Budorcas taxicolor (takin): 128048064 Help Entry 128048064         CDS       T08909                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism btax  Budorcas taxicolor (takin) Pathway btax04020   Calcium signaling pathway btax04024   cAMP signaling pathway btax04260   Cardiac muscle contraction btax04261   Adrenergic signaling in cardiomyocytes btax04371   Apelin signaling pathway btax04713   Circadian entrainment btax04911   Insulin secretion btax04921   Oxytocin signaling pathway btax04972   Pancreatic secretion btax05020   Prion disease btax05022   Pathways of neurodegeneration - multiple diseases btax05410   Hypertrophic cardiomyopathy btax05412   Arrhythmogenic right ventricular cardiomyopathy btax05414   Dilated cardiomyopathy btax05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:btax00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128048064 (RYR2)    04020 Calcium signaling pathway     128048064 (RYR2)    04024 cAMP signaling pathway     128048064 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     128048064 (RYR2)    04921 Oxytocin signaling pathway     128048064 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     128048064 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     128048064 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     128048064 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     128048064 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     128048064 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     128048064 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     128048064 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     128048064 (RYR2)    05414 Dilated cardiomyopathy     128048064 (RYR2)    05415 Diabetic cardiomyopathy     128048064 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:btax04040]     128048064 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:btax04990]     128048064 (RYR2) Ion channels [BR:btax04040]  Voltage-gated cation channels   Ryanodine receptor    128048064 (RYR2) Domain-containing proteins not elsewhere classified [BR:btax04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    128048064 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  128048064 NCBI-ProteinID:  XP_052496484 LinkDB All DBs Position 5:complement(34915927..35498915) Genome browser AA seq 4961 aa AA seqDB search MSGLLYVSHCDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICT FVLEQSLSVRALQEMLANTVEKSEGKVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYS GMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSV SSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHLDECLT VPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYL SLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHI NTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLF NRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQ NLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRK NCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGR NHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEG SAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYG FDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDG LFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTY TRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGP VRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEKVKKMKL PKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKN RRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFR IFRAEKTYAVKAGRWYFEFEAITAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWH QGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCS LGVAQVGRLNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHE HIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTAAGGIPGTS LFGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRGDKDKEATKPEFNNHKDYAQEKPSRLKQ RFLLRRTKPDYSTSHSARLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWI TSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGLE IGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPL SAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCVEPLQ FMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLL YAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNSEFIVPMTEETKSITLFPDEKKKH GLPGIGLSTSLRPRMQFSSPSFVSINTEGYQYSPEFPLDILKAKTIQMLTEAVKEGSLHA RDPVGGTTEFLFVPLIKLFYTLLIMGVFHDEDLKHVLQLIEPSVFKEAASPEEESEVAEK EPFVEDSKLEGAAEEENKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIV AFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSEC PCPEEIRDQLLDFHEDLMTHCGIELDEDRSLDGNNDLTIRGRLLSLVEKVTYLKKKQAEK PVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTY TINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLSA MEEAIKIAEDPSRDGPSPTTGSSRTPDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEM HLIHAAKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKA AMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQ HLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFW GIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPV DTSNITIPEKLEYFINKYAEHAHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEK EKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAI DMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKGGGNHPLLVPYDTLTAKEKAKDR EKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGG SRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTS LFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAE DLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDV QVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNT KSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVDLAESGIRYTQMPHVMEVILPMLCSYM SRWWEHGPENNPGRAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPI INKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKSEARGDMSEAELLILDEFTTLARDL YAFYPLLIRFVDYNRAKWLKEPNQEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEIN NMSFLIMDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQ ELIALAKNRFSLKDTEDEVRDIIRSNVHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEK TVERVLDIANVLFHLEQKSTCMRRRYYTQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMA PLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQ LILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLY QQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKD VGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLL CEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNF SKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIE LLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDL TSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKR FHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIE RVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQI SESDLNERSANKEESEKEKPEEQGPRMGFFSIMTVKSALFALRYNILTLMRMLSLKSLKK QVKKVKKMTVKDMITAFFTSYWSILMSLLHFVASVFRGFSRIIGSLLLGGSLVEGAKKIK VAELLANMPDPTQDEVRGDGEEGERKTLEGALPSEDLTDLKELTEESDLLSDIFGLDLKR EGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKANEEEKEEKEESKSEPEKAEGED GEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLA LFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENARVSSLDSSSPRIIAVHYVLEESSG YMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDI KGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKK KPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDI AMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKC DDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLI NKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14886 nt NT seq  +upstreamnt  +downstreamnt atgtcgggccttttgtatgtcagtcactgtgatgatgaagtggtcctacagtgtaccgca accatccacaaagaacaacagaaactgtgtttggcggcagaaggatttggcaacagactt tgcttcttggagtccacttcgaattccaagaatgtccctccagacctctccatctgcacc ttcgtgctggagcagtccttgtctgtccgggccctgcaggagatgctggctaacactgtg gaaaagtctgaagggaaggttgatgtggaaaaatggaaattcatgatgaagactgctcaa ggtggtggccaccgaacgctcctctacggtcatgcaatactgctgcggcattcctacagt ggcatgtatctgtgctgcctgtccacctctcggtcttcaactgataagctggcttttgat gttggcttgcaagaggatacaacaggtgaagcttgttggtggaccatccatcctgcctct aagcagcgctcagaaggagaaaaagtgcgggttggagatgacctcatcttagtgagcgtg tcctctgaaaggtacctgcacttgtcttacggtaacggcagcttgcacgtggatgctgct ttccagcagaccctctggagcgtggcgcccatcagctcaggaagtgaagcagcccaaggg tatctgattggtggtgacgtcctcaggttgctgcatggacacttggatgaatgcctcact gtcccttcaggagaacacggtgaagagcagcggagaactgttcattacgaaggtggtgct gtatcggttcacgcacgttccctgtggcgactagagacactaagagttgcgtggagtgga agccacataaggtggggacaaccttttcgactacgccatgtcacaacgggaaaatacttg agtctcatggaagacaaaagccttctactcatggacaaagaaaaagctgatgtcaaatca actgcatttacgttccgatcttccaaggaaaaattggatgtaggagtgagaaaagaagtt gatggcatgggaacctctgaaataaaatatggagactcggtatgttatatacagcatatc aatacaggcttgtggctcacttaccagtctgtggatgtgaaatcggtgagaatgggatcc atacaacgtaaggctattatgcatcatgaaggacacatggatgatggcctaaatttatcc agatctcagcatgaagaatcacggacagcacgtgtcatccggagcacagtcttccttttt aatagatttattaggggccttgatgctctcagcaaaaaggtgaaggcttccacagtagac ttacctatagagtctgtaagtctgagtctgcaggaccttattggctacttccacccacca gatgagcatttagagcatgaagataagcagaacagattacgagctctgaagaataggcag aatctcttccaggaagagggaatgatcaaccttgtgctcgagtgtatagacaggctgcat gtgtatagcagtgctgcacacttcgctgatgttgctgggagagaagcaggggaatcttgg aaatcgatactgaattctctgtatgagttgctggcggcattaattagaggaaatcgtaaa aactgtgctcaattctctggctcgcttgactggttaatcagccgactggaaagactggaa gcttcttctggtattcttgaagttttacactgtgtgttagtagaaagtccggaagctcta aacattattaaagaaggccatataaaatccattatctcacttttagacaagcatggaaga aatcacaaggttctggatgtcctatgctctctctgtgtttgccatggagtagcagtccgt tctaaccagcatctcatctgtgacaatcttctgccaggaagagacctgttattgcagaca cgccttgtgaaccatgtgagcagcatgagacccaatatttttctgggtgtcagtgaagga tctgcacagtataagaagtggtattatgagttgatggtggaccacactgagccattcgtg actgctgaagccactcacctgcgagtgggttgggcttccacagaggggtactcaccctac cctggagggggtgaagagtggggtggaaatggtgtcggagatgacctcttctcctacgga tttgatggccttcacctctggtcaggttgtattgcccggactgtcagctcaccaaaccag catctcttgagaactgatgatgtcatcagttgctgtttagatctaagtgccccaagcatc