Carassius auratus (goldfish): 113063123 Help Entry 113063123         CDS       T07313                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism caua  Carassius auratus (goldfish) Pathway caua04020   Calcium signaling pathway caua04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:caua00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113063123    04020 Calcium signaling pathway     113063123  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:caua04040]     113063123 Ion channels [BR:caua04040]  Voltage-gated cation channels   Ryanodine receptor    113063123 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 Ago_Mid EF-hand_6 Motif Other DBs NCBI-GeneID:  113063123 NCBI-ProteinID:  XP_026089089 Ensembl:  ENSCARG00000039696 UniProt:  A0A6P6LX89 LinkDB All DBs Position 45:8367325..8432327 Genome browser AA seq 4780 aa AA seqDB search MLAGQNGEGNPDRDHWAAQGGGHRTLLYGHAILLRHSFSGMYLTCLKTSRSLTDKLSFDV GLQEESTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSMSNGSIQVDASF MQTLWNVQPTCSRSNLEVGFLLGGNVLRLFRGHDESLTIPGSEQSQEQQRVVNYETGKGG SKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGYYLGQTEDQGLTLLDREKSDTTATA FCFRASKEKIDSGPKRDIDGMGVAEIKYGDSVCFIMHVSTGLWLSYLAPDAKTSRLGPPK RRAVLSPEGHMDDGLTLQLCQHEESRAARIIRNTTRLFTQFIRGLDGLNGEKSTEVTLPV CEVVQTLDDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLFKEEGMLTLVSHCIDRLNVYN SAAEFEELAGEEAGEAWKDILNLLYELLAALIRGNRTNCTQFSRKLDWLVSKLERLESSS GILEVLHCILIESPESLNIIQKAHIKSIISLLYKHGRNHKILDVLCSLCVCNGVAVRANQ NFICDHLLPRRDLLLQTRLINDVQSMRPNIFLGMSEGSAQYKKWYFELIIDQVDHYVTNE PTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRPVASINQHLL NSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNIDGFFFPVISFSAGVKVRFLLGGHHG DFKFLPPAGYAPCYEALLPKETMRVEPVKDYKRDLEGVRDLLGTTEFLSQASFIPVPVDT SQLVLPPHLENVRDKLAENIHELWGMNKIELGWMYGKVRDDNKRQHPCLVDFSKLPETEK NYNLQMSTETLKTLLALGCHVAQVNMNAEDDLKKMKLPKNYMMANGYKPTPLDLSDVKLT PGLEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRNPRLVPYALLDERTKKSNRDS LREAIRTLVGYGYFIDPPDQETAHTEKEGIESFRLFRVEKTFAVKTGKWYFEFEALTGGD MRVGWARPGCRPDKELGLDDQSFVFDGYRGRRVHMGSHFFGRNWNKGDVVGCMINMEDKS MIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQIGRMNLGKDASTFKYYTMCGL QEGFEPFAVNMNREVTMWFSKRLPTFFNVPEDHPHIEVTRIDGTVDTPPCLKVTHKTYGT QTSNDDMVCCRLSMPVEFYSGLRKTTDINEVIAEDQRAKKDDGGKIDCGSITKHFYSVRV FAGQDPSSVWVGWVTPDYHYYSKYFSLGTVRTVTVTLGDERGRVHESVRRSNCYMVCAGD VVSGSTGRSNTDLEIGCCIDLASGLVSFTANGRDLPTAYQVEPNTKLFPAVFVQPTSPNL FQFEFPKIPDAMPLSSAIFKSLQRNPEPQCPPRLDVQTLVSVLWSRMPNTFLTVEVARVS ERHGWVVQCLEPLQMMAVHIPEENRCIDIMELSENEDLRQFHYHTLKLFCALCALGNTRV AHALCSHLDQSQLLYTIDNQYLTGQLREGFYDVLISIHLETAKEAHFMMNNEFIIPVTEE