Budorcas taxicolor (takin): 128048807
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Entry
128048807 CDS
T08909
Symbol
KMT2D
Name
(RefSeq) histone-lysine N-methyltransferase 2D isoform X1
KO
K09187
[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:
2.1.1.354
]
Organism
btax
Budorcas taxicolor (takin)
Pathway
btax00310
Lysine degradation
btax01100
Metabolic pathways
btax04934
Cushing syndrome
Brite
KEGG Orthology (KO) [BR:
btax00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
128048807 (KMT2D)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
128048807 (KMT2D)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
btax03036
]
128048807 (KMT2D)
Enzymes [BR:
btax01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
128048807 (KMT2D)
Chromosome and associated proteins [BR:
btax03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
128048807 (KMT2D)
HMT complexes
MLL-HCF complex
128048807 (KMT2D)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PHD
SET
FYRC
FYRN
zf-HC5HC2H
zf-HC5HC2H_2
PHDvar_NSD
PHD_NSD
HMG_box
Motif
Other DBs
NCBI-GeneID:
128048807
NCBI-ProteinID:
XP_052497199
LinkDB
All DBs
Position
5:75580500..75620025
Genome browser
AA seq
5619 aa
AA seq
DB search
MDSPKPPGEDKDSEPAADGPAASEESGATEPDLPKPHVGEVSVPSSGGPRLQEPPQDCSG
GPVRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPNEGALPSEDLSQIGF
PEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGA
SIPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAHLEEARCAVCEGPGELCD
LFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHT
FCLKPPMEELPAHSWKCKACRVCRACGAGSAELNPNSEWFENYSLCHRCHKAPGGQPVSS
LAEQHPPVCSRFSPPEPGATPTDEPNSLYIACQGQPKGGYVTSMQPKEPGPLQCEAKPLG
REGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEDSPTSPPPEASRLSPPPEDSPLSPPP
EESPLSPPPESPPFSCPEDSPSHPPLDTPLPPPPEASPLSPPLEESPLSPPPEELPTSPP
PEASRLSPPPEESPMSPPPEESPMSPPPEASCLFPPFEESPLSPPPEESPLSPPPEASRL
SPPLEDSPMSPPPEDLPMSPPPEVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPED
SPTSPPPEDPPASPPPEDLLVSLPLEESPLLPLPEELRLCPRPEEPHLSPQPEKPRLSPA
PQEPRLSPAPQELCLSPASEEPHLSPAPQQPCLSPAPEEPRLSPAPQQLHLSPVPQQPHL
SPAPEEPRLSPAPKELRLSPAPQEPCLSTAPQELHLSLMPEEPHLSLASEELRLSPQPEE
PRLSPQPEEPRLSPRPEEPRLSPRPEEPRLSPRPEEPRLSPRPEEPCLSPRPEEPHLSPQ
PEEPIEEPGLCPASEELPLFLPPREPPLSPVLGEPALSEPGEPPLSPLPEELPLSPSGEP
SLSPQLMPPDPLPPPLSPIITTVAPPALSPLGELEYPFDAKGDSDPESPLAAPILETPIS
PPPEANCTDPEPVPPMILPPSPGSPMGPASPILMEPLPPHCSPLLQHSLPPSNSPPSQCS
PALPLSVPFPLSPMDKAVEVSEEAEPQKMETEKAPEPECPALEPSPTSPLPSPLGNLSCP
APSPAPALDDFCGLGEDTAPLDGTDTPGSQPEAGQTPGSLASELKCSPVLLDSEELAPVT
PMEVYGPECKQAGQGSPCEEQEDPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSE
PLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKA
EGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSIETLVVADI
DSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCY
HPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTV
PKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCR
HCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQY
FRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRPGLPGEAGLEGAEPSEVLGPDDKKDGD
LDTDELLKAEGSVEHMECEIKLEGPVSPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQR
KSHTRVKKGPAAQAEVLSGDGQPDEGETVLPADLPAEGSVDQSLADGDEKKKQQRRGRKK
NKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQ
KGDDGPDVADEESRGPESKADTPGPEDGGIKASPVPSDPEKPGTPGEGMLSSDLDRIPTE
ELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLPLGNLPSNSPM
DSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQR
SLQRWEKDEELGQLSTISPVLYANINFPSLKQDYPDWSSRCKQIMKLWRKVPAADKAPYL
QKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAA
PTIFIGSPTPPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAS
AYALEPRFPTVPPTYPPYPSPTGAPAPPPTLGASSRPGTGQPGEFHTTPPGTPRHQPSTP
DPFLKPRCPSLDNLAVPESPGGGGGKAAEPLLSPLPFGESRKALEVKKEELGGSSPSYGP
PNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPS
PPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSS
QSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPSEVAFKA
GPLAHTPLGAGGFPAALPSGPAGELHAKVPSVQPPNFARSPGTSAFVGTPSPMRFTFPQA
VGEPPLKPPVPQPGLPPPHGINSHFGPGPTMGKPQSTNYAVAAGNFRPSGSPLGPSSGPA
GEGYGPSPLRPPSVLPQPAPDGPLPCLPHGAAPRAGITSPVEKREDPGAGTGSSLAAPEL
SGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQMQRNTLRQEKETAAAAGAVGPPGSWGA
EPSSPAFEQLGRGQTPFAGTQDKSSLVGLPPSKLGGPILGPGAFPSDDRLSRPPPPATPS
SMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQATAAASMRLTMSARFPST
PGPELGRQTLGSPLAGISNRLPGPGEPVPGPAGPAQFIELRHNVQKGLGPGGPPFPGQGP
PQRPRFYPVTEDSHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPNLPTG
LELVSRPPSSTELGRPPPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAK
GDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKA
EREALLRGVEPGPLGPEEHPPPAADAPEPRLASGLPEVKPKVEEGGRHPSPCQFTITTPK
AEPAPVTTSLGLGVKPGQSVTGSRDTRMGTGTFSSSGHTAEKVPFGTTGGPPAHLLTPSP
LSGPGGSSLLEKFELESGALTLPGGHASGDELDKMESSLVASELPLLIEDLLEHEKKELQ
KKQQLSAQLQPVQQQQPQQHSLLSTPGPAQAVSLPHEGSSPNLAGPQQQLSLGLGGSRQP
GLAQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQNPQPVLAQKPMG
TMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGS
IGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERGAGDSSQPRPNPPTFAQGVIN
EADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEK
LKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQHSAVLALSPSQS
PRLLTKLPGQLLPGHGLQPPQGPPGGQAAGLRLTPGGMALPGQPGGPFLNTTLAQQQQQQ
HSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQHLLG
QVAIQQQQQQGPGVQANQALGPKPQGLLPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAV
LQQQQPHPGALGPQGPHRQVLLTQPRVLSSPQMAQQGQGLMGHRLVTSQQQQQHQQQGSM
AGLSHLQQGLMPHNGQPKLGAQPMAALQQQQLQQQQQQQQLQQHQQLQQQQQQQQLQQQQ
QQLQQQQQQQQQLQQQQQQQQLQQQQQQQQLQQQQQLQQQQQQQLQQQQQQLQQQQQQLQ
QQQQQQQLQQQQQQQQLQQQQQMGLLSQSRALLSPQQQQQQQQMTLGPGMPAKPLQHFSS
PGALGPTLILTGKEQSIVETALPSEASEGPSTHQGGPLPMGTVPESVATEPGEVKPSLSG
DSQLLLVQPQAQPQPNSLQLQPPLRLPGQQQPPVNLLHTAGAGSHGQPGSGSSEASSVPH
LLAQSSVSLGEQPGSVTQNLLSSQQPLGLERPMQNNIGPQPAKPGSVPQSGQSLPGAGVM
PTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLHALLMQRQLQQSQAARQAPPYPEPGTQPS
PLQGLLGRQPQPGGFPGSQTGPLQELGAGLRPQGPPRLPAPQGALSTGPVLGPVHPTPPP
SSPQEPKRPSSQLPSPSSQLPSEAQLPITQPGTPKPQGPPLELPPGRVSPAAAQLADTFF
GKGLGPWDPPDHLVEAQKLEQSSMAPGHLDQVNGQVVPEPPHLNIKQEPREEPCALGSQA
VKREANGEPVGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGPEGLRAEINGH
IDSKLAGLEQKLQGTPSTKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEA
LLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPISGQCQLRGAFGSGVLPTGPDYYSQL
LTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDTEGVLRDASE
VKSLDLLAALPTPPHNQTEDVRCRRGRDGDEELRMESDEDSDSPDSIVPASSPESILGEE
APRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPESKPYGVLDLEATRKLPAPTWEKGK
GSEVSVMLTVSAAAAKNLNGMMVAVAELLSMKIPNSYEVLFPESPARAGIEPKKGEAEGP
GGKEKSLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNV
SNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPLVELPAEPSAEPPIPSPLPLASSPES
TRPKPRARPPEEGEDSRPPRLKKWKGVRWKRLRLLLTIQKGGVRQEDEREVAEFMEQLGT
ALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALM
NVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKI
KGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMAD
FHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVMEQGLEDMVFTDA
SPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYL
FRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSK
QFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANR
REKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIIS
SRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN
NT seq
16860 nt
NT seq
+upstream
nt +downstream
nt
atggacagcccgaagccgcctggtgaggataaagattcggaaccagcagctgatggacct
gcagcctccgaggagtcaggtgccactgagccagaccttcccaaaccacatgttggggag
gtctctgtgcccagttctgggggtccccggcttcaggagcctccccaggactgcagcggg
ggtccggtgcggcgttgtgctctctgtaactgcggagagcccagtctacatgggcagcgg
gagctacggcgctttgagttgccatttgactggccccggtgtcccgtggtgtcccctggg
gggaacccagggcccaatgagggagcgctgcccagtgaggacctatcacagatcggtttc
cctgagggcctgacacctgcccacctgggagaacctggagggtcctgctgggctcaccat
tggtgcgctgcgtggtcggcaggcgtatgggggcaggagggcccagaactatgtggtgtg
gacaaggccatcttctcagggatctcacagcgctgctcccactgcaccagacttggtgcc
tccatcccttgccgctcgcctggatgttcccgtctttaccacttcccctgtgcaactgcc
agcggttccttcttatccatgaaaacactgcagctgctatgcccagagcacagtgagggg
gccgcacatctggaggaggctcgctgtgcagtatgtgaggggccaggggaattatgtgac
ctgttcttctgtaccagctgtgggcatcactatcatggggcctgtctggacactgctctg
actgcccgcaagcgtgctggctggcagtgccctgaatgcaaagtgtgccaagcttgcagg
aaacctgggaatgactctaagatgttggtctgtgagacgtgtgacaaaggataccatacc
ttctgcctgaaaccaccaatggaggaactgcctgctcactcttggaagtgcaaggcatgc
cgggtgtgccgggcctgtggggcaggctcagctgagctgaatcccaactctgagtggttt
gagaactactcgctctgtcaccgctgtcacaaagccccgggaggacagcctgtcagttct
cttgctgagcagcaccctccggtctgtagcagattctcacccccagagcctggcgctacc
cccactgatgagcccaatagtctgtacattgcgtgccaagggcagccaaagggtggatac
gtgacctctatgcaacccaaggaaccggggcccctgcaatgtgaagccaaaccactaggg
agagaaggggcccaacttgagccccagttggaggcccccctaaatgaggagatgccactg
ctgcccccacctgaggagtcgcccctgtccccaccacctgaggactcacccacgtccccg
ccgcctgaggcatcgcgcctgtccccaccgcctgaggactcacccctctctccaccgcct
gaggagtctcctctgtctcccccacctgagtcaccacccttctcttgcccagaggactcc
ccctcacatcccccacttgatacacccttacccccaccacctgaagcatcacccctgtcc
ccaccactggaggagtctcctctgtcccctccccctgaagaattgcctacttccccacca
ccggaagcatctcgcctgtctccaccaccggaagagtcacccatgtctccgccacctgaa
gagtcacccatgtctccgccacctgaggcctcttgtctgttcccaccgtttgaggagtcg
cccctgtcccctccacctgaggaatctcctctctctccgccacctgaggcgtcacgccta
