Bos taurus (cow): 537376 Help Entry 537376            CDS       T01008                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism bta  Bos taurus (cow) Pathway bta04020   Calcium signaling pathway bta04024   cAMP signaling pathway bta04260   Cardiac muscle contraction bta04261   Adrenergic signaling in cardiomyocytes bta04371   Apelin signaling pathway bta04713   Circadian entrainment bta04911   Insulin secretion bta04921   Oxytocin signaling pathway bta04972   Pancreatic secretion bta05020   Prion disease bta05022   Pathways of neurodegeneration - multiple diseases bta05410   Hypertrophic cardiomyopathy bta05412   Arrhythmogenic right ventricular cardiomyopathy bta05414   Dilated cardiomyopathy bta05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     537376 (RYR2)    04020 Calcium signaling pathway     537376 (RYR2)    04024 cAMP signaling pathway     537376 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     537376 (RYR2)    04921 Oxytocin signaling pathway     537376 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     537376 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     537376 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     537376 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     537376 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     537376 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     537376 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     537376 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     537376 (RYR2)    05414 Dilated cardiomyopathy     537376 (RYR2)    05415 Diabetic cardiomyopathy     537376 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bta04040]     537376 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:bta04990]     537376 (RYR2) Ion channels [BR:bta04040]  Voltage-gated cation channels   Ryanodine receptor    537376 (RYR2) Domain-containing proteins not elsewhere classified [BR:bta04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    537376 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  537376 NCBI-ProteinID:  XP_059738630 BGD-bta:  BT21640 Ensembl:  ENSBTAG00000022886 VGNC:  34234 LinkDB All DBs Position 28:9691348..10518983 Genome browser AA seq 4874 aa AA seqDB search MQTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWI IHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGS EAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLR VAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVG VRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDD GLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIG YFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGRE AGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVE SPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD LLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTE GYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDL SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP CYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERI REKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK TLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAE NAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG YNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWCRPG CQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEI LLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAV NTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMF YRLSMPIECAEVFSKTAAGGIPGTGLFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDR DKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLM QTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIK RSNCYMVCAGESLSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFP AVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPN QFLKVDVSRISERQGWLVQCMEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLY SAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMM NNEFIVPMTEETKSITLFPDEKKKHGLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPE FPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKH VLQLIEPSVFKEAASPEEESEVAEKEPFVEDSKLEGAAEEENKGAKRPKEGLLQMKLPEP VKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARK TKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNN DLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELV RAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKL MIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLC YFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPD LEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVV RLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTTGSSKTPDTEEEEDDT IHMGNAIMTFYSALIDLLGRCAPEMHLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQ MPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAAS LDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSL TKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYY CLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYM ESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGW IYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALY NRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELE AKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVAL LPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAA FAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPANVEDVCPNIPSLEKLMEEIVDL AESGIRYTQMPHVMEVVLPMLCSYMSRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLK SEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLED PAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYYNLVEHPQR SKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLI EDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD EEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGP MVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS TVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQ SLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNG TIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAME SHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDT RLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRM GFFSIMTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMITAFFTSYWSILMS LLHFVASVFRGFSRIIGSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKT LEGALPSEDLTDLKELSEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIP EVQEKFQEQKAKEEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEP EVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEL PTRSSSENARVSSLDSSSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV MDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV FTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIED PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI GNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP AGDCFRKQYEDQLN NT seq 14625 nt NT seq  +upstreamnt  +downstreamnt atgcagactgctcaaggtggtggccaccgaacgctcctctacggtcatgcaatactgctg cggcattcctacagtggcatgtatctgtgctgcctgtccacctctcggtcttcaactgat aagctggcttttgatgttggcttgcaagaggatacaacaggtgaagcttgttggtggatc atccatcctgcctctaagcagcgctcagaaggagaaaaagtgcgggttggagatgacctc atcttagtgagcgtgtcctctgaaaggtacctgcacttgtcttacggtaacggcagcttg cacgtggatgctgctttccagcagaccctctggagcgtggcccccatcagctcaggaagt gaagcagcccaagggtatctgattggtggtgacgtcctcaggttgcttcatggacacatg gatgaatgcctcactgtcccttcaggagaacacggtgaagagcagcggagaactgttcat tacgaaggtggtgctgtatcggttcacgcacgttccctgtggcgactggagacactaaga