Bos taurus (cow): 539899 Help Entry 539899            CDS       T01008                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism bta  Bos taurus (cow) Pathway bta04020   Calcium signaling pathway bta04371   Apelin signaling pathway bta04713   Circadian entrainment bta04921   Oxytocin signaling pathway bta04970   Salivary secretion bta05010   Alzheimer disease bta05012   Parkinson disease bta05020   Prion disease bta05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:bta00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     539899 (RYR3)    04020 Calcium signaling pathway     539899 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     539899 (RYR3)   09154 Digestive system    04970 Salivary secretion     539899 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     539899 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     539899 (RYR3)    05012 Parkinson disease     539899 (RYR3)    05020 Prion disease     539899 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     539899 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bta04040]     539899 (RYR3) Ion channels [BR:bta04040]  Voltage-gated cation channels   Ryanodine receptor    539899 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  539899 NCBI-ProteinID:  XP_015328590 BGD-bta:  BT28957 VGNC:  34235 LinkDB All DBs Position 10:complement(28727820..29286475) Genome browser AA seq 4866 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGMQHEGKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRID GTMDTPPCLKVTHKTFGTQNSSATMIYCRLSMPVECHSSFSHSPCMDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGPRTCLKPGFRFSTPCFITTNEEHQ KQSPEIPLELLKTKALGMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLIMGVFDD DDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAVEAGEKASREAPIKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQENQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED SSWTGKFCALVQRIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKLQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDDDDEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQVSVDTDGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDRWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKDIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKVLKYVDSAQEFIAHLEAIVSSGKNEKSPHDQEIKFFAKVLLPLVDQYFINHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSAGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLRADSK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEIFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDFYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLRNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEEV EKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEDEDEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYW YYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCA EADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFE PYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSADRPDEEEEEGGDSSYVLEVEGEEEEEEKSFECASAFAM ACGSVKRNVANFLKRATLKNLRKQYRKVKKMTFKELVKVFFSFFWTLFMGLFHLLFTIVG GIIQVLWSTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVPEPGIATEL VHFVKGQKGDADIMSDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDETPTLESTVRKKRK AQAAEMKAAHEAERKIESEKADMEDGEKEDTAKEEEQAEALWADVTKRKKRRCGQKVEKP EAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETED VANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRALAIIHTVISLVCVVGYYCLKVPLVV FKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGD LYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHVWKLGVVFTDNSFLY LAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLY TVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM YRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQ YEDQLG NT seq 14601 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagtttctgcggactgaagatgaa gtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaactttgtgctggaacagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccac aggaccctgctgtatggccatgcaattctcctgcggcactccttcagtggcatgtatcta acatgtttgaccacatcaagatcccagacggataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccattcatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgatgacctcatcctcgtcagtgtgtcctctgagaga taccttcatctctcaatatcaaatggtaacatacaagtggatgcctcctttatgcagaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcacgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatatactatgaagctgggggagctggcacgagagcc agatcgctatggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggacaggctttccgactccggcatctcaccacaggccactacctggccttgacagaagac caaggccttatactgcaagaccggggaaagtcggacaccaagtccacggccttctctttt cgagcatccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggagtcccagaaatcaagtatggagactctgtctgctttgtccaacatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatggattaaccctgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagccag tttgtaagtggaaacagtcgcacagctgccccggtcaccctgccaatagaagaggtcctg cagaccttacatgacctgattgcctacttccagcccccggaggaggggatgcagcatgaa ggcaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttagcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagcacac tttgcagggatcgccagggaggagagtgggatggcctggaaagaaattctgaaccttctc tacaaattgctcgctgctcttattcgtggaaacagaaacaactgtgctcaattctccaat aaccttgattggctgatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctcattgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgttggataagcacggacggaatcacaaggttctggatgtg ctgtgttccctctgtctctgtgatggggtcgcagtgagagccaaccagaatctcatctgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaatgacgtaaca agtattcggccaaacatcttcctgggagttgctgaaggctcagcacagtacaagaagtgg tacttcgagcttatcatcgaccaggtggaccccttcctcacagcagagcccacgcatctg cgggtgggctgggcctcttcctctggctacgctccttaccctggaggcggagaaggatgg gggggcaatggtgttggtgatgacctatactcctatggctttgatggacttcacctttgg tcaggtcgcatacccagagccgtggcctccatcaaccagcacctcctgaagtcagacgac gtggtaagctgttgcctggacctgggggcacccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtccgtttcctgctgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgaga ttggagcctgtcaaagagtataaacgtgatgctgaaggaattcgagatctgctgggtacc acccagttcctctcccaagcatctttcatcccatgccccatagataccagtcaggttgtt ttaccacctcatctagagaaaatacgagacaggctggctgaaaacatccatgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga cagcacccctgccttgttgagttttcaaagctgcccgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaactctcctggccctggggtgccacattgctcatgtt aacccagctgctgaggacgatctcaagaaggtcaaattgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa gttttagtggataagcttgcagaaaatgcacacaatgtctgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccacgtttggtg ccatattcattgctggatgagcgtaccaagaagtcaaaccgggacagccttcgtgaagct gtccggacgtttgttggttatggctataacattgagccatcagaccaagagctagctgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttat gccgtgagatctggaaagtggtatttcgagttcgaggtggtgaccggaggcgacatgcgt gttggctgggcccggccaggctgccgacccgacattgagctgggggcagatgaccaagcc ttcgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgat tatgagattgacaatggctttgtgcccatctgctctctggggctgtctcagatcggccgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaatcgtgacgtggccatgtggttcagcaaacgc ctcccaacatttgtcaacgtgcccaaggatcatccgcagatagaggtcgtgaggatcgac ggcaccatggatacccctccgtgcctcaaggtgacccacaagacattcggcacccagaac