tccccaccacttgaggactcacccatgtccccaccacctgaagacttgcctatgtccccc
ccgcctgaggtgtcacgcctgtcccccccgcctgaggagtctcccctgtcaccgccacct
gaggagtctcccacatcccctccacctgaggcttcacgcctgtctcctccgcctgaggac
tcccctacatccccgccacctgaagacccgcctgcttccccgcctccggaggacttgctc
gtgtccctgccgctggaggagtcaccgctgttgccactgcctgaggaactgcgactctgc
ccccggcctgaggagccacacctgtcccctcaacctgagaaaccgcgcctgtctcctgca
ccccaggagccgcgtctgtcccctgcaccccaggagctgtgcctgtcccccgcatctgag
gagccacacctgtcccctgcaccccagcagccgtgcctgtcccctgcgcccgaggagcca
cgcctgtcccctgcaccccagcagctgcacctgtcccccgtgccccaacagccacacctg
tcccctgcgcctgaggagccacgcctgtcccccgcgcccaaggagctgcgcctgtcccct
gcaccccaggagccctgcctgtccaccgcgcctcaggagctgcacctgtccctcatgcct
gaggagccacatctgtcccttgcatccgaggaactacgcctgtctccccagcctgaggaa
ccgcgcctgtctccccagcctgaggaaccacgcctgtccccccggcctgaggaaccgcgc
ctgtcccctcggcctgaggaaccgcgcctgtctcctcggcctgaggaaccgcgcctgtcc
cctcggcctgaggagccatgcctgtccccccggcctgaggaaccgcacctgtcccctcaa
cctgaggagcccattgaggagccaggcctgtgccctgcatctgaggaattgcccttattc
ctcccacccagggagccacccttatcccctgtgcttggagagccggccctgtctgagcct
ggggaaccacctctgtcccctctgcctgaggagctgccgttgtccccatctggggagcca
tctttgtcacctcagctgatgccaccagatcctcttcctcctccactttcacccatcatc
acaactgtggccccaccagccctgtctccgttgggagagttagagtacccctttgatgcc
aaaggggacagtgaccctgagtcgccactggctgcccccatcttggagacacctatcagc
cctccaccggaagctaactgcactgaccctgagcctgtaccccctatgatcctcccccca
tccccaggctcccccatgggaccggcctctcccatcctgatggagccccttccccctcat
tgttccccactcctccagcattccctgcctccctcaaactcacctccttcccagtgctct
cctgccttgccactgtcggttcctttcccgctgagtcccatggacaaggcagtggaggtc
tcagaagaggctgagccacagaagatggagactgagaaagccccagaacctgagtgccca
gccttggaacccagccctactagtcctcttccgtctcctctggggaacctttcctgccct
gcacccagccctgccccagccctggatgacttctgtggcctgggggaagatacagcccct
ctggatgggactgacactcctggttcacaaccagaggctggacagacccctggcagtttg
gctagtgaacttaagtgttcccctgtgctcctggactctgaggagctggcccctgtgacc
cctatggaggtctatggcccagaatgcaagcaggcagggcagggctcaccctgtgaagag
caagaggatccacgtgcaccagtggccccgaccccacctactctcatcaaatctgacatc
gttaatgagatctccaatctgagccagggcgatgccagtgccagttttcctggctcagag
cccctgctgggctctccagatcctgaggggggtggctccctgtccatggagttgggggta
tctacagacgttagtccagcccgagatgagggctccctgcggctctgtaccgactcgctg
ccagagactgatgactcgctattgtgtgatgctgggacagctattggaggaggcaaagcc
gagggggacaaggggaggcggcgcagctccccagctcgttcccgcatcaaacagggtcgc
agcagtagtttcccagggagacgccggccacgtggaggagcacatggaggacgtgggaga
ggacgggcccggctaaaatcaactacttcttccattgagactctggtagttgctgatatc
gatagctctcccagcaaggaggaagaagacgatgatgatgataccatgcaaaatactgtg
gttctcttctccaacacagacaaatttgtgctaatgcaggacatgtgtgtggtgtgtggc
agctttggccggggggcagagggccacctccttgcctgttcccagtgctcccagtgctat
cacccgtactgtgtcaacagcaagatcaccaaggtgatgctgctgaagggctggcgttgt
gtggaatgcatcgtgtgcgaggtgtgtggccaggcctcagacccctcccgcctcctgctc
tgtgatgactgtgacattagctaccacacgtactgcctggaccccccactgctcaccgtg
ccgaagggtggctggaagtgcaagtggtgtgtgtcttgtatgcagtgtggggccgcctcc
cctggcttccactgtgaatggcagaatagttacacacactgcgggccctgtgccagcctg
gtgacctgccctatctgtcatgccccctacgtggaggaggacctgctgatccagtgtcgc
cactgtgaacggtggatgcatgccggctgtgagagcctcttcacagaggatgatgtggag
caggcagctgatgagggcttcgactgtgtctcctgccagccttacgtggtcaagcctgct
gcgcctgtcgcacctccagagttggtacctatgaaggtgaaagagcctgagccccagtac