TRSIRLFPDDSKRHSLPGVGLSTSLAPHFNFTPPCFITPKRDQPLFSPQIPLGILKEKAM SMLTEAVQGGGAHIRDPVGGSVEYQFVPILKLIGTLLIMGALTSEEVRTILLLIDPSVFG DRKEEEEQTAVAEKGAEKEEATSNEEKAVEAGEEESKEAKQPSKGLLEKSLPESVKRQMC ELLHYFCDCELKQRIEAIVAFSDEFVSKLQYNQKFRYNELMLALNMSAAVTAKKTREFRS PPQEQINMLLNFSAGDDCTCPEELQEELQSFHDDLRLHCGIPMEEEEEEQDTSLKGRLMS LVYKIKGRPQKTEEKPTEQEQAAPTNLKELISQTMVTWAQECKIQDPALVRSMFSLLRRQ YDGIGELLRALRKSYTVSDKSVEDAINLLASLGQIRSLLSVRMGEEEGQLMIDGLGDIMN NKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKNKEIAFPKMVASCCRFLCYFCRISRQNQ KAMFDHLSYLLENSSVGLACPAMRGSTPLDVAASSVMDNNSLALALEEPDLEKVVTYLAG CGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENANVVVKLLIRRPECF GPALRGEGGQGLLAAMKEAIKISEDPTLDLPNLPEGAAPTIGEDEEEEEVAHMGNSIMSF YSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTNDLVGIISIPLKMPVVNKDGTV TEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLMHLLEVGFLPDLRASASLDSEVLRSTE TALAMNRYIGSAVLPLLTRCAHLFAHTEHYAMLVDTTLHTIYRLSKGRSLTKAQRDAIDE CLLAICMHLRPSMLQQLLRRLVFDVPQLTEYCKMPIKLLTNHYEQNWKYYCLPTGLGSYG MATEEELHLTKKLFWGLFDALSQKKYDAELFKMAMPCLSAIAGAIPPDYVDSSPGSTLVK QASVDAQGNFDPQPINTANISLPEKLDYIASKFAEHSHEKWSSEKITLGWTVGDRVDDKA KTHPLLKPYKALSEKERESYRCPVKEALKSMLAMGWNIERTKEGEAMFKQRETEKQRKIS ESSQVILIRRKVFISFPQDLENVILSRELQAMVETVAENYHNIWAKKKKKELDSKGGGSH PLLVPYDTLMAKEKYRDREKAQELFKFLQVNGYAISRGLKDMEQDSSSMEKRIAFKFLKR LLNYVDSAQEFIAHLEAIATSGKTEKSPHDQEIKFFAKVLLPLIDQYFKNHCLYFLSSPN ISLSSSGYASNKEKEMITSLFYKLAALVRHRISLFGSDSTTMVSCLHILSRSLDFRTVMK SGSELVKAGVRTFFENAAEDLEKTLENLKLGKMGQSRTQMKGVTHIISYTSAALMPVLTV LFQHITQYQFGAELLLDDIQLSCYRILTSLYSLGTGKNIYVEKQLPVLGECLSTLVGAMP VAFLEPHLNMHNPQSVFNTKTPRERAILSMPDTVEEMCPEMPDLDSLMKDIGDISESGAR YTEMPQVIEVILPMLCNYLSYWWAKGPESSPDKSNCSTTVTSEHLSLILGNILKILNNNL GIDNAPWMKRLAVYTQPIISKASPDLLRTHFLPTLEKLKKKTVKIVAEEELLRSESRTDT QEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSKWLKQPDSDSTELFKMVSEIFILWCK SHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKKRRGELYSIQTSLILA AHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLHLQEKSADPAVQWQL NLYKDVVVKNEGPPDPEQNVERVQAISAAVYHLDQVEQPLRNKKMVFQKLLSKQRKRAVV ACFRMAPLYNLPRHRSINLYLSGYQRLWIETEEYSFEEKLVQDLAKTHMTVVEEEEEEEA EVQPDPLHQLILHFSHNALTERSFLEEDPLYIAYADMMAKSCAENEEEEEEGKEKTFEEK EMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKLGISILNGGNVLVQQKM LDYLKEKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMVTEEGSSSKVLQNDDFTK DLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDV MDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMK LSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNMEMILKFF DMFLKLKDLTTSDNFKEYDPDHKGVISKKEFHKSMDSQKQYTQSEIEFLLSCVEADENDM FNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMSHDSRLSTFLDLAESVLSYFEPYLGRIE IMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTI FEMQLASQISEPDAAEQPEEEDEEELHSLLEGLSEEEDASLESGSAFIAACTSVKKSMSN FRKMLTFKSMRKQFKKFKKLTIREMITGFFSFFWMLFTGFFKGIFSIIFGFFHIIWSSMF GGGFVEGAKNMKVTDILGNMPDPTQFGIHGDVLEVEKSESSELVVSSDMVQMTGAGAEKL EADVVMDLLNPAVKKEGKHGAEPGLGDVCEVLTESSAPVEKKKSQKVATEKPESEPEKAD SENQEKGDKAKEETPEEPAAAKAAPRAKRGSPKEDSPAFMASFFAGLEVYKTKMLNYLAR NFYNLRFLALFVAFAINFILLFYKVTGEFDDEEEGSWDGEEEEGDEDDGGMEYFILQEST GYMAPTLTFLAVLHTIISLLCVVGYYCLKVPLVVFKREKEIARTLEFDGLYITEQPSDDD IKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSALDFDPTEEA VVKEASLVSWLSSIDTKYHIWKMGVVLTDNSYLYLIWYTTMSILGHYNNFFFAAHLLDIA MGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDAPDMKCD DMMTCYLFHMYVGVRAGGGIGDELVDPAGDPYELYRILFDITFFFFVIVILLAIIQGLII DAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLIN KDETEYTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14343 nt NT seq  +upstreamnt  +downstreamnt atgctcgccgggcagaatggtgaaggaaatcctgatcgtgaccattgggcagcacaggga ggtggacatcggacactgctctacggtcacgccatcctccttaggcattccttcagtgga atgtatctgacatgcctgaagacttccaggtctctgacagacaaactttcttttgatgtt ggccttcaagaggaatcaaccggggaagcttgttggtggacaattcacccggcctccaag cagaggtcagaaggtgagaaggtgcgcattggagatgacctcatcttggtcagcgtatcc tctgagaggtacctgcacctctccatgtccaatggaagcatacaagtggatgcctcattc atgcaaacactgtggaacgttcagcctacctgctccagaagcaatttggaagtgggattt cttttgggtgggaatgtgttacgcttgttccgtggtcatgatgagagtctcaccatacca ggatccgagcaaagccaagagcaacagagagtggtgaactatgagaccggcaaaggaggg tccaaggcaaggtctttatggagactggagcctcttcgaataagctggagcgggagtcac atcagatggggtcagcccttccgcctccgccatctctccaccggctactatctgggccag acagaggaccagggcctgacactgctggacagagagaagtctgacaccactgcaacggcc ttctgtttccgggcaagcaaggaaaagattgactccggcccaaagcgtgatattgatggt atgggggtcgcagagatcaaatacggcgattcggtctgcttcatcatgcatgtgtccacg ggcctgtggttgtcctacctggcgcctgatgccaaaacatctcgcctgggaccaccgaag agaagggctgtcctgtctcctgagggccatatggatgacgggctgactctgcagctttgc cagcacgaggagtcccgggcggctcgcatcattcgtaacaccacccgcctcttcactcag ttcatcagaggtctggatggtttgaatggggagaaatcaacagaggtgacactgcctgtg tgtgaagtggtgcagaccctcgatgacctcatcgtgtacttccagcagcctgactctgaa ctcgaacatgaggagaaacagaggcagctccgatctctcatcaagcgccaagatctcttc aaagaagagggaatgctaaccctggtctcgcactgcatcgatcgcctaaatgtgtacaac agtgccgctgagtttgaggagttagcaggcgaagaggccggagaggcgtggaaggacatt ctcaacctcctctatgaacttctggccgctctgattcgaggcaacaggaccaactgcaca cagttctctcgcaagctggattggctagtcagcaagctagagcgcctggagtcctcatca ggcattttagaggtgcttcactgtatcctaatcgagagtccagaatctctgaacatcatc cagaaggcccacatcaaatccattatttctctgctgtacaagcatggacgcaaccacaag attctggatgttctctgttccctctgtgtctgcaatggtgtggctgtgagagccaatcag aatttcatctgtgaccacctgcttcctaggagagaccttctgctccagacgcgattgatc