KEGG   Cercocebus atys (sooty mangabey): 105586884
Entry
105586884         CDS       T07242                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty01522  Endocrine resistance
caty04010  MAPK signaling pathway
caty04015  Rap1 signaling pathway
caty04068  FoxO signaling pathway
caty04071  Sphingolipid signaling pathway
caty04114  Oocyte meiosis
caty04148  Efferocytosis
caty04218  Cellular senescence
caty04261  Adrenergic signaling in cardiomyocytes
caty04370  VEGF signaling pathway
caty04380  Osteoclast differentiation
caty04550  Signaling pathways regulating pluripotency of stem cells
caty04611  Platelet activation
caty04613  Neutrophil extracellular trap formation
caty04620  Toll-like receptor signaling pathway
caty04621  NOD-like receptor signaling pathway
caty04622  RIG-I-like receptor signaling pathway
caty04625  C-type lectin receptor signaling pathway
caty04657  IL-17 signaling pathway
caty04658  Th1 and Th2 cell differentiation
caty04659  Th17 cell differentiation
caty04660  T cell receptor signaling pathway
caty04664  Fc epsilon RI signaling pathway
caty04668  TNF signaling pathway
caty04670  Leukocyte transendothelial migration
caty04714  Thermogenesis
caty04722  Neurotrophin signaling pathway
caty04723  Retrograde endocannabinoid signaling
caty04728  Dopaminergic synapse
caty04750  Inflammatory mediator regulation of TRP channels
caty04912  GnRH signaling pathway
caty04914  Progesterone-mediated oocyte maturation
caty04917  Prolactin signaling pathway
caty04926  Relaxin signaling pathway
caty04932  Non-alcoholic fatty liver disease
caty04933  AGE-RAGE signaling pathway in diabetic complications
caty04935  Growth hormone synthesis, secretion and action
caty04936  Alcoholic liver disease
caty05014  Amyotrophic lateral sclerosis
caty05020  Prion disease
caty05022  Pathways of neurodegeneration - multiple diseases
caty05132  Salmonella infection
caty05133  Pertussis
caty05135  Yersinia infection
caty05140  Leishmaniasis
caty05142  Chagas disease
caty05145  Toxoplasmosis
caty05152  Tuberculosis
caty05161  Hepatitis B
caty05163  Human cytomegalovirus infection
caty05167  Kaposi sarcoma-associated herpesvirus infection
caty05169  Epstein-Barr virus infection
caty05170  Human immunodeficiency virus 1 infection
caty05171  Coronavirus disease - COVID-19
caty05205  Proteoglycans in cancer
caty05208  Chemical carcinogenesis - reactive oxygen species
caty05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
caty05415  Diabetic cardiomyopathy
caty05417  Lipid and atherosclerosis
caty05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:caty00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105586884 (MAPK12)
   04015 Rap1 signaling pathway
    105586884 (MAPK12)
   04370 VEGF signaling pathway
    105586884 (MAPK12)
   04668 TNF signaling pathway
    105586884 (MAPK12)
   04068 FoxO signaling pathway
    105586884 (MAPK12)
   04071 Sphingolipid signaling pathway
    105586884 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    105586884 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    105586884 (MAPK12)
   04218 Cellular senescence
    105586884 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105586884 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105586884 (MAPK12)
   04613 Neutrophil extracellular trap formation
    105586884 (MAPK12)
   04620 Toll-like receptor signaling pathway
    105586884 (MAPK12)
   04621 NOD-like receptor signaling pathway
    105586884 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    105586884 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    105586884 (MAPK12)
   04660 T cell receptor signaling pathway
    105586884 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    105586884 (MAPK12)
   04659 Th17 cell differentiation
    105586884 (MAPK12)
   04657 IL-17 signaling pathway
    105586884 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    105586884 (MAPK12)
   04670 Leukocyte transendothelial migration
    105586884 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    105586884 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    105586884 (MAPK12)
   04917 Prolactin signaling pathway
    105586884 (MAPK12)
   04926 Relaxin signaling pathway
    105586884 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    105586884 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105586884 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    105586884 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    105586884 (MAPK12)
   04722 Neurotrophin signaling pathway
    105586884 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105586884 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105586884 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    105586884 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    105586884 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    105586884 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105586884 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105586884 (MAPK12)
   05161 Hepatitis B
    105586884 (MAPK12)
   05171 Coronavirus disease - COVID-19
    105586884 (MAPK12)
   05163 Human cytomegalovirus infection
    105586884 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105586884 (MAPK12)
   05169 Epstein-Barr virus infection
    105586884 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105586884 (MAPK12)
   05135 Yersinia infection
    105586884 (MAPK12)
   05133 Pertussis
    105586884 (MAPK12)
   05152 Tuberculosis
    105586884 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105586884 (MAPK12)
   05140 Leishmaniasis
    105586884 (MAPK12)
   05142 Chagas disease
    105586884 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    105586884 (MAPK12)
   05020 Prion disease
    105586884 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    105586884 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105586884 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    105586884 (MAPK12)
   05415 Diabetic cardiomyopathy
    105586884 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    105586884 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    105586884 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105586884 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105586884 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:caty01001]
    105586884 (MAPK12)
Enzymes [BR:caty01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     105586884 (MAPK12)
Protein kinases [BR:caty01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   105586884 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 105586884
NCBI-ProteinID: XP_011917801
Ensembl: ENSCATG00000034080
LinkDB
Position
Unknown
AA seq 390 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRVSPGGGATHQLSPSAIPRLHVLPDLKPG
NLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL
TNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTL
DEWKRVTYKEVLSFKPPRQLGARVSKETAL
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgattgggctgctggacgtattcactcccgatgagaccctggat
gacttcacagacttttacctggtgatgccattcatgggcaccgacctgggcaagctcatg
aaacatgagaagctgggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccatgctgccggcatcatccacagagtgagtcctggtggaggagccacc
catcagctctcccccagcgcaatcccccgccttcacgtcctacctgacctgaagcctggc
aacctggctgtgaacgaagactgtgagctcaagatcctggactttggcctggccaggcag
gcagacagcgagatgactggctatgtggtgacccggtggtaccgggcacccgaggtcatc
ttgaattggatgcgctacacgcagacggtggacatctggtctgtggggtgcatcatggcg
gagatgatcacaggcaagacgctgttcaagggcagcgaccacctggaccagctgaaggaa
atcatgaaagtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgag
gccaagaactacatgaagggcctccctgagttggagaagaaggattttgcctccatcctg
accaatgcaagccctctggccgtgaacctcctggagaagatgctggtgctggatgcggag
cagcgggtgacggcagccgaggcactggcccatccctacttcgagtccctgcacgacacg
gaagatgagccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctg
gatgaatggaagcgtgttacttacaaagaggtgctcagcttcaagcctccgcggcagctg
ggagccagggtctccaaggagacggctctgtga

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