tccttccgaattaatggacaacctgttcaaggcatgtttgagaatttcaacattgatggc ctcttctttccggttgtcagtttctctgcaggaatcaaagtacgctttctgcttgggggg agacatggagaatttaaattccttcctccgcctgggtatgctccttgttatgaagctgtt ctgccaaaagagaagttgaaagtggagcacagccgagagtacaagcaagaaaggacttac acgcgggacctcctgggccccacggtttccctgacacaagctgccttcacaccaatccca gtggacaccagccagattgtgttgcctccccacctggagaggatacgagaaaaactggca gagaatatccatgagctctgggtgatgaataaaattgaacttggctggcagtatggtccg gttagagacgacaataagagacagcacccgtgtctggtggagttctccaagctgcctgaa caggaacgcaattacaatttacagatgtcactcgagaccctgaagacattgttggcttta ggatgtcatgtgggtatatcagatgaacacgctgaagaaaaggtgaagaaaatgaagctg ccaaagaattaccaactgacaagcggatacaagcctgccccgatggacctgagctttatc aaactcaccccgtctcaggaggctatggtggacaagttggcggaaaacgctcataacgtg tgggctcgggatcgaattcgacagggctggacctacggcatccaacaggatgtaaagaac agaagaaaccctcggcttgttccctatgcccttctagatgaccgaactaagaaatccaat aaggatagcctccgtgaggctgtacgcacactgctgggatatggctacaacctggaggca cctgatcaagatcatgctgccagagctgaagtgtgcagcggcacaggagagaggttccgc atcttccgtgctgagaaaacgtatgctgtgaaggctggaaggtggtattttgaattcgag gcgatcactgctggagacatgcgagttggctggagcaggccagggtgtcaacctgatcag gagcttggctcagatgaacgtgcctttgcttttgatggcttcaaggcccagcggtggcac cagggcaatgagcactatgggcgctcctggcaagctggcgatgttgtggggtgtatggtt gacatgacagaacacaccatgatgttcacactgaatggcgaaatccttcttgatgattca ggttcagaactggctttcaaggactttgatgttggtgacggattcatacctgtgtgtagc ctgggagtggctcaagtgggcaggctgaactttggaaaggatgtcagcaccttgaaatat ttcaccatctgtggcttacaagagggctatgagccatttgccgttaacacaaatagggat attaccatgtggctgagcaagaggcttcctcaatttcttcaagttccatcaaaccatgaa catattgaggtgaccagaatagatggcaccatagacagttccccatgtttaaaagtcact cagaagtcctttggctctcagaacagcagcacggatatcatgttttatcgtctgagcatg cccatcgagtgtgcagaggtcttctccaagactgcagctggagggatccctggcaccagc ctctttgggcccaagaatgatctggaggattatgatgtggattcagactttgaggttctc atgaagacagctcacggccatctggtgccagatcgaggagacaaagacaaagaagctaca aaaccagagtttaataaccacaaagattatgctcaggaaaaaccctctcgtctgaaacag aggtttttgcttcgaagaacaaagccagattatagcaccagccattctgcaagactcact gaagatgtccttgcagatgagagggatgactatgattacttgatgcaaacgtccacgtac tattactcagtgagaatctttcctggacaagaacctgccaatgtctgggtgggctggatc acatccgatttccatcagtatgatacaggctttgacttggacagagttcgtacagtgacc gtgactctgggagatgaaaaaggaaaggtgcacgaaagcatcaaacgcagcaattgctac atggtgtgtgcgggtgagagcctgagcccggggcaaggacgcaacaacaatggcctggag attggctgcgtggtggatgctgccagtgggctgctcaccttcacggccaacggcaaggaa ctgagcacctattatcaggtggaaccaagcacaaaattatttcctgcagtttttgcacaa gctacaagtcccaatgtttttcagtttgagttgggaagaataaagaatgtgatgcctctc tcagcgggattattcaagagtgagcacaaaaatcctgtaccacagtgtcccccacgtctc catgtgcagtttctctcacatgtcctgtggagcagaatgcccaaccagttcttgaaggta gatgtctctcgaataagtgaacgccagggctggctggtgcagtgcgtggagcctctgcag ttcatgtcacttcatatcccagaggagaacagatctgtggacatactggaactgacagag caggaggaactgctgaaattccactaccacactctccggctctactcggcagtctgcgcg ctcgggaaccaccgggtggcccacgccttgtgcagccacgtggacgagccgcagctgctc tacgccatcgagaacaagtacatgcccggcttgctgcgcgccggctactacgacctgctg attgacatccacctcagctcctacgccaccgccaggctcatgatgaacagtgagttcatc gtccccatgaccgaggagacaaagagcatcaccctcttcccggatgagaagaaaaagcac gggctcccgggcatcggcctcagcacctccctcaggccgcggatgcagttttcctccccg agttttgtcagcattaataccgagggttaccagtatagcccggagttcccactggacatc ctgaaggccaagaccatacagatgctgacagaagccgtgaaagagggcagccttcacgcc