aatgatgtccaaagtatgagacccaacatcttcctgggcatgagtgagggctcggcacag tataagaaatggtactttgagttgattatcgatcaagtagaccactatgtgaccaatgag cccacccaccttcgtgttggctgggccaccaccaaaggctacgccccctatcctgggggt ggagagggctggggaggaaatggtgtgggtgacgatctttactcctacggttttgatggg cttcatctgtggtcagggcgaatcccacggcccgtggcctctattaaccagcacttgctg aattcagatgatgttgtgagctgttgtcttgatctcggagcccctagcatgtctttccga attaacggtcagcctgttcaaggcatgtttgaagacttcaacatagacggcttcttcttt cccgtcatcagtttctctgcaggggtcaaggtccgtttcttgttgggtggtcaccatgga gactttaagttcctgcctccagcaggctatgccccgtgctatgaagccctgcttcccaaa gaaacgatgcgtgtggagcctgtgaaggattataaaagagacctggagggagtgagagat ctgctgggcaccacagagttcctctcccaggcttcattcattcctgttcctgttgacacc agccagcttgttctgcctccgcatcttgaaaatgtacgggacaagttagctgagaacatc catgagctctggggcatgaacaaaatagagcttggctggatgtatggcaaggtccgagat gacaacaagagacagcacccttgtcttgtggacttctctaaactgccagaaacagaaaag aattataacctgcaaatgtcaactgaaactttgaagaccctgcttgctttgggatgccat gttgcacaagtcaatatgaatgctgaagacgacctgaaaaaaatgaaactccccaagaac tacatgatggcaaatggttataaacctacaccactggacctctctgatgtgaaactgaca cctggtctagaggttctagttgataaactggctgaaaatgctcataatgtttgggctaaa gatcgcataaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcgtaat cctcgtctggtgccatatgctttattagatgaacgcactaagaaatcgaacagagacagt cttcgagaggccatccgtactctggttggatatggatatttcatagacccacctgatcag gagactgctcacacagagaaggaaggcattgaatccttccgtctcttccgtgtggagaag accttcgctgtgaagacaggaaagtggtattttgagtttgaggcgctcaccggaggtgac atgcgggtgggttgggcacggcccggatgcagacctgataaagaactgggactagatgac cagtccttcgtctttgatggctacaggggccgacgggttcatatgggcagtcatttcttt gggaggaattggaataaaggagatgtggtgggctgcatgatcaacatggaggacaaatcc atgatattcaccctgaatggagagatcttaattaccaacaagggctccgagctctgcttt gccgactttgaaactgaagatggattcatcccagtgtgcagcctgggtctttcccaaatt ggccgcatgaatttaggaaaagacgctagtacttttaagtactacactatgtgtggcctc caggaaggctttgaaccctttgctgtcaacatgaatcgagaggtcaccatgtggttcagc aaacgcctgcctacattttttaatgtaccagaggaccatccccatattgaggttactaga atagatgggactgtggacacacctccatgtctaaaggtaacacacaagacatatgggacc cagaccagcaatgatgacatggtctgttgtcgtctaagcatgcctgttgagttctactct ggccttcggaagacaactgatatcaatgaggtgatcgctgaggaccaaagagccaagaag gatgatggaggcaagattgattgtggcagcattacaaagcacttttattctgtgagagtg tttgctggacaagatccatcgtccgtttgggtgggctgggtgacaccagactaccactac tacagcaagtacttcagcctcggcacagttcgcaccgtcactgtcacactgggagatgag cggggacgtgttcacgagagtgtgaggaggagtaattgttacatggtctgcgctggtgat gttgtcagcggctccacaggccgtagtaacactgatctggagatcggctgctgcatagac ctggcctcaggcctggtgtcattcactgccaatgggagagatctgcctactgcataccag gttgagcctaacacgaagctcttccctgctgtgtttgttcaacccacaagtcccaacctc ttccagtttgagtttccaaaaatcccagatgcaatgcccctgtcttcggccatctttaag