Carassius auratus (goldfish): 113071634 Help Entry 113071634         CDS       T07313                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism caua  Carassius auratus (goldfish) Pathway caua04020   Calcium signaling pathway caua04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:caua00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     113071634    04020 Calcium signaling pathway     113071634  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:caua04040]     113071634 Ion channels [BR:caua04040]  Voltage-gated cation channels   Ryanodine receptor    113071634 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  113071634 NCBI-ProteinID:  XP_026100727 Ensembl:  ENSCARG00000065562 UniProt:  A0A6P6MVV7 LinkDB All DBs Position Unknown AA seq 4884 aa AA seqDB search MAEGGDAEDEIQFLRTDDEVVLQCVACIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPP DLCICSFVLEQSLSVRALQEMLAKTGQNNDQFIRKAAQSGGHRTLLYGHAVLLRHSFSRM YLTCLKTSRSVTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSS ERYLHLSISNGSIQVDVSFMQTLWNVHPTCSGSNVEEGYLLGGHVMRLFHGHDEVLTIPG SDQSEEEQRLVNYETGKAGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALT DDRGVVLQDRERSDTTSTAFCFRASKEKLECGLKRDIEGMGVAEIKYGDSLCFLMHVATG LWLSFQAPDVKSARLGPLKRRVCLHSEGHMDDGLTLQRCQHEESRAARIIRNTTRLFSCF IRELDGLSAKNRSSVLLPIEEVLQTLNDLIAYFRLPDAELEHEKKQIKLRSLKNRQNLFK QEGMLSLVSSCIDRLSVYNSAAHFGECAGEEAGVAWKDILNLLYELLAALIRGNRNNCTQ FSHNLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKTIISLLYKHGRNHKI LDVLCSLCVCNGVAVRANQNLICDHLLPRRDLLLQTRLVNDVQSMRPNIFVGVSEGSAQY RKWYFELMIDHVDHFLTGEPSHLRVGWASTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGL HLWSGRIPRTVASVKQHLLASDDVVSCCMDLNAPSISFRINGQPVQGMFENFNIDGLFFP VVSFSAGVKVRFLLGGRHGDFKFLPPSGYAPCYEALLPKEKMRVEPVKEYKRDADGVRDL LGNTHFISQTSFIPKPVDTSQIGMPPHLEKVRDRLAENIHELWGMNKIELGWSYGKIRED NKRQHPCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVKVNAEEELKKLKLPKNY MMSNGYKPSPLDLSDVKLSAGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDVKNKRNP RLVPYALLDERTKKSNRDSLREAIRTLIGYGYNVEPPDQDAGHVLERLSIDKIRFFRVER TYAVKTGRWYFEFEAVTGGDMRVGWARPGCRPDVELGTDEQAYVFDGHRGHRLHSGSRLF GRCWHAGDVVGCMINLEDKSMIFTLNGEILITNKGSELCFADFDIDDGFIPVCSLGLSQV GRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFCNVPKDHHHIAVTR IDGTVDGPPCLKVTHKTFGTQNSNADMVFCRLSMPVESHSSFRSSSCTHINGLCEDEPLK LRHRHPVKSTKHSEEVRRTDYSTITTYYHSVRIFAGQDPSCVWVGWVTPDYHYYSNHFSL SKNRSVTVTLGDERGRVHESVKRSNCYMVWGGDITSTAHAAGRSNVDLEIGCLIDLATGL LSFTVNGKELPTTYQVEPSTKLFPAVFVRPTSSSLFQFELAKIKNAMPISSAIFKSEHKN PVPQCPPRLDVQTINSVLWSRMPNTFLKVETARVSERHGWMVQCVEALQMLAVHIPEENR CVDIMELSEQEELRRFHYHTLKLYCALCAHGNTRVAHALCSHLDQSQLLYTIDNQYLSGL LREGFYDVLISVHLETARAARRMMSSEFIIPITAETRSIRLFPDASKQHRPPGVGLSTCL