Culicoides brevitarsis: 134838128 Help Entry 134838128         CDS       T10947                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism cbri  Culicoides brevitarsis Brite Ion channels [BR:cbri04040]  Voltage-gated cation channels   Ryanodine receptor    134838128 Domain-containing proteins not elsewhere classified [BR:cbri04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    134838128 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 TPR_TTI1_C EF-hand_5 BPD_transp_2 CTD7 Motif Other DBs NCBI-GeneID:  134838128 NCBI-ProteinID:  XP_063709662 LinkDB All DBs Position 1:15213643..15255267 Genome browser AA seq 5126 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSSTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETGNAGLGKGTGSGHRTLLYGNAILLRHGNSDMYLA CLSTSSSQDKLSFDVGLQDHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENEESIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW STQPGQNMVVYEGGSVMSQARSLWRLELARTKWSGGFINWYHPLRIKHITTGRYLGINEN NELLLMRREEATTAASTFCLRQEKDDQKVVLEDKDLEVIGSAIIKYGDSTVILQHCETSL WLSYKSFETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCNHLFTKF INGLETLQGNRRTSLFFQSVNLGEMVMCLEDLILYFCQPEDDMEHEEKQNRLKALRNRQD LFQEEGVLNLVLDAIDKINLITSQGFLASFLANDESGQSWDMISMYLYQLLAAIIKGNHT NCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLE KHGRDPKVLDVLCSLCVGNGVAVRSSQNNITDFLLPGKNLLLQTQLVDHVSSVRPNIFVG RVEGSAVYHKWYFEVTMDHIEQMTHMMPHLRIGWANSTGYMPYPGGGEKWGGNGVGDDIF SFGFDGVYLWTGGRKTAVVETIPPEPFIQKGDVIGCALDLSVPIITFTFNGSPVRGSFTN FNLDGMFFPVLSCSSKLSCRFLFGGDHGRLRYNPPLGFSPLYQCLMPHQNLSLDPCFYFG NLSKSVLSGPWLIEDDTAFVPNPVDITPVMLPALVDNIKDKLAENIHEMWALNKIEAGWS WGERRDDLHRIHPCLTSFEKLPAAEKRYDCQLAVQTLKTIIALGYYITLDKPPARIRPIR LPNDIYMQGNGYKPAPLDLSAVTLNPKMEELVDQLAENTHNLWAKERIQQGWTYGLEEDS ETLRSPHLVPYSKVDEAIKKANRDTASETVRTLLVYGYNLDPPTGEANEALLAEALRLKY AAFRTYRVEKTYAVTSGKWYFEFEVLTAGPMRVGWARADVSPGTMLGNDEASWAFDGYNE EKVYGGSGETFGKQWGPGDVVGVFLDLVDHTISFSLNGELLMDALGGETSFADVTADGVG FVPACTIGVGQKARLTYGQNVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDLPIFEN TEDIQGGVIDVNRIPGGADTPPCLKISHNTFETMEKANWEFLRLSLPVTCDSQFITEQEK ARRWEEIRLRQHRLINEVENVMTSNMDHIMKSGFTMNDIKNLHRNYDEAEADENMGRNGP NRPPRKGSVSRPSGFDAPTLEVNGSGMQRSTSALDMARDTGEHDDKRKRGRSPFRLFGKK RDQSKDKVKAQQEDAQRRPMTHGRNVVQAQLGTRNPTVRVSNADLRSQAPSPTAKQSISA PQGNVESAGNEIFDAECLRLINEYFYGVRIYPGQDPTHVYVGWVTTQYHFHGHEFNKEKV RRASVCIAGDYENQILQQVDRQSCYMVRADELFNEVTQDASGKGASQGMFVGCFVDTATG