KEGG   Bos taurus (cow): 537631
Entry
537631            CDS       T01008                                 
Symbol
MAPK10
Name
(RefSeq) mitogen-activated protein kinase 10 isoform 2
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
bta  Bos taurus (cow)
Pathway
bta01522  Endocrine resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04024  cAMP signaling pathway
bta04068  FoxO signaling pathway
bta04071  Sphingolipid signaling pathway
bta04137  Mitophagy - animal
bta04140  Autophagy - animal
bta04141  Protein processing in endoplasmic reticulum
bta04210  Apoptosis
bta04215  Apoptosis - multiple species
bta04217  Necroptosis
bta04310  Wnt signaling pathway
bta04380  Osteoclast differentiation
bta04510  Focal adhesion
bta04530  Tight junction
bta04620  Toll-like receptor signaling pathway
bta04621  NOD-like receptor signaling pathway
bta04622  RIG-I-like receptor signaling pathway
bta04625  C-type lectin receptor signaling pathway
bta04657  IL-17 signaling pathway
bta04658  Th1 and Th2 cell differentiation
bta04659  Th17 cell differentiation
bta04660  T cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04668  TNF signaling pathway
bta04722  Neurotrophin signaling pathway
bta04723  Retrograde endocannabinoid signaling
bta04728  Dopaminergic synapse
bta04750  Inflammatory mediator regulation of TRP channels
bta04910  Insulin signaling pathway
bta04912  GnRH signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04917  Prolactin signaling pathway
bta04920  Adipocytokine signaling pathway
bta04926  Relaxin signaling pathway
bta04930  Type II diabetes mellitus
bta04931  Insulin resistance
bta04932  Non-alcoholic fatty liver disease
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta04936  Alcoholic liver disease
bta05010  Alzheimer disease
bta05012  Parkinson disease
bta05016  Huntington disease
bta05017  Spinocerebellar ataxia
bta05020  Prion disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05132  Salmonella infection
bta05133  Pertussis
bta05135  Yersinia infection
bta05142  Chagas disease
bta05145  Toxoplasmosis
bta05152  Tuberculosis
bta05161  Hepatitis B
bta05162  Measles
bta05166  Human T-cell leukemia virus 1 infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05169  Epstein-Barr virus infection
bta05170  Human immunodeficiency virus 1 infection
bta05171  Coronavirus disease - COVID-19
bta05200  Pathways in cancer
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05212  Pancreatic cancer
bta05231  Choline metabolism in cancer
bta05415  Diabetic cardiomyopathy
bta05417  Lipid and atherosclerosis
bta05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bta00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    537631 (MAPK10)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    537631 (MAPK10)
   04012 ErbB signaling pathway
    537631 (MAPK10)
   04014 Ras signaling pathway
    537631 (MAPK10)
   04310 Wnt signaling pathway
    537631 (MAPK10)
   04668 TNF signaling pathway
    537631 (MAPK10)
   04068 FoxO signaling pathway
    537631 (MAPK10)
   04071 Sphingolipid signaling pathway
    537631 (MAPK10)
   04024 cAMP signaling pathway
    537631 (MAPK10)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    537631 (MAPK10)
   04137 Mitophagy - animal
    537631 (MAPK10)
  09143 Cell growth and death
   04210 Apoptosis
    537631 (MAPK10)
   04215 Apoptosis - multiple species
    537631 (MAPK10)
   04217 Necroptosis
    537631 (MAPK10)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    537631 (MAPK10)
   04530 Tight junction
    537631 (MAPK10)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    537631 (MAPK10)
   04621 NOD-like receptor signaling pathway
    537631 (MAPK10)
   04622 RIG-I-like receptor signaling pathway
    537631 (MAPK10)
   04625 C-type lectin receptor signaling pathway
    537631 (MAPK10)
   04660 T cell receptor signaling pathway
    537631 (MAPK10)
   04658 Th1 and Th2 cell differentiation
    537631 (MAPK10)
   04659 Th17 cell differentiation
    537631 (MAPK10)
   04657 IL-17 signaling pathway
    537631 (MAPK10)
   04664 Fc epsilon RI signaling pathway
    537631 (MAPK10)
  09152 Endocrine system
   04910 Insulin signaling pathway
    537631 (MAPK10)
   04920 Adipocytokine signaling pathway
    537631 (MAPK10)
   04912 GnRH signaling pathway
    537631 (MAPK10)
   04914 Progesterone-mediated oocyte maturation
    537631 (MAPK10)
   04917 Prolactin signaling pathway
    537631 (MAPK10)