KPRLSFGPPCFISSKREQHLFSPEIPLDVLKERAICMLTEAVQGGGDHIRDPVGGSVEFQ FVPILRLIGALLTMGVLNSRDVHKILLLIEPGVFGERRDDGAKEGLTGAEEKAVEAGEEE EARDGKVLVKSLLEKKLPESVKRQMCELLHYFCDCELRHRVEAIVSFSDSFVSKLQVNQK FRYNELMLALNMSAAVTAKKTREFRSPPQEQINMLLNFTVGEDCPCPADIQEELYDFHSE LRLHCGIPVEEDEEDQDSSIKARLLALIYKIKGQPQRSERESTEEEQAAPSNLKELISQT MVSWAQETHIQDPELVRLMFSLLRRQYDSIGELLRAMRKTYTISAASVHDTIHLLASLGQ IRSLLSVRMGKEEEQLMIHGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKSQ EIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAS SVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDISWNPIEGERYLSFLRFA VFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISENPSLDLPSAG PAHASDASTEGEEEEEVVHMGNAILSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILR SLVPTEDLVGIISIPLKMPVVNKDGGVSEPDMSATFCPDHKAPMVLFLERVYGIEDQSFL LHLLEVGFLPDLRAAASLDTEALRTTETALAMNRYIGSAVLPLLTRCAPHFSGTEHHAAL IDSTLYTVYRLSKGCSLTKAQRDAIEECLLAICRYLRPSMLQHLLRRLVFDVPLLSEYCK MPLKLLTNHYEQNWKYYCLPSGWGSYGQASEEELLLTKKIFWGIFDSLSQKKYEQDLFKM AMPCLSAIAGALPPDYIDSTLSTTLEKQVSVDTQGNFNPRPVNTANICLPEKLEYIANKY AEHSHEKWAAEKVLLGWKHGENIDEKAKTHPMLRSYKSLTEKEKEMYCWTVRESLKSMLA MGWSIDRTREEDSVFQQREMEKMRRISQASQGNGFNPNPLDMSSVLLSRELQSMVEVVAE NYHNIWAKKKKSDLCSRAAGGAHPLLVPYDTLTAKEKTRDRERAQDLFRFLQINGYAVSR RLKHMEQDSSSMEKRFAYRFLKKLLKYVDSAQEFIAHLEAMATSGKNDRSPHEQEIKFFA KVLLPLIDQYFKNHSLYFLSSPTKNLSSSGYASNKEKEMVTSLFCKLATLVRHRISLFGS DSTTIVSCLHILAHTLDTRTVMKSGSELVKAGLRTFFESAAEDLEKTLENLKLGKFTHSR SQMKGVSQNINYTTVALLPILTALFEHITEHQFGSDLLLDDVQVSCYRILTSLYSLGTGK NIYVERQLPALGECLATLAGAMPVAFLEPQLNTHNPCSVFNTKTSRERALVGLPESVEDV CPEMPRLDGLIKDITDVSESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENRPRPAGVC SSTVTSEHLSLVLGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKTHFLPTLE KLKKKTVKVVSEEELLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDTDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKMAKSFL PKAGGQDQERKHKKRRGDFYSVQTSLIVAALKKMLPIGLNMCTPGDQELILLAKTRYGLK DTDEEVKEHIRQNLHLQEKSADPAVQWQLNLYKDVKVKTDDTLDPERSIERIQSISAAVF HLEQVEQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHTINNYFLNSYCHFWLGR IQASSYRDGLLAVLTKLKTKTDEEEEEITDTQPDPLHQLILHFSHNALTERSSLEEDQLY IAYADMMAKSCAENEEEDEEGKEKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASK GHLGPMVTFTLKLGISILNGGNITVQQKMLDYLKEKRDVGFFKSLSGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSINVRERGSKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQT GNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVMDEAGQRNFSKALAVAKQIFNSLTE YIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMIVMM LSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSENFKEHDPDRKGV ISKKEFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEEFVNRFHEPAKDIGFNVAVLL