Carassius auratus (goldfish): 113055877 Help Entry 113055877         CDS       T07313                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism caua  Carassius auratus (goldfish) Pathway caua04020   Calcium signaling pathway caua04260   Cardiac muscle contraction caua04261   Adrenergic signaling in cardiomyocytes caua04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:caua00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113055877 (ryr2)    04020 Calcium signaling pathway     113055877 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     113055877 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     113055877 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:caua04040]     113055877 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:caua04990]     113055877 (ryr2) Ion channels [BR:caua04040]  Voltage-gated cation channels   Ryanodine receptor    113055877 (ryr2) Domain-containing proteins not elsewhere classified [BR:caua04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    113055877 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  113055877 NCBI-ProteinID:  XP_026078039 Ensembl:  ENSCARG00000030045 UniProt:  A0A6P6L0I5 LinkDB All DBs Position 37:complement(2275357..2355112) Genome browser AA seq 4961 aa AA seqDB search MTDGEAEDEIQFLRTDDEVVLQCSAMLQKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD LSICTFVLEQSLSVRALQEMLANTEERAEGLIDMEKWKFMMKTAQGGGHRTLLYGHAVLL RHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDL ILVSVSSERYLHLSYGNCSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHM DECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVT TGKYLSMMEDQGLLLMDKEKADVKSTAFCFRSSKEKLDFGLRKEVDGMGVPDIKYGDSVC FIQHVDTGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRS TVFLFNRFIRGLDTLSKKGKTSSLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRA LKSRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYEHLAALI RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL GVSEGTAQYRKWYYELIVDHVEPFVTAEATHLRVGWASTQGYGPYPGGGEGWGGNGVGDD LYSYGFDGLHLWAGCVARSVSSPNQHVLRVEDVVSCCLDLSAPSISFRINGQPVQGMFEN FNSDGLFFPVVSFSSGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYK HDHGRTRDLLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG WTYGAVRDDNKRQHPCLVEFSRLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKV KNLKLSAKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGVQ QDIKNKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARADVCNLS AERFRIFRAEKTYSVSGGRWYFELEVVTAGEMRVGWARPGCQPDLELGSDDQAFVFDGFK AQRWHQGNEHFGRSWQSGDVVGCMVDMNERTMIFTLNGEVLLDDSGSELAFKDFEVWEGF IPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDLTMWISKRLPQFIPV PLNHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSSTDIMFYRLSMPIECSEAFLRSASGS FFSPKRDLEDFETVSDFEVLMKTPHSHMSSNGPDRERDEFNNHKDHNQEKPSKLKQRFML