Cygnus atratus (black swan): 118254100 Help Entry 118254100         CDS       T09349                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism cata  Cygnus atratus (black swan) Pathway cata04020   Calcium signaling pathway cata04260   Cardiac muscle contraction cata04261   Adrenergic signaling in cardiomyocytes cata04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:cata00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118254100 (RYR2)    04020 Calcium signaling pathway     118254100 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     118254100 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     118254100 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:cata04040]     118254100 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:cata04990]     118254100 (RYR2) Ion channels [BR:cata04040]  Voltage-gated cation channels   Ryanodine receptor    118254100 (RYR2) Domain-containing proteins not elsewhere classified [BR:cata04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    118254100 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  118254100 NCBI-ProteinID:  XP_050565782 LinkDB All DBs Position 3:80507617..80822066 Genome browser AA seq 4991 aa AA seqDB search MDEPSTNMSTLNGQFFNMDLLLLADDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLEST SNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKSAQGGGHRT LLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEG EKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGD VLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWG QPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAP EIKYGDSMCFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEE SRTARVIRSTVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEH EDKQNRLRALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGREAGEAWKSILNS LYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEG HIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHV SSMRPNIFLGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAE WGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDLSAPSISFRING QPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKL KVEHSREYKQDRSYTRDLLGPTLSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHEL WVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGI ADEHAEEKVKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRI RQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHA TRLDICNGIMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDD EAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAF KDFEVGDGFLPVCSMGPSQVGRMNFGKDVSTLKFFTICGLQEGYEPFAVNTNRDITIWLS KRLPQFLPVPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAE VFSRTAAGGLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKSELNN HKDYVQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRI FPGQEPANVWVGWITSDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGE SMSPGQGRNNNGLEIGCLIDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNV FQFELGRIKNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRIS ERQGWMIQCLNPLQFMALHVPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRV AHAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDE TKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTI EMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFK EAVSQEDESDFSEKELSSDELKSEEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYL CDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQI NMLLNFKDDKNDCPCPEEIQDQLLDFHEDLMTHCGIELDEDGSLDGSSDLTIRGRLLYLM EKVTYLKKKQAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYD GIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKA MFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCG LQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGP ALRGEGGNGLLAAMEEAIKISEDPTRDGPSPSNGSSKTLEMEEQEDDTIHMGNAIMTFYA ALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVE PDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAVLSATDMA LALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECL LSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAA SEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQS SMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKV QPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQI SVDAVHGYSPRAIDMSNVTLSRDVHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLV PYDTLTAKEKAKDREKAQDILKFLQINGYIVSRGFKDLELDTPSIEKRFAYSFLQQLIRY VDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSS GGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLES VKMALRAFLDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHI GQHQFGEDLILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLE THLNKHNIYSIYNTKNARERAVLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMP HIMEVILPMLCSYMSHWWEHGPENNPDKTEMCCTALTSEHMNTLLGNILKIIYNNLGIDE GAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAE LLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNSEAEELFRMVAEVFIYWSKSHNF KREEQNFVVQNEINNMSFLISDTKSKMSKSAVSDQERKKMKRKGDRYSMQTSLIVAALKR LLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYK DLPNRTEDSSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFR MAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDENLKRVDPL HQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKH DIIKDLRNIFASLGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAA TLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGL GMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDY LLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAH SRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGK QMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKH YTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQT FLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVV NEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEENEKDKPEEQDPGMGFFS LVSMKLALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHF ACSVFRGFFHIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTETA LPTEDLTDLRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEE QEKIQEQMKEDEKEEKEETKSEPEKAEGEDGEKEEKTKEDKGKQKLRQLHTHRYGEPEVQ ESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKEVPVV STGESMKLNTLESDSQRIIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVP LVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDK YGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSVDVKYQMWKLGVVFTD NSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAG DEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGND YFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGD CFRKQYEDQLN NT seq 14976 nt NT seq  +upstreamnt  +downstreamnt atggacgagccatccactaacatgtctacactaaatgggcagtttttcaacatggattta ctcttacttgcagatgatgaagtggttctgcagtgcactgcaacagttcacaaggagcaa cagaaactgtgtcttgctgcagaaggatttggcaacagactttgctttttggaatccaca tcaaattctaagaatgtgccacctgatttgtccatctgtacctttgtgctggagcagtct ctgtcagtacgagccctccaggaaatgctggctaacacagaggaaaaggcagaagggcta gttgatgtggaaaaatggaaatttatgatgaagtctgcacaaggtggtggtcatcgaaca ctactctatgggcatgcaatcctgctgcgccattcctacagtggcatgtatctatgctgc ctgtctacatctagatcttcaatggataagctggcatttgatgtaggattgcaagaggat acaacaggtgaggcatgctggtggaccatccatcctgcttccaagcagcgatcagaagga gaaaaagtgcgtgttggagatgatcttattttagtcagcgtctcttcagaaagatacctg catctctcttatggcaatggtagcttacatgttgatgcagccttccagcaaacactctgg agtgtagcaccaatcagttcaggaagtgaagttgcccaaggatatctgataggaggggat gttctgaggttgttgcatggtcacatggatgaatgcttgacagtcccttcaggtgaacat ggagaagaacaaagaagaactgtccattacgaaggtggtgctgtgtcaattcacgcacgt tctctttggcgattagagactctaagagttgcgtggagtggcagccacataagatgggga cagccattcagattaagacatataacaacaggaaaatatttaagtctcctggatgacaag agtcttcttcttacagacaaagagaaagcagatgtaaaatctacggcgttctgttttcgt tcttccaaggaaaagttggacatagggacaagaaaagaggtggatggaatgggggcacct gagattaaatatggagattcaatgtgcttcatacaacatgtagacacgggcctatggctc acgtaccagtctgctgatgcaaagtctgtaagaatgggttctgtgcagcgcaaggcaata atgcaccatgaaggtcacatggatgacggtttaacattgtccagatctcagcatgaagaa tcccgcacggcacgtgtcatccgtagtacagtcttccttttcaacaggtttataaggggt cttgatgctctcagcaagaaagtgaagtcttccacagtagatttacctattgagtcggtc agtctgagccttcaagacttgattggctactttcatccccctgatgaacatttagagcat gaagacaaacaaaacaggctccgagcactgaagaatcgccagaacctcttccaggaagag ggtatgatcaaccttgttcttgaatgtattgatcgcttgaatgtatacagcagtgcagct cattttgcagatgtagctgggagggaagctggagaagcatggaaatccattctgaattct ttgtatgaattactagcggctctgattcgagggaatcgtaaaaactgtgctcaattttct ggatctcttgattggttgatcagcagattagaaagactggaagcttcttctggaattcta gaggttttacactgtgtgttggtggaaagccctgaagctctaaacataattaaagaagga catattaaatcaatcatctgtcttttggataaacatggaagaaaccataaggttttggat gtcttgtgttctctctgtgtatgtcatggagtagctgtgcggtctaatcaacatctaatc tgtgataatctcttgcctggaagagatctgctattacagacacgcctagtcaaccatgtg agcagcatgcgacccaatatctttttggggattagtgaaggctctgcccagtacagaaaa tggtactatgaacttatggtggaccatctagagccctttgtgaccgcagaatcaactcat ctacgagtgggctgggcttcaacagagggctactcaccgtatccagggggaggagcagaa tggggaggaaatggtgttggtgatgacttgtattcctatggcttcgatggtctgcatctg tggtcaggttgtgtagcacgaacagtaaattctcccaaccaacatctgttaagaactgat gatgttattagctgctgtttggatctgagtgctcccagcatctcttttcggataaatggt cagccagttcaaggaatgtttgagaatttcaacatagatggcctcttcttcccggttgtc agcttctctgcaggaataaaggtacgtttcttgcttggaggtcgccatggagagttcaag ttccttcctccacctggatatgccccctgctttgaagctgtcctaccaaaagagaaactt aaagtggagcatagccgagagtacaagcaggatcgcagctacacaagagacctactgggt cccactctttctctgtcacaagcagcttttaccccagttcctgtggatactagccagatt gttttgcctcctcacctggaaaggattagagaaaaattagcagagaacattcatgaactt tgggttatgaataagattgaacttggctggcagtatggaccagttagagatgacaacaaa agacaacacccatgcttagtggagttctcaaaattgccagagcaggagagaaattataac