TNLSEHMPHDSRLSTFLNLAESVVNYFEPYLGRIEIMGGGKRIERVYFEISESSRTQWEK PQVKESKRQFIFDVVNKGGESEKMELFVNFCEDTIFEMQLASLISEPDAAERQEEVDDED DARSVDLDEDDEDAAQESSSAFALACVSMRKSLSNLRQLLTFRSMRRQYRKLRKMSVREM IRGFFFFFWMIFTGMFRFLYSLVWGFFHILWSTLFGGGLVEGAKNMKVTDILGNMPDPTQ FGIHGDVLELEKLEYCDVSSVAELGRMTAGDQAEMELMTELMYMQPRREGGKHGMEPGLG DVSEVIGVDTPSLASAVHQKKAQEAASKQTDESETKSESEKADVEDREKKDQDKGREESV SDSLTDEEKKPQKKRRGQRKEQAEAFMAAFLASLDVHQTKTLNYLARNFYNLRFLALFVA FAINFILLFYKVTGEDSDDLDPWTRREEEDDEAALEYFVLQESTGYMAPTLRFLAVMHTV ISFLCVLGYYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFP NNYWDKFVKRKVINKYGNLYGAERIAELLGLDKSALDFNPTEETVIKDASLLSWLSSIDT KYHVWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSADEDEPDMKCDDMMTCYLFHMYVGVRA GGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKED METKCFICGIGNEYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKM YQERCWDFFPAGDCFRKQYEDQLG NT seq 14655 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagacgcggaggatgagatccagttcctgcgcacggatgatgaggtg gttctgcagtgtgtggcctgcattcagaaggagaaccgcaagttctgtctgagcgccgag ggtttggggaaccgcttgtgttacctggagcccacatcagaggctaagtatgttcctcca gatctgtgcatctgtagttttgtgctggagcagtcgctgtccgtccgagcgctgcaggag atgctcgccaaaaccggacagaacaacgaccagttcatcagaaaggcggctcagagcgga ggacaccggacgttactgtacggccacgctgtgctcctcagacactccttcagcaggatg tatctgacctgtttgaagacgtcgcgctcagtgacggataaactgtcgtttgatgtggga cttcaggaagactcgacaggtgaggcctgctggtggaccattcatcctgcatctaaacag agatcagaaggggagaaggtgcggatcggagatgatctcatactcgtcagcgtctcatca gagcgatatctgcatctgtccatatccaacggcagcatccaggtggatgtgtccttcatg cagacgctgtggaacgtccatcccacctgctcagggagcaacgtggaggaaggatacctt cttggaggtcatgtgatgcgtctttttcatggacacgatgaggttctgaccatcccggga tctgatcagagtgaagaagagcagagattggtgaactatgagacaggtaaagccggagca aaagcccgatctctctggcggctggagccactacgcatcagttggtgtggcagtcacatc cgctggggtcagccgttccgtctgcgtcacctgaccaccggtcactatctggcgcttaca gatgaccgaggcgtcgttctgcaggacagagagagatcagacaccacgtccacagccttc tgcttcagagcctccaaggaaaagctggagtgtggtctgaagcgggacatcgaggggatg ggagtggccgagatcaaatacggagattctctgtgtttcttgatgcacgtggcgacgggt ctctggctgtcctttcaggcaccagatgtcaaatctgctcgactcgggccgctcaaacgc cgggtgtgtcttcattcagaaggacacatggacgatggtttgacgttacagcgatgtcaa cacgaggagtcgagagccgctcgaatcatccgcaacaccacgcgactcttcagctgcttc atcagagagctggacggtttgagtgccaagaaccgctcgtctgtgcttctgcccatcgaa gaggttctccagactcttaacgacctgatcgcgtacttcagacttcctgacgccgagctg gagcacgagaagaagcagatcaagctgcgctcgctgaagaaccgacagaacctcttcaag caggaggggatgctgtccctggtgtccagctgcatcgaccgcttgagtgtttataacagc gcggctcatttcggagagtgtgcgggtgaagaggccggagtcgcgtggaaggacatcctc aaccttctctacgagcttctggccgctctgatccgcgggaaccggaacaactgcacacag ttctcacacaacctggactggctcgtcagcaaactggagcgactggagtcgagttcaggg atcttggaggttcttcactgtattctgattgaaagtcccgaggctctgaacatcatccag