gttgcgtggagtggaagccacataaggtggggacaaccttttcgactacgccatgtcaca acaggaaaatacttgagtctcatggaagacaaaagccttctactcatggacaaagaaaaa gctgatgtcaaatcaactgcatttaccttccgatcttccaaggaaaaattggatgtagga gtgagaaaagaagttgatggcatgggaacctctgaaataaaatatggagactcagtatgt tatatacagcatatcaatacaggcttgtggctgacttaccagtctgtggatgtgaaatcg gtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggacacatggatgat ggcctaaatttatccagatctcagcatgaagaatcacggacagcacgcgtcatccggagc acagtcttcctttttaatagatttattaggggccttgatgctctcagcaaaaaggtgaaa gcttccacagtagacttacctatagagtctgtaagtctgagtctgcaggaccttattggc tacttccacccaccagatgagcatttagagcatgaagataagcagaacagattacgagct ctgaagaataggcagaatctcttccaggaagagggaatgatcaaccttgtgctcgagtgt atagacaggctgcatgtgtatagcagtgctgcacacttcgctgatgttgctgggagagaa gcaggggaatcttggaaatcgattctgaattctctgtatgagttgctggcggcattaatt agaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttaatcagccga ctggaaagactggaagcttcttctggtattcttgaagttttacactgtgtgttagtagaa agtccagaagctctaaatattattaaagaaggccatataaaatccattatctcactttta gacaagcatggaagaaatcacaaggttctggatgtcttatgctctctctgtgtttgccat ggagtagcagtccgttctaaccagcatctcatctgtgacaatcttctgccaggaagagac ctgttattgcagacacgccttgtgaaccacgtgagcagcatgagaccaaatatttttctg ggtgtcagtgaaggatctgcacagtataagaagtggtattatgagttgatggtggaccac actgagccattcgtgactgctgaagccactcacctgcgagtgggctgggcttccacagag gggtactcaccctaccctggagggggtgaagagtggggtggaaatggtgtcggagatgac ctcttctcctacggatttgatggccttcacctctggtcaggttgtattgcccggacggtc agctcaccaaaccagcatctcttgagaactgatgatgtcatcagttgctgtctagatcta agtgccccaagcatctccttccgaattaatggacaacctgttcaaggcatgtttgagaat ttcaacattgatggcctcttctttccagttgtcagtttctctgcaggaatcaaagtacgc tttctgcttggggggagacatggagaatttaaattccttcctccacctgggtatgctcct tgttatgaagctgtactgccaaaagagaagttgaaagtggagcacagccgagagtacaag caagaaaggacttacacgcgggacctcctgggccccacggtttccctgacacaagctgcc ttcacaccaatcccagtggacaccagccagattgtgttgcctccccacctggagaggata cgagaaaaactggcagagaatatccatgagctctgggtgatgaataaaattgaacttggc tggcagtatggtccggttagagatgacaataagagacagcacccgtgtctggtggagttc tccaagctgcctgaacaggaacgcaattacaatttacagatgtcacttgagaccctgaag acgttgttggctttaggatgtcatgtgggtatatcagatgaacacgctgaagaaaaagtg aaaaaaatgaagctgccaaagaattaccaactgacaagtggatacaagcctgccccaatg gacctgagctttattaaactcaccccatctcaggaggctatggtggacaagttggcagaa aatgctcataacgtgtgggctcgggatcgaattcgacaaggctggacctatgggatccaa caggatgtaaagaatagaagaaaccctcggcttgttccctatgcccttctagatgaccga actaagaaatccaataaggatagcctccgtgaggctgtacgcacactgctgggatatggc tacaacctggaggcacctgatcaagatcatgctgccagagctgaagtgtgcagcggcacg ggagagaggttccgcatcttccgtgctgagaaaacatatgctgtgaaggctggaaggtgg tattttgaattcgaggcggtcactgctggagacatgcgagttggctggtgcaggccaggg tgtcaacctgatcaggagcttggctcagatgaacgtgcctttgcttttgatggcttcaag gcccagcggtggcaccagggcaatgagcactatgggcgctcttggcaagctggcgacgtt gtggggtgtatggttgacatgacagaacacaccatgatgttcacactgaatggcgaaatc cttcttgatgattccggttcagagctggctttcaaggactttgatgttggtgatggattc atacctgtgtgtagcctgggagtggctcaagtgggcaggctgaactttggaaaggatgtc agcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccatttgccgtt aacacaaatagggatattaccatgtggctgagcaagaggcttcctcaatttctccaagtt ccatcaaaccatgaacatattgaggtgaccagaatagatggcaccatagacagttccccg tgtttaaaagtcactcagaagtcctttggctctcagaacagcagcacggatatcatgttt tatcgtctgagcatgcccatcgagtgtgcagaggtcttctccaagactgcagctggaggg atccctggcaccgggctctttgggcccaagaatgatctggaggattatgatgtggattca gactttgaggttctcatgaagacagctcacggccatctggtgccagatcgaggagataga gacaaagaagctacaaaaccagagtttaataaccacaaggattatgctcaggaaaaaccc tctcgtctgaaacagaggtttttgcttcgaagaacaaagccagattatagcaccagccat tctgcacgactcactgaagatgtccttgcagatgagagggatgactatgattacttgatg caaacgtccacgtactattactcagtgagaatctttcctggacaagaacctgccaatgtc tgggtgggctggatcacatccgatttccatcagtatgatacaggctttgacttggacaga