agcagtgccaccatgatctactgccgcctgagcatgcccgtcgagtgccactcctccttc agtcacagcccctgtatggacagtgatgctttccagaaaaggaaacagatgcaagaaata ctctctcacacaacaacacagtgctactatgcgatccgcatctttgccggacaggacccc tcctgcgtgtgggtcggatgggtgactccggattatcacttgtacagtgaaaagtttgac ctgaataaaaactgtactgtgactgttactctgggggatgaaagaggccgagtccacgaa agcgtgaaacgcagcaattgctacatggtctggggtggggacatcgtggctacatcccaa agagcgagtcgcagcaacgtggacctggagattggctgcctcgtggatctggcgatgggc atgttgtccttttcagccaacgggagggaacttggcacctgctaccaggtggagcccaat accaaagtgtttccagccgtcttcctgcagcccacaagcacctctctgtttcaatttgaa cttgggaagctgaagaatgccatgcccctgtcagcagccatatttaagagtgaagagaag aaccccgtccctcaatgcccaccacggctggatgtccaaaccatccagcctgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagagggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcactccacatcccggaagagaac aggtgtgtggatatcctggagctctgtgagcaggaggacctcatgcggttccattaccat acactgagactctacagcgccttgtgcgccctgggaaatagccgcgtggcctacgccctg tgcagccatgtggacctctcccaactcttctatgccattgacaacaagtacctccctggc ctcctgcgctcaggcttctatgacctgctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcaccaccaggaaaatc cgcctgtacccggatgagtccaagaggcacgggctccctggagtgggcccgagaacgtgc ctcaagccagggttcaggttctccaccccctgcttcatcaccaccaacgaggagcaccag aagcagagccccgagattcccttggagcttctcaagacgaaggcactgggcatgctgacg gaggcagtgcagtgcagcggtgctcacatccgggaccctgtcgggggttccgtggaattc cagtttgtgcctgtgctgaagctcatcggaaccctgctgatcatgggggtgtttgatgat gatgacgttcggcagatcctcctcctcatcgacccctctgtgtttggggagcacagtggg gagacggaggagggagcagagaaggaggaggtgacgcaggtggaggagaaggctgtggag gctggggaaaaggccagcagggaggctcccatcaaaggcttgttgcagacccgattaccg gagtccgtcaagctgcagatgtgtgagctgctcagctatctctgtgactgtgagctgcag caccgggtggaggccattgtggccttcggtgacatctatgtctccaagctccaggaaaat cagaagttccgctacaacgagctcatgcaggccctgaacatgtctgcggccctgaccgcc cggaagaccagggagttccgctcgcccccacaggaacagatcaacatgcttcttaacttt caactgggggagaactgcccatgcccagaagagatccgggaagagctgtacgacttccat gaggaccttctccttcactgcggggttcccctggaagaagaggaagaggaggaagaggat tcctcctggactggaaaattctgtgccttggtgcagagaatcaaaggccctcccaagcca gagaaggaacaaccaacggaggaagaagagagatgccctacgaccctgaaggagctcatc tcacagaccatgatccgctgggcccaggaggaccagatccaggatgcagagctggtccgg atgatgttcaaccttctgcggcggcagtacgacagcatcggggagctgctgcaggcgctg cgcaagacctataccatcagccaggcctccgtgagcgacaccatcagcctgctagctgcc ctgggccaaattcgctgcctgctcagcgtcaggatgggcaaggaggaggagctactcatg atcaacgggctgggagacataatgaacaacaaggtattttaccagcaccccaacctcatg agagtcctcggcatgcatgagaccgtcatggaggtgatggtgaacgtgctgggtgcagaa aagttgcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaatcagccgacaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagtgttggcctagcttccccctccatgagaggatccaccccactggatgtggcc gcttcctccgtgatggacaacaatgagttagcgctgggcttagaggagccagacctcgag aaggtggtgacctacttggctggctgtggcctacagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgccccgagtgcttcggccccgccctgcggggtgaaggaggaaacggtctg ttggcggccatgcaaggcgccattaagatctctgagaacccagccctcgacctcccctca cagggctacaagagggaagtcacagaggacgatgatgatgaagaagagatcgtgcacatg ggcaatgcaatcatgtcattttattcggctcttatagacctgctgggccgctgtgctcct gagatgcaccttatccagacagggaagggagaagccatccggatcaggtccatcctgcgc tccctggttcccaccgaggacttggttggaatcatcagcatccccttgaaactgccttcc ctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccctgaccac aaggcgcccatggtactgttcttggaccgtgtgtatggcatcaaggatcaaacttttctg ctccacttgctggaagttggatttttacctgacttaagagcctctgcctctctagataca gtttccctaagcaccaccgaggctgcactggcactgaacaggtacatatgttctgctgtg ctcccactcctcacaagatgcgcccctctctttgccgggacagagcactacacttctttg attgactctacactgcagacaatatacaggctttccaaggggcgatccctcaccaaagct cagagggacaccatagaggagtgtttgctggccatttgcaatcacttgaggccttccatg ttacagcaactcctgcgacgtctagtttttgatgtgccccaactcaatgaatactgcaaa