KRTKPEMTSSNSSSNARLSEEVLSEERDDCENLKQTSAYYYSVRIFPGQEPSSVWVGWVT SDFHQHDPAFELSTVRTVTVTLGDEKGKVHESIKRSNCYMVWGGECSSPSQGRSNNGLEI GCVVDTANGLLTFTSNGKELGTFYQVEPSTKLFPAVFAQATSPNVFQFELGRIKSVMPLS AGLFKSERKNTVPQCPPRLHVQFLTPVSWSRVPNQFLRAEVSRVSERLGWMVQSSEPLQF MTLHIPEENRSVDILELTEQRELLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLY AIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTPETKSITLFPNEKKKHG LPGIGLSTSLQPRMRFSSPSFVGAVAGHHGNCFQYSPEFPLETLKSRTMEMLTEAVREGS LHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVFSQDGGESGGGAS EPEDGCGRSQLEGGGAEKHDLKGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIE AVVAFSDDFVANLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDEK QDCPCPEDIREQLLDFHEDLMTHCGIETDDDKSGDGDDFTIRGRLMSLVEKVTYLKKKMT DIPKKKKSKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPK TYTINAVSVEDTISLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQHPNLMRA LGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLEN SSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLMSRG YPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLL AAMEEAIKISEDPSRDGPSPSTEESRTLNDIMEEEEDDTIHMGNAIMTFYAALIDLLGRC APEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPDMSAGFCP DHKAAMVLFLDRVYGIEDQNFLFHLLEVGFLPDLRAAASLDTVSLSATDMALALNRYLCT AVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRP SMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGVASDEELHLSR KLFWGIFDALARKKYEVELFKLALPCLSAVGGALPPDYMESNYMAMMEKQSSMDAEGNFN PQPADTSSVVVPEKLDHFINKYAEYSHEKWSMEKFAVGWVHGEQMCESSKVHPVLKPYKC LSEKDKEVYRWPIRESLKTMLSWGWSIERMRESDASTLHNRTRRISLSSQRSIEGAHGFS PRPVDMSNVTLSRDLHTMAELLAENYHNIWALKKKLELESKGGGSHPLLVPYDTLTAKEK SRDREKAQDILKFFQINGYSVSRAMKEQDLDAPSIEKRFAYTFLQQLITYVDEAHTHMLE YDAGIRPKAEKIPHEQQFKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASNKEKE MVTSLFCKLAVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGQDSVKAALRMFFD NAAEDLEKTMENLRQGQFTHTRTQPKGVTQIINYTTIALLPVLSSLFEHIGQNLFGEDLI LDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPSLNRHNTFS IYNCKSSRERTALGLPAQVDEVCALVPSLERALEEIMELAESGMRYTQMPHVMEVLLPML CSYMSHWWEHGPESVPERSESCCTSLTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVF SQPIIGKARSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGRGEMSESELLILDEFTVL VRDLYAFYPLLIRFVDYNRAKWLKEPNTEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQ NEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSLQTSLIVAALKRLLPVGLNICA PGDQELIGLAKSRFTQKDTEDEVRETIRNNLHLQGKLEDPAIRWQMALYKDMPNRSENTS DPEKTVHRVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRH RAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDEMTKHIDPLHQLIQLFSR TALTEKCKLEEDHLYMAYADIMAKSCHDEEEEDEEEVKSFEEKEMEKQKLLYQQARLHDR GAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKRDVGFFQSLA GLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVLRDDEFTCDLFRFLQLLCE GHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKEVIDEQGQRNFSK AINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELL KELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTS SDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFH EPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERV YFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSD AGERSASKEDSEREKPEEKSPEMGFFSVTTVRTALFALRYNVMLLMKVLSMKSLKKQVKK AKKMTVKDMVTTLVSFYWSVLLGLLHFGFSVARGFFRIVYNSFLGGSLVEDAKTMKVSEL LANMPDPTQDEVRGETEESEKKPTDKTSPEEDLADLTVATDDTELLSDIFGLDLKREGGQ YKLMPHNPNASLTDLLNTPIPPPPTPSPELRRRHQTKSSSSSADVSEPADETKAVPEKAE GENGEKAQKKKEEVVKRKVRQHYEPDLQESAFWKKIMAYQRKLLNYFARNFYNMRMLALF VAFAINFILLFYKVSTSSAVSEGKEVLFGSSSDTSVRWDPLTDASARPDAVHFVLEESSG YMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDI KGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHEKK KPKRDSSLAAVLNSVDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNFFFAAHLLDI AMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKC DDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLI IDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFFMYLI NKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14886 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcgaagccgaagatgagatccagttcttacggaccgatgatgaggtggtc ctccagtgctccgcgatgcttcagaaggagcagcagaagctctgtctggctgcagagggc ttcgggaacagactgtgtttcctcgagtccacgtcaaactcaaagaacgttcctccggat ctgtccatatgtacgtttgtgctggagcagtctctgtctgtacgagcgctgcaggagatg ctggctaacaccgaggagagagcagaagggctcatagacatggagaaatggaaattcatg atgaagacggcgcagggcggaggtcaccggacgctgctctacggtcacgcagtcttactg agacactcctacagcgggatgtatctgtgctgtctgtctacagctcgctcatccacagac aaactagcatttgacgtggggcttcaggaagacacgacaggtgaggcgtgctggtggacc atccacccagcgtccaagcagaggtcagagggtgagaaggtgcgagtgggcgatgacctc atcctggtcagtgtgtcgtctgaacgatacctgcacttgtcgtatggtaactgcagtctg cacgtggacgcagctttccagcagacgctctggagcgtggctcccatctgctccggcagt gaagtggctcagggcttcctgattggtggagatgttctgcggctgctgcacggtcacatg gacgagtgtttgaccgtcccgtcaggagaacacggagaggagcagcgcaggacggtgcat tacgagggtggagctgtgtccatccacgccagatccctgtggaggctggagacgctgcga gtggcgtggagtggcagtcacatccgctggggtcagccgtttcggctgcgtcacgtgacc acagggaagtatctcagcatgatggaggatcaagggctgctgctgatggacaaggagaaa gcagacgtcaaatcaacggctttctgcttccgttcctcaaaagagaagctggactttggt ctgaggaaggaggtggatgggatgggcgtcccggacatcaaatacggcgactcggtctgt ttcatccagcatgtggacaccgggctctggctcacgtaccagtctgtggacgccaagtgt gcgcggatgggtggagttcagaggaaggccataatgcatcatgagggtcacatggatgac ggtttgacgctctcacgatcacagcacgaggagtcacgcaccgctagagtcattcgcagc acggttttcctcttcaaccgcttcatcaggggtctagacactctgagtaagaaggggaag acgtccagcctggatctgcccatcgagtcggtcagtctgagtcttcaggatctgatcgga tacttccagccgccggacgaacacctggagcacgaggacaaacagaaccggctgcgagcg