KEGG   Bos taurus (cow): 533199
Entry
533199            CDS       T01008                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04015  Rap1 signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04062  Chemokine signaling pathway
bta04066  HIF-1 signaling pathway
bta04068  FoxO signaling pathway
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04114  Oocyte meiosis
bta04140  Autophagy - animal
bta04148  Efferocytosis
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04210  Apoptosis
bta04218  Cellular senescence
bta04270  Vascular smooth muscle contraction
bta04370  VEGF signaling pathway
bta04371  Apelin signaling pathway
bta04380  Osteoclast differentiation
bta04510  Focal adhesion
bta04540  Gap junction
bta04550  Signaling pathways regulating pluripotency of stem cells
bta04613  Neutrophil extracellular trap formation
bta04620  Toll-like receptor signaling pathway
bta04650  Natural killer cell mediated cytotoxicity
bta04660  T cell receptor signaling pathway
bta04662  B cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04668  TNF signaling pathway
bta04720  Long-term potentiation
bta04722  Neurotrophin signaling pathway
bta04725  Cholinergic synapse
bta04726  Serotonergic synapse
bta04730  Long-term depression
bta04810  Regulation of actin cytoskeleton
bta04910  Insulin signaling pathway
bta04912  GnRH signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04915  Estrogen signaling pathway
bta04916  Melanogenesis
bta04917  Prolactin signaling pathway
bta04919  Thyroid hormone signaling pathway
bta04921  Oxytocin signaling pathway
bta04926  Relaxin signaling pathway
bta04928  Parathyroid hormone synthesis, secretion and action
bta04929  GnRH secretion
bta04934  Cushing syndrome
bta04935  Growth hormone synthesis, secretion and action
bta05010  Alzheimer disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05034  Alcoholism
bta05132  Salmonella infection
bta05135  Yersinia infection
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05163  Human cytomegalovirus infection
bta05164  Influenza A
bta05165  Human papillomavirus infection
bta05166  Human T-cell leukemia virus 1 infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05170  Human immunodeficiency virus 1 infection
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05206  MicroRNAs in cancer
bta05207  Chemical carcinogenesis - receptor activation
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05212  Pancreatic cancer
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05216  Thyroid cancer
bta05218  Melanoma
bta05219  Bladder cancer
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
bta05230  Central carbon metabolism in cancer
bta05231  Choline metabolism in cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    533199 (MAP2K1)
   04015 Rap1 signaling pathway
    533199 (MAP2K1)
   04668 TNF signaling pathway
    533199 (MAP2K1)
   04066 HIF-1 signaling pathway
    533199 (MAP2K1)
   04068 FoxO signaling pathway
    533199 (MAP2K1)
   04072 Phospholipase D signaling pathway
    533199 (MAP2K1)
   04071 Sphingolipid signaling pathway
    533199 (MAP2K1)
   04024 cAMP signaling pathway
    533199 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    533199 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    533199 (MAP2K1)
   04150 mTOR signaling pathway
    533199 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    533199 (MAP2K1)
   04148 Efferocytosis
    533199 (MAP2K1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    533199 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    533199 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    533199 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    533199 (MAP2K1)
   04660 T cell receptor signaling pathway
    533199 (MAP2K1)
   04662 B cell receptor signaling pathway
    533199 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    533199 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    533199 (MAP2K1)
   04062 Chemokine signaling pathway
    533199 (MAP2K1)
  09152 Endocrine system
   04929 GnRH secretion
    533199 (MAP2K1)
   04915 Estrogen signaling pathway
    533199 (MAP2K1)
   04917 Prolactin signaling pathway
    533199 (MAP2K1)
   04921 Oxytocin signaling pathway
    533199 (MAP2K1)
   04926 Relaxin signaling pathway
    533199 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    533199 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    533199 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    533199 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    533199 (MAP2K1)
   04726 Serotonergic synapse
    533199 (MAP2K1)
   04720 Long-term potentiation
    533199 (MAP2K1)
   04730 Long-term depression
    533199 (MAP2K1)
   04722 Neurotrophin signaling pathway
    533199 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    533199 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    533199 (MAP2K1)
   05206 MicroRNAs in cancer
    533199 (MAP2K1)
   05205 Proteoglycans in cancer
    533199 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    533199 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    533199 (MAP2K1)
   05230 Central carbon metabolism in cancer
    533199 (MAP2K1)
   05231 Choline metabolism in cancer
    533199 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    533199 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    533199 (MAP2K1)
   05212 Pancreatic cancer
    533199 (MAP2K1)
   05225 Hepatocellular carcinoma
    533199 (MAP2K1)
   05226 Gastric cancer
    533199 (MAP2K1)
   05214 Glioma
    533199 (MAP2K1)
   05216 Thyroid cancer
    533199 (MAP2K1)
   05221 Acute myeloid leukemia
    533199 (MAP2K1)
   05220 Chronic myeloid leukemia
    533199 (MAP2K1)
   05218 Melanoma
    533199 (MAP2K1)
   05211 Renal cell carcinoma
    533199 (MAP2K1)
   05219 Bladder cancer
    533199 (MAP2K1)
   05215 Prostate cancer
    533199 (MAP2K1)
   05213 Endometrial cancer
    533199 (MAP2K1)
   05224 Breast cancer
    533199 (MAP2K1)
   05223 Non-small cell lung cancer
    533199 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    533199 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    533199 (MAP2K1)
   05161 Hepatitis B
    533199 (MAP2K1)
   05160 Hepatitis C
    533199 (MAP2K1)
   05164 Influenza A
    533199 (MAP2K1)
   05163 Human cytomegalovirus infection
    533199 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    533199 (MAP2K1)
   05165 Human papillomavirus infection
    533199 (MAP2K1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    533199 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    533199 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    533199 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    533199 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    533199 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    533199 (MAP2K1)
   01522 Endocrine resistance
    533199 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    533199 (MAP2K1)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     533199 (MAP2K1)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: STE group
  STE7 family
   533199 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 533199
NCBI-ProteinID: NP_001124224
BGD-bta: BT26665
Ensembl: ENSBTAG00000033983
VGNC: 31183
UniProt: Q0VD16
LinkDB
Position
10:13276354..13351219
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcgttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccaacccagcacacccacccatgcggctggcgtctaa

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