KEGG   Budorcas taxicolor (takin): 128045803
Entry
128045803         CDS       T08909                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
btax  Budorcas taxicolor (takin)
Pathway
btax00562  Inositol phosphate metabolism
btax01100  Metabolic pathways
btax01521  EGFR tyrosine kinase inhibitor resistance
btax01522  Endocrine resistance
btax01524  Platinum drug resistance
btax04012  ErbB signaling pathway
btax04014  Ras signaling pathway
btax04015  Rap1 signaling pathway
btax04024  cAMP signaling pathway
btax04062  Chemokine signaling pathway
btax04066  HIF-1 signaling pathway
btax04068  FoxO signaling pathway
btax04070  Phosphatidylinositol signaling system
btax04071  Sphingolipid signaling pathway
btax04072  Phospholipase D signaling pathway
btax04081  Hormone signaling
btax04140  Autophagy - animal
btax04150  mTOR signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04152  AMPK signaling pathway
btax04210  Apoptosis
btax04211  Longevity regulating pathway
btax04213  Longevity regulating pathway - multiple species
btax04218  Cellular senescence
btax04360  Axon guidance
btax04370  VEGF signaling pathway
btax04380  Osteoclast differentiation
btax04510  Focal adhesion
btax04550  Signaling pathways regulating pluripotency of stem cells
btax04611  Platelet activation
btax04613  Neutrophil extracellular trap formation
btax04620  Toll-like receptor signaling pathway
btax04625  C-type lectin receptor signaling pathway
btax04630  JAK-STAT signaling pathway
btax04650  Natural killer cell mediated cytotoxicity
btax04660  T cell receptor signaling pathway
btax04662  B cell receptor signaling pathway
btax04664  Fc epsilon RI signaling pathway
btax04666  Fc gamma R-mediated phagocytosis
btax04668  TNF signaling pathway
btax04670  Leukocyte transendothelial migration
btax04722  Neurotrophin signaling pathway
btax04725  Cholinergic synapse
btax04750  Inflammatory mediator regulation of TRP channels
btax04810  Regulation of actin cytoskeleton
btax04910  Insulin signaling pathway
btax04914  Progesterone-mediated oocyte maturation
btax04915  Estrogen signaling pathway
btax04917  Prolactin signaling pathway
btax04919  Thyroid hormone signaling pathway
btax04923  Regulation of lipolysis in adipocytes
btax04926  Relaxin signaling pathway
btax04929  GnRH secretion
btax04930  Type II diabetes mellitus
btax04931  Insulin resistance
btax04932  Non-alcoholic fatty liver disease
btax04933  AGE-RAGE signaling pathway in diabetic complications
btax04935  Growth hormone synthesis, secretion and action
btax04960  Aldosterone-regulated sodium reabsorption
btax04973  Carbohydrate digestion and absorption
btax05010  Alzheimer disease
btax05017  Spinocerebellar ataxia
btax05020  Prion disease
btax05100  Bacterial invasion of epithelial cells
btax05132  Salmonella infection
btax05135  Yersinia infection
btax05142  Chagas disease
btax05146  Amoebiasis
btax05160  Hepatitis C
btax05161  Hepatitis B
btax05162  Measles
btax05163  Human cytomegalovirus infection
btax05164  Influenza A
btax05165  Human papillomavirus infection
btax05166  Human T-cell leukemia virus 1 infection
btax05167  Kaposi sarcoma-associated herpesvirus infection
btax05168  Herpes simplex virus 1 infection
btax05169  Epstein-Barr virus infection
btax05170  Human immunodeficiency virus 1 infection
btax05171  Coronavirus disease - COVID-19
btax05200  Pathways in cancer
btax05203  Viral carcinogenesis
btax05205  Proteoglycans in cancer
btax05206  MicroRNAs in cancer
btax05207  Chemical carcinogenesis - receptor activation
btax05208  Chemical carcinogenesis - reactive oxygen species
btax05210  Colorectal cancer
btax05211  Renal cell carcinoma
btax05212  Pancreatic cancer
btax05213  Endometrial cancer
btax05214  Glioma
btax05215  Prostate cancer
btax05218  Melanoma
btax05220  Chronic myeloid leukemia
btax05221  Acute myeloid leukemia
btax05222  Small cell lung cancer
btax05223  Non-small cell lung cancer
btax05224  Breast cancer
btax05225  Hepatocellular carcinoma
btax05226  Gastric cancer
btax05230  Central carbon metabolism in cancer
btax05231  Choline metabolism in cancer
btax05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
btax05415  Diabetic cardiomyopathy
btax05417  Lipid and atherosclerosis
btax05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:btax00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    128045803 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    128045803 (PIK3CB)
   04014 Ras signaling pathway
    128045803 (PIK3CB)
   04015 Rap1 signaling pathway
    128045803 (PIK3CB)
   04370 VEGF signaling pathway
    128045803 (PIK3CB)
   04630 JAK-STAT signaling pathway
    128045803 (PIK3CB)
   04668 TNF signaling pathway
    128045803 (PIK3CB)
   04066 HIF-1 signaling pathway
    128045803 (PIK3CB)