ctcaagagcagacagaacctcttccaggaggagggaatgatcaacctggtgctggagtgt atcgatcgtctgcatgtgtacagcagtgcggctcattttgcagacgtggccggtaaagag gccggagaatcctggaagtccatcctgaactccctctatgagcatctggctgctctgatc agaggaaacaggaagaattgtgctcagttttccggctctctggattggctgatcagtcgt ctggagaggctggaagcgtcgtccgggattctggaggttctgcactgtgttctggtggag agtccagaagctctgaacatcattaaagaaggacacatcaaatccatcatctcactgctg gacaaacacggacgcaaccacaaggtgctggacgtcctgtgttctctgtgtgtgtgtcac ggtgtggccgttcgctccaatcagcacctgatctgtgataacctgctgcccggcagagac ctgctgctgcagacacgactcgtcaatcacgtcagcagcatgaggcccaacatcttcctg ggtgtgagtgaaggcaccgcccagtacaggaagtggtattatgagctgatcgtggaccat gtggagccgttcgtgacggccgaagccactcacctgcgggtgggctgggcgtccacacag ggctatgggccgtatccgggcggaggagagggctggggcgggaacggtgtcggggacgac ctctactcatacggctttgatggactacacctgtgggcaggctgtgtggcgcgttcggtc agctcacccaatcagcacgtgctgcgggtcgaggatgtggtcagctgctgtctggatctc agcgctcccagcatctccttccgcatcaacggccagccggtccagggaatgtttgagaac ttcaactcagacggactcttcttccccgtcgtgtccttctcctctggagtcaaagtgcgc ttcctgttgggtggtcgtcatggagagttcaagttcctgcctccatctggttacgctcca tgttttgaggctgttttacctcgagagaagctgcgtgtggagcacagtcaagaatacaaa catgatcatgggagaacacgtgacctcctgggacccacagtcacactgtcacaggcagcc ttcacgccaacaccggtggacaccagtcagatcgtgttgcctccacatctcgagcggatc cgggagaagctggcagagaacatccatgagctgtgggtgatgaacaagattgagctggga tggacgtacggagcggtgagggatgataataaacggcagcatccgtgtctggtggagttc tccagacttcctgaacaggagcgcagctacaacctgcagatgtctcaggagacactcaag actcttctggcgttgggctgtcatgttggagtggcggacgaacgagccgctgagaaagtc aaaaatctgaagctttcagcgaaatacgagctgtccagcgggtataaaccagccccaatg gacctcagccacatcaaactggcgtctacccaggaggccatggtggacaagctggcagag aacgctcacaacgtctgggcacgagaccgcatacgacagggctggacctacggcgtccag caggacatcaagaacaagagaaaccctcgtctggttccttacgttcttctggacgagaga accaagaaatctaacaaggacagtctgcgggaagctgtacgcacgctgctgggatacgga tacaacctggaggccccggatcaggaccacgcggcccgagcagacgtgtgtaatctgtcc gcggagcgcttccggatattccgagcggagaagacgtacagcgtgagcggagggaggtgg tacttcgagctggaggtggtgacggcgggggagatgcgggtgggctgggcgagaccagga tgtcagccggacctggagctgggctcagacgaccaggccttcgtcttcgatgggttcaag gctcagcgctggcatcagggaaacgagcacttcggccgctcctggcagtctggagacgtg gtgggctgcatggtggacatgaacgaacgcaccatgatcttcacgctcaacggagaggtg ctgctcgacgactccggctcggaactcgccttcaaagacttcgaggtttgggaaggattc atcccggtctgtagtctgggcgtgtgtcaggtgggccggatgaactttgggaaggacgtg agcacgctgaagtacttcaccatctgcggcctgcaggagggatacgaacccttcgccgtc aacatgaaccgtgatctgaccatgtggatcagcaaacgtctgccccagttcatccccgtc ccactcaaccacgagcacatcgaggtcacgcggatcgacgggacggtggagagcccgccg tgtctaaaggtcacccagaggtcgttcggctcacagaacagcagcacagacatcatgttc tatcgtctcagcatgcccatcgagtgctcggaggcgttcctgcgctcggccagcggaagc ttcttctctcccaagagagatctggaggacttcgagaccgtgtcagacttcgaggtcctg atgaagacgccacacagtcacatgagctcgaacggacctgacagagagcgagacgagttc aacaaccacaaggatcacaatcaggagaagccctcgaaactcaagcagaggttcatgttg