Budorcas taxicolor (takin): 128054439 Help Entry 128054439         CDS       T08909                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism btax  Budorcas taxicolor (takin) Pathway btax04020   Calcium signaling pathway btax04371   Apelin signaling pathway btax04713   Circadian entrainment btax04921   Oxytocin signaling pathway btax04970   Salivary secretion btax05010   Alzheimer disease btax05012   Parkinson disease btax05020   Prion disease btax05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:btax00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     128054439 (RYR3)    04020 Calcium signaling pathway     128054439 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     128054439 (RYR3)   09154 Digestive system    04970 Salivary secretion     128054439 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     128054439 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     128054439 (RYR3)    05012 Parkinson disease     128054439 (RYR3)    05020 Prion disease     128054439 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     128054439 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:btax04040]     128054439 (RYR3) Ion channels [BR:btax04040]  Voltage-gated cation channels   Ryanodine receptor    128054439 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  128054439 NCBI-ProteinID:  XP_052503030 LinkDB All DBs Position 10:complement(27243931..27817271) Genome browser AA seq 4872 aa AA seqDB search MAEGAEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGMQHEGKQSKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLMDKHGRNHKVLDV LCSLCLCDGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKMRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYSLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGVDDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRID GTMDTPPCLKVTHKTFGTQNSSATMIYCRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRKVCLYPDESKRHGLPGVGPRTCLKPGFRFSTPCFITTNEEHQ KQSPEIPLELLKTKALGMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSVEMEEGAEKEEVTQVEEKAVEAGEKASREAPIKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQENQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYEFHEDLLLHCGVPLEEEEEEEED TSWTGKFCALVQRIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQVQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTEDDEDEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDT RISATLEKQVSVDADGNFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKF LKKVLKYVDSAQEFIAHLEAIVSSGKNEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSAGPWCTKVTSEHLSVILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLRADS KGDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNSRSNWLKSPDADSDQLFRMVAEIFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDFY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRSNLHLQEKS DDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVQE EEEEEVEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEDEEEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPIVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKEIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPDEEEDEDGDSSYVLEVEGKEEEEEKSLEC ASAFAMACASVKRSVANFLKRATLKNLRKQYRKVKKMTFKELVKLLFSFFWTLFVGLFHL LFTIVGGIIQVLWGTVFGGGLIEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVPEP GITTELAHFVKGEKGDADIMSDLFGLHPKKEGGLKYGPEVGLGDLSEIIGKDEPPTLEST VRKKRKAQAAEMKAAHEAEGKIESEKADMEDGEKEDTAKEEEQAEALWADVTKRKKRRCG QKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPL EEETEDVANLWNSFNDEEEEEAVVFFVLQESTGYMAPALRALAIIHTVISLVCVVGYYCL KVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKV INKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSVDMKYHVWKLGVVFT DNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPA GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGN DYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG DCFRKQYEDQLG NT seq 14619 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggggcagaaggaggcgaagacgagatccagtttctgcggactgaagatgaa gtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggcagcc gagggacttgggaatcgcctgtgctttttggaacccacttcagaagccaagtacgttcct ccagatctctgcgtctgcaactttgtgctggagcagtccctctctgtcagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctgtatggccatgcaattctcctgcggcactccttcagtggcatgtatcta acatgtttgaccacatcaagatcccagacggataaacttgcctttgatgtaggtctacgg gaacacgccacaggagaagcctgttggtggaccattcatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgatgacctcatcctcgtcagtgtgtcctctgaaaga taccttcatctctcaatatcaaatggtaacatacaagtggatgcctcctttatgcagaca ctctggaatgtacatcctacgtgctcaggaagtagcattgaagaaggatacctgcttggt ggccatgtagtacgtcttttccatggacatgatgagtgtttgacgataccatctacagac cagaatgattcccagcacaggaggatatactatgaagctgggggagctggcacgagagcc agatcgctatggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggacaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaagac cagggccttatcctgcaagaccggggaaagtcagacaccaagtccacagccttctctttt cgagcatccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggagtcccagaaatcaagtatggagactctgtctgctttgtccaacatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgatgggttaacactgcagagatgc cagcgtgaggagtcccaggctgctcggatcatccggaacacgaccgccttattcagccag tttgtaagtggaaacagtcgcacagctgccccggtcaccctgccgatagaagaggtcctg cagaccttacatgacctgattgcctacttccagcccccggaggaggggatgcagcatgaa ggcaagcagagcaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttagcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagcacac ttcgcagggatcgccagggaggagagtgggatggcctggaaagaaattctgaacctcctg tacaaattgctcgctgctcttattcgtggaaacagaaacaactgtgctcaattctccaat aaccttgactggctgatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctcattgaaagcccagaagccttaaacctgatagcagagggccac atcaagtccatcatctccctgatggataagcacggacggaatcacaaggttctggatgtg ctgtgttccctctgtctctgcgatggggtcgcagtgagagccaaccagaatctcatctgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgacgtaaca agtattcggccaaacatcttcctgggagttgctgaaggctcagcacagtacaagaagtgg tactttgagcttatcatcgaccaggtggaccccttcctcacagcagagcccacgcatctg cgggtgggctgggcctcttcctctggctacgctccttaccccggaggtggagaaggatgg ggaggcaatggtgttggtgatgacctatactcctatggctttgatggacttcacctctgg tcaggtcgcatacccagagccgtggcctccatcaaccagcacctcctgaagtcagacgac gtggtaagctgttgcctggacctgggggcacccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacggatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcctgctgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaggaaaagatgaga ttggagcctgtcaaagagtataaacgtgatgctgaaggaattcgagatctgttgggtacc acccagttcctctcccaagcctctttcatcccatgccccatagataccagtcaggttgtt ttaccacctcatctagagaaaatccgagacaggctggctgaaaacatccatgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatgcgggatgacaataaaaga cagcacccctgccttgtcgagttttcaaagctgcccgaaactgagaagaattataaccta caaatgtcaactgaaaccctaaaaactctcctggccctggggtgccacattgctcatgtt aacccagctgctgaggacgatctcaagaaggtcaaattgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacacaatgtctgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttaaagaacaaaagaaatccacgtttggtg ccgtattcactgctggatgagcgtaccaagaagtcaaacagggacagccttcgtgaagct gtccggacgtttgttggttatggctataacattgagccatcagaccaagagctagctgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttat gccgtgagatcgggaaagtggtatttcgagttcgaggtggtgaccggaggcgacatgcgt gttggctgggcccggccaggctgccgacccgacgttgagctgggggtggatgaccaagcc ttcgtgtttgaaggcagcaggggccagcggtggcatcaagggagtgggtatttcggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcaatgatc ttcacgctgaatggggagctgctgatcaccaacaaaggctctgaacttgccttcgctgac tacgagattgacaatggctttgtgcccatctgctctctggggctgtctcagatcggccgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggtctccaagag ggctttgagccttttgctgtcaacatgaatcgcgacgtggccatgtggttcagcaaacgc ctcccaacatttgtcaacgtgcccaaggatcatccgcagatagaggtcgtgaggatcgac ggcaccatggatacccctccatgcctcaaggtgacccacaagacattcggcacccagaat agcagtgccaccatgatctactgccgcctgagcatgcccgtcgagtgccactcctccttc agtcacagcccctgtctggacagtgatgctttccagaaaaggaaacagatgcaagaaata ctctctcacacaacaacacagtgctactatgcaatccgcatctttgccggacaggacccc tcctgcgtgtgggtcggatgggtgactccggattatcacttgtacagtgaaaagtttgac ctgaataaaaactgtactgtgactgttactctgggggacgaaagaggccgagtccacgaa agcgtgaaacgcagcaactgctacatggtctggggtggggacatcgtggctacatcccaa agagcgagtcgcagcaatgtggacctggagatcggctgccttgtggatctagcgatgggc atgttgtccttttcagccaacgggagggaacttggcacctgctaccaggtggagcccaat accaaagtgtttccagccgtcttcctgcagcccacaagcacctctctgtttcaatttgaa cttgggaagctgaagaatgccatgcccctgtcggcagccatatttaagagtgaagagaag aaccccgtcccgcagtgcccaccacggctggatgtccaaaccatccagcctgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagagggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctacagatgatggcactccacatcccggaagagaac aggtgtgtggatatcctggagctctgcgagcaggaggacctcatgcggttccattaccat acgctgagactctacagcgccttgtgtgccctgggaaacagccgggtggcctacgccctg tgcagccatgtggacctctcccaactcttctatgccattgacaacaagtacctccctggc ctcctgcgctcaggcttctacgacctgcttatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcaccaccaggaaagtc tgcctgtacccggatgagtccaagaggcatgggctccctggggtgggcccgagaacgtgc ctcaagccagggttcaggttctccaccccctgcttcatcaccaccaacgaggagcaccag aagcaaagccccgagattcccttggagcttctcaagacgaaggcgctgggcatgctgacg gaggcagtgcagtgcagcggggctcacatccgggaccctgtcggggggtctgtggagttc cagtttgtgcctgtgctgaagctcatcggaaccctgctggtcatgggggtgtttgatgat gatgacgttcggcagatcctcctcctcatcgacccctctgtgtttggggagcacagtgtg gagatggaggagggagcagagaaggaggaggtgacgcaggtggaggagaaggctgtggag gctggggaaaaggccagcagggaggctcccatcaaaggcttgttgcagacccgattaccg gagtccgtcaagctgcagatgtgtgagctgctcagctatctctgtgactgtgagctgcag caccgggtggaggccattgtggccttcggtgacatctatgtctccaagctccaggaaaat cagaagttccgctacaacgagctcatgcaggccctgaacatgtctgcggccctgaccgcc cggaagaccagggagttccgctcgcccccacaggaacagatcaacatgcttcttaatttt caactgggggagaactgcccatgcccagaagaaatccgggaagagctgtacgagttccat gaggaccttctccttcactgcggggttcccctggaagaagaggaagaggaggaagaggat acctcctggactggaaaattctgtgccttggtgcagagaatcaaaggccctcccaagcca gagaaggagcaaccaacggaggaagaagagagatgccctacgaccctgaaggagctcatc tcacagaccatgatccgctgggcccaggaggaccaggtccaggatgcagagctggtccgg atgatgttcaaccttctgcggcggcagtacgacagcatcggggagctgctgcaggcgctg cgcaagacctataccatcagccaggcctccgtgagcgacaccatcagcctgctagccgcc ctgggccaaattcgctgcctgctcagcgtcaggatgggcaaggaggaggagctactcatg atcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg agagtcctcggcatgcatgagacagtcatggaggtgatggtgaacgtgctgggtgcagaa aagtctcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaatcagccgacaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagtgttggcctagcttccccctcgatgagagggtccaccccgctggatgtggcc gcttcctccgtgatggacaacaatgagttagcgctgggcttagaggagccagacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctagccaaa ggataccctgatgttggctggaaccccattgaaggggagcgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaatgctagtgtggtggtcaagctg ctcatcagacgccccgagtgcttcggccccgccctgcggggtgaaggaggaaatggcctg ttggcagccatgcaaggcgccattaagatctccgagaacccggccctcgacctcccctca cagggctacaagagggaagtcagcacagaggacgatgaagatgaagaagagattgtgcac atgggcaatgcgatcatgtcattttattcggctcttatagacctgctgggccgctgtgct cctgagatgcaccttatccagacaggaaagggagaagccatccggatcaggtccatcctg cgctccctggttcccactgaggacttggttggaatcatcagcatccccttgaaactgcct tccctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccctgac cacaaggcgcccatggtactgttcttggaccgtgtgtatggcatcaaggatcaaactttt ctgctccacttgctggaagttggatttttacctgacctaagagcctctgcctctctagat acagtttccctaagcaccaccgaggctgcactggcactgaacaggtacatatgttctgca gtgctcccactcctcacaagatgcgcccctctctttgccgggacagagcactgcacttct