ctgcaaatgtcacttgaaacactgaaaaccctgctggcattaggctgccatgttggaatt gctgatgaacatgctgaagaaaaagtgaaaaaaatgaaacttccaaagaactaccagttg ttgagtggatataagcctgctcccatggatctgagttttatcaaactgaccccctctcaa gaagctatggtggataaactagcagagaatgctcacaatgtgtgggcaagggaccgtatc aggcaaggctggacctatggtatccagcaggatgtgaaaaatcgacgaaatcctcgcctt gtaccttatgctcttttggatgatcggacgaagaagtcaaacaaagacagtcttcgtgaa gcagtccgcacccttttaggctatggttacaacctggaagctcctgaccaagatcatgcg acgagattggatatatgcaatgggataatggaaaaatttaggatcttccgcacagagaag acttatgcagtgaaggctgggaagtggtacttcgagtttgaggcagttacagcaggagac atgagagttggctggacaaggccgggttgcctgccagatcaggaacttggctcagatgat gaagcttttgtttttgatggctttaaggcacagcggtggcatcagggtaatgagcatttt ggccgctcatggctggcaggagatgttgttggatgtatggttgacatgaatgaacacact atgatgttcaccttaaatggtgaaatccttctcgatgactcaggttcagaacttgcattc aaggactttgaagttggtgatggatttctacctgtgtgcagcatgggcccatctcaagtg ggaagaatgaactttggaaaagatgtcagcactctaaaatttttcactatctgtggctta caggaagggtatgaaccctttgctgttaatacaaacagagacatcaccatttggctgagt aaaagactccctcagtttctaccagtgccacaaaatcatgaacatattgaggtgatgaga attgatggcaccatagacagctgtccctgcctgaaggtcacgcagaagtcctttggttca cagaacagtaaaacagacgtcatgttttttcgattaagtatgcctattgaatgtgctgag gtgttctccagaacagctgcaggagggttaccaggcactggtctttttggcccaaagaat gatttggaggattatgatgctgattctgattttgaggttctaatgaaaactgctcatggt catctagtgcctgaccggacagaaagagaaaaagatgccacaaaatcagagttaaataac cataaagattatgttcaagaaaagccttcacgtcttaaacaaagatttatgctcaggagg acaaagccagattatagcacaagccattctgcacggcttaccgaggatgtgctagcagat gatagggatgactatgattatttgatgcaaacttccacgtattattattcagtgagaata tttcctggccaagaacctgcgaatgtctgggtaggctggattacctctgactttcatcag tatgacacaagctttgacttggacagagtgcgtacggtcacagtgacactgggagatgaa aaaggaaaggttcatgagagtataaagcgtagcaactgctatatggtgtgcgcaggagag agcatgagccctggacaaggacgtaataataatggtctggaaattggttgcttaattgat gctgccagtggcctgctgaccttcacagctaatggcaaggaactgggcacgtactatcag gttgaacctagtacgaagttatttcctgctgtatttgctcaagctacaagccccaatgtt ttccagtttgaattgggtagaataaagaatgtaatgccattgtctgctggcttattcaaa agtgaacacaaaaacccagtgtctcaatgtcctccacgtctccatgtccagtttctgact catgtgctttggagcagagtgccaaaccacttcttgaaggttgatgtctctcgaatcagt gaacgtcaaggctggatgatacagtgcctgaatcctttgcagttcatggcccttcacgtt cctgaagaaaacagaacgattgatattttagagctgacagaacaagaagaactgctgaaa tttcactaccataccctccgattatattcagctgtttgtgctttagggaacaaccgagtg gcccatgctatgtgtagccatgtggatgaatctcagctcctatatgctattgagaataaa tatatgccaggattattacgtgcaggatattatgacttacttattgacatccatctcaat acttatgcaactgccaggttaatgatgaataatgaatttattgtcccaatgacagatgag accaagagtattaccttgtttcctgatgaaaacaaaaaacatggccttcctggtatagga cttagcacttccttgagaccaagaatgcagttctcctcaccaagttttgtaagcattagc agtgaatgctttcagttcagtcctgaattccctcttgaaatcctaaaagccaaaacaata gagatgctaactgaagctgttcaggagggcagcctccatgtcagggatccagttggaggt tctacagaatttctgtttgttcctctcatcaagctcttttacactctcctaattatgggc atcttccacaatggggatctgaaacacatcttgcagttgattgagcccagggttttcaaa gaagctgtgagccaggaggatgaaagtgatttctcagagaaggagctgagttcggatgag ctcaagtcagaagaaggagaggaagaaaccagaggggagcaggtgccaaaggaaggactg cttcagatgaaacttcctgaacctgttaaactacagatgtgtcatctactccagtacctg tgtgattgccaggtacgacaccggatagaagccattgtagcattttcggatgattttgtg gccaagcttcaagagaatcagcgcttccggtacaatgaggtgatgcaggccttgaacatg