   04068 FoxO signaling pathway
    128045803 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    128045803 (PIK3CB)
   04072 Phospholipase D signaling pathway
    128045803 (PIK3CB)
   04071 Sphingolipid signaling pathway
    128045803 (PIK3CB)
   04024 cAMP signaling pathway
    128045803 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    128045803 (PIK3CB)
   04152 AMPK signaling pathway
    128045803 (PIK3CB)
   04150 mTOR signaling pathway
    128045803 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    128045803 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    128045803 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    128045803 (PIK3CB)
   04218 Cellular senescence
    128045803 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    128045803 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    128045803 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    128045803 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    128045803 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    128045803 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    128045803 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    128045803 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    128045803 (PIK3CB)
   04660 T cell receptor signaling pathway
    128045803 (PIK3CB)
   04662 B cell receptor signaling pathway
    128045803 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    128045803 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    128045803 (PIK3CB)
   04670 Leukocyte transendothelial migration
    128045803 (PIK3CB)
   04062 Chemokine signaling pathway
    128045803 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    128045803 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    128045803 (PIK3CB)
   04929 GnRH secretion
    128045803 (PIK3CB)
   04915 Estrogen signaling pathway
    128045803 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    128045803 (PIK3CB)
   04917 Prolactin signaling pathway
    128045803 (PIK3CB)
   04926 Relaxin signaling pathway
    128045803 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    128045803 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    128045803 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    128045803 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    128045803 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    128045803 (PIK3CB)
   04722 Neurotrophin signaling pathway
    128045803 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    128045803 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    128045803 (PIK3CB)
   04380 Osteoclast differentiation
    128045803 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    128045803 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    128045803 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    128045803 (PIK3CB)
   05206 MicroRNAs in cancer
    128045803 (PIK3CB)
   05205 Proteoglycans in cancer
    128045803 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    128045803 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    128045803 (PIK3CB)
   05203 Viral carcinogenesis
    128045803 (PIK3CB)
   05230 Central carbon metabolism in cancer
    128045803 (PIK3CB)
   05231 Choline metabolism in cancer
    128045803 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    128045803 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    128045803 (PIK3CB)
   05212 Pancreatic cancer
    128045803 (PIK3CB)
   05225 Hepatocellular carcinoma
    128045803 (PIK3CB)
   05226 Gastric cancer
    128045803 (PIK3CB)
   05214 Glioma
    128045803 (PIK3CB)
   05221 Acute myeloid leukemia
    128045803 (PIK3CB)
   05220 Chronic myeloid leukemia
    128045803 (PIK3CB)
   05218 Melanoma
    128045803 (PIK3CB)
   05211 Renal cell carcinoma
    128045803 (PIK3CB)
   05215 Prostate cancer
    128045803 (PIK3CB)
   05213 Endometrial cancer
    128045803 (PIK3CB)
   05224 Breast cancer
    128045803 (PIK3CB)
   05222 Small cell lung cancer
    128045803 (PIK3CB)
   05223 Non-small cell lung cancer
    128045803 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    128045803 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    128045803 (PIK3CB)
   05161 Hepatitis B
    128045803 (PIK3CB)
   05160 Hepatitis C
    128045803 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    128045803 (PIK3CB)
   05164 Influenza A
    128045803 (PIK3CB)
   05162 Measles
    128045803 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    128045803 (PIK3CB)
   05163 Human cytomegalovirus infection
    128045803 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    128045803 (PIK3CB)
   05169 Epstein-Barr virus infection
    128045803 (PIK3CB)
   05165 Human papillomavirus infection