gttcgtacagtgaccgtgactctgggagatgaaaaaggaaaggtgcacgaaagcatcaaa cgcagcaattgctacatggtgtgtgcgggtgagagcctgagcccggggcaaggacggaac aacaacggcctggagattggctgcgtggtggatgctgccagtgggctgctcaccttcacg gccaacggcaaggaactgagcacctattatcaggtggaaccaagcacaaaattatttcct gcagtttttgcacaagctacaagtcctaatgtttttcagtttgagttgggaagaataaag aatgtgatgcctctctcagcgggattattcaagagtgagcacaaaaatcctgtgccacag tgtcccccacgtctccatgtgcagtttctctcacatgtcctgtggagcagaatgcccaac cagttcttgaaggtagacgtctctcgaataagtgaacgccagggctggctggtgcagtgc atggagcctctgcagttcatgtcacttcacatcccagaggagaacagatctgtggacata ctggaactgacagagcaggaggaactactgaaattccactaccacactctccggctctac tcggccgtctgcgcgctcgggaaccaccgggtggcccacgccttgtgcagccacgtggac gagccgcagctgctctacgccatcgagaacaagtacatgcccggcttgctgcgcaccggc tactacgatctgctgattgacatccacctcagctcctacgccaccgccaggctcatgatg aacaacgagttcatcgtccccatgaccgaggagaccaagagcatcaccctcttcccggat gagaagaaaaagcacgggctcccgggcatcggcctcagcacctccctcaggccgcggatg cagttttcctccccgagttttgtcagcattaataccgagggttaccagtacagcccagag ttcccgctggacatcctgaaggccaagaccatacagatgctgacagaagccgtgaaagag ggcagccttcatgcccgagaccccgttgggggcaccactgagttcctcttcgtccctctc atcaagctgttctataccctgctcatcatgggtgtcttccacaacgaggacttgaaacac gtcttgcagttgattgagcctagtgtgttcaaggaagccgccagcccggaggaggagagc gaggtggcggagaaggaaccctttgtggaagactccaagctggaaggagccgctgaggaa gaaaacaaaggggctaagaggcccaaggagggcctgctccaaatgaaactgccagagcca gtaaaattgcagatgtgcctgctacttcaatacctctgtgactgccaggtccggcaccgg atagaagccattgtggccttttcagatgactttgtagccaagctccaagacaatcaacga ttccgatataatgaagttatgcaagccttaaacatgtcggctgcactcacagccaggaag acaaaggaattcagatccccgcctcaagaacagatcaatatgcttctcaattttaaggat gacaaaagtgaatgtccatgtcctgaagaaatccgagaccaactcttggattttcacgaa gatttgatgacacattgtggaattgagctggatgaagataggtctctagatggaaacaat gatttaactattagaggacgcctgctgtccttggtagagaaggtgacatacctgaagaag aagcaagcggaaaagccagttgagagtgactccaagaagtcatccactcttcagcagttg atttctgagaccatggtccgatgggctcaagagtctgttattgaagaccctgagttggtg agggccatgtttgtattgctccatcgacagtatgatggcattgggggtctggtacgggct ctgccaaagacctacactataaatggtgtttctgtggaggataccatcaatctgctggca tctcttggtcagattcgttctctgctaagtgtgagaatgggcaaagaggaagagaaactt atgattcgtggattaggggatatcatgaacaataaagtgttttaccagcatcctaatctc atgagggcccttggtatgcatgagacagtgatggaggtcatggtgaatgtccttggaggt ggagagtccaaggaaatcacttttccgaagatggtggccaactgttgccgttttctctgt tacttctgtcgtataagcaggcagaatcagaaagctatgtttgatcatctgagttattta ctggaaaacagcagtgttggtcttgcctcaccagctatgagaggttcaacaccactggat gtggcagcagcctcagtgatggataataatgaactagctttagctttgcgggagccagat ctggaaaaggtggttcggtatttggctggttgtggactgcagagttgccagatgctagtg tcaaagggttatccagacattgggtggaatccagttgaaggagagagatatcttgacttt ctcagatttgctgtcttctgtaatggggaaagcgtggaggagaatgcaaatgtagtggtg agattgctcatccggaggcctgagtgtttcggtcccgccttgaggggagaaggtgggaat ggcctgcttgcagccatggaagaagccataaaaatagccgaggatccctctagagatggt ccctcaccaactaccggatccagcaaaacccctgatacagaagaggaagaggatgatacc atccacatgggaaatgccatcatgaccttttattcagctttaattgacctgttaggacga tgtgctcctgaaatgcatttgattcatgctgccaaaggagaagccatcagaatcaggtct attttgagatctctgattccattgggagatttggtgggagtgatcagcatcgcttttcag atgcccacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttttgt ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggttcaa gatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgcttct ttagacacggctgctttgagtgctacagacatggccctggcgctcaatcggtacctgtgc acagccgtgttacccttgttaacaaggtgtgctcctctttttgctggcaccgagcaccat gcttctctcattgactcattacttcacactgtgtacaggctttctaagggctgctcactt accaaagctcaacgggattccatagaagtgtgtttactctctatttgtggccaattgaga ccttctatgatgcaacacttactcagaagattagtatttgatgtcccattattaaatgaa catgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaaatattac tgcctgcctggagggtggggcaactttggagctgcctcagaagaagaacttcatttgtca