cgagaccccgttgggggcaccactgagttcctcttcgtgcctctcatcaagctgttctat accctgctcatcatgggtgtcttccacgacgaggacttgaaacacgtcttgcagttgatt gagcctagtgtgttcaaggaagccgccagccccgaggaggagagcgaggtggcggagaag gaaccctttgtggaagactccaagctggaaggagccgctgaagaagaaaacaaagggggt aagaggcccaaggagggcctgctccaaatgaaactgccagagccagtaaaattgcagatg tgcctgctacttcaatacctctgtgactgccaggtccggcaccggatagaagccattgtg gccttttcagatgactttgtagccaagctccaagacaatcaacgattccgatataatgaa gttatgcaagccttaaacatgtcagctgcactcacagccaggaaaacaaaggaattcaga tccccgcctcaagaacagatcaatatgcttctcaattttaaggatgacaaaagtgaatgt ccatgtcctgaagaaatccgagaccaactcttggattttcacgaagatttgatgacacat tgtggaattgagctggatgaagataggtctctggacggaaacaacgatttaactattaga ggacgcctgctgtccttggtagaaaaggtgacatacctgaagaagaagcaagctgaaaag ccagttgagagtgactccaagaagtcatccactcttcagcagttgatttctgagaccatg gtccgatgggctcaagagtctgtaattgaagaccctgagttggtgagggccatgtttgta ttgctccatcgacagtatgatggcattgggggtctggtacgggctctgccaaagacctac actataaatggtgtttccgtggaggataccatcaatctgctggcatctcttggtcagatt cgttctctgctaagtgtgagaatgggcaaagaggaagagaaacttatgattcgtggattg ggggatatcatgaacaataaagtgttttaccagcatcctaatctcatgagggcgcttggg atgcacgagacagtgatggaggtcatggtgaatgtccttggaggcggagagtccaaggaa atcacttttccgaagatggtggccaactgttgccgttttctctgttacttctgtcgtata agtaggcagaatcagaaagctatgtttgatcatctcagttatttactggaaaacagcagt gttggtcttgcctcaccagctatgagaggttcaacaccactggatgtggcagcagcctcg gtgatggataataatgaactggctttagctttgcgggagccagatctggaaaaggtggtt cgatatttggctggttgtggactgcagagttgccagatgctagtgtcaaagggttatcca gacattggttggaatccagttgaaggagagagatatcttgactttctcagatttgctgtc ttctgtaatggggaaagcgtggaggagaacgcaaatgtcgtggtgagactgctcatccgg aggcctgagtgtttcggtcccgccctgaggggggaaggtgggaatggcctgctctcagcc atggaagaagccataaaaatagctgaggatccctctagagatggtccctcaccaactacc ggatccagcaggacccctgatacagaagaggaagaggatgataccatccacatgggaaat gccatcatgaccttttatgcagctttgattgacctgttaggacgctgtgctcctgaaatg catttgattcatgctgccaaaggagaagccatcagaatcaggtctattttgagatctctg attccattgggagatttggtgggagtaatcagcattgcttttcagatgcccacaatagcc aaagatgggaatgtggtggagcctgacatgtctgcagggttttgtccagatcacaaggca gccatggttttgttccttgacagggtctatggaattgaggttcaagatttcctcctccat cttctcgaggttggctttctgccagatctccgggctgctgcttctttagacacggctgct ttgagtgctacagacatggccctggccctcaatcgctacctgtgcacagccgtgttaccc ttgttaacaaggtgtgctcctctttttgctggcaccgagcaccatgcttctctcattgac tcattacttcacactgtgtacaggctttctaagggctgctcacttaccaaagctcaacgg gattccatagaagtgtgtttactctctatttgtggccaattgagaccttctatgatgcaa cacttactcagaagattagtatttgatgtcccattattaaatgaacatgcaaagatgcct cttaagctgctgacaaatcattatgaaagatgctggaaatattactgcctgcctggaggg tggggcaactttggagctgcctcagaagaagaacttcatttatcaagaaagctgttctgg ggcatctttgatgctctgtctcaaaagaaatatgaacaagaacttttcaaactggcactg ccttgcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtc agtatgatggaaaaacagtcatcaatggattctgaagggaactttaatccacaacctgtt gatacctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcagaa catgcacatgacaagtggtcaatggataagttggcaaatggatggatttatggagaaata tattcagactcatctaaagttcaaccattaatgaagccatataaactattatctgaaaag gaaaaagaaatttatcgctggccaatcaaagaatctttaaaaactatgctggcttgggga tggagaattgaaaggacccgagagggagacagcatggccctttataaccgtactcgtcgt atttctcagacaagtcaggtttccgtagatgccgcccatgggtacagcccacgagccatt gacatgagcaatgtcacactctccagagatctgcacgccatggcagaaatgatggctgaa aactaccataatatatgggcaaagaaaaagaaactggaactggaggccaaaggaggtgga