Budorcas taxicolor (takin): 128052316 Help Entry 128052316         CDS       T08909                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism btax  Budorcas taxicolor (takin) Pathway btax01521   EGFR tyrosine kinase inhibitor resistance btax04062   Chemokine signaling pathway btax04148   Efferocytosis btax04151   PI3K-Akt signaling pathway btax04217   Necroptosis btax04550   Signaling pathways regulating pluripotency of stem cells btax04630   JAK-STAT signaling pathway btax04658   Th1 and Th2 cell differentiation btax04659   Th17 cell differentiation btax04725   Cholinergic synapse btax04917   Prolactin signaling pathway btax04920   Adipocytokine signaling pathway btax04933   AGE-RAGE signaling pathway in diabetic complications btax04935   Growth hormone synthesis, secretion and action btax05140   Leishmaniasis btax05145   Toxoplasmosis btax05152   Tuberculosis btax05161   Hepatitis B btax05164   Influenza A btax05167   Kaposi sarcoma-associated herpesvirus infection btax05168   Herpes simplex virus 1 infection btax05200   Pathways in cancer btax05207   Chemical carcinogenesis - receptor activation btax05235   PD-L1 expression and PD-1 checkpoint pathway in cancer btax05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:btax00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     128052316 (JAK2)    04151 PI3K-Akt signaling pathway     128052316 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     128052316 (JAK2)   09143 Cell growth and death    04217 Necroptosis     128052316 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     128052316 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     128052316 (JAK2)    04659 Th17 cell differentiation     128052316 (JAK2)    04062 Chemokine signaling pathway     128052316 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     128052316 (JAK2)    04917 Prolactin signaling pathway     128052316 (JAK2)    04935 Growth hormone synthesis, secretion and action     128052316 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     128052316 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     128052316 (JAK2)    05207 Chemical carcinogenesis - receptor activation     128052316 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     128052316 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     128052316 (JAK2)    05164 Influenza A     128052316 (JAK2)    05168 Herpes simplex virus 1 infection     128052316 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     128052316 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     128052316 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     128052316 (JAK2)    05140 Leishmaniasis     128052316 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     128052316 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     128052316 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     128052316 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:btax01001]     128052316 (JAK2) Enzymes [BR:btax01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      128052316 (JAK2) Protein kinases [BR:btax01001]  Non-receptor tyrosine kinases   JAK family [OT]    128052316 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  128052316 NCBI-ProteinID:  XP_052500794 LinkDB All DBs Position 8:complement(42483103..42567149) Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSASPVHQNGDISGNANSVKQIDPVLQVYLYHSLGKAEEDYLKFPTG EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFHKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNVLLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDSMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccgcatcccctgtacat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaaagctgaggaggattatctgaagtttccaactgga gagtatgttgctgaagagatttgtattgctgcttctaaagcttgtggaatcacacctgta tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttt ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtacccgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaacgccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataagatacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgaacttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactctatgtacttcgatgcagtcctaaggactttcataaatactttctgacttttgct gttgagcgagagaatgttattgaatataagcactgtttgattacaaaaaatgagaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcggacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagacgagaaataggagactatggtcagctgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggaatttgtaaaatttggatcactagatacatatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatgttctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgtagtggaggagataagccgctgagtgctttggattctcaa agaaaactacaattttatgaagataggcaccagcttcctgcaccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttagaccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagactttgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata tgcaagggcatggaatatcttggtacaaaaaggtatatccacagggatctggcaacaagg aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgagaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgatcgtgtttcatttgatagaa ctcctgaagaataatggaagattaccgagaccagatggatgcccagatgagatttacgtg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacagcatgactggatga

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