agaaagctgttctggggcatctttgatgccctgtctcaaaagaaatatgaacaagaactt ttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcctccagactacatg gagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaacttt aatccacaacctgttgatacctcaaatattacaattcctgagaagttggaatacttcatt aacaaatatgcagaacatgcccatgacaagtggtcaatggataagttggcaaatggatgg atttatggagaaatatattcagactcatctaaagttcaaccattaatgaagccatataaa ctattatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaaact atgctggcttggggatggagaattgaaaggacccgagagggagacagcatggccctttat aaccgtactcgtcgtatttctcagacaagtcaggtttctgtagatgccgcccatgggtac agcccacgagccattgacatgagcaatgttacactatccagagatctgcacgctatggca gaaatgatggctgaaaactaccataatatatgggcaaagaaaaagaaactggaactggag gccaaaggaggtggaaaccatcccctactggtaccttatgatacactgacagccaaagag aaagccaaggatagggaaaaagcacaggacatcctcaagttcctgcagatcaatggctat gctgtatccagagggttcaaagacctggaactggacacaccttctattgagaaacggttt gcctatagtttccttcagcaactcattcgctatgtagacgaggcccatcagtatatcctg gagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatcaag ttctttgctaaagtcgttcttcctttaattgatcagtatttcaaaaaccaccgtttatac ttcttatctgcagcaagcagacctctctgttctggaggacatgcatcaaacaaagagaaa gaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttcacta tttgggaacgatgcaacatcaattgtcaactgtcttcatattttgggtcagactttggat gcaaggactgtgatgaagactggcctggagagtgttaaaagtgcactcagagccttcctg gacaatgccgcagaggatctggagaagacgatggagaatcttaagcagggccagttcacc cacacccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggcactg ttaccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagatctc atattggaagatgtacaggtgtcatgttatagaattctgactagcttgtatgctttggga accagcaagagtatttatgtggaaaggcaacgttctgcattgggagaatgtctggctgct tttgctggtgcctttcctgtagcatttttggaaactcacctggacaagcacaatatttac tccatctacaatacaaagtcttcgagagagagagcagctcttaatttgcctgctaacgtg gaagatgtttgtccaaatataccgtctttggagaagctcatggaagaaattgtggacttg gctgagtccgggattcgctacacacagatgccacatgtgatggaagttgtcctgcccatg ctttgtagttacatgtctcgttggtgggagcatgggcctgagaataatccgggaagggct gagatgtgctgtacagctctgaactcagagcacatgaacacgctgctgggcaatatcctg aaaatcatatataataacttgggtattgatgagggagcctggatgaagaggttagcagtg ttttcccagcctattataaataaagtgaaacctcagctcttgaaaactcatttcttgccg ttaatggagaagctcaagaaaaaggcagcaatggtggtatcagaagaggaccatctgaaa tctgaggccaggggagatatgtctgaagccgaacttctcatcctagatgagttcaccaca ctggccagagatctctatgccttctatccgctcctgattagatttgtggactataacagg gcaaaatggctgaaagagcctaaccaagaagcagaagatcttttccgcatggttgctgag gtgtttatctactggtcaaaatcccataatttcaaaagggaggagcagaactttgtggtg cagaatgaaatcaacaatatgtctttccttattatggacaccaagtcaaagatgtccaag gcagctgtttctgatcaggaaaggaagaaaatgaagcgcaaaggggaccgatattccatg cagacatctcttattgtggctgctctgaagcggttgctgcccattgggttgaacatctgt gcccctggggaccaggagctcattgcactggccaaaaatcgctttagtctgaaagacact gaggatgaagttcgagatataatccgcagtaatattcacttacaaggcaagttggaggat cctgctattagatggcaaatggctctttacaaagacttacccaataggacagaagacact tcagatcctgagaagacagtggaaagggtcttggatatagcaaatgtactttttcatctt gaacagaaatctacatgtatgcgccggagatattacaatctggttgagcatcctcagaga tcaaaaaaggccgtgtggcacaaactgctctctaagcagaggaaacgagctgtggttgct tgcttccggatggctcctttatataatctgccgaggcatcgggctgtcaatctctttctt cagggatatgaaaagtcttggattgagacagaagaacattactttgaagataaattgata gaagacttagcgaaacctggagcagaacctccagaagaagatgaaggaactaagagggtt gatcctcttcatcagctgatccttctgtttagtcgaacagctttaacagagaaatgcaaa ctggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcatgat gaggaagatgatgatggggaagaggaagtgaagagttttgaagtcacaggatcccaacgc agcaaggaaaaagaaatggaaaagcaaaagcttctataccaacaagccaggctccatgac cgcggtgctgctgagatggtgctgcagaccatcagtgccagcaaaggtgaaactggaccc atggtggctgctactttgaaacttggaattgctatcttaaatggagggaactctacagta cagcagaaaatgcttgactacctcaaggagaaaaaggacgtgggcttctttcagagcctg gctggcctgatgcagtcatgcagtgtcctcgacctaaatgcatttgagcgacaaaacaaa