aaccatcccctgctggtaccttatgatacgctgacggccaaagagaaagccaaggatagg gaaaaagcacaggacatcctcaagttcctgcagatcaatggctatgctgtgtccagaggg ttcaaagacctggaactggatacaccttctattgagaaacgatttgcctatagtttcctt cagcaactcattcgctatgtagatgaggcccatcagtatatcctggagtttgatggtggc agcagaagcaaaggagaacatttcccttatgaacaagaaatcaagttctttgctaaagtc gttcttcctttaattgatcaatatttcaaaaaccaccgtttatacttcttatctgcagca agcagacctctctgttctggaggacatgcatcaaacaaagagaaagaaatggtgactagc ctattctgcaaacttggagttcttgtcaggcataggatttcactatttgggaatgatgca acatcaattgtcaactgtcttcatattttgggtcagactttggatgcaaggactgtgatg aagactggcctggagagtgttaaaagtgcgctcagagccttcctggacaatgccgcagag gatctggagaagacgatggagaatcttaagcagggccagttcacccacacccgaaaccaa cccaaaggtgttactcagattatcaattataccacggtggcactgttgccaatgctgtca tcattatttgagcatattggccagcatcaattcggagaagatctaatattggaagatgta caggtgtcatgttatagaattctgactagcttgtatgctttgggaaccagcaagagtatt tatgtggaaaggcaacgttctgcattgggagaatgtctggctgcttttgctggtgccttt cctgtagcatttttggaaactcacctggacaagcacaatatttactccatctacaataca aagtcttcgagagagagagcagctcttaatttgcctactaacgtggaagatgtttgtcca aatataccgtctttggagaagctcatggaagaaattgtggacttggctgagtccggtatt cgctacacacagatgccacacgtgatggaagttatcctgcccatgctttgtagctacatg tctcgttggtgggagcatggacctgagaataatccaggaagggctgagatgtgctgtact gctctgaactcagagcacatgaacacactgctgggcaatatcctgaaaatcatatataat aacttgggtattgatgagggagcctggatgaagaggttagcagtgttttcccagcctatt ataaataaagtgaaacctcagcttttgaaaactcatttcttgccattaatggagaagctc aagaaaaaggcagcgatggtggtatcagaagaggaccatctgaaatctgaggccagggga gatatgtctgaagccgaacttctcatcctagatgagttcaccaccctggccagagatctc tatgccttctatccactcctgattagatttgtggactataacagggcaaagtggctgaaa gagcctaaccaagaagcagaagatcttttccgcatggttgctgaggtgtttatctactgg tcaaaatcccataatttcaaaagggaggaacagaacttcgtggtgcagaatgaaatcaac aatatgtctttccttattatggacaccaaatcaaagatgtcaaaggcagctgtttctgat caggaaaggaagaaaatgaagcgcaaaggggaccgatattccatgcagacatctcttatt gtggctgctctgaagcggttactgcccattgggttgaacatctgtgcccctggggaccag gagctcattgctctggccaaaaatcgctttagtctgaaagacactgaggatgaagttcga gatataatccgcagtaatgttcacttacaaggcaagttggaggatcctgctattagatgg caaatggctctttacaaagacttacccaataggacagaagacacttcagatcctgagaag acagtggaaagggtcttggatatagcaaatgtactttttcatcttgaacagaaatctaca tgtatgcgccggagatattacactcaggttgagcatcctcagagatcgaaaaaggccgtg tggcacaaactgctctccaagcagaggaaacgtgccgtggttgcctgcttccggatggct cctttatataatctgccgaggcatcgggctgtcaatctctttcttcagggatatgaaaag tcttggattgaaacagaagaacattactttgaagataaattgatagaagacttagcgaaa cctggagcagaacctccagaagaagatgaaggaactaagagggttgatcctcttcatcag ctgatccttctgtttagtcgaacagctttaacggagaaatgcaaactggaggaagatttt ttatatatggcttatgcagatattatggcaaagagttgtcatgatgaggaagatgatgat ggggaagaggaagtgaagagttttgaagaaaaagaaatggaaaagcaaaagcttctatac caacaagccaggctgcacgaccgcggtgctgctgagatggtgctgcagaccatcagtgcc agcaaaggtgaaactggacccatggtggctgctactttgaaacttggaattgctatctta aatggaggaaactctacagtacagcagaaaatgcttgactacctcaaggagaaaaaggac gtgggcttctttcagagcctggctggcctgatgcagtcctgcagcgtcctcgacctaaat gcatttgagcggcaaaacaaagctgaaggacttgggatggtgactgaggaaggatcagga gaaaaggttctgcaggatgacgaattcacctgtgacctcttccgcttcttgcaactgctt tgtgagggacacaactcagattttcaaaattatctgagaactcagactggcaataataca actgtcaacataatcatctctactgtagactaccttctgagagttcaggaatcaattagt gatttctattggtattactctgggaaagatgtcattgatgaacaaggacaaaggaatttc tccaaagctattcaagtggcaaaacaagtctttaacactcttacagagtacattcagggt