KEGG   Budorcas taxicolor (takin): 128048391
Entry
128048391         CDS       T08909                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
btax  Budorcas taxicolor (takin)
Pathway
btax01522  Endocrine resistance
btax04010  MAPK signaling pathway
btax04015  Rap1 signaling pathway
btax04068  FoxO signaling pathway
btax04071  Sphingolipid signaling pathway
btax04114  Oocyte meiosis
btax04148  Efferocytosis
btax04218  Cellular senescence
btax04261  Adrenergic signaling in cardiomyocytes
btax04370  VEGF signaling pathway
btax04380  Osteoclast differentiation
btax04550  Signaling pathways regulating pluripotency of stem cells
btax04611  Platelet activation
btax04613  Neutrophil extracellular trap formation
btax04620  Toll-like receptor signaling pathway
btax04621  NOD-like receptor signaling pathway
btax04622  RIG-I-like receptor signaling pathway
btax04625  C-type lectin receptor signaling pathway
btax04657  IL-17 signaling pathway
btax04658  Th1 and Th2 cell differentiation
btax04659  Th17 cell differentiation
btax04660  T cell receptor signaling pathway
btax04664  Fc epsilon RI signaling pathway
btax04668  TNF signaling pathway
btax04670  Leukocyte transendothelial migration
btax04714  Thermogenesis
btax04722  Neurotrophin signaling pathway
btax04723  Retrograde endocannabinoid signaling
btax04728  Dopaminergic synapse
btax04750  Inflammatory mediator regulation of TRP channels
btax04912  GnRH signaling pathway
btax04914  Progesterone-mediated oocyte maturation
btax04917  Prolactin signaling pathway
btax04926  Relaxin signaling pathway
btax04932  Non-alcoholic fatty liver disease
btax04933  AGE-RAGE signaling pathway in diabetic complications
btax04935  Growth hormone synthesis, secretion and action
btax04936  Alcoholic liver disease
btax05014  Amyotrophic lateral sclerosis
btax05020  Prion disease
btax05022  Pathways of neurodegeneration - multiple diseases
btax05132  Salmonella infection
btax05133  Pertussis
btax05135  Yersinia infection
btax05140  Leishmaniasis
btax05142  Chagas disease
btax05145  Toxoplasmosis
btax05152  Tuberculosis
btax05161  Hepatitis B
btax05163  Human cytomegalovirus infection
btax05167  Kaposi sarcoma-associated herpesvirus infection
btax05169  Epstein-Barr virus infection
btax05170  Human immunodeficiency virus 1 infection
btax05171  Coronavirus disease - COVID-19
btax05205  Proteoglycans in cancer
btax05208  Chemical carcinogenesis - reactive oxygen species
btax05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
btax05415  Diabetic cardiomyopathy
btax05417  Lipid and atherosclerosis
btax05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:btax00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    128048391 (MAPK12)
   04015 Rap1 signaling pathway
    128048391 (MAPK12)
   04370 VEGF signaling pathway
    128048391 (MAPK12)
   04668 TNF signaling pathway
    128048391 (MAPK12)
   04068 FoxO signaling pathway
    128048391 (MAPK12)
   04071 Sphingolipid signaling pathway
    128048391 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    128048391 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    128048391 (MAPK12)
   04218 Cellular senescence
    128048391 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    128048391 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    128048391 (MAPK12)
   04613 Neutrophil extracellular trap formation
    128048391 (MAPK12)
   04620 Toll-like receptor signaling pathway
    128048391 (MAPK12)
   04621 NOD-like receptor signaling pathway
    128048391 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    128048391 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    128048391 (MAPK12)
   04660 T cell receptor signaling pathway
    128048391 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    128048391 (MAPK12)
   04659 Th17 cell differentiation
    128048391 (MAPK12)
   04657 IL-17 signaling pathway
    128048391 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    128048391 (MAPK12)
   04670 Leukocyte transendothelial migration
    128048391 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    128048391 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    128048391 (MAPK12)
   04917 Prolactin signaling pathway
    128048391 (MAPK12)
   04926 Relaxin signaling pathway
    128048391 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    128048391 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    128048391 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    128048391 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    128048391 (MAPK12)
   04722 Neurotrophin signaling pathway
    128048391 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    128048391 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    128048391 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    128048391 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    128048391 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    128048391 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    128048391 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    128048391 (MAPK12)
   05161 Hepatitis B
    128048391 (MAPK12)
   05171 Coronavirus disease - COVID-19
    128048391 (MAPK12)
   05163 Human cytomegalovirus infection
    128048391 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    128048391 (MAPK12)
   05169 Epstein-Barr virus infection
    128048391 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    128048391 (MAPK12)
   05135 Yersinia infection
    128048391 (MAPK12)
   05133 Pertussis
    128048391 (MAPK12)
   05152 Tuberculosis
    128048391 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    128048391 (MAPK12)
   05140 Leishmaniasis
    128048391 (MAPK12)
   05142 Chagas disease
    128048391 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    128048391 (MAPK12)
   05020 Prion disease
    128048391 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    128048391 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    128048391 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    128048391 (MAPK12)
   05415 Diabetic cardiomyopathy
    128048391 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    128048391 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    128048391 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    128048391 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    128048391 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:btax01001]
    128048391 (MAPK12)
Enzymes [BR:btax01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     128048391 (MAPK12)
Protein kinases [BR:btax01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   128048391 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 128048391
NCBI-ProteinID: XP_052496731
LinkDB
Position
5:complement(163246538..163254503)
AA seq 367 aa
MSSPSPARKGFYRQEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRVQFLVYQTLKGLKYIHAAGVIHRDLKPSNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASVLTNASPLAVSLLEKMLVLDAEQRV
TAAEALAHPYFESLHDTEDEPQAQKYDESFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAK
ASKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctccccgtcgcccgcccgcaagggcttttatcgccaggaggtgaccaagacggcc
tgggaggtgcgcgtcgtgtaccaggatctgcagcccgtgggctccggcgcctacggcgcc
gtgtgctcggcggtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
ccctttcagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctgaagcac
atgcgccacgagaacgtgattgggctgctggacgtgttcacgcccgacgagacactggat
gacttcacggacttctacctggtgatgccgttcatgggcaccgacctgggaaagctcatg
aagcacgagaagctgagtgaagaccgggtgcagttcctcgtctaccagacgctcaagggg
ctgaagtacatccacgctgccggcgtcatccatagggacctgaagcccagcaacctggct
gtgaacgaggactgtgagctgaagatcctggacttcggcctggcccggcaggcagacagc
gagatgaccggctacgtggtgacccggtggtaccgcgcgcccgaggtcatcttgaactgg
atgcgctacacgcagacggtggacatctggtccgtgggctgcatcatggctgagatgatc
acagggaagacgctcttcaaaggcaacgaccacctggaccagctgaaggagatcatgaag
gtgacagggacgcctcccgcggagtttgtgcagaggctgcaaagtgacgaggccaagaac
tacatgaagggccttcctgagctggagaagaaggattttgcctccgtcctgaccaacgcg
agccccctggccgtgagcctcctggagaaaatgctggtactggacgcagagcagcgggtg
acggcggccgaggcgctggcccatccctactttgagtcactgcacgacacggaggacgag
ccccaggcccagaagtacgatgagtcctttgacgatgtggaccgcacgctggacgagtgg
aagcgtgtcacatataaagaggtgctcagcttcaagcctccccggcagctgggggccaag
gcctccaaggagacagccttgtga

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