   04926 Relaxin signaling pathway
    537631 (MAPK10)
   04935 Growth hormone synthesis, secretion and action
    537631 (MAPK10)
  09156 Nervous system
   04728 Dopaminergic synapse
    537631 (MAPK10)
   04723 Retrograde endocannabinoid signaling
    537631 (MAPK10)
   04722 Neurotrophin signaling pathway
    537631 (MAPK10)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    537631 (MAPK10)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    537631 (MAPK10)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    537631 (MAPK10)
   05208 Chemical carcinogenesis - reactive oxygen species
    537631 (MAPK10)
   05231 Choline metabolism in cancer
    537631 (MAPK10)
  09162 Cancer: specific types
   05210 Colorectal cancer
    537631 (MAPK10)
   05212 Pancreatic cancer
    537631 (MAPK10)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    537631 (MAPK10)
   05170 Human immunodeficiency virus 1 infection
    537631 (MAPK10)
   05161 Hepatitis B
    537631 (MAPK10)
   05171 Coronavirus disease - COVID-19
    537631 (MAPK10)
   05162 Measles
    537631 (MAPK10)
   05167 Kaposi sarcoma-associated herpesvirus infection
    537631 (MAPK10)
   05169 Epstein-Barr virus infection
    537631 (MAPK10)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    537631 (MAPK10)
   05135 Yersinia infection
    537631 (MAPK10)
   05133 Pertussis
    537631 (MAPK10)
   05152 Tuberculosis
    537631 (MAPK10)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    537631 (MAPK10)
   05142 Chagas disease
    537631 (MAPK10)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    537631 (MAPK10)
   05012 Parkinson disease
    537631 (MAPK10)
   05016 Huntington disease
    537631 (MAPK10)
   05017 Spinocerebellar ataxia
    537631 (MAPK10)
   05020 Prion disease
    537631 (MAPK10)
   05022 Pathways of neurodegeneration - multiple diseases
    537631 (MAPK10)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    537631 (MAPK10)
   05418 Fluid shear stress and atherosclerosis
    537631 (MAPK10)
   05415 Diabetic cardiomyopathy
    537631 (MAPK10)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    537631 (MAPK10)
   04936 Alcoholic liver disease
    537631 (MAPK10)
   04932 Non-alcoholic fatty liver disease
    537631 (MAPK10)
   04931 Insulin resistance
    537631 (MAPK10)
   04933 AGE-RAGE signaling pathway in diabetic complications
    537631 (MAPK10)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    537631 (MAPK10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    537631 (MAPK10)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     537631 (MAPK10)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   537631 (MAPK10)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like APH FTA2
Other DBs
NCBI-GeneID: 537631
NCBI-ProteinID: NP_001077197
BGD-bta: BT11390
Ensembl: ENSBTAG00000020048
VGNC: 31213
UniProt: A4FV00
LinkDB
Position
6:complement(100907861..101530086)
AA seq 426 aa
MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
MNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAG
PLGCCR
NT seq 1281 nt   +upstreamnt  +downstreamnt
atgagcaaaagcaaagttgacaaccagttctatagcgtggaagtgggagactcaacgttc
acggttctcaaacgctaccagaatctaaagcctattggctctggggctcagggaatagtc
tgcgctgcgtatgatgctgttcttgacagaaatgtggccattaagaagctcagcagaccc
tttcagaaccaaacgcatgccaagagagcctaccgggagctggtcctcatgaagtgtgtg
aatcataaaaacattattagtttattaaatgtcttcacaccccagaaaacactggaggag
ttccaagatgtttacttagtcatggagctgatggatgctaacttgtgtcaggtgattcag
atggagttagaccacgagcgaatgtcttacctgctctaccaaatgttgtgtggcatcaag
caccttcactctgctgggattattcacagggacttaaaaccaagtaacattgtagtcaag
tctgattgtacattgaaaatcctagactttgggctggccagaacagcaggcacaagcttc
atgatgactccctacgtggtaacacgttattaccgggcccccgaggtcattctgggaatg
ggctacaaggagaacgtggatatatggtctgtgggatgcattatgggagaaatggttcgc
cacaaaatcctgtttccaggaagggactatattgaccagtggaataaggttattgagcaa
ctaggaacaccatgtccagaattcatgaagaaattgcaacccaccgtaagaaactatgtg
gagaatcggcccaagtatgcaggactcaccttccccaagctctttccagattccctcttc
ccagcggactctgagcacaataaactcaaagccagccaagccagagacttgctgtcaaag
atgctagtgattgacccagcaaaaaggatatcagtggatgacgccttacaacatccgtac
atcaatgtctggtatgaccctgctgaagtggaggcgcccccacctcagatatatgacaaa
cagctggatgagagagagcacaccattgaagaatggaaagaacttatctataaggaagta
atgaactcggaagaaaagacgaagaatggcgttgtgaaaggacagccttctccttcaggt
gcagccgtgaacagcagtgagagcctccctccttcctcatccgtcaatgacatctcctcc
atgtccaccgaccagaccctggcatctgacactgacagcagcctggaagcctcggcagga
cccctgggttgttgcaggtga

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