tttcgcttcgagggcgtgtggctgacagaaacgggcatggcggtgctgcgtaacctgacc
atgtcgcctctgcacaagcggcgtcagaggcgtggacggcccggcctcccaggtgaggcg
gggctggagggggccgagccttcagaggtcctgggccctgatgacaagaaggatggtgac
ctggacacggacgagctgctcaaggctgaaggtagtgtggagcacatggagtgtgaaatt
aaactggagggtcctgtcagccctgatggagagcctggcaaagaggagactgaggagagc
aaaaaacgcaaacgcaaaccctatcggcctggcatcggtggtttcatggtgcgacagcgg
aaatcccacacacgtgtgaaaaaagggcctgcagcacaggcggaggtgttgagtggggat
gggcagcccgacgagggtgagacggtgttgcctgctgacctgcctgccgagggctctgtg
gaccagagcttagccgatggggatgagaagaagaagcagcagcggcgagggcgcaagaag
aacaaactggaggacatgttccctgcttacctgcaggaagccttctttgggaaggagctg
ctagacctgagccggaaggccctgtttgcagttggcgtgggccggccaagctttggattg
ggaacccccaaagccaagggcgatggaggctcagagaggaaggagctcccgacctcacag
aaaggagatgatggtccagatgttgcagatgaagaatcccgtggccctgagagcaaggct
gatacaccaggacctgaggatggtggcataaaggcatccccagtgcccagtgaccccgag
aagccaggcaccccgggtgaagggatgcttagctctgacttagacaggattcccacagaa
gaactgcctaagatggaatccaaggacctgcagcagcttttcaaggacgttctgggttcc
gaacgagagcagcatctgggttgcggaacccctggcctggacggcagccggacaccgctg
cagaggccctttcttcaaggtggactccctttgggcaatctcccctccaacagcccaatg
gactcttacccgggcctctgccagtccccattcctggattctagggagcgcgggggcttc
ttcagcccagaacccggtgagccagacagcccctggacaggctcggggggcaccacgccc
tccacccccaccacccccaccacggagggtgagggcgacgggctctcctataatcagcgg
agtcttcagcgctgggagaaggacgaggagttgggccagctctccaccatctcgcctgtg
ctgtacgccaatattaacttccccagtctcaagcaggattacccagactggtcaagccgc
tgcaaacaaatcatgaagctgtggagaaaagttccagctgctgataaagccccctacctg
caaaaggccaaagataaccgggcagctcaccgcatcaacaaggtgcagaagcaggctgag
agccagatcaacaagcagaccaaggtgggcgacatggcccgcaagactgaccgaccggcc
ctacatctccgcattcccccccagccaggggccctgggcagtccgcctcccgctgctgcc
cccaccattttcattggcagccccactccccccgccggcttgtctacctctgcggacggg
ttcctgaagccgccggcgggcacggtgcccggccccgactcgcctggtgagctcttcctc
aagctcccgccccaggtgcccgcccaagtgccttcgcaggacccctttggactggcctct
gcctatgctctggagccccgcttccccacagtaccacccacctaccctccctatcctagt
ccgactggggcccctgcaccgcccccgacgctgggtgcctcgtctcgtcctgggactggc
cagccaggggagttccacactaccccacctggcaccccccgacaccagccctccacgcct
gaccccttcctcaaaccccgctgcccctcgctggacaacctggctgtgcctgagagccca
gggggagggggaggcaaggctgctgagcctctgctgtcgcctctgccttttggggagtct
cggaaggccctggaggtgaagaaggaagagcttgggggatcctctccaagctatgggccc
ccaaacctgggctttgttgactctccctcctcaggcccccacctgggtggcctggagtta
aaggcacctgatgttttcaaagcccccctgacccctcgggcatctcaggtagagccccag
agcccgggcttgggcctaaggccccaggagccaccccctgcccaggctttggccccttct
cctcccagccactcggacatctttcgccctggtccctaccctgacccctacgcccaaccc
ccgctgacccctcggccccagcccccaccacctgagagctgctgtgccctgcctccccgc
tcactgccctctgaccctttctcccgagtgcccgccagtccccagtcccagtccagctcc
cagtccccattaacaccccgtcctctgtctgctgaggctttctgcccatcccctgttacc
cctcgcttccaatcccctgacccttattcccgtccaccctcgcgccctcagtcccgggat
ccatttgccccattgcataagcccccccgcccccagccctctgaagttgccttcaaggct
gggcctctagcccacactccgctgggggctgggggtttcccagcagccctgccctcaggg
ccagcaggtgagctccatgccaaggtcccaagtgtgcaaccccccaattttgcccggtcc
cctgggaccagtgcatttgtgggcaccccttctcccatgcgtttcactttccctcaggcg
gtcggggagcctcccttaaagccccctgtccctcagcctggtctccctccaccccatggg
atcaacagccattttgggcccggccctaccatgggcaagcctcaaagcacaaactacgca
