KEGG   Cercocebus atys (sooty mangabey): 105590503
Entry
105590503         CDS       T07242                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty01521  EGFR tyrosine kinase inhibitor resistance
caty01522  Endocrine resistance
caty04010  MAPK signaling pathway
caty04012  ErbB signaling pathway
caty04068  FoxO signaling pathway
caty04270  Vascular smooth muscle contraction
caty04650  Natural killer cell mediated cytotoxicity
caty04720  Long-term potentiation
caty04726  Serotonergic synapse
caty04730  Long-term depression
caty04810  Regulation of actin cytoskeleton
caty04910  Insulin signaling pathway
caty04914  Progesterone-mediated oocyte maturation
caty04928  Parathyroid hormone synthesis, secretion and action
caty05010  Alzheimer disease
caty05022  Pathways of neurodegeneration - multiple diseases
caty05034  Alcoholism
caty05160  Hepatitis C
caty05161  Hepatitis B
caty05200  Pathways in cancer
caty05205  Proteoglycans in cancer
caty05208  Chemical carcinogenesis - reactive oxygen species
caty05210  Colorectal cancer
caty05211  Renal cell carcinoma
caty05212  Pancreatic cancer
caty05213  Endometrial cancer
caty05214  Glioma
caty05215  Prostate cancer
caty05218  Melanoma
caty05219  Bladder cancer
caty05220  Chronic myeloid leukemia
caty05221  Acute myeloid leukemia
caty05223  Non-small cell lung cancer
caty05224  Breast cancer
caty05225  Hepatocellular carcinoma
caty05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:caty00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105590503 (ARAF)
   04012 ErbB signaling pathway
    105590503 (ARAF)
   04068 FoxO signaling pathway
    105590503 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105590503 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    105590503 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105590503 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    105590503 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    105590503 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105590503 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    105590503 (ARAF)
   04720 Long-term potentiation
    105590503 (ARAF)
   04730 Long-term depression
    105590503 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105590503 (ARAF)
   05205 Proteoglycans in cancer
    105590503 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    105590503 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105590503 (ARAF)
   05212 Pancreatic cancer
    105590503 (ARAF)
   05225 Hepatocellular carcinoma
    105590503 (ARAF)
   05226 Gastric cancer
    105590503 (ARAF)
   05214 Glioma
    105590503 (ARAF)
   05221 Acute myeloid leukemia
    105590503 (ARAF)
   05220 Chronic myeloid leukemia
    105590503 (ARAF)
   05218 Melanoma
    105590503 (ARAF)
   05211 Renal cell carcinoma
    105590503 (ARAF)
   05219 Bladder cancer
    105590503 (ARAF)
   05215 Prostate cancer
    105590503 (ARAF)
   05213 Endometrial cancer
    105590503 (ARAF)
   05224 Breast cancer
    105590503 (ARAF)
   05223 Non-small cell lung cancer
    105590503 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    105590503 (ARAF)
   05160 Hepatitis C
    105590503 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105590503 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    105590503 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    105590503 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105590503 (ARAF)
   01522 Endocrine resistance
    105590503 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:caty01001]
    105590503 (ARAF)
Enzymes [BR:caty01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105590503 (ARAF)
Protein kinases [BR:caty01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   105590503 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 105590503
NCBI-ProteinID: XP_011925553
Ensembl: ENSCATG00000030301
UniProt: A0A2K5LIL6
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPRPHTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGGDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacagtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccaggccccacactcagcactgtgacccggagcacttccccttccct
gccccggccaacgcccccctgcagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtggtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgtgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaagtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaagctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggattcgccatc
atcacacagtggtgtgaaggctccagcctctaccatcacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctatgcctacggggttgtgctctac
gagctcatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctctagcaactgccctaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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