KEGG   Cercocebus atys (sooty mangabey): 105591436
Entry
105591436         CDS       T07242                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty01522  Endocrine resistance
caty04010  MAPK signaling pathway
caty04012  ErbB signaling pathway
caty04014  Ras signaling pathway
caty04024  cAMP signaling pathway
caty04068  FoxO signaling pathway
caty04071  Sphingolipid signaling pathway
caty04137  Mitophagy - animal
caty04140  Autophagy - animal
caty04141  Protein processing in endoplasmic reticulum
caty04210  Apoptosis
caty04215  Apoptosis - multiple species
caty04217  Necroptosis
caty04310  Wnt signaling pathway
caty04380  Osteoclast differentiation
caty04510  Focal adhesion
caty04530  Tight junction
caty04620  Toll-like receptor signaling pathway
caty04621  NOD-like receptor signaling pathway
caty04622  RIG-I-like receptor signaling pathway
caty04625  C-type lectin receptor signaling pathway
caty04657  IL-17 signaling pathway
caty04658  Th1 and Th2 cell differentiation
caty04659  Th17 cell differentiation
caty04660  T cell receptor signaling pathway
caty04664  Fc epsilon RI signaling pathway
caty04668  TNF signaling pathway
caty04722  Neurotrophin signaling pathway
caty04723  Retrograde endocannabinoid signaling
caty04728  Dopaminergic synapse
caty04750  Inflammatory mediator regulation of TRP channels
caty04910  Insulin signaling pathway
caty04912  GnRH signaling pathway
caty04914  Progesterone-mediated oocyte maturation
caty04917  Prolactin signaling pathway
caty04920  Adipocytokine signaling pathway
caty04926  Relaxin signaling pathway
caty04930  Type II diabetes mellitus
caty04931  Insulin resistance
caty04932  Non-alcoholic fatty liver disease
caty04933  AGE-RAGE signaling pathway in diabetic complications
caty04935  Growth hormone synthesis, secretion and action
caty04936  Alcoholic liver disease
caty05010  Alzheimer disease
caty05012  Parkinson disease
caty05016  Huntington disease
caty05017  Spinocerebellar ataxia
caty05020  Prion disease
caty05022  Pathways of neurodegeneration - multiple diseases
caty05132  Salmonella infection
caty05133  Pertussis
caty05135  Yersinia infection
caty05142  Chagas disease
caty05145  Toxoplasmosis
caty05152  Tuberculosis
caty05161  Hepatitis B
caty05162  Measles
caty05166  Human T-cell leukemia virus 1 infection
caty05167  Kaposi sarcoma-associated herpesvirus infection
caty05169  Epstein-Barr virus infection
caty05170  Human immunodeficiency virus 1 infection
caty05171  Coronavirus disease - COVID-19
caty05200  Pathways in cancer
caty05208  Chemical carcinogenesis - reactive oxygen species
caty05210  Colorectal cancer
caty05212  Pancreatic cancer
caty05231  Choline metabolism in cancer
caty05415  Diabetic cardiomyopathy
caty05417  Lipid and atherosclerosis
caty05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:caty00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    105591436 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105591436 (MAPK8)
   04012 ErbB signaling pathway
    105591436 (MAPK8)
   04014 Ras signaling pathway
    105591436 (MAPK8)
   04310 Wnt signaling pathway
    105591436 (MAPK8)
   04668 TNF signaling pathway
    105591436 (MAPK8)
   04068 FoxO signaling pathway
    105591436 (MAPK8)
   04071 Sphingolipid signaling pathway
    105591436 (MAPK8)
   04024 cAMP signaling pathway
    105591436 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105591436 (MAPK8)
   04137 Mitophagy - animal
    105591436 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    105591436 (MAPK8)
   04215 Apoptosis - multiple species
    105591436 (MAPK8)
   04217 Necroptosis
    105591436 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105591436 (MAPK8)
   04530 Tight junction
    105591436 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    105591436 (MAPK8)
   04621 NOD-like receptor signaling pathway
    105591436 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    105591436 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    105591436 (MAPK8)
   04660 T cell receptor signaling pathway
    105591436 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    105591436 (MAPK8)
   04659 Th17 cell differentiation
    105591436 (MAPK8)
   04657 IL-17 signaling pathway
    105591436 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    105591436 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105591436 (MAPK8)
   04920 Adipocytokine signaling pathway
    105591436 (MAPK8)
   04912 GnRH signaling pathway
    105591436 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    105591436 (MAPK8)
   04917 Prolactin signaling pathway
    105591436 (MAPK8)
   04926 Relaxin signaling pathway
    105591436 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    105591436 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    105591436 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    105591436 (MAPK8)
   04722 Neurotrophin signaling pathway
    105591436 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105591436 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105591436 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105591436 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    105591436 (MAPK8)
   05231 Choline metabolism in cancer
    105591436 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105591436 (MAPK8)
   05212 Pancreatic cancer
    105591436 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105591436 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    105591436 (MAPK8)
   05161 Hepatitis B
    105591436 (MAPK8)
   05171 Coronavirus disease - COVID-19
    105591436 (MAPK8)
   05162 Measles
    105591436 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105591436 (MAPK8)
   05169 Epstein-Barr virus infection
    105591436 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105591436 (MAPK8)
   05135 Yersinia infection
    105591436 (MAPK8)
   05133 Pertussis
    105591436 (MAPK8)
   05152 Tuberculosis
    105591436 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105591436 (MAPK8)
   05142 Chagas disease
    105591436 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105591436 (MAPK8)
   05012 Parkinson disease
    105591436 (MAPK8)
   05016 Huntington disease
    105591436 (MAPK8)
   05017 Spinocerebellar ataxia
    105591436 (MAPK8)
   05020 Prion disease
    105591436 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    105591436 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105591436 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    105591436 (MAPK8)
   05415 Diabetic cardiomyopathy
    105591436 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105591436 (MAPK8)
   04936 Alcoholic liver disease
    105591436 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    105591436 (MAPK8)
   04931 Insulin resistance
    105591436 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105591436 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105591436 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:caty01001]
    105591436 (MAPK8)
Enzymes [BR:caty01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     105591436 (MAPK8)
Protein kinases [BR:caty01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   105591436 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 105591436
NCBI-ProteinID: XP_011927573
Ensembl: ENSCATG00000009935
LinkDB
Position
Unknown
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctgaaacggtatcagaatttaaaacctataggctcaggagcgcaaggaatagta
tgcgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccgacca
tttcagaatcagactcatgccaagcgggcctacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtagtaaaa
tctgactgcactttgaagattcttgacttcggtctggccaggactgcaggaacgagtttt
atgatgacgccttacgtagtgactcgctactacagagcacccgaggtcatccttggcatg
ggctacaaggaaaacgtggatttatggtctgtggggtgcattatgggagaaatggtttgc
cacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagcttcgagaaactcttccctgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccaacacccgtac
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatccctgacaag
cagttagatgaaagggaacacacaatagaagagtggaaagaattgatatataaggaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcggatacagacagcagtctagaagcatcagct
gggcctctgggctgctgtagatga

DBGET integrated database retrieval system