ttgattgactctacactgcagacaatatacaggctttccaaggggcgatccctcaccaaa gctcagagggacaccatagaggagtgtttgctggccatctgcaatcacttgaggccttcc atgttacagcaactcctgcgacgtctagtttttgatgtgccccaactcaatgaatactgc aaaatgcctcttaagcttctgacgaatcactacgaacagtgctggaagtattattgtctg ccttcgggctgggggagctacggtctggccgtggaggaagagctacatctgacagagaag ctcttctgggggatttttgactccctctcccataagaggtatgacccagatcttttccgg atggccctgccctgtctcagtgcaatagcgggggccctgccaccagattatttagatacc agaatctcagccacattggagaaacaggtctcagtggacgcagatggcaactttgacccc aaacccatcaacactgtgaacttctccttgcctgaaaaattggaatacatcgtcaccaag tatgctgagcactcccacgataaatgggcctgtgacaagagtcagaatgggtggaaatac ggcatttccctggatgaaaatgtgaagacccatccattgatccggcctttcaagacatta accgagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctg gctgtgggctggactgtagagaggaccaaagagggagaagctctggttcaacagcgggaa aatgagaagcttcgaagtgtgtcccaggccagccagggcaacagctacagccctgcccct ctggatctctccaatgtcgtgctctccagagagctccaggggatggtggaggtggtagct gagaactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtggt ggcagtcaccctcttttggtaccctatgataccttgactgccaaggagaagttcagagac cgagagaaggcccaggacctgtttaaattcctccaagtgaatggcattgtggtttccaga ggtatgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagttt ttgaagaaggttctgaaatatgttgattcggctcaagagtttattgcccatttggaagcc attgtcagcagtgggaaaaatgaaaagtctccccatgaccaggagatcaaattctttgcc aaagttctcctcccactggttgaccagtacttcaccaatcatcgcctctacttcctgtcc tcccctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtg gccagcctgttctgcaaactcgctgctctggttcgacacaggatttccctcttcgggagc gattctacaacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacg gtcatgaagtcaggctcagagctggtgaaagctgggttacgggcgttctttgaaaatgca gcggaagacttagagaagactttggaaaacctgaagctcggcaagtttacccattccaga acgcagatcaaaggtgtctctcaaaatattaactacaccacggtggctctgctccccatc ttgacatccatctttgagcacgtggctcagcatcagttcggggtggacttactcttgggt gatgttcagctttcatgctaccatatactgtgcagcctctactccctcgggacaggaaag aacatctatgttgaaaggcagcgtcctgcccttggagaatgcctggcctcactggcagcc gccataccagtggcattcctggagcccacccttaaccgctacaacccgctctccgtcttc aacaccaaaacccccagggagaggtctattctggggatgccagacacagtggaggagatg tgccccgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggctgagtca ggggcccggtacacagagatgccccacgtcattgaggtcatcttgcccatgctgtgcaac tacctatcctactggtgggagcgggggcctgagcacctgccccccagtgcagggccctgg tgcaccaaggtcacgtctgaacacctcagtgtcatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgatgaggcctcttggatgaagcgcattgcagtgtacgcccaa ccgatcatcagcaaagccaggccagacctgctgagaagccacttcatcccgaccctggag aagctgaagaagaaggccatcaagaccgtgcaggaggaggagcagctgcgagcggacagc aagggcgacacgcaggaggccgagctgctcatcctggatgagtttgctatcctctgcaga gacctctatgccttctaccccatgctcatccgctacgtggacaacagcagatctaactgg ctcaaaagccctgatgcagactctgaccagctcttccgcatggtggcagagatcttcatc ctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaa attaataatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaa gtaaagtctggaggacaggaccaggagcggaagaagacaaagcggaggggagacttttat tccatccagacctccctcatcgtggctgcgctcaagaaaatgctgcccattggtctgaat atgtgcaccccaggcgatcaggagctgatctccctcgcaaaatcacggtacagctacagg gacacagatgaagaggtgaaggagcatctgcggagtaacttgcacttgcaggaaaagtct gatgatccagctgtaaagtggcaactgaacctatacaaggatgttttaaagagtgaagaa ccttccaacccagaaaagacagtggagcgtgtgcagaggatttcagcagctgtcttccac ctagagcaggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgctatca aagcagcggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacttgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctaaatctcccaaggtgcaagag gaggaggaggaagaggtggaaaagcagccagacccgcttcatcagatcatcctccacttt agccgcaacgctctcacggagaggagcaaactggaagacgaccctttgtacacctcctat gccagcatgatggccaagagttgtcagagtggggaagacgaagacgaggaggaagacaag gagaaaacatttgaagagaaagaaatggaaaagcagaaaaccctctatcagcaagcccgg ctgcatgagcgtggagccgccgagatggtccttcagatgatcagcgccagcaaaggtgag atgagccccatagtggtggagactctgaagctggggatcgccattctgaatgggggcaat