Bos taurus (cow): 537201 Help Entry 537201            CDS       T01008                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism bta  Bos taurus (cow) Pathway bta01521   EGFR tyrosine kinase inhibitor resistance bta04151   PI3K-Akt signaling pathway bta04217   Necroptosis bta04380   Osteoclast differentiation bta04550   Signaling pathways regulating pluripotency of stem cells bta04620   Toll-like receptor signaling pathway bta04621   NOD-like receptor signaling pathway bta04630   JAK-STAT signaling pathway bta04658   Th1 and Th2 cell differentiation bta04659   Th17 cell differentiation bta05140   Leishmaniasis bta05145   Toxoplasmosis bta05152   Tuberculosis bta05160   Hepatitis C bta05161   Hepatitis B bta05162   Measles bta05163   Human cytomegalovirus infection bta05164   Influenza A bta05165   Human papillomavirus infection bta05166   Human T-cell leukemia virus 1 infection bta05167   Kaposi sarcoma-associated herpesvirus infection bta05168   Herpes simplex virus 1 infection bta05169   Epstein-Barr virus infection bta05171   Coronavirus disease - COVID-19 bta05200   Pathways in cancer bta05203   Viral carcinogenesis bta05212   Pancreatic cancer bta05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     537201 (JAK1)    04151 PI3K-Akt signaling pathway     537201 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     537201 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     537201 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     537201 (JAK1)    04621 NOD-like receptor signaling pathway     537201 (JAK1)    04658 Th1 and Th2 cell differentiation     537201 (JAK1)    04659 Th17 cell differentiation     537201 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     537201 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     537201 (JAK1)    05203 Viral carcinogenesis     537201 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     537201 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     537201 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     537201 (JAK1)    05161 Hepatitis B     537201 (JAK1)    05160 Hepatitis C     537201 (JAK1)    05171 Coronavirus disease - COVID-19     537201 (JAK1)    05164 Influenza A     537201 (JAK1)    05162 Measles     537201 (JAK1)    05168 Herpes simplex virus 1 infection     537201 (JAK1)    05163 Human cytomegalovirus infection     537201 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     537201 (JAK1)    05169 Epstein-Barr virus infection     537201 (JAK1)    05165 Human papillomavirus infection     537201 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     537201 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     537201 (JAK1)    05140 Leishmaniasis     537201 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     537201 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bta01001]     537201 (JAK1) Enzymes [BR:bta01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      537201 (JAK1) Protein kinases [BR:bta01001]  Non-receptor tyrosine kinases   JAK family [OT]    537201 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  537201 NCBI-ProteinID:  NP_001193463 Ensembl:  ENSBTAG00000003147 VGNC:  30364 LinkDB All DBs Position 3:80444566..80584006 Genome browser AA seq 1158 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTVTVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT FQNLIEGFEALLRSMSNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg agctccaagaaggcggagatgaatctggaggcccctgagccgggggtggaggtgctcttc tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg tgcatccgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagaacaccaagctctggtatgctccgaatcgcaccgtcaccgtcgacgacaaa acgtcactccggcttcactaccggatgaggttctatttcaccaactggcatgggaccaac gacaatgaacaatcagtatggcgacattctccaaagaagcagaaaaacggctatgagaaa aaaaaagttccagatgcaacacctctccttgacgccagctcgctggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtcttgggatggccgtgctggccatctcccactac gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaagattttctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtccacgcacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag gaggccttgtccttcgtgtccctggtcgatggctacttccggctcacggcagacgcccat cactacctctgcactgacgtggctcccccattgatcgtccacaacatacagaatggctgt catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag gggatgtacgtgctgcggtggagctgcaccgactttgacaacatccttatgaccgtcacc tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggac ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcacggattacaaggatgacgaagggacttctgaagagaagagaataaaagtcatcctg aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgcgtccgagatgtg gagaatatcatggtggaagagtttgtggaggggggacccctggacctcttcatgcatcgg aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctt ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc atccccatcactgtgctctccaggcaagagtgcatagaacgaatcccctggattgctccc gagtgtgttgaagactccaagaatctgagtgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgattgag aaagagagattctatgaaagccggtgcaggccagtgaccccatcttgtaaggagctagct gacttgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagatggtggaaatggtattaagctcatcatggagtttctgccttca gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatacgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac cgggacttagcagcaagaaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac ttcggtctcaccaaagccatcgaaaccgataaggagtactacacagtcaaggacgaccgg gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc tctgatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagat tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta acaagactcgtgaatacattaaaagaaggaaaacgcttgccatgtccaccgaactgtcca gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

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