tctgctgccttgacagctagaaaaacaaaggaatttcgatcaccacctcaggagcagatt aacatgctgctgaactttaaggatgataaaaatgattgtccttgtcctgaagaaattcag gaccagctcttggacttccatgaagacctaatgacgcactgtggaattgaactagatgaa gatggatccttggatggaagcagtgatttaaccattaggggtcgcctcctgtaccttatg gaaaaagttacatatctgaagaagaagcaagctgagaagccagttgatgatgatgctaag acatcctctactcttcaacagctgatttcagacacaatggtgcgctgggcccaggaatca gtaatagaagacccagagttagtcagggccatgtttgtactgcttcatcgccagtatgat ggtattggtggcttggttcgagccctgccaaagacctatactataaatagtgtgtctgtg gaagacacaatcaatcttctggcatccctcggccaaatacgttccttgctcagtgtcagg atgggaaaagaggaagagaaacttatgattcgtggattaggagacatcatgaataacaaa gtattttaccaacatccaaatctcatgagagctttaggcatgcatgagactgtcatggaa gtgatggtaaacgtgcttggtggaggagaatccaaggaaatcactttcccaaaaatggta gcaaattgctgtcgtttcctatgttatttttgccgcatcagcaggcagaatcaaaaagct atgtttgatcatcttagctatttgttggaaaatagtagtgttggccttgcttctccttct atgagaggatcaactcctttagatgttgcagcagcatctgtgatggataacaatgaactt gcactagctttaagggagcctgatttggagaaggtggttcgctacttggctggttgtgga ttgcagagttgtcctttgctgatttctaaagggtatccagacattggatggaatccagtt gaaggagagcgatatttggattttcttcgttttgctgtattttgcaacggagagagtgtg gaggagaatgctaatgttgttgtcagactgcttattcgtcgaccagaatgttttggtcca gctctaagaggagaaggaggcaatggtctacttgctgccatggaggaagcaataaaaata tcagaagatccaacaagagatggaccttcgccaagtaatggatctagtaaaactcttgaa atggaagaacaagaagatgacactattcacatgggaaatgcaatcatgaccttttatgct gctttgattgatctcttaggacgttgtgcccctgaaatgcatctaatccatgctggtaaa ggggaagccattagaatcaggtcaattctaaggtctttgattccactagaagatttggtg ggcgtaattagtattcctttccacatgccgaccatagctaaagatggaactgtggtggaa cctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgac agggtctatggaattgaggatcaggattttcttcttcaccttcttgaagttggctttctg ccagatctccgtgctgctgcttctttagatacagctgtcttaagtgctacggatatggct ttggctctgaatcgatacctttgcacagcagtcttgcctctgttgaccagatgtgctcct ctttttgctggcacagagcaccatgcttccctcattgattccttattacatactgtgtac agactgtcaaagggctgctctcttaccaaagctcagcgagattccattgaagagtgttta ctgtctatttgtgggcaattgaggccttccatgatgcagcatttgctgagaagattggta tttgatgttcctctattaaatgaacatgcaaagatgcctctcaagttgctgacaaatcat tatgaaagatgctggaagtattattgtttgccaggtggatggggtaattttggtgctgcc tcagaagaagaacttcatttatccagaaagttgttctggggtatttttgatgctttgtct caaaagaaatatgaacaagaattgttcaaactggctttgccttgtttgagtgcagttgca ggggccttacctccagactatatggaatcaaattatgtaaatatgatggaaaaacagtct tcaatggattcagaagggaactttaatcctcaacctgttgatacatccaacatcacaatc cctgaaaagctagaatatttcattaacaaatatgcagaacattctcatgataaatggtca atggaaaagtttgccaatggatggacatatggtgaaacatattctgaatctgcaaaagtg caaccattaatgaaacaatacaaattactctctgaaaaggagaaagaaatttatcgatgg ccaatcaaagaatcactgaaaaccatgctggcatggggatggcgcattgaaaggacacgg gagggagattccatggcactgtataatcggacacgtcgcatatctcaaaccagtcaaatc tcagtagatgcagtccatggttacagtcctcgagcaattgacatgagcaatgtcaccctc tccagagatgtacatgctatggcagagatgatggctgaaaactaccataatatatgggca aagaaaaagaaaatggagcttgaagcaaaagtaggaggaggcaaccatcctcttcttgtt ccttatgacactctcacagccaaagaaaaagccaaggacagagaaaaagcacaggatatt ctgaaatttctgcagattaatggatatattgtctccagaggatttaaggacctggagttg gacacaccttccattgaaaaacgctttgcctacagtttccttcagcaacttataagatat gtggatgaagcccatcagtatattttggagtttgatggtggcagcagaggaaaaggagag cactttccatatgaacaagaaatcaagttttttgccaaagttgtgctccctttgattgat