KEGG   Budorcas taxicolor (takin): 128064538
Entry
128064538         CDS       T08909                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
btax  Budorcas taxicolor (takin)
Pathway
btax01521  EGFR tyrosine kinase inhibitor resistance
btax01522  Endocrine resistance
btax01524  Platinum drug resistance
btax04010  MAPK signaling pathway
btax04012  ErbB signaling pathway
btax04020  Calcium signaling pathway
btax04066  HIF-1 signaling pathway
btax04151  PI3K-Akt signaling pathway
btax04510  Focal adhesion
btax04520  Adherens junction
btax04530  Tight junction
btax05200  Pathways in cancer
btax05205  Proteoglycans in cancer
btax05206  MicroRNAs in cancer
btax05212  Pancreatic cancer
btax05213  Endometrial cancer
btax05215  Prostate cancer
btax05219  Bladder cancer
btax05223  Non-small cell lung cancer
btax05224  Breast cancer
btax05226  Gastric cancer
btax05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:btax00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    128064538 (ERBB2)
   04012 ErbB signaling pathway
    128064538 (ERBB2)
   04066 HIF-1 signaling pathway
    128064538 (ERBB2)
   04020 Calcium signaling pathway
    128064538 (ERBB2)
   04151 PI3K-Akt signaling pathway
    128064538 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    128064538 (ERBB2)
   04520 Adherens junction
    128064538 (ERBB2)
   04530 Tight junction
    128064538 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    128064538 (ERBB2)
   05206 MicroRNAs in cancer
    128064538 (ERBB2)
   05205 Proteoglycans in cancer
    128064538 (ERBB2)
   05230 Central carbon metabolism in cancer
    128064538 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    128064538 (ERBB2)
   05226 Gastric cancer
    128064538 (ERBB2)
   05219 Bladder cancer
    128064538 (ERBB2)
   05215 Prostate cancer
    128064538 (ERBB2)
   05213 Endometrial cancer
    128064538 (ERBB2)
   05224 Breast cancer
    128064538 (ERBB2)
   05223 Non-small cell lung cancer
    128064538 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    128064538 (ERBB2)
   01524 Platinum drug resistance
    128064538 (ERBB2)
   01522 Endocrine resistance
    128064538 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:btax01001]
    128064538 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:btax04147]
    128064538 (ERBB2)
   04090 CD molecules [BR:btax04090]
    128064538 (ERBB2)
Enzymes [BR:btax01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     128064538 (ERBB2)
Protein kinases [BR:btax01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   128064538 (ERBB2)
Exosome [BR:btax04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   128064538 (ERBB2)
CD molecules [BR:btax04090]
 Proteins
  128064538 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 ABC1 Haspin_kinase Kinase-like APH CcmD
Other DBs
NCBI-GeneID: 128064538
NCBI-ProteinID: XP_052513255
LinkDB
Position
19:39779890..39804153
AA seq 1255 aa
MELAAWCRWGLLLALLPPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPADASLSFLQEIQEVQGYVLIAHNRVSQVPLQRLRIVRGTQLFEEHYALAVLDNG
DFLEGAAPAAGTAPGGLQELQLRSLTEILKGGVLIQRNPQLCHQDTILWEDIFHKNNQLP
LKQIDTNRSRACAPCSPACKAPNCWGESSEDCQSLTRTVCASGCARCKGPQPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSKPCAPVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFAGDPDSNITPLQAEQLKVFESLEEITGYLYISAWPDSLP
DLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELSSGLALIHRNARLCFVHTV
PWDQLFQNPHQALLHSANRPEDECVGEGLACYPLCAQGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVKDRYCLPCHPECLPQNGSVTCFGSEADQCVACAHYKDPPFCVARC
PSGVKPDLSFMPIWKFPDAEGICQPCPINCTHSCVDLDDKGCPAEQRASPVTSIIAAVVG
VLLVVLVGLVFGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVTEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGTAHRRHRSTSTRSGGGELTLGLEPSEEEPPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQPLPQHDSSPLQRYSEDPTVPLSPEADGYVAPLTCSPQPEYV
NQPEVRPQPPSPLEGPLPPPRPAGSTLERPKTLSPGKNGVVKDVFAFGAAVENPEYLAPR
GRAAPQSHPSPAFSPAFDNLYYWDQDPSERGTPSSSFEGTPTAENPEYLGLDMPV