agaggacacatcaaaaccatcatctctctgctctacaaacacggacgaaaccacaagatc ctggacgtcctctgctctctgtgtgtgtgtaacggagtcgctgtcagagccaatcagaac ctgatctgtgatcacctgctgcccagacgagatctgctgctgcagacgcgattggtcaac gacgtccagagcatgaggcccaatatcttcgtgggagtcagcgaaggctccgcccagtac aggaagtggtattttgagctgatgatcgatcacgtggatcacttcctgacgggcgagccg tcgcacctgcgggtgggctgggcgtccactaaaggctatgctccctacccgggcggcgga gagggctgggggggcaatggtgtaggggacgatctctactcctacggcttcgatggactg cacctgtggtcaggacgcatcccgaggacagtggcgtctgtgaagcagcatcttctggcg tctgatgatgtggtgagctgctgcatggatctgaacgctcccagcatctccttcaggatc aacgggcagccggtgcaggggatgttcgagaacttcaacatcgacggcctcttcttcccc gtcgtcagcttctccgccggcgtcaaggtgcgcttcctgttgggcggtcgccacggagac ttcaagttcctgccaccgtcgggttatgcgccgtgttacgaggctctgctgcccaaagag aagatgagggttgagccggtcaaagaatacaagagagacgcggacggagtgagagaccta ctgggaaacacacacttcatatcacagacctccttcatacccaaacctgtggacacgtct cagatcgggatgcctcctcatctggagaaggttcgggatcgtctggcggagaacatccat gagctctggggaatgaacaagatcgagctgggctggtcctacgggaagatcagagaggat aacaagcggcagcacccgtgtctggtagatttctccaaactgccagaaaccgagaggaac tacaacctgcagatgtccaccgaaacactcaagactctgctggcgttgggctgtcatgtg gtccaggtgaaggtcaacgctgaagaggagctgaagaagctcaagctccctaagaattat atgatgtctaacggctataagccatcgccgctggatctgtcagacgtcaaactgagcgcc ggtcaggaactgctcgtggacaaactggcagaaaacgctcacaatgtctgggccaaagac cgcatcaaacagggctggacctacggcatccagcaggatgtgaagaacaagcgaaaccct cgtctggtgccgtacgctttacttgatgagcgcaccaagaagtctaaccgtgacagtctt cgggaggccattcgcacgctgatcggatacggatacaacgtggagccgcccgaccaggac gcaggtcatgtgttagagcggctgagcatcgataagatccgtttcttccgtgtggagcgc acgtatgcggtgaagacgggccggtggtatttcgagttcgaggcggtgacggggggagac atgcgtgttggctgggctcggcccggctgtagaccagatgtggagctgggaacggacgag caggcctatgtcttcgacggtcaccggggtcatcggctgcactcgggcagccgtctgttc ggacgctgctggcacgctggggatgttgtgggttgtatgatcaacttggaggacaaatcc atgatcttcaccctgaacggagaaatcctgatcaccaacaagggctctgagctgtgcttt gccgactttgacattgacgacggtttcatcccggtctgtagtttgggtctgtctcaggtg ggccgtatgaatctggggaaggacgccagcacctttaagtactacaccatgtgtggccta caggagggcttcgagcccttcgccgtcaacatgaaccgtgaagtgaccatgtggttcagc aaacgcctgcctaccttctgcaacgtgcccaaagaccaccatcacatcgcggtcacccgg atcgacgggacggtggacggtccgccgtgtctcaaagtcacccataagacgttcgggacg cagaacagtaacgctgacatggtgttctgcagactcagcatgcctgtggagtctcactcc agcttcaggagcagctcttgcacacacatcaacggcctgtgtgaggacgagccgctcaag ctcagacacaggcatccagtgaagtccaccaaacactcggaagaagtcaggagaacagat tacagcaccatcaccacatactatcattcggtcaggatattcgcaggtcaggacccatct tgtgtgtgggtcggatgggtcacccctgactaccattactatagcaaccacttcagcctc agcaagaaccgctcagtgaccgttaccctgggagatgagcggggccgcgtgcatgagagc gtgaagaggagtaactgttacatggtgtggggtggagacatcaccagcaccgctcatgca gccggccgcagcaacgtggatttagagatcggatgcctcatcgatttggccacgggtctg