KEGG   Cercocebus atys (sooty mangabey): 105582089
Entry
105582089         CDS       T07242                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty00562  Inositol phosphate metabolism
caty01100  Metabolic pathways
caty04015  Rap1 signaling pathway
caty04020  Calcium signaling pathway
caty04022  cGMP-PKG signaling pathway
caty04062  Chemokine signaling pathway
caty04070  Phosphatidylinositol signaling system
caty04071  Sphingolipid signaling pathway
caty04072  Phospholipase D signaling pathway
caty04081  Hormone signaling
caty04082  Neuroactive ligand signaling
caty04261  Adrenergic signaling in cardiomyocytes
caty04270  Vascular smooth muscle contraction
caty04310  Wnt signaling pathway
caty04371  Apelin signaling pathway
caty04540  Gap junction
caty04611  Platelet activation
caty04613  Neutrophil extracellular trap formation
caty04621  NOD-like receptor signaling pathway
caty04713  Circadian entrainment
caty04720  Long-term potentiation
caty04723  Retrograde endocannabinoid signaling
caty04724  Glutamatergic synapse
caty04725  Cholinergic synapse
caty04726  Serotonergic synapse
caty04728  Dopaminergic synapse
caty04730  Long-term depression
caty04742  Taste transduction
caty04750  Inflammatory mediator regulation of TRP channels
caty04911  Insulin secretion
caty04912  GnRH signaling pathway
caty04915  Estrogen signaling pathway
caty04916  Melanogenesis
caty04918  Thyroid hormone synthesis
caty04919  Thyroid hormone signaling pathway
caty04921  Oxytocin signaling pathway
caty04922  Glucagon signaling pathway
caty04924  Renin secretion
caty04925  Aldosterone synthesis and secretion
caty04926  Relaxin signaling pathway
caty04927  Cortisol synthesis and secretion
caty04928  Parathyroid hormone synthesis, secretion and action
caty04929  GnRH secretion
caty04933  AGE-RAGE signaling pathway in diabetic complications
caty04934  Cushing syndrome
caty04935  Growth hormone synthesis, secretion and action
caty04961  Endocrine and other factor-regulated calcium reabsorption
caty04970  Salivary secretion
caty04971  Gastric acid secretion
caty04972  Pancreatic secretion
caty04973  Carbohydrate digestion and absorption
caty05010  Alzheimer disease
caty05016  Huntington disease
caty05017  Spinocerebellar ataxia
caty05022  Pathways of neurodegeneration - multiple diseases
caty05142  Chagas disease
caty05143  African trypanosomiasis
caty05146  Amoebiasis
caty05163  Human cytomegalovirus infection
caty05200  Pathways in cancer
caty05415  Diabetic cardiomyopathy
caty05417  Lipid and atherosclerosis
Module
caty_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:caty00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105582089 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105582089 (PLCB4)
   04310 Wnt signaling pathway
    105582089 (PLCB4)
   04371 Apelin signaling pathway
    105582089 (PLCB4)
   04020 Calcium signaling pathway
    105582089 (PLCB4)
   04070 Phosphatidylinositol signaling system
    105582089 (PLCB4)
   04072 Phospholipase D signaling pathway
    105582089 (PLCB4)
   04071 Sphingolipid signaling pathway
    105582089 (PLCB4)
   04022 cGMP-PKG signaling pathway
    105582089 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105582089 (PLCB4)
   04081 Hormone signaling
    105582089 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105582089 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105582089 (PLCB4)
   04613 Neutrophil extracellular trap formation
    105582089 (PLCB4)
   04621 NOD-like receptor signaling pathway
    105582089 (PLCB4)
   04062 Chemokine signaling pathway
    105582089 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    105582089 (PLCB4)
   04922 Glucagon signaling pathway
    105582089 (PLCB4)
   04929 GnRH secretion
    105582089 (PLCB4)
   04912 GnRH signaling pathway
    105582089 (PLCB4)
   04915 Estrogen signaling pathway
    105582089 (PLCB4)
   04921 Oxytocin signaling pathway
    105582089 (PLCB4)
   04926 Relaxin signaling pathway
    105582089 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    105582089 (PLCB4)
   04918 Thyroid hormone synthesis
    105582089 (PLCB4)
   04919 Thyroid hormone signaling pathway
    105582089 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    105582089 (PLCB4)
   04916 Melanogenesis
    105582089 (PLCB4)
   04924 Renin secretion
    105582089 (PLCB4)
   04925 Aldosterone synthesis and secretion
    105582089 (PLCB4)
   04927 Cortisol synthesis and secretion
    105582089 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105582089 (PLCB4)
   04270 Vascular smooth muscle contraction
    105582089 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    105582089 (PLCB4)
   04971 Gastric acid secretion
    105582089 (PLCB4)
   04972 Pancreatic secretion
    105582089 (PLCB4)
   04973 Carbohydrate digestion and absorption
    105582089 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105582089 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    105582089 (PLCB4)
   04725 Cholinergic synapse
    105582089 (PLCB4)
   04728 Dopaminergic synapse
    105582089 (PLCB4)
   04726 Serotonergic synapse
    105582089 (PLCB4)
   04720 Long-term potentiation
    105582089 (PLCB4)
   04730 Long-term depression
    105582089 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    105582089 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    105582089 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    105582089 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105582089 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105582089 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105582089 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105582089 (PLCB4)
   05142 Chagas disease
    105582089 (PLCB4)
   05143 African trypanosomiasis
    105582089 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105582089 (PLCB4)
   05016 Huntington disease
    105582089 (PLCB4)
   05017 Spinocerebellar ataxia
    105582089 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    105582089 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105582089 (PLCB4)
   05415 Diabetic cardiomyopathy
    105582089 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105582089 (PLCB4)
   04934 Cushing syndrome
    105582089 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:caty04131]
    105582089 (PLCB4)
Enzymes [BR:caty01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105582089 (PLCB4)
Membrane trafficking [BR:caty04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105582089 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105582089 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 105582089
NCBI-ProteinID: XP_011907483
Ensembl: ENSCATG00000036713
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSVRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGIDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQSQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtgttcggtcgggagccataccaaaggatcccaaaatcttg
gctgcccttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcatagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtgactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaacgatgaaattgag
cccacggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttatctgactggcagacagttcggcgggaag
tcttcggtagaaatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcagacctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagcggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagtgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacatgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtggatatgtatggg
ttgcccactgacactatacgtaaggaattccgaactcgtatggttatgaataatggacta
aatccagtttacaatgaagagtctttcgtatttcggaaggtgatcctgccagacctggct
gtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaagcaggataccgacacatttcccttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagccgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaataccaccaaagcaaacgtgacccctcag
agtagctctgagctcagaccaaccaccacagctgccctggcctctggtgtggaagccaag
aaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaggcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaatcgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

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