gtagccgcagggaacttccgcccatcgggcagccccctggggcccagcagcgggcctgca
ggagagggctacgggccgtccccgctgcgccccccgtcagtccttccccaacccgcaccc
gacgggcccctcccctgcctgccccatggggccgcaccacgggcgggcatcacctctccg
gtcgagaagcgagaagacccaggggctggcacgggcagctctttggcggcacctgagctt
tcaggtacccaggacccaggcatgtctggcctcagtcagacagaactagagaagcagcga
cagcgccagcgactgcgggagctgttgattcggcagcagatgcagcgcaacacccttcgg
caggagaaggagactgcggcagctgccggagcagtgggacccccaggcagctggggtgct
gagcctagtagccctgcgtttgagcagctgggtcgaggccagaccccctttgctgggacc
caggacaagagcagccttgtggggctgcccccaagcaagctgggtggccccatcctgggg
ccaggggctttccccagtgatgaccgactctcccggccacctccaccagccaccccttcc
tctatggatgttaacagccggcaattggtggggggctcccaagccttctatcagcgagca
ccgtatcctgggtccctgcccttacagcagcagcagcagcagcaactgtggcagcagcag
caacaggcaacagcagcagcttccatgcgacttaccatgtctgcgcgctttccctcaact
cctgggcctgaacttggtcgccaaaccctaggttcccctttggctggaatttccaaccgc
ctgcctggccctggtgaaccagtgcctggcccagctggtcctgcccagttcattgagttg
cggcacaatgtacagaaaggactcggaccgggggggcctccatttcccggtcagggccct
ccacagagaccccgtttttaccctgtaactgaggattcccaccgactggcccctgaaggg
cttcgtggcctagcagtctcaggccttcctccacagaaaccttcagccccaccagctcct
gaactgaacaacagcctccatccaacgccccacaccaagggtcccaacctgcccactggc
ttggagctagtcagccggcccccctccagcactgagcttggccgcccccctcctctggcc
ctggaagctggaaaactaccttgtgaggatcctgagctggatgatgactttgatgcccac
aaggccttggaggacgatgaggagcttgctcacttgggcctgggtgtggatgtggccaag
ggagacgatgagctgggtactctggaaaacctagagaccaatgatccccacctcgatgac
ctgctcaatggggatgagtttgacctgctggcctatactgaccctgagctggacacgggg
gacaagaaggacatcttcaatgagcatctgaggctggtggagtcagccaatgaaaaggct
gaacgagaggctctgttgcgaggggtggagccaggacccttgggccccgaggagcaccct
cccccggctgcggatgcgcctgagccccgtctggcatcagggcttcccgaggtgaagccc
aaggtggaggagggtgggcgccacccttccccttgccagtttaccattaccacccccaag
gcagagccagcacctgtcaccacttccctaggcctgggggtgaagccaggtcagagtgtg
acgggcagccgggacactcgaatgggcacaggaactttttctagcagtgggcacacagct
gagaaggtcccctttgggaccacaggaggaccaccagctcacctgctgacgcccagccca
ctgagtggcccgggagggtcctccctactggaaaagtttgagctagagagtggggccctg
actttgcctggtggacatgcatctggggatgagctggacaagatggagagctcactggta
gccagtgagttacccctgctcattgaggacctgttggaacatgagaagaaagagctgcag
aagaagcagcagctttcagcgcagctgcagcctgtgcagcagcagcagccccagcagcat
tccctgctgtccacgccaggccctgcccaggctgtgtctttgccccatgagggctcttct
cccaatttggctggccctcaacagcagctttccctgggacttggaggctcccgacagcca
ggcttggcccaaccgttgatgcccacccagccaccagctcatgccctccagcagcgcctg
gccccatccatggccatggtatccaaccaagggcatatgctaagtgggcagcatggggga
caggcaggcttggtgccccagcagaacccacagccagtgctggcacagaagcccatgggt
accatgccaccgtccatgtgcatgaaaccacagcagctggcaatgcagcagcagttggct
aacagctttttcccagatacagacctggacaaattcgctgcagaagatatcattgatcct
attgcaaaggccaagatggtggctttgaaaggcatcaagaaggtgatggctcagggcagc
attggagtggcacctggtatgaacaggcagcaagtgtccctgctagctcagaggctctca
ggggggcccggtagtgatctgcagaaccacgtggcagctgggagtggccaggagcggggt
gccggtgactcctcccagcctcgtcccaatccacccacttttgcccagggagtgatcaat
gaggctgaccagcggcagtatgaggagtggctgttccatacccagcagctcctacaaatg
caactgaaggtgctagaggagcagataggggtgcaccgcaagtcccggaaagccctgtgt
gccaagcagcgcactgccaagaaggctggccgggagttccccgaggctgatgctgagaag
ctaaagctggttacagaacaacagagcaagatccagaaacagctggatcaggtccggaag