ccttgcactggcaaccagcagagtttggctcacagcaggctctgggatgctgtggtgggt tttcttcacgtatttgcccacatgcagatgaagctgtctcaggactccagtcaaattgag ctactaaaagaattgatggatcttcagaaggacatggtggtcatgttgctgtccatgttg gaaggcaatgttgttaatggcaccattggcaaacagatggttgatatgctcgtggaatct tccaacaacgtggagatgattctcaagttttttgacatgttcttaaagctcaaggatttg acatcttctgatactttcaaagagtatgaccccgatggtaagggagttatttccaagagg gactttcacaaagccatggagagccataaacactacacccagtccgagactgagtttctc ctgtcctgtgcagagacagatgaaaatgaaaccctggactatgaagaatttgtcaaacgg ttccacgagcctgccaaggacattggcttcaacgtggcagtgcttctgacaaacctctcc gaacacatgcccaatgacacccggctgcagacttttctggaattggccgagagcgtgctc aattacttccagcccttcctgggccgcatcgagatcatgggcagtgccaagcgcatcgag agggtgtattttgaaatcagtgagtccagccgaacccagtgggagaagccccaggtcaag gaatccaaaaggcaatttatatttgacgtggtcaatgaagggggagagaaagagaagatg gagctcttcgtgaacttctgcgaggataccatctttgagatgcagctggcggctcagata tcagagtcagatctgaatgagaggtcagcgaataaagaggagagtgagaaggagaagccg gaggagcagggtccgaggatgggtttcttttccatcatgacggtcaagtccgccctgttt gccctcaggtacaatatcttgacccttatgcggatgctcagcctgaaaagcttgaagaag caggtgaagaaggtgaagaagatgacagtgaaggacatgatcacagccttctttacatcc tactggagtattttgatgagcctcctgcactttgtagccagcgttttcagaggcttctct cgcatcatcggcagcctcctgctgggaggaagcctggtcgaaggtgcaaagaagatcaaa gtggcggagctcttggccaacatgccagaccccacgcaagatgaggttcgaggagacggg gaggagggggagaggaaaaccctggaaggggccctgccctctgaagatctgacggacttg aaggaactgacagaggagagtgacctgctttccgatatctttggcttggacctgaagcga gaaggggggcagtacaaactgattcctcacaatcccaatgctggcctgagtgacctcatg agcaaccccgtccctatcccagaggtgcaagaaaagttccaggaacagaaggcaaacgaa gaagaaaaggaagaaaaagaagaaagcaaatccgaacccgagaaagctgaaggagaagac ggagaaaaagaagaaaaagccaaagaagacaagggtaaacaaaagctgagacagctccac acacacagatacggagagccagaagttcctgagtcagcattctggaagaaaatcatagcc tatcaacagaaacttctaaactattttgctcgcaacttctacaatatgagaatgttagcc ttatttgtcgcatttgccatcaatttcatcttgctcttttataaggtctccacttcttct gtggttgaaggaaaggaactacccactcgcagttcaagtgaaaatgccagagttagcagc ttggacagcagctcgcctagaatcatcgcagtgcactatgtgctggaggagagcagtggc tacatggagcccacactgcggatattagccattctgcacacggtcatctctttcttctgc atcattggatactactgcttgaaagtcccactggttatttttaagcgagaaaaggaagta gctcgaaaattggaatttgatgggctttatattacagaacagccttcagaagatgatatt aaaggccagtgggatagactcgtaatcaacacacagtcatttcccaacaactactgggac aaatttgttaaaagaaaggttatggataaatatggagagttctatggccgagacagaatc agcgagttacttggcatggacaaagctgccttggacttcagtgatgcccgggaaaagaag aaaccaaagaaagacagctccttgtcagctgtactgaactctattgatgtgaagtatcag atgtggaaactaggagtcgttttcactgacaactccttcctctaccttgcctggtatatg accatgtccattcttggacactacaacaactttttttttgctgctcatcttctggacatt gctatgggattcaagacgttaagaaccatcttgtcatcggtaactcacaatggcaaacag cttgtattaactgttggcttattggctgttgttgtatacctatatactgtcgtggcattc aattttttccgaaaattctacaataaaagtgaagatggcgatacaccagacatgaagtgt gatgacatgctaacgtgctatatgtttcacatgtatgttggagtacgtgccggagggggt atcggtgatgaaattgaagatccagcaggtgatgagtatgagatatatcgaatcatcttt gacatcaccttcttcttttttgtaattgtcattctcttggccataatacaaggtttaatc atcgatgcttttggggaactaagagaccaacaggaacaggtcaaagaagacatggagacc aagtgcttcatctgtgggataggcaatgattactttgacactgtgccacatggctttgaa acccacactttacaggaacacaacttggccaattatctgttttttctgatgtatctcata aacaaagatgaaacggagcacacaggacaggaatcttatgtttggaagatgtatcaagaa aggtgctgggaatttttcccagccggagactgtttccggaaacagtatgaagaccagcta aattaa

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