NT seq 3768 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgctgggggctcctcctcgccctcctgccccccggagcc
gcgggcacccaagtgtgcaccggcacagacatgaagctgcggctgccagccagtcccgag
acccacctggacatgctgcgccacctctaccaaggctgtcaggtggtgcagggtaacctg
gagctcacctatctgcctgctgatgccagcctctccttcctgcaggaaatccaggaggtg
cagggctatgtgctcatcgctcacaatcgagtgagtcaggtcccactgcagagactgcgg
atcgtgcgaggcacccagctctttgaggaacactacgccctggccgtgcttgacaatgga
gactttctggaaggtgctgcacctgctgcgggcacggccccaggagggctgcaggagctg
cagctgcgaagcctcacagagatcctcaagggaggggtcttgatccagcggaacccccag
ctctgccaccaggacacgattttgtgggaggatatcttccacaagaacaaccagctgccc
ctcaagcagatagacaccaaccgctcacgggcctgcgcaccctgttctccagcttgtaaa
gctcccaactgctggggagaaagttctgaggactgtcagagcttgacgcggaccgtctgt
gccagtggctgtgcccgctgtaagggcccacagcccaccgactgctgccacgagcagtgc
gctgccggctgtactggccccaagcactctgactgcctggcctgcctccacttcaaccac
agcggcatctgtgagctgcactgcccagctctggtcacctacaacacggacaccttcgag
tcgatgcccaaccccgaggggcgttataccttcggtgccagctgtgtgaccgcctgtcct
tacaactacctgtctacggatgtgggatcctgcaccctggtttgtcccctgaacaaccaa
gaggtgacagctgaggatggaacccagaggtgtgagaaatgcagcaagccctgtgcccca
gtgtgctacggtctgggcatggaacacctgcgggaggtgagggcggtcaccagtgccaac
atccaggagtttgccggctgcaagaagatttttgggagcctggcgtttctgccagagagc
tttgcaggggacccagactctaacatcaccccactgcaggctgagcagctcaaagtgttt
gagtctctggaggagatcacaggttacctgtacatctcagcatggccagacagcctgcct
gacctcagcgtcttccagaacctgcgagtaatccggggacgagttctgcatgatggtgcc
tactcgctgaccctgcaagggctgggcatcagctggctggggctgcgctcgctgcgggaa
ctgagcagcgggctggccctcatccaccgcaacgcccgcctctgcttcgtacacacggtg
ccctgggaccagctcttccagaacccccaccaggctctgctccacagcgccaacaggcca
gaggatgagtgcgtgggtgagggcctggcctgctacccactgtgcgcccaagggcactgc
tggggtcccgggcccacccagtgcgtcaactgcagccagttccttcggggccaggaatgc
gtggaggaatgccgagtactacaggggcttccccgggagtacgtgaaggacaggtactgt
ctgccgtgccaccccgagtgtcttccccagaatggctcagtgacctgctttggctcggag
gctgaccaatgtgtggcttgtgcccactacaaggatcctcccttctgcgtggctcgctgc
cccagtggtgtgaagcctgacctctccttcatgcccatctggaagtttccagatgcggag
ggcatatgccagccatgccccatcaactgcacccactcctgtgtggacttggatgacaag
ggctgccccgccgagcagagagccagccctgtgacatccatcattgccgctgtggtgggc
gttctgctggttgtccttgtggggctggtgttcggcatcctcattaagcgaaggcggcag
aagatccggaagtatacaatgcggaggctgctgcaggagacggagctggtggagcccctg
acgcccagcggagcgatgcccaatcaggctcagatgcggatcttaaaagagacagagctg
aggaaagtgaaggtgctaggatctggagcttttggcaccgtctacaagggcatctggatc
cccgatggggaaaatgtgaaaatccccgtggccatcaaggtgttgagggaaaacacatct
cccaaagccaacaaggaaatcttggacgaagcatatgtgatggctggtgtaggctcccca
tatgtgtcccgcctcctgggcatctgcctgacatccacagtgcagctggtgacacagctt
atgccctatggctgcctcctcgaccacgtccgagaacaccgtgggcgcctgggctcccag
gacctgctgaactggtgtgtgcagattgccaaggggatgagctacttggaggatgtgcgg
ctcgtgcatagggacctggctgcccggaacgtgctggtcaagagtcccaaccatgtgaag
ataacagacttcgggctagctcggctgctagacattgacgagacagagtaccacgcagat
gggggcaaggtgcccatcaagtggatggcattggagtccattctccgccggcggttcacc
caccagagtgacgtgtggagctatggtgtgactgtgtgggagctgatgacttttggggcc
aaaccttatgatgggatcccagcccgggagattcctgacctgctggagaagggagaacgg
ctgccccagccccccatctgcaccattgatgtctacatgatcatggtcaaatgttggatg
attgactctgaatgtcggccgaggttccgggagttagtgactgaattctcccgcatggcc
agggacccccagcgctttgtggtcatccagaatgaagacttgggccctgctagccccctg
gatagcaccttctaccgctcgctgctggaggatgacgacatgggcgacctggtggatgcg
gaggagtacctggtaccccagcagggcttcttctgcccagaccctgccccaggagctgga
ggcacggcccaccgcaggcaccgcagcacatccaccaggagtggtggtggtgagctgaca
ctggggctggagccctctgaggaggagccccccagatctccgctggcaccttccgaaggg
gcaggctctgatgtgtttgatggcgacttgggaatgggggcggccaaggggctgcagccc
ctcccccaacacgactctagccctctacagcggtacagcgaggaccccacagtacccctt
tctcccgaggctgatggctacgttgcccccttgacctgcagcccccagcccgaatacgtg
aaccagccagaggttcgcccacagcccccatcacccctagagggtcctctgccgcctcct
cgacctgcaggttctactctggaaaggcccaagacgctctcccctgggaagaatggggtt
gtcaaagacgtttttgcctttggggctgctgtggagaaccccgagtacttggcaccccgg
ggcagggccgcccctcagtcccacccttctccagccttcagcccagcctttgacaacctc
tactactgggaccaggacccatcagagcggggcactccatccagctcctttgaagggacc
cctacggcagagaaccctgagtacctgggcctggacatgccagtatga

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