    128045803 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    128045803 (PIK3CB)
   05135 Yersinia infection
    128045803 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    128045803 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    128045803 (PIK3CB)
   05142 Chagas disease
    128045803 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    128045803 (PIK3CB)
   05017 Spinocerebellar ataxia
    128045803 (PIK3CB)
   05020 Prion disease
    128045803 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    128045803 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    128045803 (PIK3CB)
   05415 Diabetic cardiomyopathy
    128045803 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    128045803 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    128045803 (PIK3CB)
   04931 Insulin resistance
    128045803 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    128045803 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    128045803 (PIK3CB)
   01524 Platinum drug resistance
    128045803 (PIK3CB)
   01522 Endocrine resistance
    128045803 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:btax04131]
    128045803 (PIK3CB)
Enzymes [BR:btax01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     128045803 (PIK3CB)
Membrane trafficking [BR:btax04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    128045803 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 128045803
NCBI-ProteinID: XP_052494231
LinkDB
Position
1:194393761..194521847
AA seq 1070 aa
MCFYFMMPPAMADVLDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISCIKQMLW
KQVTNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKHTYPPEL
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
VSPYDCVLQVSGRVEYVFGDHSLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMVAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMTRLCFAVYAVLDKVKTKKSTKTM
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPHALPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALCDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttctacttcatgatgcctcctgctatggcagacgtccttgacatctgggcagtg
gactcacagatagcgtctgatggctccatacccgtggattttcttttgcccactgggatt
tatatccagttggaggtgcctcgtgaagctaccatttcttgtattaagcagatgttatgg
aaacaagttaccaattacccaatgtttaacctccttatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggaactcgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
cagtcgcttgtgggattatcttggatggattggctaaagcatacctatccacctgaactt
gaaccatccatccctgaaaatttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaggtatctcctaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtctaactattcatgggaaagaagatgaa
gttagcccttatgactgtgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cactcactaattcagttccagtatatccggaactgtgtgatgaacagaacattgccccat
tttatacttgtggaatgttgcaagatcaagaagctgtatgaacaggaaatggttgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaagga
aataaacttaacacagaagaaactgtaaaagttcatgtcagggccggcctttttcatggt
accgaactcctgtgtaaaactgttgtaagctcagagatatcagggaagaatgatcatatt
tggaatgaaccactggaatttgatatcaatacttgtgacctgccacgaatgactcgatta
tgttttgctgtttatgcagttttggataaagtgaaaactaagaaatcaactaaaaccatg
aatccctctaagtatcagaccatcaggaaatctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagatataatattacac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatacagaaaatgcaacagctttgcacataaaattcccagagaataaaaaa
caaccttattactatcctcccttcgataagattattgaaaaagcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtactgaaagaa
atcttggacagggatccattgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacacgcattgccgaaattgctgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
ctgcccccccgggaggcccttgagcttctagatttcaactatccagatcagtatgtgcga
gaatatgctgtgggctgcctgcaacagatgagtgatgaagaactctctcaatatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccttgtctagattccta
ctagaaagagcacttgctaatcggaggatagggcagtttttattttggcacctcagatct
gaagtacacattcctgctgtttcagtacaatttggtgttatccttgaagcgtactgccgg
ggaagcgtaggtcacatgaaagcgctttctaagcaggttgaagcactcaataaactaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaatagagccaaagggaaagaa
gcaatgcatacttgtctaaaacagaatgcttaccgtgaagccctctgtgacctgcagtca
cctctgaacccatgtgttatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggcttgtatacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacactccagatgctg
cgcttgatggatttactctggaaagaagctggtctggacctccggatgctaccttatggc
tgcttagcaacaggagaccgttctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgttgctgcagcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggag
tttaccctatcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acttatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgccggcatgggaatctcttc
atcacgctgtttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcag
ttcaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtcaattggatg
gcccacacagttcggaaagactacagatcttaa

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