KEGG   Cercocebus atys (sooty mangabey): 105577494
Entry
105577494         CDS       T07242                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty00562  Inositol phosphate metabolism
caty01100  Metabolic pathways
caty04015  Rap1 signaling pathway
caty04020  Calcium signaling pathway
caty04022  cGMP-PKG signaling pathway
caty04062  Chemokine signaling pathway
caty04070  Phosphatidylinositol signaling system
caty04071  Sphingolipid signaling pathway
caty04072  Phospholipase D signaling pathway
caty04081  Hormone signaling
caty04082  Neuroactive ligand signaling
caty04261  Adrenergic signaling in cardiomyocytes
caty04270  Vascular smooth muscle contraction
caty04310  Wnt signaling pathway
caty04371  Apelin signaling pathway
caty04540  Gap junction
caty04611  Platelet activation
caty04613  Neutrophil extracellular trap formation
caty04621  NOD-like receptor signaling pathway
caty04713  Circadian entrainment
caty04720  Long-term potentiation
caty04723  Retrograde endocannabinoid signaling
caty04724  Glutamatergic synapse
caty04725  Cholinergic synapse
caty04726  Serotonergic synapse
caty04728  Dopaminergic synapse
caty04730  Long-term depression
caty04742  Taste transduction
caty04750  Inflammatory mediator regulation of TRP channels
caty04911  Insulin secretion
caty04912  GnRH signaling pathway
caty04915  Estrogen signaling pathway
caty04916  Melanogenesis
caty04918  Thyroid hormone synthesis
caty04919  Thyroid hormone signaling pathway
caty04921  Oxytocin signaling pathway
caty04922  Glucagon signaling pathway
caty04924  Renin secretion
caty04925  Aldosterone synthesis and secretion
caty04926  Relaxin signaling pathway
caty04927  Cortisol synthesis and secretion
caty04928  Parathyroid hormone synthesis, secretion and action
caty04929  GnRH secretion
caty04933  AGE-RAGE signaling pathway in diabetic complications
caty04934  Cushing syndrome
caty04935  Growth hormone synthesis, secretion and action
caty04961  Endocrine and other factor-regulated calcium reabsorption
caty04970  Salivary secretion
caty04971  Gastric acid secretion
caty04972  Pancreatic secretion
caty04973  Carbohydrate digestion and absorption
caty05010  Alzheimer disease
caty05016  Huntington disease
caty05017  Spinocerebellar ataxia
caty05022  Pathways of neurodegeneration - multiple diseases
caty05142  Chagas disease
caty05143  African trypanosomiasis
caty05146  Amoebiasis
caty05163  Human cytomegalovirus infection
caty05200  Pathways in cancer
caty05415  Diabetic cardiomyopathy
caty05417  Lipid and atherosclerosis
Module
caty_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:caty00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105577494 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105577494 (PLCB3)
   04310 Wnt signaling pathway
    105577494 (PLCB3)
   04371 Apelin signaling pathway
    105577494 (PLCB3)
   04020 Calcium signaling pathway
    105577494 (PLCB3)
   04070 Phosphatidylinositol signaling system
    105577494 (PLCB3)
   04072 Phospholipase D signaling pathway
    105577494 (PLCB3)
   04071 Sphingolipid signaling pathway
    105577494 (PLCB3)
   04022 cGMP-PKG signaling pathway
    105577494 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105577494 (PLCB3)
   04081 Hormone signaling
    105577494 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105577494 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105577494 (PLCB3)
   04613 Neutrophil extracellular trap formation
    105577494 (PLCB3)
   04621 NOD-like receptor signaling pathway
    105577494 (PLCB3)
   04062 Chemokine signaling pathway
    105577494 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    105577494 (PLCB3)
   04922 Glucagon signaling pathway
    105577494 (PLCB3)
   04929 GnRH secretion
    105577494 (PLCB3)
   04912 GnRH signaling pathway
    105577494 (PLCB3)
   04915 Estrogen signaling pathway
    105577494 (PLCB3)
   04921 Oxytocin signaling pathway
    105577494 (PLCB3)
   04926 Relaxin signaling pathway
    105577494 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    105577494 (PLCB3)
   04918 Thyroid hormone synthesis
    105577494 (PLCB3)
   04919 Thyroid hormone signaling pathway
    105577494 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    105577494 (PLCB3)
   04916 Melanogenesis
    105577494 (PLCB3)
   04924 Renin secretion
    105577494 (PLCB3)
   04925 Aldosterone synthesis and secretion
    105577494 (PLCB3)
   04927 Cortisol synthesis and secretion
    105577494 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105577494 (PLCB3)
   04270 Vascular smooth muscle contraction
    105577494 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    105577494 (PLCB3)
   04971 Gastric acid secretion
    105577494 (PLCB3)
   04972 Pancreatic secretion
    105577494 (PLCB3)
   04973 Carbohydrate digestion and absorption
    105577494 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105577494 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    105577494 (PLCB3)
   04725 Cholinergic synapse
    105577494 (PLCB3)
   04728 Dopaminergic synapse
    105577494 (PLCB3)
   04726 Serotonergic synapse
    105577494 (PLCB3)
   04720 Long-term potentiation
    105577494 (PLCB3)
   04730 Long-term depression