KIRFTCEGKETSHVWQMEPDTKLFPAIFVEATSKDVLQVELGRTPTTLPLSAAVLPTGDK HVNPQSPPRLKVQCLKPHSWARVPNTALQIHALKLSDLRGWSMLCEDPVSMLALHIPEED RCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHNLCQHVDQKQLLYAIQAEYMSG PLRQGFYDLLIALHLESHATTMEVCKNEFIIPLGDDLKELYSDPEMCHSLRSQRTESVRP LMKMTDIGSNNSVVPNPVPDSSEPIPVIDQLYSPKFPLEIVRAYVMGAVKEAVEINQIHN RDPIGGSNENLFLPLIKLIDRLLLVGVLTDEDIEKLLIMIDPETWDPTYEKEGKDEHRKG LLTMKMAEGAKLQMCYLLHHLCDLQLRHRVESIIAFSLNFVGDLQADQLRRYIEIKQSDL PSAVAAKKTREFRCPPREQMNAILGFKNLEEDDQENCTCGLDLRAYLNDFHSELMAKVSL NALQEPEVEEVVTTDDNKHGPIKKLMNFINTVKELEEDPKPPEEPVTKTPEEIFRKVLIR TIVSWAEETQIETPKLVREMFSLLVRQYDTIGELIRALQKTYVINSKTKDDVAIMWVGLS QIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRILRVHENVMAVMMNTLGRRAQ AQSDAPAVTEGGEAPAKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLENSNI LLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYPD LGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGDGLLKAII DANKMSERIADRRKMQDEAEGTISTLGFNHPLPESEDDEDYIDTGAAILNFYCTLVDLLG RCAPDIAVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFVIQNPAAGEDKPKSDIPPGL IPGHKQSVVLFLERVYGIETPELFFRLLEDAFLPDLRAATILDRTDGSESDMALAMNRYI GNSILPLLISHSRFYNEAENYASLLDASLHTVYRLSKNRMLTKGQREGVSDFLVALTAAM QPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYDRCAKYYGSTSGQGAYGTSSDEEKRL TMMLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKTSDDDLYGKPTGQPDQ PQYNPQPINTGSVNLNNDLNNIVQKFSEHYHDAWASRKLEYGWTYGDSWTDTNKTHPRLK PYNMLNDYERERYKEPIRESLKALLAIGWTVEHQESDLPSSNRGSIRRQSASHDSPNKGF QDSPFNYHPHPVDMTNLTLSREMQNMAERLAENAHDIWAKKKMEELQTCGGAVHPQLVPY DLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPHRGGVDEEQLTGAAAAETRFAYTLLEKL IAYLDKATINMKLLKPSSTFSRRTSFKTSSRDIKFFSKVVLPLIEKYFNTNRGYFIAVAT ATNNVGAASLKEKEMVAALFCKLASLLRNRLSAFGADIRITVRCLQVLVKSIDAKSIVKN CPEFIRTSMLTFFNNTADDLGQTIHNLQEGRYSHLRGTHLKTSTSLGYINTVILPVLTSL FDHLATNDYGSDLLLDEIQVASYKILQSLYCLGTDNTLHQDRKFLKTEFERGKPALGSCL GAFSSTFPVAFLEPHCNKNNQFSLLNRIADTSLEAQEIMATMEGAMPTLEAILQEVDQYV ESEKNYMEAQHVIDVILPLLCSYLPYWWAQGPDNVSPTSGNHVTMVTSDYMNQLLKNVLK MIKKNIGNETAPWMTRIAAYTQQIIINSSEELLKDVFLPLAERVKKRVDTMFHKEESLRG FLKSSNDDTSQIEGQIQEDWSLLVRDIYSFYPLLIKYVDLQRNHWLRDNVAEAEELYNYV AEIFNVWSKSQYFLKEEQNFISANEIDNMALIMPTASRRQTTMSEGGPVQGGKAKKKKKD RSKKRDKDKEIQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKLPEEEVSEFAH AQITAPAKLDPADEMSWQHYLYSKLGKKEENIDEILEKSTSLDKKKETIIQDTVERVVAM