Neutrophil extracellular trap formation
bta04620  Toll-like receptor signaling pathway
bta04625  C-type lectin receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04650  Natural killer cell mediated cytotoxicity
bta04660  T cell receptor signaling pathway
bta04662  B cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04668  TNF signaling pathway
bta04670  Leukocyte transendothelial migration
bta04722  Neurotrophin signaling pathway
bta04725  Cholinergic synapse
bta04750  Inflammatory mediator regulation of TRP channels
bta04810  Regulation of actin cytoskeleton
bta04910  Insulin signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04915  Estrogen signaling pathway
bta04917  Prolactin signaling pathway
bta04919  Thyroid hormone signaling pathway
bta04923  Regulation of lipolysis in adipocytes
bta04926  Relaxin signaling pathway
bta04929  GnRH secretion
bta04930  Type II diabetes mellitus
bta04931  Insulin resistance
bta04932  Non-alcoholic fatty liver disease
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta04960  Aldosterone-regulated sodium reabsorption
bta04973  Carbohydrate digestion and absorption
bta05010  Alzheimer disease
bta05017  Spinocerebellar ataxia
bta05020  Prion disease
bta05100  Bacterial invasion of epithelial cells
bta05132  Salmonella infection
bta05135  Yersinia infection
bta05142  Chagas disease
bta05146  Amoebiasis
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05162  Measles
bta05163  Human cytomegalovirus infection
bta05164  Influenza A
bta05165  Human papillomavirus infection
bta05166  Human T-cell leukemia virus 1 infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05168  Herpes simplex virus 1 infection
bta05169  Epstein-Barr virus infection
bta05170  Human immunodeficiency virus 1 infection
bta05171  Coronavirus disease - COVID-19
bta05200  Pathways in cancer
bta05203  Viral carcinogenesis
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05207  Chemical carcinogenesis - receptor activation
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05212  Pancreatic cancer
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05218  Melanoma
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05222  Small cell lung cancer
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
bta05230  Central carbon metabolism in cancer
bta05231  Choline metabolism in cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bta05415  Diabetic cardiomyopathy
bta05417  Lipid and atherosclerosis
bta05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    517948 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    517948 (PIK3CB)
   04014 Ras signaling pathway
    517948 (PIK3CB)
   04015 Rap1 signaling pathway
    517948 (PIK3CB)
   04370 VEGF signaling pathway
    517948 (PIK3CB)
   04630 JAK-STAT signaling pathway
    517948 (PIK3CB)
   04668 TNF signaling pathway
    517948 (PIK3CB)
   04066 HIF-1 signaling pathway
    517948 (PIK3CB)
   04068 FoxO signaling pathway
    517948 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    517948 (PIK3CB)
   04072 Phospholipase D signaling pathway
    517948 (PIK3CB)
   04071 Sphingolipid signaling pathway
    517948 (PIK3CB)
   04024 cAMP signaling pathway
    517948 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    517948 (PIK3CB)
   04152 AMPK signaling pathway
    517948 (PIK3CB)
   04150 mTOR signaling pathway
    517948 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    517948 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    517948 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    517948 (PIK3CB)
   04218 Cellular senescence
    517948 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    517948 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    517948 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    517948 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    517948 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    517948 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    517948 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    517948 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    517948 (PIK3CB)
   04660 T cell receptor signaling pathway
    517948 (PIK3CB)
   04662 B cell receptor signaling pathway
    517948 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    517948 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    517948 (PIK3CB)
   04670 Leukocyte transendothelial migration
    517948 (PIK3CB)
   04062 Chemokine signaling pathway
    517948 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    517948 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    517948 (PIK3CB)
   04929 GnRH secretion
    517948 (PIK3CB)
   04915 Estrogen signaling pathway
    517948 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    517948 (PIK3CB)
   04917 Prolactin signaling pathway
    517948 (PIK3CB)
   04926 Relaxin signaling pathway
    517948 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    517948 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    517948 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    517948 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    517948 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    517948 (PIK3CB)
   04722 Neurotrophin signaling pathway
    517948 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    517948 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    517948 (PIK3CB)
   04380 Osteoclast differentiation
    517948 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    517948 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    517948 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    517948 (PIK3CB)
   05206 MicroRNAs in cancer
    517948 (PIK3CB)
   05205 Proteoglycans in cancer
    517948 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    517948 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    517948 (PIK3CB)
   05203 Viral carcinogenesis
    517948 (PIK3CB)
   05230 Central carbon metabolism in cancer
    517948 (PIK3CB)
   05231 Choline metabolism in cancer