ttatcatttaccgtcaatgggaaagagcttcccacaacctaccaggtggagcccagcaca aaactttttcccgctgtgtttgtgaggcccacaagctcaagtctcttccagtttgaactg gccaaaatcaagaacgccatgcccatatcgtcggccatctttaagagcgaacacaagaat cccgttcctcagtgtcctccacgactggacgtccagaccattaactcggtgctgtggagc cgaatgcccaacaccttcctgaaggtggagacggcccgtgtcagcgagagacacggatgg atggtgcagtgtgtagaagcgctgcagatgctggccgtacacatccccgaggagaaccgg tgtgtggacatcatggagctgtcggagcaggaggagctacgtaggttccactatcacacg ctaaagctgtactgcgctctgtgtgctcatgggaacacgcgtgtggctcacgcgctctgc agtcacctcgaccaatcacagctgctctacaccatcgataaccagtacctgtcagggctg ctgcgcgagggcttttacgacgtcctcatcagcgtgcacctggagacggccagagctgcc cgccgcatgatgagcagcgagttcatcatccccatcaccgccgagacgcgcagcatccgc ctcttccccgacgcctccaaacagcaccggcctccaggtgtcgggctcagcacctgcctc aaacccagactcagcttcggcccgccctgcttcatcagcagcaagcgcgagcagcacctc ttcagcccggagatcccgctggatgtgctgaaggagagggccatctgcatgctgacggag gccgtgcagggcggaggagaccacatccgtgaccccgtgggaggaagcgtggagttccag ttcgtgccgatcctgcggctcatcggcgcgctgctcaccatgggagtcctgaacagccgt gacgtgcacaagatcctgctgctcatcgagcccggcgtgtttggggagcgcagggacgac ggagccaaagaagggctgacgggagccgaggagaaggcggtggaggccggagaggaggag gaggcccgagacgggaaagtgctggtgaagagcctgctggagaagaaactccccgagtct gtcaaacgacagatgtgcgagctgctgcactatttctgtgactgtgagctgaggcaccgc gtcgaggccatcgtgtcgttctccgacagcttcgtctctaagctgcaggtcaatcagaag ttccgctataacgagctgatgctggcgctcaacatgtcagccgccgtcaccgccaaaaag acccgagagttccgctcgccgccgcaggaacagattaacatgctgctgaacttcaccgtg ggcgaggactgtccgtgtcccgcagatatacaggaggagctgtacgacttccacagcgag ctgcggctgcactgcgggattccagtggaggaggatgaggaggatcaggactcgtctatt aaagctcgtctgctcgctctcatctataagatcaaaggtcaaccgcagcgatctgagcgc gagtccacagaggaagagcaggccgctccctcgaatctgaaggagctgatctctcagacg atggtgagctgggctcaggagacacacatccaggacccggagcttgtgcggctgatgttc agtctgctgagacgacagtacgacagcatcggagagctgctccgagccatgaggaagacc tacaccatcagcgctgcctccgtccacgacaccatccacctgctggcgtctctgggccag atccgctcgctgctgagcgtccgcatggggaaggaggaagagcagctgatgatccacggc ctcggggacatcatgaataataaggtgttctaccagcatcccaacctgatgcgtgttctg gggatgcacgagaccgtgatggaggtgatggtgaacgtcctgggtggaggaaagtctcag gaaatcgcctttcctaagatggtggcgagctgctgtcgcttcctgtgctacttctgtcgc atcagtcgtcagaaccagaaggccatgtttgatcacctgagctacctgctggagaacagc agcgtgggattggcgtctccgtccatgagagggtccactcctctagacgtggcggcttca tcagtgatggacaacaacggtctggcgctggcgctggaggagcccgacctggacaaggtc gtgacgtatctggccggctgcggtctgcagagctgtccgatgctcctggccaaaggatat ccagacatcagctggaaccctatcgagggagaacgttacctgtccttcctgcgattcgcc gtgtttgtcaacggtgagagcgtggaggagaactccagtgtggtggtgaagctcctgatt cgtcggcccgagtgtttcggtcctgctctgagaggagaaggaggaaacgggctgctggcc gcaatgaaggaagccatcaagatctcagagaaccccagcctggatctgcccagcgccggg ccggctcacgcttcagacgcctctactgagggcgaggaggaagaggaagtggttcacatg