    105577494 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    105577494 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    105577494 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    105577494 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105577494 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105577494 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105577494 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105577494 (PLCB3)
   05142 Chagas disease
    105577494 (PLCB3)
   05143 African trypanosomiasis
    105577494 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105577494 (PLCB3)
   05016 Huntington disease
    105577494 (PLCB3)
   05017 Spinocerebellar ataxia
    105577494 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    105577494 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105577494 (PLCB3)
   05415 Diabetic cardiomyopathy
    105577494 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105577494 (PLCB3)
   04934 Cushing syndrome
    105577494 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:caty04131]
    105577494 (PLCB3)
Enzymes [BR:caty01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105577494 (PLCB3)
Membrane trafficking [BR:caty04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105577494 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105577494 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 105577494
NCBI-ProteinID: XP_011897286
Ensembl: ENSCATG00000031941
UniProt: A0A2K5LSS9
LinkDB
Position
Unknown
AA seq 1234 aa
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQVLLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGGPDS
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEGALEKPSLEPRKSLGE
EGLNRGPYALGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQEMCQDTQSQQL
GSQLSPNPTPSPLDASPRRPPGPTTSPTSTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLQSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQADGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKTRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGETPEGLG
DGLLVACASNGHAPGSSGHLSGADSESQEENTQL
NT seq 3705 nt   +upstreamnt  +downstreamnt
atggcgggcgcccagcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgtgtggaccccagtggcttcttcttgtactggacaggccccaacatggag
gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgtctg
cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag
gagaagctgatgacggtggtgtctgggccggacccagtgaacacagtgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacgaagctg
aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggtgccaagggcaagccatac
ctgacactggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac
gaagtgctgtacccgccgctgcggccctcccaggcccgactgctcatcgaaaagtatgag
cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaacggcatcctgcccctggaagccctggatctgagcgccgacatgacc
cagccgctgagtgcctacttcatcaactcctcgcataacacctatctcactgctgggcag
ctggccgggacctcgtcggtggagatgtaccgccaggtgctgctgtggggctgccgctgt
gtggagctggatgtgtggaaaggacggccgcccgaggaggaacccttcatcacccatggc
ttcaccatgaccacggaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggcaaagatggctgagtactgccgctccatctttggagatgcgctactcatcgag
cctctggacaagtacccgctggccccaggtgttcccctgcccagcccccaggacctgatg
ggccgtatcctggtgaagaacaagaaacggcacagacccagcacaggtggcccagacagc
gccgggcgcaagcggccgctggagcagagcaattcggccctgagcgagagctccgctgcc
actgagccctcctccccgcagcttgggtcgcccagctctgacagctgcccaggcctgagc
aacggggaggagggggcccttgagaagcccagcctggagcctcggaagtctttgggtgag
gagggcctgaaccggggcccctatgctcttggacctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaggagcagacagaccccaaaaagccgaccacagatgagggcacggcc
agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgat
gtggcgatgcagctcaatgcgggcgtttttgagtacaacgggcgcagcgggtacctgctc
aagccggagttcatgcggcggcctgacaaatccttcgaccccttcactgaggtcatcgtg
gatggcattgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctatccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgacacgcggcgc
aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
ttcgacttccccaaggtggtgctgcctacgttggcttcacttcgcatcgcagcctttgag
gaggggggtaaatttgtagggcaccggatcctgcctgtctctgccatccgctctgggtac
cactacgtctgcctgcggaacgaggccaaccagccgctgtgccttccggccctgctcatc
tacactgaagcctcggactacattcctgatgaccaccaggactacgcggaggccctgatc
aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt
ggggagagtgaggctcaggctggccaagagatgtgccaggacacccagtctcagcagctg
gggtctcagctgtccccaaaccccacccctagcccactggatgcctccccccgccggccc
cccggccccaccacctcccctaccagcacctccctcagcagcccagggcagcgcgacgat
ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac
aaggctctggtcaagctccagagccggcaagagcgagacctgcgggagctgcgcaagaag
catcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcaggcacag
gctgacggcaggtgccggctgcggccaggtgccctaggcggggccgctgatgtggaggac
acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag
agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggagcat
ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc
aagaggctgaaagagatgaacgagagggagaagaaggaactgcagaagatcctggacaga
aagcgccataacagcatctcggaggccaagacgagggacaagcataagaaggaggcggaa
ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag
ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg
gcgaggctcccccaggagatccgcaggagcctgctgggcgagacgccggaggggctgggg
gatgggcttctggtggcctgtgccagcaacggtcacgcacctgggagcagcgggcacctg
tcgggcgctgactcggagagccaggaggagaacacgcagctctga

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