aaaagaacgaagcctgagatgaccagcagtaactccagcagtaacgctcgtctgtcagag gaggtcttgtctgaggagagagacgactgtgagaatctcaaacagacatcagcgtattat tactcggtgaggatcttccccgggcaggagccgtccagcgtgtgggtcggatgggtgacc tcagactttcatcagcacgacccggccttcgagctcagcacggtccgaacggtcaccgtt accctgggagacgagaagggcaaagttcacgagagcatcaagcgcagtaactgctacatg gtgtgggggggcgagtgcagcagtcccagtcagggccgcagtaataacggcctggagatc gggtgtgtggtggacacagccaacggcctcctcaccttcacctccaacggaaaagagctc ggcaccttctaccaggtggagcccagtactaaactgttccctgcagtgtttgcacaagca accagtccaaacgtcttccagttcgaactgggacgcatcaagagcgtcatgccgctctct gcaggtctgtttaaaagcgagcggaagaacacggttcctcagtgtccgccgcggctacac gtgcagttcctcacacctgtgtcatggagccgtgtgcccaatcagttcctgagggcagag gtcagcagggtcagtgagagactgggctggatggtgcagagttcagaaccactgcagttc atgacgctccatatacctgaggagaacaggtctgtggatatcctggagctgacggagcag agagagctgttgaagttccactatcacacgctgcgcttgtattctgccatctgtgctctg gggaacaaccgtgtggctcacgctctctgcagtcacgtagacgaggcgcagctgctgtac gccatccagaacaaatacatgccgggtctgctgcgcaccggatactacgacctgctgatc gacatccacctgagcagctacgccactgctcgcctcatgatgaactctgagtacatcgtg cccatgacccctgagaccaagagcatcacgctcttccccaacgagaagaagaagcacggg ctgccggggatcggcctgagcacctctctgcagccgcgcatgcgcttctcctcgcccagc ttcgtgggtgccgtcgccggtcaccacggtaactgtttccagtacagccctgagttcccg ctggagacgctgaagagccgcacgatggagatgctgacggaggcggtgcgggagggaagc ttgcacgtgcgtgaccccgtgggcggcagcaccgagttcctgttcgtcccgctcattaaa ctcttctacacgctcctgatcatgggcatcttccacaacggagacctgaagaccatcctg cagctcatcgagcccagcgtcttctcgcaggacgggggggagagcggaggcggggcctcg gagccagaggacggctgtgggcggagccagctggagggaggcggggccgagaagcacgac ctgaaaggaaagatgcccaaagaaggacttctgcagatgaagcttcctgaacccgtcaaa ctccagatgtgtcacctgctgcagtacctgtgtgactgtcaggtgcgtcaccgcatcgag gctgtggtggccttctctgacgactttgtggcgaatcttcaggagaaccagcgtttccgc tataatgaagtgatgcaggcactgaacatgtcagccgctctgacggcacgcaagaccaaa gagttccgctctcctccacaggaacagatcaacatgctgctgaattttaaggatgagaag caggactgtccgtgtccagaggacatccgtgaacagctgctggacttccatgaagatctg atgacacactgtggtattgagacggatgatgataaatcaggagatggagatgatttcacc atcaggggccgtctgatgtctctggtggagaaggtgacctacctgaagaagaaaatgact gatataccaaagaagaagaagtcaaagaaacccagcaccttgcagcagctgatctcggag acgatggtgcgctgggctcaggagtcggtcatcgaggatcccgagctggtgcgggccatg tttgtgttgctccaccggcagtacgacggcatcggcggtcaggtgcgagcgctgcccaag acctacaccatcaacgccgtctctgtggaggacaccatcagcctgctggcgtctctgggt cagatccgctctctgctcagcgtcaggatgggccgcgaggaggagaagctcatgatccac ggcctcagtgacatcatgaataacaaggtgttctaccagcatccgaacctgatgagagcg ctcggcatgcacgagaccgtcatggaggtgatggtgaacgtcctgggtggaggagagtcc aaggaaatcacctttccgaagatggtggccaactgctgtcgcttcctgtgctacttctgt cggatcagccgtcagaatcagaaggccatgtttgatcacctgagctacctgctggagaac agcagcgtgggtctggcgtctccgtccatgcgagggtccactcctctggatgtggccgct gcgtctgtgatggacaataatgaactggctctggcgctgagagagccggacctcgagaag gtggtccagtatctggccggctgtggtctccagagctgtgtgatgctgatgtctagagga