agtttacaaagaaacccagagccccagtgtcctcctcggctggatgtgcagacacttgtg tctgtgctgtggagcagaatgcccaacacgttcctgacggtggaggtggcccgtgtgagt gagaggcatggctgggtggtgcagtgtctagagcccttgcagatgatggctgttcatata ccagaggagaacaggtgtatcgacatcatggaactatcagaaaatgaagatctacggcag ttccactatcacactttaaagctcttctgcgccctatgcgccctgggcaacacccgcgtt gctcatgccctctgtagccatcttgaccaatcgcagctcttatacaccattgataaccag tacctgactggtcaactgcgtgaaggcttttacgatgtcctcatcagcattcacctggag acggccaaagaggcccatttcatgatgaacaacgagtttataatcccagtaacagaagag acgaggagcatccgcctcttccctgacgactctaagcgtcactctcttcctggcgtaggc ttgagcacttcacttgcccctcatttcaacttcacccctccgtgtttcattacccccaag cgcgatcagcctctcttcagcccacagatccccctgggtatcctgaaggagaaagccatg agcatgcttacggaagccgtgcagggtggaggcgcccacattcgagatcctgtgggtgga agtgttgagtatcagtttgtgccgattctcaagttgattggcaccctgctgataatgggg gcgctgaccagtgaagaggtaaggaccatcctgcttctcattgaccccagtgtgtttggg gaccgtaaggaggaggaggaacagacagcagtggcagaaaagggagccgagaaagaggag gcaaccagtaatgaagagaaggctgtggaggctggggaggaagagagtaaagaggccaag cagccttctaagggtctcctggagaaaagcttgcctgaatcagtcaaacggcagatgtgt gaactgctgcactatttctgtgactgtgagctgaagcagcgcattgaggctatagtggcc ttctcagatgaatttgtgtccaagctgcaatacaatcagaagttccgctacaacgagttg atgctagccctcaacatgtcagctgctgtcactgccaagaagacaagagagtttcgctca cctccccaagagcagataaatatgttgctgaacttcagtgctggtgatgattgcacctgc cctgaggagctgcaagaggagcttcaaagctttcatgatgacctgcgactccactgtggc atccctatggaggaggaagaggaggagcaggacacatctcttaaaggccgcctaatgtcc ctggtatacaagattaaaggtcgcccccaaaaaacggaggaaaaaccaacagagcaagaa caggctgctcccaccaacttgaaggagctgatatcacaaactatggtcacctgggcacag gagtgcaagatccaagacccagcactggtccgcagcatgttcagccttttgagaaggcag tatgatggcatcggtgagctgctcagggccttgaggaagagctacactgtcagtgacaag tctgtagaggacgcgatcaacctgctggcctcgctgggccagatccgctcactacttagc gtccgcatgggagaagaggagggccagctcatgattgatggcctgggggacatcatgaac aacaaagtgttttaccagcatccaaatctgatgcgtgttcttggcatgcatgagacagta atggaggtcatggtcaatgtgctggggggagacaagaataaggagattgccttccccaag atggtggccagctgttgtcgcttcctgtgctacttctgtcgcatcagccgtcagaaccag aaggctatgtttgaccacctgagctacctcctggagaacagcagtgtggggctggcatgc ccagccatgagaggctccacacctttagatgtggctgcttcctctgttatggacaacaac agtttagctctggcacttgaagaacctgatctagagaaggtggtgacatatctggcaggc tgcggcttacagaactgcccaatgctcattgctaggggatacccagatatcggctggaac ccaatagaaggagaacgctatctgtccttcctacggtttgctgtctttgttaatggtgaa agtgttgaagagaacgctaatgtagtggtaaagcttttgatcaggcgtccggagtgcttt ggacctgctctcagaggagagggagggcaaggtttactcgctgccatgaaggaagccatc aaaatctcagaagatcctactttagatctgccaaacttacccgagggggctgcacccacc atcggagaggatgaagaggaggaggaggtcgcccacatgggcaactctattatgtccttc tactcagcccttattgatcttctgggtcgctgtgcacctgagatgcatcttataaacaaa