ggaaacgccatcctgtccttctactcggctctgatcgatcttctgggccgctgcgctcct gagatgcacctgatcaataagggtaaaggtgaagctctgaggattcgtgccatccttcgt tctctggttcccacggaggatctggtgggcatcatcagcatccctctcaagatgcccgtc gtcaataaagacggcggcgtgtctgagcctgacatgtcggccacgttctgcccggaccac aaggccccgatggtgctgttcctggagcgtgtgtatggcatcgaggaccagagcttcctg ctgcatctgttagaggtgggcttcctgccggacctgagagccgctgcctcgctggacacg gaggctttgcgcaccacagaaaccgctctggcgatgaacaggtacatcggttcggccgtg ttgcccctgctgacccgctgcgctcctcacttctccggcacagagcatcacgccgcgctc atcgactccacgctttacaccgtctaccgtctgtccaagggctgctcgctcaccaaagcc caacgcgacgccatcgaggagtgtctgctggccatctgcaggtacctcagaccctccatg ctccagcatctgctgcgccgactggtgtttgacgtcccgttgttgtctgaatactgtaag atgcctctaaagctgttgacgaatcattacgagcagaactggaagtattactgtctgccg tccggatgggggagttacggtcaagcgtccgaggaggagctgctgcttaccaagaagatc ttttggggaatctttgactctctgtctcagaagaagtatgagcaggatctgttcaagatg gccatgccgtgtctgagtgccatcgctggagctctgccgccggactacatcgactccacg ctcagcaccacgctggagaaacaggtgtctgtcgacacgcagggaaacttcaaccccaga cccgtaaacacagccaacatctgcctgccggagaagctggagtacattgcaaacaaatat gctgaacattcccatgagaaatgggctgctgagaaggtgcttctgggctggaaacatgga gaaaacatcgacgagaaagcaaaaactcatccgatgctgagatcctacaagtccctgaca gagaaggagaaggagatgtattgctggacggtgcgcgagtccttgaagagcatgttagcg atgggctggagcatcgaccgcaccagagaagaagacagcgtgttccagcagagagagatg gagaagatgcgccgcatctcacaggcctctcagggtaacggcttcaatccaaacccgctg gacatgagcagcgtccttctgtccagagaactgcagtcgatggttgaggtcgtagctgaa aactatcacaacatctgggccaagaagaagaagagtgatctgtgcagcagagccgcagga ggagctcatccgctgctggtgccctacgacacgctcacggccaaagagaagaccagagac cgcgagcgagcgcaggatctcttccgcttcctgcagatcaacggatacgccgtcagcagg cgtctgaagcacatggagcaggactcgtcttcgatggagaaacgcttcgcctaccgcttc ctgaagaagctgctgaagtacgtggactcggcgcaggagttcatcgctcacctcgaggcg atggctaccagcggaaagaatgacagatcgccacatgaacaggaaatcaagttctttgct aaggtgctcctccccctcatagaccagtactttaaaaaccactcgctctacttcctgtcg tcacccactaagaatctgagcagcagcggatacgcgtcgaacaaagagaaggagatggtc accagtctgttctgtaagctggccactctggttagacacaggatctctctgtttggaagt gactccaccacgatagtcagctgtctgcacatcctcgcacacacgctggacaccaggact gtgatgaagtccggatcggagctggtcaaggccggtttgaggacgttctttgagagcgcg gctgaagatctggagaagacgctggagaacctgaagctggggaagttcacgcactcccgc agtcagatgaagggcgtctcgcagaacatcaactacaccacagtggctctgctgcccatc ctgaccgctctgttcgagcacatcactgaacaccagttcggctccgaccttctgctggat gatgtgcaggtgtcgtgttatcggatcctgaccagtttatactcgctggggaccgggaag aacatctacgtggagaggcagctgccggcgctgggggagtgtttggcgactctagccggt gcgatgcccgtggcgtttctggagccgcagctaaacacacacaacccctgctccgtcttc aacaccaagacgtctcgagaacgagctctggtcgggctgccggagtcggtggaggacgtg tgtcctgagatgcctcgtctggacggtctgatcaaggacatcactgacgtgtcagagtcc ggcgcgcgctacacagagatgccgcacgtcatcgaggtggtgctgcccatgctgtgtaat tatctgtcgtactggtgggagcgaggcccggagaaccgtccccgtcccgcaggcgtctgc