cagcagaaggagcacactaacttaatggcagaatatcggaataagcagcagcagcagcaa
caacagcagcagcaacagcagcagcactcagccgtacttgcccttagcccttcccagagt
ccccggctactcaccaagcttcctggtcagctactcccaggccatgggctgcagccacct
caaggaccccctggggggcaagctgcaggtcttcgcctgacccccgggggcatggcccta
cctggacagcctggtggccccttcctcaacaccaccctggcccaacagcagcagcagcaa
cattctggtggagctggggccctggctggcccctcggggggctttttccctggcaacctt
gctcttcgaggcctgggacctgactcgaggcttttacaggaaaggcagctgcagctccaa
cagcagcgcatgcagctggcccagaaactgcaacagcagcagcagcagcatctcctagga
caggtggcaatccagcagcaacagcagcagggtccaggagtacaggcaaaccaggctctg
ggtcccaagccccagggccttctgcctcccagcagccaccagggcctcttggtccagcag
ctgtccccccaaccaccccaggggccccagggcatgctgggccctgcccaggtggcagta
ttgcagcagcagcaaccacaccctggagctttgggcccccagggccctcacagacaggtg
ctcctgacccagccgcgggtgctaagttctccccagatggcacagcagggtcagggccta
atgggacaccggctggtcacatcccagcagcagcaacagcaccaacagcaaggatccatg
gccgggctttcccatcttcagcagggtctgatgccacacaatgggcagcccaaactgggt
gctcagcccatggccgccttgcagcagcaacagttgcaacagcagcagcagcagcagcaa
cttcaacaacaccaacagcttcaacaacagcagcagcaacagcagctacaacaacagcag
cagcagttacaacagcagcagcagcagcaacagcagctacaacaacagcagcagcaacag
cagcttcaacagcaacagcagcaacagcagcttcagcagcagcagcagcttcagcagcag
cagcaacagcagcttcaacagcagcagcagcagcttcaacagcagcagcagcagcttcaa
cagcagcagcagcaacagcagcttcaacagcagcagcagcaacagcagcttcaacagcag
cagcagatgggcctcttgagccagagtcgagctttactgtctcctcaacagcaacagcag
cagcaacagatgacacttggccctggcatgccagccaagcctctgcaacacttttctagc
cccggagccctgggcccaaccctcatcctaacgggcaaggaacaaagcatcgtagagaca
gctcttccttcagaggccagtgaggggccctccacacatcagggagggcccttaccaatg
gggactgtaccagagtccgtggccactgaaccaggagaggtgaagccctcactgtctggg
gactcacaactcctgcttgtccagccccaggcgcagcctcagcccaattctctgcagctg
cagccacctctgaggctcccaggacaacagcagccgccagttaacttgctccacacagca
ggcgcaggaagccatgggcaaccaggcagtggatcgtctgaggcctcgtctgtgccccac
ctactggcccaatcctctgtttccttaggggaacagcctggatccgtaacccagaacctt
ctgagctcccaacagccccttggactagagcggcctatgcaaaataacatagggccacag
cctgccaagccgggatctgtcccgcagtctggccagagcctgccaggggctggggtcatg
cctacagtgggtcagcttcgggcacagctccaaggagtcctggccaaaaacccacagctg
cggcatttgagtcctcagcagcagcagcagctccacgcgcttctcatgcagaggcagcta
cagcagagtcaggcagcacgccaggccccaccctacccggagcctgggacccagccctct
cccctccaaggcctcctgggccgccagccccaacctgggggcttccctggatcccagaca
ggccctcttcaggagctaggggccgggcttcgacctcagggcccaccccgactccccgcc
ccacaaggagccttatccacaggaccagttcttggccctgtccatcccacacctccacca
tccagcccccaagagccaaagagaccttcctcccaattaccttcccctagctcccagctc
ccctccgaggcccagctccctatcacccagccaggaacccccaagccccaggggccaccc
ttggagcttcctcctgggagggtctcacctgctgctgcccagcttgcggataccttcttt
ggcaagggactgggaccttgggaccccccagaccacctagtggaagcccagaagctggag
caaagcagcatggcacctgggcatctggaccaggtgaatgggcaggtggtacctgagcca
ccacatctcaacatcaagcaggagcctcgggaagagccgtgtgccctggggtcccaggcg
gtgaagagggaggccaacggggagcctgtaggggcaccaggtaccagcaaccacctcctg
ctggcagggccccgctcagaagccgggcatctgctcttgcagaagcttctacgagcaaag
aatgtgcaactcagtactgggcgggggcccgaggggctgcgagctgagatcaacgggcac
attgacagcaagcttgctgggctggagcagaaactgcagggtacccccagcaccaaggag
gatacagcagcaaggaagcctttgacaccgaagcccaagcgggtacagaaggcaagcgac
aggttggtgagctcccgaaagaagctgcggaaggaggacggggtcagggccagcgaggcc
ttgctgaaacagctgaaacaggagctgtccctgctgcccctcacggagcctaccatcacc