tatcctgacatcggctggaacccggtggagggtgaacgttacctggacttcctccggttc gcggtcttctgtaacggggagagtgtggaggagaacgctaacgtggtggtgcgcctcctg attcgccggcccgagtgttttggccccgccctgcgaggagaaggcgggaacgggctgctg gcggcgatggaggaagccataaagatctcagaagatcccagcagagacggtccatcaccc agcacagaggagagccggacgcttaatgacatcatggaggaagaggaggatgacaccatc cacatggggaacgccatcatgaccttctacgccgctctgatcgatctgttgggccgctgc gctccagagatgcacctgatccacgcggggaagggagaggccatccgtatccgggccatc ctgcgctcgctcattcccattgaggatctggtgggagtgatcagcatcccgttcctgatg cccacgctggccaaagacggttctgtgatcgagccggacatgtcagcagggttctgtcct gaccacaaagctgccatggttctgttcctggaccgtgtttatggcatcgaggaccagaac ttcctcttccacctgctggaggtgggctttcttcctgacctcagagccgccgcctcattg gacacggtgtctctgagcgccacagacatggctctggctctgaaccggtacctgtgcacc gcggtcctgccgctgctcaccaaatgtgctcctctgttcgccgggacggagccgttcgcg tctctcatcgactctctgctgcacaccgtctacagactgtccaagggctgctgtctgacc aaagcacagagagacgccatcgaggagtgtctgctggccgtgtgcggtaaactgcgtccc tcgatgatgcagcatctgctgaggcgtctggtgtttgacgttcctgtgctcaacgaacac actaagatgcccctgaagctcctgaccaatcactacgagcgctgctggaagtactactgt ctgtccggaggatggggaagcttcggcgtggcctcggacgaggagctgcatctgtccaga aagctcttctgggggatctttgatgctctggccagaaagaagtacgaggtggagttgttc aagctggcgctgccgtgtctgagcgctgtgggcggagctttacctcctgattacatggag tcaaactacatggccatgatggagaaacagtcttccatggacgccgagggaaacttcaac ccgcagcccgccgacaccagcagtgttgttgttcctgagaaactcgatcatttcatcaat aaatatgcagaatactcccatgagaaatggtccatggagaagtttgccgtcggatgggtt catggagagcagatgtgtgaatcatctaaagttcatccggtgctcaagccctacaaatgt ttatctgagaaggataaggaggtgtaccgctggccaatcagagagagtctgaagacgatg ctgtcgtggggctggagcatcgagaggatgagagagagcgacgcttccacgttacacaac cgcacgcgccgcatctctctgtccagtcagcgctccatagagggcgctcacgggttcagc ccgcggccggtcgacatgagcaacgtgacgctgtccagagacctgcatacgatggcggag ctgctggccgagaactatcacaacatttgggctctgaagaaaaaactggagctggaatcc aaaggaggaggaagtcatccactactggttccttatgacactctaactgccaaagagaaa tccagagaccgagagaaagcacaagacatccttaagttctttcagatcaacggatacagc gtctcaagggctatgaaggaacaggatctggacgctccgtctatagagaaacgcttcgcc tacacgttcctgcagcagctgatcacgtatgtggatgaagctcacacacacatgctggag tacgatgctggaattcgacccaaagcagagaaaatcccccacgagcagcagttcaagttc ttcgggaaggttgtgctgccactggtggaccagtacttcaaaaaccatcggctctacttc ctgtccaccgccgttcgtccaatcagcagcggcggccacgcctccaataaagagaaggag atggtgaccagtctgttctgtaagctggccgttctggtgcggcaccggatctcactcttt gggaatgatgccacgtccatcgtgaactgtctgcacatcctgggacagacgctggacgct aggaccgtgatgaaaaccggccaggactctgtcaaagcggctctgaggatgttttttgat aacgcagcagaagatctggagaagacgatggagaacctgcgacagggtcagttcacacac acacggacgcagcccaaaggagtcacacagatcatcaactacaccaccatcgctctgctg cccgtcctctcgtcgctgttcgaacacatcggtcagaacctgttcggagaggatctcata ctggatgatgtccaggtttcctgctatcggattctcaacagtttgtactcgcttggaacc agtaaaagtatttatgttgagaggcagcgtccggctctcggcgagtgtctggctgcgttt tcgggtgcgtttcctgtggccttcctggagcccagtctgaacagacacaacacattctcc