ggcaaaggtgaagctctgcgtatccgggccatcctccgttccttagttcccactaatgat ttggttggaattatcagtattccactcaaaatgccggttgtcaataaagatggcactgtg acagagccagatatgaatgccagtttctgtccggagcacaaggcacccatggtgcttttc ctggaccgtgtctatggtattgacgaccaaagcttcttgatgcacctgctggaggtgggc ttcctgccagatctgcgagcctcagcctccctggactcagaggtgctcagatccacagag acagcgctggccatgaaccgctacattggatccgcagtgctccctctgttgacccgctgt gctcatctattcgctcacactgagcactatgcaatgctcgttgacaccacgctgcacact atctatcgcctctcaaagggccgatcactcaccaaggcccagagagatgctattgatgaa tgtctactggccatctgcatgcatctgcggccatcaatgctacagcagctgttgcgtcgt cttgtattcgatgttccccagcttacagagtactgcaagatgcccatcaagcttttgacc aatcactatgaacagaactggaagtactactgtctgccgacaggcctgggcagctatggc atggcaacagaggaggaactccacctcaccaagaaactcttctggggacttttcgatgct ctttctcaaaagaaatatgatgcagagcttttcaaaatggccatgccatgtcttagtgcc atagctggtgccataccacctgactacgtcgactccagtccaggttccacattagttaag caggcctctgtggatgcgcaaggcaactttgacccccagccaattaacactgctaacatc tcgctgcccgaaaagctagattacattgcaagcaagtttgctgagcattcccatgagaaa tggtcctctgagaagatcactcttggctggactgtgggagatagagtagatgacaaagct aagactcatccactgctgaaaccgtacaaagcactgagtgaaaaggaaagggagagttac cgctgtcctgtgaaagaggctctaaagagcatgttagcaatgggatggaatattgagagg accaaagaaggagaggccatgttcaagcaaagggaaaccgagaaacagcgcaagatatca gagtcctcacaggtaatattaatcaggaggaaggtgtttatttctttcccacaagatttg gaaaatgttattctatcaagagaactacaggcgatggttgaaacagttgcagaaaattac cacaacatttgggcaaagaagaagaaaaaggaacttgacagtaaaggaggaggaagtcat ccgttgctggtaccatacgacacgctgatggcaaaggagaagtacagagatcgagagaag gcccaggaactctttaaattcctgcaggtcaatggatacgccatcagcagaggtctgaag gacatggagcaggattcctcttctatggaaaagaggatcgcctttaagtttctcaagagg ctcttgaattatgtcgattctgcacaggagtttattgctcatcttgaggctatagctacc agtgggaagacagaaaaatctccccatgatcaagagatcaagttttttgctaaggttctg ctgcccctcatagatcagtacttcaaaaaccactgcttgtacttcctgtcatcccccaac atcagcctgagcagcagtggctatgcatccaacaaagagaaggagatgatcaccagtcta ttctataagctggcagcccttgtcagacatagaatatcactctttggaagtgactccacc accatggtgagctgcttgcacatcctgtcacgctcactggacttcaggactgtgatgaag tctggctcagagctggtgaaggctggtgtccggacgttcttcgagaatgcagcagaagac ctggagaagactctggagaacttaaagctagggaagatgggtcagtcacgcacacagatg aagggcgttacccacatcatcagctacacctcagcggccctgatgcccgtcctgacggtt ctttttcagcatatcacccaataccagtttggagcggagctgcttttggatgacattcag ctgtcctgctaccgtatcctgaccagcctctactctttgggcactggcaagaacatctat gtggaaaaacagcttccagtgctgggcgaatgtttatctactctggttggagccatgcct gttgcattcctggaaccccacctaaatatgcacaatccccaatctgtcttcaacaccaag acaccaagagaacgagctattttgagcatgccagacactgtggaggagatgtgtcctgag atgcccgatctggacagcctgatgaaggacattggtgacatttctgaatccggagcacgc tacacagagatgccacaggtcatcgaggtcatcctgcccatgttgtgtaactacctgtct tactggtgggcaaaaggcccagaaagctccccagataaatccaattgcagcacaactgtc