    517948 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    517948 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    517948 (PIK3CB)
   05212 Pancreatic cancer
    517948 (PIK3CB)
   05225 Hepatocellular carcinoma
    517948 (PIK3CB)
   05226 Gastric cancer
    517948 (PIK3CB)
   05214 Glioma
    517948 (PIK3CB)
   05221 Acute myeloid leukemia
    517948 (PIK3CB)
   05220 Chronic myeloid leukemia
    517948 (PIK3CB)
   05218 Melanoma
    517948 (PIK3CB)
   05211 Renal cell carcinoma
    517948 (PIK3CB)
   05215 Prostate cancer
    517948 (PIK3CB)
   05213 Endometrial cancer
    517948 (PIK3CB)
   05224 Breast cancer
    517948 (PIK3CB)
   05222 Small cell lung cancer
    517948 (PIK3CB)
   05223 Non-small cell lung cancer
    517948 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    517948 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    517948 (PIK3CB)
   05161 Hepatitis B
    517948 (PIK3CB)
   05160 Hepatitis C
    517948 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    517948 (PIK3CB)
   05164 Influenza A
    517948 (PIK3CB)
   05162 Measles
    517948 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    517948 (PIK3CB)
   05163 Human cytomegalovirus infection
    517948 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    517948 (PIK3CB)
   05169 Epstein-Barr virus infection
    517948 (PIK3CB)
   05165 Human papillomavirus infection
    517948 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    517948 (PIK3CB)
   05135 Yersinia infection
    517948 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    517948 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    517948 (PIK3CB)
   05142 Chagas disease
    517948 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    517948 (PIK3CB)
   05017 Spinocerebellar ataxia
    517948 (PIK3CB)
   05020 Prion disease
    517948 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    517948 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    517948 (PIK3CB)
   05415 Diabetic cardiomyopathy
    517948 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    517948 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    517948 (PIK3CB)
   04931 Insulin resistance
    517948 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    517948 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    517948 (PIK3CB)
   01524 Platinum drug resistance
    517948 (PIK3CB)
   01522 Endocrine resistance
    517948 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bta04131]
    517948 (PIK3CB)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     517948 (PIK3CB)
Membrane trafficking [BR:bta04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    517948 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 517948
NCBI-ProteinID: NP_001192976
BGD-bta: BT22392
Ensembl: ENSBTAG00000006909
VGNC: 32890
LinkDB
Position
1:130293123..130472309
AA seq 1070 aa
MCFYFMMPPAMADVLDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISCIKQMLW
KQVTNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKHTYPPEL
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHSLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMVAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMTRLCFAVYAVLDKVKTKKSTKTM
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPHALPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKTEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttctacttcatgatgcctcctgctatggcagacgtccttgacatctgggcagtg
gactcacagatagcgtctgatggctccatacccgtggattttcttttgcccactgggatt
tatatccagttggaggtgcctcgtgaagctaccatttcctgtattaagcagatgttatgg
aaacaagttaccaattacccaatgtttaacctccttatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggaactcgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
cagtcgcttgtgggattatcttggatggattggctaaagcatacctatccacctgagctt
gaaccatccatccctgaaaatttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaggtatctcctaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtctgactattcatgggaaagaagatgaa
gttagcccttatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cactcactaattcagttccagtatatccggaactgtgtaatgaacagaacattgccccat
tttatacttgtggaatgttgcaagatcaagaagctgtatgaacaggagatggttgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaagga
aataaacttaacacagaagaaactgtaaaagttcatgtcagggccggcctttttcatggt
accgaactcctgtgtaaaactgtcgtaagctcagagatatcagggaagaatgatcatatt
tggaatgaaccactggaatttgatatcaacacttgtgacctgccacgaatgactcgatta
tgttttgctgtttatgcagttttggataaagtgaaaactaagaaatcaactaaaaccatg
aatccctctaagtatcagaccatcaggaaatctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagatataatattacac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatacagaaaatgcaacagctttgcacataaaattcccagagaataaaaaa
caaccttattactatcctcccttcgataagattattgaaaaagcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacacgcgttgccgaaattgctgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
ctgcccccccgggaggcccttgagcttctagatttcaactatccagatcagtatgtgcga
gaatatgctgtgggctgcctgcaacagatgagtgatgaagaactctctcaatatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccttgtctagattccta
ctagaaagagcacttgctaatcggaggatagggcagtttttattttggcacctcagatct
gaagtacacattcctgctgtttcagtacaatttggtgttatccttgaagcgtactgccgg
ggaagcgtaggtcacatgaaggcgctttctaagcaggttgaagcactcaataaactaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaatagagccaaagggaaagaa
gcaatgcacacttgtttaaaacagaatgcttaccgtgaagccctctctgacctgcagtca
cctctcaacccatgtgttatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggcttgtgtacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacactccaaatgctg
cgcttgatggatttactctggaaagaagctggtctggaccttcggatgctaccttacggc
tgcttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgttgctgcagcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggag
tttaccctatcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acttatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgccggcatgggaatctcttc
atcacgctctttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagactgaagaagaagcactcaagcaa
ttcaagcaaaaatttgatgaggcactcagggaaagttggactactaaagtcaattggatg
gcccacacagttcgcaaagactacagatcttaa

DBGET integrated database retrieval system