atgcctcttaagcttctgacgaatcactacgaacagtgctggaagtactattgtctgcct tcgggctgggggagctacggtctggccgtggaggaagagctacatctgacagagaagctc ttctgggggatttttgactccctctctcataagaggtatgacccagatctcttccggatg gccctgccctgtctcagtgcaatagcgggggccctgccaccagattatttagataccaga atctcagccacattggagaaacaggtctcagtggacacagatggcaactttgaccccaaa cctatcaacactgtgaatttctccttgcctgaaaaattggaatacattgtcaccaagtat gctgagcactcccatgatagatgggcctgtgacaagagtcagaatggatggaaatacgga atttcgctggatgaaaatgtgaagacccatccattgatccggcctttcaagacattaacc gagaaggagaaggacatttatcgctggcctgccagagagtccctgaaaaccatgctggct gtgggctggactgtagagaggaccaaagagggagaagctctggttcaacagcgggaaaat gagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgcccctctg gatctctccaatgtcgtgctctccagagagctccaggggatggtggaggtggtagctgag aactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggtggc agtcaccctcttttggtaccctatgataccttgactgccaaggaaaagttcagagaccga gagaaggcccaggacctgtttaaattcctccaagtgaatggcattgtggtttccagaggt atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagtttttg aagaaggttctgaaatatgttgattcggctcaagagtttattgcccatttggaagccatt gtcagcagtgggaaaaatgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccactggttgaccagtacttcatcaatcatcgcctgtacttcctgtcctcc cctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaactcgctgctctggttcgacacaggatttccctcttcgggagcgat tctacgacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacggtc atgaagtcaggctcagagctggtgaaagccgggttacgggcattctttgaaaatgcagcg gaagacttagagaaaactttggaaaacctgaagctcggcaagtttacccattccagaaca cagatcaaaggcgtctctcaaaatattaactacaccacggtggctctgctccccatcttg acatccatctttgagcacgtggctcagcatcagttcggggtggacttacttttgggtgat gtgcagctttcatgctaccatatactgtgcagcctctactccctcgggacaggaaagaac atctatgttgaaaggcagcgtcctgcccttggagaatgcctggcctcactggcagccgcc ataccagtggcattcctggagcccacccttaaccgctacaacccgctctccgtcttcaac accaaaacccccagggagaggtctattctggggatgccagacacagtggaggagatgtgc cctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtcaggg gcccggtacacagagatgccccacgtcattgaggtcatcttgcccatgctctgcaactac ctgtcctactggtgggagcgggggcccgagcacctgccccccagtgcagggccctggtgc accaaggtcacgtctgaacacctcagtgtcatcctgggcaacattctgaaaatcatcaac aacaacctgggcatcgacgaggcctcttggatgaagcgcattgcagtgtacgcccaaccg atcatcagcaaagccaggccagacctgctgagaagccacttcatcccgaccctggagaag ctgaagaagaaggccatcaaaactgtgcaggaggaggagcagctgagagctgacagcaag ggcgacacgcaggaggctgagctgctcatcctggacgagtttgctgtcctctgcagagac ctctatgccttctaccctatgctcatccgatacgtggacaacaacagatctaactggctc aaaagccccgatgcagattctgaccagctcttccgcatggtggcagagatcttcatcctg tggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggaggacag gaccaggagcggaagaagacaaagcgaaggggagacttttattccatccagacctccctc atcgtggctgcgctcaagaaaatgctgcccattggtctgaatatgtgcaccccaggcgat caggagctgatctccctcgcaaaatcacggtacagctataaggacacagatgaagaggtg aaggaacatctgcggaataacttgcacttgcaggaaaagtctgatgatccagctgtaaag tggcaactgaacctatacaaagatgttttaaagagtgaagaaccttccaacccagaaaag acagtggagcgtgtgcagagaatttcagcagctgtcttccacctagagcaggtggaacag cctttgaggtccaagaaggcggtctggcacaaactgctatcaaagcagcggaaacgggca gtggtggcctgtttcaggatggcccctctctacaacttgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggatttggctaaatctcccaaggtggaagaggaggaggaggaagaggtg gaaaagcagccagacccgcttcatcagatcatcctccactttagccgcaacgctctcacg gagaggagcaaactagaagacgaccctttgtacacctcctatgccagcatgatggccaag agctgtcagagtggggaagacgaagatgaggacgaagacaaggagaaaacatttgaagag aaagaaatggaaaagcagaaaaccctctatcagcaagcccggctgcatgagcgtggagcc gccgagatggtccttcagatgatcagcgccagcaaaggtgagatgagccccatggtggtg gaaactctgaagttggggatcgccattctgaatgggggcaatgccggtgtgcagcagaaa atgctagattacctaaaggagaaaaaggatgctgggttctttcaaagtctttctggtctt atgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggc ctggggatggttactgaggaaggaacactcattgttcgtgagcgtggtgaaaaagtactc cagaatgacgagtttacacgagatctctttagattcctgcagttactttgtgaaggacac aacagtgatttccagaacttcctgaggactcagatgggcaacaccaccacggtgaacgtc atcatcagtaccgtggactaccttctgcgtctgcaggaatcaatcagtgatttctactgg tattactcagggaaggacatcattgatgaatctggacagcacaatttttccaaagccctg gctgtcaccaagcagatcttcaattctcttacagaatacatccagggcccctgcattggg aaccagcagagcctggctcacagcaggctgtgggacgcggtggtcggcttcctccatgtg tttgctaacatgcagatgaaactctcccaggattccagtcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg gttaatggaaccattggcaagcagatggttgacacactggtagagtcatctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagac accttcaaagaatatgaccccgatgggaaaggaatcatttccaaaaaggaattccagaag gccatggaagggcaaaagcagtacacacagtcggagatagactttctcctttcatgcgca gaagctgatgaaaatgacatgtttaattacatcgattttgttgaccggttccatgagcca gccaaggacatagggtttaatgtggcagtgttattgacaaacctctctgagcacatgcca aacgattctcgccttaagtgtctgttggacccagcagaaagtgtactcaattacttcgaa ccatacctgggacgcattgagatcatgggtggggccaagaaaattgagcgtgtttatttt gagatcagcgagtccagtcgaactcagtgggagaagccccaggtgaaggagtctaagcga cagttcatctttgacgttgtcaatgaaggtggggagcaagagaagatggagctgttcgtg aacttctgtgaggacaccatctttgagatgcagttagcatcgcagatctcggaatctgac tcagccgacaggccagatgaggaggaggaagaaggtggagattcttcttatgtgttagaa gtggagggtgaggaggaggaggaggagaagtcctttgagtgtgcctctgcatttgccatg gcttgtggctcagtgaagagaaacgtggccaactttctgaagagggccaccctgaagaac ctcaggaagcagtacaggaaggtgaagaagatgaccttcaaggagctggtgaaggtgttc ttctctttcttctggacgttgttcatggggctcttccacttgctcttcactatagtggga ggaatcattcaggtcctctggagcacagtgttcggagggggactcatagaaggggcaaag aacataagagtcaccaagatcctgggtgacatgcctgacccaacccagtttggtatccac gatgatgctatggaagctgagagggcagaagtgcctgagccaggcatcgccacagaactc gtgcacttcgtaaaggggcagaagggagatgcagacatcatgtcagatctctttggactc cacccaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgacctctct gagattattggcaaggacgaaacccctaccttagagagtactgtccggaagaaaaggaaa gcacaggcagcagaaatgaaagcagctcatgaagcagaaagaaaaatagagtctgagaag gcagacatggaagatggggagaaagaggacacagccaaagaagaagagcaggccgaggcc ctgtgggcagacgtgaccaaaaggaagaagcgacggtgtggccagaaggttgagaagcct gaagccttcatggccaatttctttaaagggctggaaatctatcagaccaagttgctgcac tacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgctatc aacttcatcctgctcttttacaaggtcaccgaagaacctttagaagaagagacagaggat gttgcaaacctgtggaattcctttaatgacgaggaagaggaagaggcagtggtgttcttt gtcctgcaggagagcactgggtacatggcgccaaccctgcgggccctggccatcatccac accgtcatctctttagtctgcgtggtgggctactactgcctaaaggtccctttggtcgta ttcaaaagagaaaaagaaatcgccaggaagctggagtttgatggcctgtatatcactgaa cagccttctgaagatgacatcaaggggcagtgggatcgcttggtaatcaacacgccatct ttccctaataactactgggacaagtttgtaaagagaaaggtgatcaacaaatatggagat ctctatggagcagaacgcattgctgaactcctgggtttggacaaaaatgcccttgacttt agcccagtggaagagaccaaagcagaggcggcctccctggtgtcatggctaagttccatc gacatgaagtaccatgtctggaagctgggagttgtttttactgacaattcctttctctac ctcgcctggtacacgaccatgtcagtcctgggccactacaacaactttttcttcgcggct catcttctggatatcgcgatgggcttcaagactctgaggactattctgtcctctgtcact cacaatggcaaacagttggtcctgaccgttggtctcctggctgtggtggtttatctctat accgtggtggcattcaacttcttccgcaagttctacaacaaaagtgaagacgacgacgag cccgacatgaagtgtgatgacatgatgacgtgttacctgttccacatgtacgtgggagtg agagctggaggtggcattggtgatgaaattgaagaccctgctggggacccgtatgaaatg tatcgcatcgtttttgacattaccttcttcttcttcgtcattgtcatcctgctagccatc atccaaggtcttattattgatgcttttggggagctgagagaccagcaggaacaagtacga gaggatatggagactaaatgtttcatctgtgggattggcaatgactactttgacacaacg cctcatggttttgaaacacacaccctgcaagagcacaacttagccaactacctgttcttc ctcatgtatttgattaacaaagatgagacagagcacacgggacaggaatcttatgtctgg aagatgtaccaagaaaggtgctgggatttcttcccagctggtgactgcttccggaaacaa tacgaagatcagcttggataa

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