gccaactttagcctctttgctccctttggcagcggctgcccgatcagtgggcagtgccag
ctgagaggggccttcggaagtggggtgctgcccacgggccctgactactattcccagctg
cttaccaagaataacctgagtaacccgccgacaccaccctcgtcgctgccccccacccca
cccccatcggtgcagcagaagatggttaatggcgtcactccgtctgaagagctgggggag
caccccaaggatgccgcctctgcccgggacactgaaggggtgctgagggatgcttcagaa
gtgaaaagtctagacctgctggccgctttgcctacgccccctcacaatcagactgaggat
gtcaggtgcagaaggggcagagatggggatgaggaattgaggatggagagtgatgaggac
agcgattctcctgacagcatcgtgccagcttcatcccctgagagcatcctgggggaggag
gccccccgtttccctcagctgggctcaggccggtgggagcaggatgaccgggctctctcc
cccgtcatccccatcattcctcgggccagcattccagtcttcccagagagcaaaccttat
ggggtcctggatctggaggccaccaggaagctgcctgccccaacttgggaaaagggcaaa
ggaagcgaggtgtcagtcatgctgacggtttctgctgctgccgccaagaacctgaatggc
atgatggtggcagtggcagagctgctgagcatgaagatccccaattcctatgaggtgctg
ttcccagagagccctgcccgggccggcatcgagcctaagaagggggaggctgagggccct
ggtgggaaagaaaagagtctgggaggcaagagcccagaggctggccctgattggctgaag
cagtttgatgctgtgttgcctggctatacactcaagagtcagttagacatcttgagtctc
ctcaaacaggagagccctgccccagagccccccacccagcacagctacacctacaacgtc
tccaacctggatgtgcgacagctctcggccccacctcctgaagaaccctccccaccccct
tcccctctggcaccctctcctgccagcccccctgctgaacccttggttgaacttccagct
gaaccctcagctgagccaccgatcccctcgcctctgccactggcctcgtcccctgaatct
acccggcccaagccccgagcccggcctcctgaggaaggtgaagattcccggccccctcgc
ctcaagaagtggaagggggtgcgctggaagcggctccggctgctgctgactatccagaag
ggtggtgtgcggcaggaggatgagcgggaagtggctgagttcatggaacagctcggcaca
gccttgcgacctgacaaggtgcctcgagacatgcggcgctgctgcttctgtcatgaggag
ggggatggggccacggatgggcctgcccgcctgctgaacctggacttggacttgtgggtg
cacctcaactgtgccctgtggtccacagaggtatatgagacccagggcggggcgctgatg
aacgtggaggttgccctgcaccgaggcctgctcaccaagtgctccctgtgccagcgcacc
ggtgccaccagcagctgcaatcgaatgcgttgccccaatgtctaccattttgcctgcgcc
atccgcgccaagtgcatgttcttcaaggacaagaccatgctgtgtccaatgcataagatc
aaagggccctgtgagcaggagctgagctcttttgctgtcttccggagggtctacatcgag
cgggatgaggtgaagcagattgccagcatcatccagcggggagagcggctgcacatgttc
cgggtgggcggccttgtgttccacgccattggacagctgctgccccaccagatggccgac
ttccacagtgccactgccctctatccagtgggctacgaggccacgcgcatctactggagc
ctccgcactaacaaccgtcgctgctgctaccgctgctccatcggcgagaacaatgggcgg
ccggagttcgtgatcaaagtcatggagcagggcctggaggacatggtcttcacggacgcc
tctccccaggccgtttggaatcgcatcattgagcctgtggcagccatgaggaaagaggcc
gacatgctgcgtctcttccccgagtacctgaaaggcgaggagctctttgggctgacagtg
cacgccgtgctgcgcatagctgaatcactgcctggagtggaaagctgtcaaaattattta
ttccgctatggacgccaccccctgatggagctaccactcatgatcaaccccactggctgt
gctcggtcagagcctaaaatcctcacacactacaaacggccccacactctgaacagcacc
agcatgtccaaggcatatcagagcaccttcacaggcgagaccaacaccccgtacagcaag
cagtttgtgcactccaagtcatctcagtaccggcggctgcgcactgagtggaagaacaat
gtctacctggctcgctcccgtatccagggcctgggtctctatgcagccaaggacctagaa
aagcacacaatggtcatcgagtacattggcaccatcattcgcaatgaagtggccaaccgg
cgggagaaaatctatgaggagcagaatcgaggcatctacatgtttcgaataaacaacgaa
catgtcattgatgctacgttgaccggaggccccgccaggtacattaaccattcttgtgcc
cctaactgtgtggcggaagtcgtgacatttgacaaggaggacaaaatcatcatcatctcc
agccggcgaatccccaaaggagaggagctgacatatgactatcagtttgattttgaggac
gatcagcacaagatcccctgccactgtggagcctggaattgtcggaaatggatgaactaa
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