agcagcaccgtcacctccgaacacctcagcctcgtcctcgggaacatcctcaagatcctc aacagcaacctgggcatcgacgaggcctcctggatgaagcgcatcgcagtgtacgctcag cccatcatcagtaaggcgcgcgctgatctgctgaagacacacttcttgccgacgctggag aagctgaagaagaagacggtgaaggtggtgtcggaggaggagcttctgaaagctgatggg aagggcgacacccaggaggcggagcttctgatcctggatgagtttgcagtgctgtgcaga gatctgtacgccttctaccccatgctcatccgctacgtggacaacaacaggtctcggtgg ctgaaggagccggacacagattccaacgagctcttcaggatggtcgcagagatcttcatc ctgtggtgtaaatcacacaacttcaagagagaagagcagaactttgtggttcagaacgag atcaacaacctctcgttcctcaccggagacagtaaaaccaagatggcaaagtcattcctc cccaaggctggtggtcaggatcaggagcgaaagcataagaagcgccgtggagacttttac tccgtccagacgtctctgatcgtggcggcgctgaagaagatgcttcccatcggtctgaac atgtgcacgccgggagaccaggagctcatcctgctggctaagacacgatacggcctgaag gacacagatgaagaggtgaaggagcacatcagacagaacctgcacctgcaggagaagtcg gcggatccggctgttcagtggcagctcaacctctataaggatgtgaaggtgaagacagat gacactctggatccggagcggagcattgagagaatccagagcatctcagccgctgtattc caccttgagcaggttgagcagccgttgcgctctaagaagtgtgtttggcagaagttgttg tctaagcagcggaagcgagccgttgtggcgtgtttcagaatggctccactctacaacctg cccaggcacacaattaataattacttcctgaattcgtactgtcacttttggctgggcaga attcaggcgagttcttaccgtgacggtctgctggctgtgctgacgaagctaaagacgaag actgatgaagaggaggaggagatcacagacactcagccagaccctcttcatcaactcatc ctgcacttcagtcacaacgcactgacagaacgcagctcactagaagaggatcagctgtac atcgcatacgcagacatgatggctaagagctgtgctgaaaatgaggaagaggatgaggaa ggaaaagaaaaaacatttgaggagaaggagatggagaagcagaagactctgtaccaacag gcccgactccatgacagaggagcagcagagatggtcttacagatgatcagcgctagtaaa ggtcatttgggtccaatggtcacgttcacgctgaagctcggcatctccattctcaacggt ggaaacatcacagtccagcagaaaatgctggactatttgaaggagaagcgagatgtgggt ttcttcaagagtctgtcaggactgatgcagtcgtgcagtgttctggatctgaacgcgttc gagcgtcagaataaggccgagggtttggggatggtgactgaggaaggctccatcaacgtg agggagcgcggctctaaagttcttcagaatgacgagttcaccagagatctgttcaggttc ctgcagctcctgtgtgagggacacaataacgacttccagaactttctcaggacgcagaca ggaaacacgaccacagtcaatataatcatcagcacagtggactatctgctcagactgcag gagtcaatcagtgatttttactggtattactctggtaaagacgtgatggacgaggcaggt cagcggaatttctccaaagctctcgctgtagccaaacagatcttcaactcactcactgaa tacatacagggtccgtgtatcgggaaccagcagagtttggctcacagcagactttgggat gccgtcgtcggatttctgcacgtcttcgccaacatgcagatgaagctgtcacaggactcc agtcagatcgagctgctgaaggagctgatggatctgcagaaggacatgatagtcatgatg ctgtcactgctggaaggaaatgtggtgaatgggaccatcggcaagcagatggtggacact cttgtggagtcctccagcaacgtggagatgattctcaagttcttcgacatgttcctcaag ctgaaagatctaacaacctcggagaacttcaaggagcatgaccccgaccgtaaaggcgtc atctccaagaaggagttccagaagtccatggagaaccagaagcagtactctcagtccgag atcgagttcctgctgtcctgcgccgaggccgacgagaacgacatgttcaactacgaagag ttcgtcaatcgcttccacgaacccgccaaagacatcggcttcaatgtggcggttcttctc accaatctgtcggagcacatgcctcacgattcccgactgtccaccttcctgaacctggcc