atatacaactgcaagagctctcgagagcgaacagcgctcggtctccccgctcaggtggac gaggtgtgtgctctggtgccgtctctggagcgagcgctggaggagatcatggagctggcc gagtctggcatgcgttacacacagatgcctcacgtgatggaggtgctgctgcccatgctg tgcagctacatgtctcactggtgggaacacggacccgagagcgtcccggagcgctccgag agctgctgcacctcgctgacctccgaacacatgaacacactgctgggaaacatcctcaag atcatctacaacaacctgggcatcgacgagggagcctggatgaagagactcgcagtgttc tctcagcccatcatcggtaaagcgcgctctcagctgctgaagactcacttcctgccgctg atggagaagctgaagaagaaggcggcgacggttctgcaggacgaggagcacatgaaggcg gaaggacgaggagagatgtctgagtctgagctcctcatcctggacgagttcacggtcctg gtgcgagacctgtacgccttctacccgctgctcatacgcttcgtggactacaacagagcg aagtggctgaaggagccgaacactgaggcagaggagttattccgtatggtggccgaagtc ttcatattctgggccaaatcacataactttaaaagagaagagcagaactttgtggttcag aatgaaatcaacaacatgtccttcctcataactgataccaaatccaagatgtccaaggga gccgtgtcggatcaggagaggaagaagatgaagaagcgcggtgacagatactccctccag acatcgctgatcgtcgccgctctcaaacgcttacttcctgtgggactgaacatctgtgca ccgggagaccaggagctgatcggactcgccaagagccgcttcacacagaaagacactgag gacgaggtgcgagagaccatacgaaacaacctccacctgcagggaaagctggaggatcct gcgatccgctggcagatggcgctgtataaagacatgcccaaccgcagcgagaacacgtct gaccccgagaagaccgtccacagagtgctgaacatcgcacacgtgctcttccacctcgat caggtggaacatcctcagcgcagtaaaaaggccgtgtggcacaagctgctgtccaaacag aggaagagagccgtagtggcctgtttcaggatggcaccgctttacaacctgcccaggcac agagctgtgaacctgttcctccagggctatgagaagtcctggatcgagacagaagagcat tactttgaggacaagctgattgaggatttggccaaaccgggtggagaggagccgtcggag gaggacgagatgaccaaacacatcgacccgcttcaccagctcatacaactgttcagcaga accgcgctgaccgagaaatgtaaactggaggaggaccatctctacatggcttacgctgat atcatggctaagagctgtcatgatgaagaggaggaggatgaagaagaggtcaagagtttt gaggagaaagagatggagaagcagaagctgctgtatcaacaggcccgactgcacgaccgc ggcgcggcggagatggtgctgcagaccatcagcgccagcaaaggagagatggggccgatg gtggcctccacgctgaagctgggcatcgctatcctgaatggaggaaactccaccgtccag cagaagatgctggactacctgaaggacaaacgagacgtgggctttttccagagtctggcg gggctgatgcagtcgtgcagtgttctagatctcaacgccttcgagaggcagaataaagct gaaggtctcgggatggtgacggaggagggatcagtcatcactcatgagcgtggtgagaag gtcctgcgagacgacgagttcacctgtgacctcttccgcttcctgcagctgctgtgtgag ggacacaactctgacttccagaactatctgagaacacagacggggaacaacaccacggtc aacatcatcatctccaccgtggattacctgctcagagtccaggagtccatcagtgacttc tactggtattactccgggaaagaggtcatcgatgaacaaggccagcgcaacttctccaaa gcaatcaatgtagccaaacaggtcttcaacacgctcacagagtacatccagggcccttgc acggggaatcagcagagtctggctcacagccgtctgtgggacgcagtcgttggtttctta cacgtattcgcacacatgcagatgaagctgtctcaggattcgagtcaaatcgagctgctg aaggagctcatggatcttcagaaggatatggtcgtgatgctcttgtccatgttggaagga aacgttgtgaacggcaccattggaaagcagatggtggacatgttggtggagtcctcgaac aacgtggagatgattctgaagttcttcgacatgttcctcaaactgaaagatctgacgtcg tcagacgccttcaaagagtacgaccccgacggcaaaggagtgatctccaagagagacttc cacaaggccatggagagccacaaacattacacccaatccgagaccgagttcctgctgtcc tgcgccgaaactgacgaaaacgagctcttggattatgaggagttcgtcgaacgcttccac