cagtatttcaaaaatcatcgcctgtatttcttatctgcagcaagtagacctctcagcagt ggaggccatgcctctaataaagagaaggaaatggtgacaagcctgttctgcaaacttgga gttcttgtcaggcataggatttcactgtttggaaatgatgcaacatcaatagtcaactgt cttcacatactgggccagaccttggatgcaaggactgtgatgaaaactggtctggagtct gttaagatggcacttagagcttttttggacaatgctgctgaggatctggagaagacaatg gaaaatctgaaacaaggccagtttacacacagcagaaaccagcccaagggagttacacaa atcattaattataccacagtggctctcctgccagtgctatcttcattatttgagcatatt ggacagcaccagtttggggaagatttgatattggaagatgttcaggtctcctgttacaga atattggccagtttgtatgctctgggaaccagcaagagcatttatgtagagcggcaacga tcagcactaggagaatgcttggctgccttctcaggtgcctttccagtggcttttttggaa actcatttgaacaaacataatatctactcaatttacaataccaagaatgcaagagagaga gcagttctcaatttgcctactagtgtagaagaggtttgcccaaatattccttccttggtg aagctaatggaagaaattgtggaactggcagagtctggcattcgttacacacaaatgcca catataatggaagtgatactgcctatgctatgtagctacatgtcacactggtgggagcat gggccagaaaacaaccctgacaagactgaaatgtgttgtacagccttgacatcagagcac atgaacactctgttgggtaacatattgaaaatcatctataacaaccttggtattgatgaa ggagcctggatgaagaggttagcagtgttttcccagcccatcataagcaaagcgaaacca cagctcttaaagacacacttcctgccgctgatggataagctaaagaaaaaagcagcagtg gttgtatcggatgaagaacatctaagagcagaaggcagaggtgacatgtcggaggctgaa ctgctcatcctagatgagttcaccactttggcacgggacctctatgccttctaccctttg ttgattagatttgtggactataacagggcaaaatggctgaaagagcccaacagtgaagct gaggaattgtttcgcatggtggctgaagtcttcatttactggtcaaagtctcataatttc aaaagggaagagcagaactttgtggtacaaaatgaaatcaataacatgtctttccttatc agcgacaccaaatctaagatgtccaagtcagcagtttctgaccaagagaggaagaagatg aagcggaaaggtgaccggtactctatgcagacctctctcattgtggcagcactgaagaga ttacttcccattggcctaaatatttgtgcccctggagatcaagaactaattgcactggcc aaaaaccgattcagcatgaaagatactgaggatgaagtacgagacatcatacgcagtaat cttcatctccagggcaagcttgaggatcccgccattagatggcagatggcactttacaaa gatttgccaaacaggactgaagattcctcagatccagagaagactgtggaaagagttctt gatatagctaatgtactttttcatctggaacaggttgaacatcctcaacggtccaaaaaa gcagtgtggcataagctgctgtctaaacagaggaaaagagcagtggttgcctgctttaga atggcaccattatataatctgccaaggcatcgagctgtcaatctctttcttcaaggctat gataaatcatggattgagacagaagaacactattttgaagacaaactgatagaagattta gcaaaacctggagaggaaccaccagaagaagatgaaaaccttaaaagagttgatccttta catcaacttattctgctattcagtcgaacagccttaactgaaaaatgcaaattggaggaa gattttctctatatggcttatgctgacattatggcaaagagttgccatgatgaagaagat gatgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaacgcagcaagcac gatattatcaaagatttaagaaacatatttgccagcctcggcgagaactctctggaaaaa gaaatggaaaagcaaaaacttctgtatcagcaagccagactgcatgaccggggtgctgct gagatggttcttcagacaatcagtgctagtaaaggtgagatggggccaatggttgcagct accctaaagctagggattgccatcttaaatggaggaaattctacagttcaacagaaaatg cttgactacctcaaggataagaaagatgtgggtttctttcagagtcttgctggtcttatg cagtcctgtagtgttcttgacctaaatgcatttgaacgtcagaacaaagcagaaggcctt ggcatggtgactgaagagggatcaggagaaaaggtgatgcaggatgatgagttcacctgt gacctcttccgctttcttcaactgctttgtgaaggacataactcagattttcaaaattac ctgagaactcagactggtaacaacacaactgttaatattatcatttccactgtggattac ttattgagagttcaggagtccattagtgatttctattggtattattctgggaaggacgtt attgatgagcaaggacaacgaaatttttccaaagccatccaggttgcaaaacaggttttc aatactctcacagagtatatccaggggccatgtactgggaatcagcaaagtctggcacac agcaggctatgggatgctgtagttggttttcttcatgtgtttgcccacatgcagatgaag ctgtcccaggattccagtcaaattgaattactgaaagaattaatggatcttcagaaggat atggttgtcatgttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaag cagatggttgatatgcttgtggaatcgtccaacaatgtggagatgattctgaagtttttt gatatgttcttaaaactgaaggatttgacttcctctgatgcattcaaagagtatgaccca gatggtaaaggcataatttcaaaaagggatttccacaaagcaatggaaagccataaacat tacactcagtctgaaactgagtttctgctatcttgtgctgaaactgatgagaatgagact ctggactatgaggagtttgtgaaacggttccatgaacctgccaaagacattggtttcaat gttgctgttctcttgaccaacctctcagaacacatgccccatgatacccgcttgcaaact tttcttgaactgtcagagagtgtgctgaattattttcagcctttccttggacgcatagaa atcatgggcagtgcaaagcgcattgaacgagtatattttgaaataagtgagtcaagtcgg actcagtgggagaaacctcaggtaaaagagtcaaagaggcaatttatatttgatgttgta aatgaaggtggggagaaagaaaagatggagctttttgtcaatttctgtgaggataccatc tttgaaatgcaactggctgcacagatttctgagtcagatctgaatgaaaggtcagctaat aaagaggaaaatgagaaagataagcctgaggagcaggatcctggaatgggtttcttctct cttgtatctatgaagttagcattagtagctctcaagtataatttgatgactcttatgaaa atgcttagcatgaaaagcctgaagaaacagatgaaaaaagtgaagaaaatgaccatgaag gacatggttatggctttgttttcttcctactggagcattttgatgggcttactgcatttt gcttgtagtgtcttccggggcttctttcacatcatatgcagtttgctgcttggaggaagc ctagtagaaggagcaaagaaaatcaaggtggctgaactattagccaatatgccagatccc acgcaggatgaggtgcgtggggaaggagaagagggggagaggaagcccacagaaactgca ttgcctacagaagacttgacagatttgagaactttatcagatgagagtgatctactctcg gatatatttggtttggatttgaaacgggaaggtggacagtataaattgatccctcataat ccaaatgctggtttgagcgatttgctgagcactccttccttagctccaatgcctgaagag caggaaaaaatccaggaacaaatgaaagaagatgaaaaggaagagaaggaggaaacaaaa tctgaacctgaaaaagcagaaggagaggatggagaaaaagaagagaaaaccaaggaagac aaagggaaacagaaattaagacagcttcatactcatagatatggagaaccggaagttcag gaatcggctttctggaagaaaataattgcctatcaacaaaagcttcttaactattttgct cgaaacttttataacatgaggatgttggcattgtttgttgcttttgccatcaacttcatc ctgcttttctacaaggtctccacctctgctgtgacagaagaaaaggaagttcccgtggtg tctactggagaaagtatgaagttgaacaccttggagagtgacagccagaggatcattgca gttcattatgtcctagaagaaagcagtggctacatggagcccacgctgcggattttggcc atcttacacacaatcatctccttcttctgcatcatagggtattactgtttgaaagttcca ctggttatttttaagagggaaaaggaagtagcaaggaaattggaatttgatgggctgtat ataactgaacagccctcagaagatgatattaaagggcaatgggatagacttgtaatcaac acacagtcttttccaaacaactattgggacaaatttgtaaaaagaaaggtcatggataaa tacggtgagttttatggccgtgacagaatcagtgagttactaggaatggacaaagctgct cttgattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgct gtgctaaactctgttgatgttaagtatcaaatgtggaaattaggagttgttttcactgat aattctttcctttacctagcttggtacatgaccatgtcagtccttggccattacaacaat tttttctttgctgctcatcttcttgacattgcaatgggattcaagacattacgaactatc ctgtcatcagtgacccacaatggtaaacagcttgtcctaacagtgggattactggcagta gtggtatacttgtacacagtagtggcattcaatttttttcgcaagttctacaacaagagt gaagatggtgatatgccagacatgaaatgtgatgatatgttaacatgctacatgtttcac atgtatgttggagtacgtgctggtggaggaattggtgatgaaatagaggatccagcagga gatgaatatgaaatctatcggattatctttgatatcactttcttcttctttgtgatcgtc atcctgcttgccattattcaaggtttaattattgatgcttttggtgagttaagagatcaa caagaacaagttaaagaagatatggagacaaagtgctttatctgtggaataggaaatgat tactttgatacggtgccccacggctttgaaacacacacactgcaggagcacaacttggcc aattacttgtttttcctgatgtatcttattaataaagatgaaacagagcatacaggacag gaatcctatgtatggaaaatgtatcaagaacggtgctgggagttttttcctgctggtgat tgcttccgaaaacaatacgaagaccagctcaactaa

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