gctgaaggacttgggatggtgactgaggaaggatcaggagaaaaggttctgcaggatgac gaattcacctgtgacctcttccgcttcttgcaactgctttgtgagggacacaactcagat tttcaaaattatctgagaactcagactggcaataatacaactgtcaacataatcatctct actgtagactaccttctgagagttcaggaatcaattagtgatttctattggtattactct ggaaaagatgtcattgatgaacaaggacaaaggaatttctccaaagctattcaagtggca aaacaagtctttaacactcttacagagtatattcagggtccttgcactggcaaccagcag agtttggctcacagcaggctctgggatgctgtggtgggttttcttcatgtatttgcccac atgcagatgaagctgtctcaggactccagtcaaattgagctactgaaagaattgatggat cttcagaaggacatggtggtcatgttgctgtccatgttggaaggcaatgttgttaatggc accattggcaaacagatggttgatatgctcgtggaatcttccaacaacgtggagatgatt ctcaagttttttgacatgttcttaaagctcaaggacttgacgtcttctgatactttcaaa gagtatgaccccgatggtaagggagttatttccaagagggactttcacaaagctatggag agccataaacactacacccagtccgagactgagtttctcctgtcctgtgcagagacagat gaaaatgaaaccctggactacgaagaatttgtcaaacggttccacgagcctgccaaggac attggcttcaatgtggcagtgcttctgacaaacctctccgaacacatgcccaatgacacc cggctgcagactttcctggaattggccgagagcgtgctcaattacttccagcccttcctg ggccgcatagagatcatgggcagtgccaagcgcatcgagagggtgtattttgaaatcagt gagtccagccgaacccagtgggaaaagccccaggtcaaggaatccaaaaggcaatttata tttgacgtggtcaatgaaggaggggagaaagagaagatggagctcttcgtgaacttctgc gaggataccatctttgagatgcagctggcggctcagatttcagagtcagatctgaatgag aggtcagcgaataaggaggagagtgagaaggagaagccggaggagcagggtccgaggatg ggtttcttttccatcatgacggtcaagtccgccctgtttgccctcaggtacaatatcttg acccttatgcggatgctcagcctgaaaagcttgaagaagcagatgaagaaggtgaagaag atgacagtgaaggacatgatcacagccttctttacatcctactggagtattttgatgagc ctcctgcactttgtagccagcgttttcagaggcttctctcgcatcatcggcagcctcctg ctgggaggaagcctggtcgaaggtgcgaagaagatcaaagtggcggagctcttggccaac atgccagaccccacacaagatgaggttcgaggagacggggaggagggggagaggaaaacc ctggaaggggccctgccctctgaagacctgacggacttgaaggaactgtcagaggagagt gacctgctttctgatatctttggcttggacctgaagcgagaaggagggcagtacaaactg attcctcacaatcccaatgctggcctgagtgacctcatgagcaaccccgtccccatccca gaggtgcaagaaaagttccaggagcagaaggcaaaagaagaagaaaaggaagaaaaagaa gaaagcaaatccgaacctgagaaagctgaaggagaagatggagaaaaagaagaaaaagcc aaagaagacaagggtaaacaaaaactgaggcagctccacacacacagatatggagagcca gaagttcctgagtcagcattctggaagaaaatcatagcctatcaacagaaacttctaaac tattttgctcgcaacttctacaacatgagaatgttagccttatttgtcgcatttgcgatc aatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggaacta cccactcgcagttcaagtgaaaatgccagagttagcagcttggacagcagctcgcctaga atcatcgcagtgcactatgtgctggaggagagcagtggctacatggagcccacactgcgg atattagccattctgcacacggtcatctctttcttctgcatcattggatactactgcttg aaagtcccactggttatttttaagcgagagaaggaagtagctcgaaaattggaatttgat gggctttatattacagaacagccttcagaagatgatattaaaggccagtgggatagactc gtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggtt atggataaatatggagagttctatggccgagacagaatcagcgagttactcggcatggac aaagctgccttggacttcagtgatgcccgggaaaagaagaagccaaagaaagacagctcc ctgtcagctgtactgaactctattgatgtgaagtatcagatgtggaaactaggagtcgtt ttcactgacaactccttcctctaccttgcctggtatatgaccatgtccattcttggacac tacaacaactttttttttgctgctcatcttctggacattgctatgggattcaagacgtta agaaccatcttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggctta ttggctgttgttgtatacctatatactgtcgtggcattcaattttttccgaaaattctac aataaaagtgaagatggcgatacaccagacatgaagtgtgatgacatgctaacgtgctat atgttccacatgtatgttggagtacgtgctggagggggtatcggtgatgaaatcgaagat ccagctggtgatgagtatgagatatatcgaatcatctttgacatcaccttcttctttttt gtaattgtcattctcttggccataatacaaggtttaatcatcgatgcttttggggaacta agagaccaacaggaacaggtcaaagaagacatggagaccaagtgcttcatctgtgggata ggcaatgattactttgacaccgtgccacatggctttgaaacccacactttacaggaacac aacttggccaattatctgttttttctgatgtatctcataaacaaagatgaaacggagcac acaggacaggaatcttatgtttggaagatgtatcaagaaaggtgctgggaatttttccca gccggagactgtttccggaaacagtatgaagaccagctaaattaa

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