gccggtgtgcagcagaaaatgctagattacctaaaggagaaaaaggatgctgggttcttt caaagtctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctggggatggttactgaggaaggaacactcattgttcgtgag cgtggtgaaaaagtactccagaatgacgagtttacacgagatctctttagattcctacag ttactttgtgaaggacacaacagtgatttccagaacttcctgaggactcagatgggcaac accaccaccgtgaatgtcatcatcagtactgtggactaccttctgcgtctgcaggaatca atcagtgatttctactggtattactcagggaaggagatcattgatgaatctggacagcac aatttttccaaagccctggcggtcaccaagcagatcttcaattcgcttacagaatacatc cagggcccctgcattgggaaccagcagagcctggctcacagcaggctgtgggacgcagtg gtcggcttcctccatgtgtttgctaacatgcagatgaaactctcccaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctcctggaagggaatgtggtaaatggaaccattggcaagcagatggttgacacactggta gagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaaccagctcagacaccttcaaagaatatgatcccgacgggaaaggaatcatttcc aaaaaggaattccagaaggccatggaagggcaaaagcagtacacacagtcggagatagac tttctcctttcgtgcgcagaagctgatgaaaatgacatgtttaattacatcgattttgtt gaccggttccatgaaccagccaaggacatagggtttaatgtggcagtgttattgacaaac ctctctgagcatatgccaaacgattctcgccttaagtgtctgttggacccagcagaaagt gtactcaattacttcgaaccatacctgggacgcattgagatcatgggtggggccaagaaa attgagcgtgtttattttgagatcagtgagtccagccgaactcagtgggagaagccccag gtgaaggagtctaagcgacagtttatctttgacgttgtcaatgaaggcggggagcaagag aagatggagctgttcgtgaacttctgtgaggacaccatcttcgagatgcagttagcatcg cagatctcggaatctgactcagccgacaggccagatgaggaggaggacgaagatggagac tcttcgtacgtgttagaagtggagggcaaggaggaggaggaggagaagtctttggagtgt gcctctgcatttgcgatggcttgcgcctcagtgaagagaagcgtggccaactttctgaag agggccaccctgaagaacctcaggaagcagtacaggaaggtgaagaagatgaccttcaag gagctggtgaagctgctcttctctttcttctggacgttgttcgtggggctcttccacttg ctcttcactatagtgggagggatcattcaggtcctctggggcacagtgttcggaggggga ctcatagaaggggcaaagaatataagagtcaccaagatcctgggcgacatgcctgaccca acccagtttggcatccacgatgatgcgatggaagctgagagggcagaagtgccggagcca ggcatcaccacggaacttgcgcacttcgtaaagggggagaagggagatgcagacatcatg tcagacctctttggactccatccaaagaaagaaggtggcttaaagtatgggcccgaagtg ggtttgggtgacctttctgagattattggcaaagacgaaccccctaccttagagagtact gtccggaagaaaaggaaagcgcaggcagcagaaatgaaagcagctcatgaagcagaagga aaaatagagtctgagaaggcagacatggaagatggggagaaagaggacacagccaaagaa gaagagcaggccgaggccctgtgggcagacgtgaccaaaaggaagaagcgacgatgtggc cagaaggttgagaagcctgaagccttcatggccaatttctttaaagggctggaaatctat cagaccaagttgctgcactacctggccaggaatttctacaacctgaggttccttgctctg tttgtagccttcgctatcaacttcatcctgctcttttacaaggtcaccgaagaaccttta gaagaagagacagaggatgttgcaaacctgtggaattcctttaatgacgaggaagaggaa gaggcggtggtgttctttgtcctgcaggagagcactgggtacatggcgccagccctgcgg gccctggccatcatccacaccgtcatctctttagtctgcgtggtgggctactactgccta aaggtccctttggtcgtattcaaaagagaaaaagaaatcgccaggaagctggagtttgat ggcctgtatatcactgaacagccttctgaagatgacatcaaggggcagtgggatcgcttg gtcatcaacacgccatcttttcctaataactactgggacaagtttgtaaagagaaaggtg atcaacaaatatggagatctctacggagcagaacgcattgctgaactcctgggtttggac aaaaatgcccttgactttagcccagtggaagagaccaaagcggaggcggcctccctggtg tcatggctaagttccgtcgacatgaagtaccatgtctggaagctgggagttgtttttact gacaattcctttctctacctcgcctggtacacaaccatgtcagtcctgggccactacaac aactttttcttcgctgctcatcttctggatatcgcgatgggcttcaagactctgaggact attctgtcatctgtcactcacaatggcaaacagctggtcctgaccgtcggtctcctggcc gtggtggtttatctctataccgtggtggccttcaacttcttccgcaagttctacaacaaa agtgaagacgacgacgagcccgacatgaagtgtgatgacatgatgacgtgttacctgttc cacatgtacgtgggagtgagagctggaggtggcatcggggatgaaattgaagaccctgct ggggacccgtatgaaatgtaccgcatcgtttttgacattaccttcttcttcttcgtcatt gtcatcctgctagccatcatccaaggtctcattattgatgcttttggggagctgagagac cagcaggaacaagtacgagaggatatggagactaaatgtttcatctgtgggattggcaat gactactttgacacgacccctcatggttttgaaacacacacgctgcaggagcacaaccta gccaactacctgttcttcctcatgtatttgattaacaaagatgagacagagcacacggga caggaatcttacgtctggaagatgtaccaagaaaggtgctgggatttcttcccagctggt gactgcttccggaaacaatatgaagatcagcttggataa

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