KEGG   Bos taurus (cow): 540421
Entry
540421            CDS       T01008                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04068  FoxO signaling pathway
bta04270  Vascular smooth muscle contraction
bta04650  Natural killer cell mediated cytotoxicity
bta04720  Long-term potentiation
bta04726  Serotonergic synapse
bta04730  Long-term depression
bta04810  Regulation of actin cytoskeleton
bta04910  Insulin signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04928  Parathyroid hormone synthesis, secretion and action
bta05010  Alzheimer disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05034  Alcoholism
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05212  Pancreatic cancer
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05218  Melanoma
bta05219  Bladder cancer
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    540421 (ARAF)
   04012 ErbB signaling pathway
    540421 (ARAF)
   04068 FoxO signaling pathway
    540421 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    540421 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    540421 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    540421 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    540421 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    540421 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    540421 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    540421 (ARAF)
   04720 Long-term potentiation
    540421 (ARAF)
   04730 Long-term depression
    540421 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    540421 (ARAF)
   05205 Proteoglycans in cancer
    540421 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    540421 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    540421 (ARAF)
   05212 Pancreatic cancer
    540421 (ARAF)
   05225 Hepatocellular carcinoma
    540421 (ARAF)
   05226 Gastric cancer
    540421 (ARAF)
   05214 Glioma
    540421 (ARAF)
   05221 Acute myeloid leukemia
    540421 (ARAF)
   05220 Chronic myeloid leukemia
    540421 (ARAF)
   05218 Melanoma
    540421 (ARAF)
   05211 Renal cell carcinoma
    540421 (ARAF)
   05219 Bladder cancer
    540421 (ARAF)
   05215 Prostate cancer
    540421 (ARAF)
   05213 Endometrial cancer
    540421 (ARAF)
   05224 Breast cancer
    540421 (ARAF)
   05223 Non-small cell lung cancer
    540421 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    540421 (ARAF)
   05160 Hepatitis C
    540421 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    540421 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    540421 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    540421 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    540421 (ARAF)
   01522 Endocrine resistance
    540421 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    540421 (ARAF)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     540421 (ARAF)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   540421 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 540421
NCBI-ProteinID: NP_001014964
BGD-bta: BT25852
Ensembl: ENSBTAG00000005039
VGNC: 26054
UniProt: Q5BIM4
LinkDB
Position
X:85918891..85929325
AA seq 606 aa
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRPLNEPL
TPQSPSSCTQHRDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLTGQNFN
TDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgctaacggggccgagccctcccggtcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtctatgactctctagacaaggcactcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtggaggtcctcgaagacgtccccctgaccatgcacaat
tttgtacggaagacgttcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacagcacgaggttccctcaaaccgccccctgaatgagccgctc
acccctcagagtcccagctcctgcacccagcaccgcgaccccgagcacttctccttccct
gcccaggccaacacccctctccagcgcatccgctccacatccacccccaatgtccacatg
gtcagcaccacagcccccatggactccggcctcatccagctcactggccagaatttcaac
actgatgctgctgggaatagaggtggtggtgatggagccccccgggggagccccagccca
gccagtgtgtcctcgggaaggaagtccccacattccaagtccccatcagagcagcgggaa
cggaagtcgttggctgatgacaagaagaaagtgaagaatttggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagttgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggtgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccaggatttgccatc
atcacacagtggtgtgagggctccagtctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcattgatgtggcccgccagactgctcagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctgcacgagggg
cttacggtgaagatcggggacttcggcctggctacagtaaagacgcggtggagtggggcc
cagcccttggagcaaccctcgggctctgtgctatggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcactgccttacagccacattggcagccgagaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaattgccccaag
gccatgaggcgcctgctgtctgactgcctgaagttccagcgggaggagcggccccttttt
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccttccttgcaccgtacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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