acatctgagcatctcagtctaattctgggcaatatccttaagattctcaataacaacctt ggcattgacaatgccccgtggatgaaaagacttgcagtatacacccagccaatcattagc aaggctagcccagatcttcttagaacgcacttcctgccgacgctggagaaactgaagaag aagacagtgaagatagtggctgaggaggagctgcttaggtctgaaagcaggacagacact caggaagctgaactgcagattctggatgagtttgctgttctctgcagggatctgtatgcc ttctatccaatgctcatccgttatgtggacaacaacagatccaaatggctgaagcaacca gattcagattcaactgaacttttcaaaatggtgtcagagattttcatcctttggtgtaaa tctcataactttaaaagggaagagcaaaattttgtggtgcaaaatgaaattaacaacctg gcattcctcactggagacagcaagacgaagatgtcaaaatctggaggtcaagaccaagag agaagaggaaaaaagagaagaggagagttgtactccatccagacttccctcatcttagca gctcacaagaagatgttgcctattggtctgaacatgtgcactcctggagaccaggagctc atttcccttgccaagatccgctacagtctgaaagacacagatgacgaggttaaggattac ttgaggaagaacctccatcttcaggagaagtcagcagatccagcagtgcagtggcagctg aacctctacaaagatgttgtggtgaagaatgagggacctccagacccagagcaaaacgtg gagagagttcaggccatctccgctgctgtctaccaccttgatcaggttgagcagccgctg aggaataagaagatggtttttcaaaagctgctgtcgaagcaaagaaagcgtgccgtggtt gcctgtttccgcatggcaccactctacaacttaccaaggcatcgctcaattaacctctac ctcagtggctatcaaagactttggatagagacagaggagtactcctttgaggagaagcta gtgcaggacctggcaaaaactcacatgactgtggtagaggaagaagaggaagaagaagct gaagttcagccggaccctcttcatcagctcatccttcacttcagtcacaatgctctgaca gaaagaagtttcctagaagaggatccactctacattgcttacgctgatatgatggcaaag agctgtgccgagaatgaggaagaggaagaggagggaaaagaaaaaacgtttgaggaaaaa gaaatggagaagcagaagattctttaccagcaggccagacttcacgccagaggagctgct gagatggtgctacagatgatcagtgccagtaaaggccgacttggtcccatggtgactggc acccttaaactgggcatttctatcctaaatggaggcaacgttcttgtccagcagaaaatg ctggattatttgaaggaaaaacgagatgcgggcttctttaaaagtttatctggactaatg atgtcatgcagtgtgctggatttaaatgcgtttgaaaggcaaaataaggcagagagtctt gggatggtgactgaagaggggtcaagttcgaaagtcctacaaaatgatgactttacgaag gatctattcaggtttttgcaacttctgtgcgagggacacaataatgatttccaaaacttc ttgcggacacagaccggaaacactactactgtcaacatcatcattagcactgtggactac ttgttacgtctacaggaatctataagtgatttttattggtattactctgggaaagatgtc atggatgaggctgggcaacttaacttctccaaagctttggcagtagccaaacaaatcttt aactcgctcactgagtacattcagggcccttgtattgggaatcagcaaagtttggcacac agcaggttgtgggatgcagtggtcggattcctgcatgtttttgcaaacatgcaaatgaaa ctgtcacaggattctagtcaaatcgagttattgaaagagctgatggatttgcagaaagat atggtggtcatgatgttatctcttctggagggtaatgtggtgaatggaactatcggtaag cagatggttgacacattagtggagtcctccagcaatatggaaatgatcctcaagttcttc gacatgttcctcaaactgaaggacctcactacatctgacaacttcaaggagtacgaccca gatcacaaaggcgttatatccaagaaagagtttcataagtctatggatagccaaaagcaa tacacacagtctgagatcgagtttcttctctcctgtgtggaggcagatgaaaacgacatg ttcaactacaaggagtttgtggaacgcttccatgaaccagccaaggacatcggcttcaat gtggctgtgcttcttactaacctatcagagcacatgtctcacgactcacgcctgtccacc