gagagcgttgtgaactacttcgagccctacctgggccgcatcgagatcatgggcggcggc aagagaatcgagagggtttacttcgagattagcgagtccagccgaacgcagtgggagaaa ccgcaggtcaaagagtccaagcggcagtttatcttcgatgtcgtcaacaagggcggagaa tctgagaagatggagctgttcgtgaacttctgcgaggacaccatcttcgagatgcagcta gcatctctgatctccgagccggacgctgctgagagacaagaggaggtcgatgatgaagat gatgctcggagcgtggatctagacgaggacgatgaagatgccgcacaggagtcttcctca gcgttcgctctggcttgcgtctccatgaggaagagtctgtccaacctgcggcagctgctg accttcaggagcatgaggagacagtatcgcaagctgaggaagatgagcgtccgcgagatg atccgaggattcttcttcttcttctggatgatcttcactggcatgttccgcttcctctac agcctggtctggggcttcttccacatcctgtggtccacgctgttcggcggcggtctcgta gaaggagccaagaacatgaaggtgacggacattctggggaacatgccggatcccacgcag ttcgggatccacggagacgttctggagctggagaagctggagtactgcgacgtgtcgtcg gtggcggagctggggcgcatgacggcgggagatcaggcggagatggagctcatgacggag ctgatgtacatgcagcccaggagggaaggaggcaagcatggcatggagccggggctggga gacgtgtccgaggtgatcggagtggacactccgtctttagccagcgccgtccatcagaag aaagctcaggaagccgccagtaaacagactgatgaatcagagaccaaatcagagtcggag aaggcagatgttgaggacagagagaagaaagaccaggacaagggtagagaggagagtgtg tcagactcgctgacagacgaagagaagaagccgcagaagaagagacgcggccagaggaag gagcaggccgaggccttcatggcggcgttcttagccagtctagacgtccatcagaccaaa accctgaattatctggccagaaacttctacaacctgcgattcctggctctgtttgtggcg tttgccatcaacttcatcctgcttttctacaaggtgaccggtgaggactctgatgatctg gacccgtggacgcggcgagaggaggaggatgatgaagcagcgctggagtattttgttctt caggagagcacgggttacatggctccgaccctgcgcttcctggccgtcatgcacaccgtc atctccttcctctgtgtgctgggatattactatctgaaggtgccgctggtggtgttcaag cgtgagaaggagatcgcacgcaagctggagttcgatgggctctacatcaccgagcagccg tctgatgatgatattaaaggccagtgggacagactcgtcatcaacacgccgtcgttcccc aacaactactgggacaagtttgtcaaacggaaggttattaataagtacggcaatctgtac ggagccgagcggatcgcggagctgctgggtttggacaaaagtgctttagacttcaatccc accgaagagacggtcattaaagacgcctcgctgctgtcctggttgagctccattgacacc aagtatcacgtgtggaagatgggcgtcgtgttcactgataactcgttcctgtatctggtc tggtacaccaccatgtccatcctgggacattataataatttcttcttcgccgctcatctg ctggacatcgccatgggcttcaaaacactgaggaccatcctgtcctccgtcacacacaac ggcaaacagctggtgcttacagtcgggctgctcgctgtggtcgtgtacctctacaccgtc gtagcgttcaacttcttccgcaagttttataacaagagcgctgacgaggacgagcccgat atgaagtgtgatgacatgatgacgtgttatctgttccacatgtacgtgggcgtccgtgct ggcggcgggatcggtgacgagattgaggaccccgcgggcgacccgtacgaactctaccgg atcctgttcgacattaccttcttcttcttcgtcattgtgatcctgctggccatcatacaa ggtttgatcatcgatgcgtttggagagctgagagaccagcaggagcaggtcaaagaggac atggagaccaaatgcttcatctgtggaatcgggaacgagtatttcgacacgacgccgcac ggcttcgagactcacacgttacaagagcacaacctcgccaactacctatttttcttgatg tacctgatcaacaaggatgaaaccgagcacactggtcaggagtcgtacgtgtggaagatg taccaggagcgatgctgggatttcttcccggccggagactgtttccgtaagcagtatgaa gaccagctgggctga

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