gagccggcgaaagacatcggcttcaacgtagctgtccttctaaccaacctctcggagcac atgccccacgactcacgcctgcagaccttcctggagctggccgagagcgtgctgaactac ttccagccctacctgggccgcatcgagatcatgggcagcgctaaacgcatcgagcgcgtc tacttcgagatcagcgagtccagtcgcacacagtgggagaagccacaggtcaaagagtcc aagcgccagttcatcttcgacgtggtcaacgaaggtggcgagaaggagaagatggagctc ttcgtcaacttctgtgaagacaccatctttgagatgcagctggcggcgcagatgtcggac gccggagagcgctcggccagcaaagaggacagcgagagagagaaacccgaggagaagagt cctgagatgggcttcttctccgtcaccaccgtgagaaccgctctgttcgccttacgatac aacgtgatgctcttgatgaaggtgctgtctatgaagagcctgaagaagcaggtgaagaaa gccaagaagatgacggtgaaggacatggtgaccacactagtgtccttctactggagcgtc ctgctgggactcctgcacttcggcttcagcgtcgctcgaggattcttccggatcgtctac aacagctttctgggaggcagtctggtggaggacgccaagaccatgaaggtgtcggagctc ctggctaacatgcctgacccgactcaagacgaggtgagaggagagacggaggagagcgag aagaaacccacggacaaaacctccccagaggaagacctggccgatctgacggtggccaca gacgacaccgagctcctctctgatatattcggtttggatctgaagagagaaggagggcag tataaactgatgcctcacaatccgaacgctagcctcacggatctgctcaacacacccatc cctcctccacctacaccgtcaccagagctgcgcaggagacaccagaccaagagctcttca tcctcagcagacgtcagtgaacctgcggacgagaccaaagctgtgcctgagaaagcagaa ggggaaaacggagagaaagcacagaagaagaaggaggaagtggtgaagcgtaaggtcaga cagcactacgagcctgatctgcaggagtcggccttctggaagaagatcatggcttaccaa cgcaagctgctgaactacttcgcacgaaatttctacaacatgagaatgttggctttgttt gtggcctttgcaatcaacttcattctgctgttttacaaggtgtccacgtcctcggccgtc tctgaggggaaggaggtgttgttcggctcgtcttcagacaccagtgtgcgctgggatcct ctgacagacgcgagcgctcggcctgacgctgtgcacttcgtgctggaggagagcagcggc tacatggagcccacgctgaggatcttagccatcctgcacaccgtcatctccttcttctgc atcatcggctactactgcctgaaggttcctctggtgatattcaagcgtgagaaggaagtg gccaggaagctggagttcgacggtctgtacatcactgagcagccctcggaggacgatatt aaaggccagtgggaccgactggtcatcaacacacagtccttcccaaacaattactgggat aagtttgtgaagcggaaggtgatggataagtatggagagttttatggacatgatcggatc agtgagctgctggggatggataaagctgcgctggacttcagtgacgcacatgagaaaaag aaaccaaagagagacagttcactggccgcagtactgaactctgtggatgtgaagtatcag atctggaagctgggtgtggtcttcactgataactcgttcctgtatctggcctggtacatg agcatgtccatcctcggacactacaacaacttcttcttcgccgcccacctgctggacatc gccatgggcttcaagaccctcagaaccatcctgtcctccgtcacacacaacggcaaacag ctggtcctgaccgtcggtctgctggcggttgtggtctatctctacactgtggtggctttc aacttcttccgtaaattctacaacaagagtgaagatggagaatcaccagacatgaagtgt gacgacatgctaacgtgctatatgttccacatgtatgttggcgtgcgagccggcggaggc atcggggatcagatcgaagatccagccggtgacgagtacgagatctaccgcatcatcttt gacatcaccttcttcttcttcgtcatcgtcatcctcctggccatcattcagggtctgatc atcgatgcgttcggagagctaagagaccagcaagagcaggtgaaagaagacatggagacg aagtgcttcatctgtgggattggaaacgactacttcgacacggttcctcacggcttcgag acacacacgctgcaggaacacaacctggccaactatctatttttcttcatgtatctcatc aacaaggatgaaacggagcacacaggccaggagtcgtacgtttggaaaatgtaccaggaa cgatgctgggaattcttccctgctggagactgtttccggaaacaatacgaggaccagctc aattaa

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