tttttagacctagctgaaagcgttctcagttactttgagccttacctgggccgtattgag atcatggggggtgccaagagaattgagagggtttactttgagatcagcgagtctagcaga acccaatgggaaaagcctcaggtcaaagagtccaaacggcaattcatctttgatgtggtc aatgaaggtggtgagagtgagaagatggagttatttgtgaacttctgtgaggacaccatc tttgagatgcagttggcctctcagatctctgagccagatgcagcagagcaacctgaggag gaggatgaggaggagttgcacagtctgcttgaaggcttgtctgaggaggaggatgcatct cttgagtcaggctcggctttcatagcggcctgcacctctgtgaagaagagcatgtccaat ttccggaaaatgttgacatttaagagtatgaggaaacagtttaagaaattcaagaaactg accatcagggaaatgatcacagggttcttctccttcttctggatgctctttaccgggttc ttcaaaggcatttttagcataatcttcgggttcttccatattatttggtcctccatgttt ggagggggtttcgtggagggtgctaaaaacatgaaagtgacagatatcttgggtaacatg cctgatccaacacagtttgggatccatggtgatgtactggaagtagaaaaaagcgagagc agcgagttggtggtgtcgtcagatatggtgcagatgactggggccggtgctgagaagctg gaagcggatgtggtcatggatctacttaatccagctgtgaagaaggaggggaagcatggg gcggaacctggtctgggtgatgtctgtgaagtcctgacagagtctagcgcccctgttgag aaaaagaagagccagaaagtagcaacagagaagccagaatccgagccagagaaagcggac tctgagaatcaggagaagggagacaaggctaaagaggaaacgcctgaggaaccagcagca gcaaaagcagctccaagagccaaacgtggctcaccaaaggaagactctccagcgttcatg gccagcttcttcgcagggcttgaagtctacaaaaccaaaatgctgaactacctggctcgc aatttctacaaccttcgttttctggctctgtttgtggcttttgccatcaacttcatcctg ctcttctacaaggtgactggagaattcgatgatgaggaagagggatcctgggatggtgaa gaggaggaaggtgacgaagatgatggaggaatggaatacttcattcttcaggagagcact ggctacatggcccccacattaacattcttggctgtactgcacacaatcatctcgttactc tgtgttgttggatattactgccttaaggttcctttagtcgtgttcaagcgggagaaggag atcgctaggacgcttgagtttgatggtttgtatattaccgagcagccgtctgatgatgac atcaaaggacaatgggatcgtttggtcattgcaactccgtccttccctaacaattactgg gacaagtttgttaagaggaaggtcatcaataaatatggtgacttgtacggggctgaacgc atagctgaactcctgggtctggataagagtgctctggactttgatcccactgaagaagct gtggtaaaggaagcctccctggtgtcctggttgagctcaattgataccaagtaccacatc tggaaaatgggggtggtgctgacggacaactcttacctctacctgatctggtacaccacc atgtctattttgggacattacaataacttcttctttgccgctcatttgctggacattgcc atgggcttcaagaccttgaggaccatcctctcttctgtgacccacaatggcaaacagctg gtgttgacggtggggctcctggcggtcgtggtctacctgtacaccgtggtggcttttaac ttcttccgcaagttctacaacaagagcgaggatgaggatgcgcctgacatgaagtgtgat gacatgatgacttgctacctgttccacatgtacgtgggtgtgagagctggcggtggcatc ggggatgaactcgtggacccggccggtgacccatacgagctctaccgcattctgtttgac atcaccttcttcttcttcgtcattgtcattctgctggccatcattcagggtttgatcatt gatgccttcggtgagttgagagaccagcaggagcaggtgaaagaggacatggagacgaaa tgcttcatctgtggaattggaaatgactacttcgacacaaccccgcatggctttgagacc cataccttacaagagcacaatctggccaactatttattcttcctgatgtatcttatcaac aaagatgagaccgaatacactggtcaggaatcgtatgtttggaagatgtatcaggagagg tgctgggatttcttccctgccggagactgtttccggaagcagtacgaggaccagctgggc tag

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