AKVLYGLHMIDHPQQQSKNVYQKVVSFQRKRAVIACFRQTSLHSLPRHKACNIFARTYCD LWLEEENVGQEIMIEDLTQSFEDAEKSKKDEEEGESKPDPLTQLVTTFCRGAMTERSGAL QEDPLYMSYAEIAAKSCGEEEEEEEGGDEEEGGASIHEQEMEKQKLLFHQARLSNRGVAE MVLLHISASKGVPSDMVMKTLELGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMN SCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYL RTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEVIDPAGKANFFKAIGVASQVFN TLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHASQNDLLKELLNLQKDM ITMMLSMLEGNVVNGTIGKQMVDTLVESAANVELILKYFDMFLKLKDLTTSASFLEIDAN GDGWISVKDFKEKMEQQKSYTPDEIEFLLACCETNHDGKVDYIAFTDRFHEPAKEIGFNL AVLLTNLSEHMPNEPRLAKFLETAGSVLNYFESFLGRIEIMGSSKRIERVYFEIKEDNIE QWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHATELMATEDESGNVNR EYATNTYIGDDDEDPSAKDPVKRTIQNVKEGLKTAFVSLSPGNIKHQIAVLQTKSVPELI IGFFKMIFYAFYYSGYGVSLVIKFFVNILMSLMRGPVEEEAPPPTDDLLVPALPSLPKEE PPGPVQAFGMDISKEDNGQYKLAPHQSPVGSPTSSVDETGESSQDESGVALGVVGDAQMG EQMEMPMTLVDLLGGEAAKRAQQEREEAQKLQQATLAALDAEAKKGKDVSSEPAAVNQID FSSYTKKAVSFLARNFYNLKYVALVLAFCINFMLLFYKVRTFGEAEAEIEGSGDSLFGLI SGSGAGSGGGGLDIGSGAGSGDGITTGGDDDDDGPQEVVEVDEDFFYMEHVMKVAAILHS IVSLCMLIAYYHLKVPLAIFKREKEIARRLEFDGLFIAEQPEDDDIKSHWDKLVISAKSF PVNYWDKFVKKKVRQKYCETYDFDSISNLLGMEKNAFAAQEQTEGGGGIINFITNIDWRY QVWKAGVTVTDNAFLYSLWYFTFSILGNFNNFFFAAHLLDVAVAVAALRTILQSVTHNGK QLMLTVMLLTIIVYIYTVIAFNFFRKFYVQEEDDEVDRKCHDMLTCFVFHLYKGVRAGGG IGDEIGDPDGDEYEVYRIMFDITFFFFVIVILLAIIQGLIIDAFGELRDQLQSVQDDMES NCFICGIGKDYFDKVPHGFDTHVQQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQ RCWDFFPVGDCFRKQYEDELGGGGGS NT seq 15381 nt NT seq  +upstreamnt  +downstreamnt atggcagaagctgaaggaggatccgagcaggatgatgtttcatttcttaggacggaagat atggtctgtctttcgtccacagcaacgggcgagcgtgtttgtctcgccgccgaaggtttc ggcaatcgtcattgtttcctcgagaacatcgccgacaagaatatcccgccagatctatcg caatgcgtgtttgtcatcgaacaagccttgtcagttcgtgccttgcaggaattggtgaca gcagcaggctctgaaacgggaaatgccggtttaggaaaaggcactggttcgggacataga acattgctgtatggtaatgccattttgttgcgacatggaaacagtgatatgtacttggca tgtctttcaacgtcttcgtcgcaagataaattgtcgtttgacgtgggtttgcaagatcac agtcaaggcgaggcttgttggtggaccgtgcatcccgcaagtaaacaaagatccgagggt gagaaggtccgtgttggtgacgacttgattctcgtgtctgtggcgacggaacgttatttg cataccacgaaggaaaatgaggagtcgatcgttaatgcaagcttccatgtgacgcattgg agtgttcaaccctatggcacgggtatttcgcgcatgaagtatgtcggttacgtttttggc ggcgatgtgcttcgtttcttccatggcggcgacgaatgtttgacaattcctagcacttgg agtacgcaacctggacaaaacatggtcgtttacgagggcggttccgtaatgtctcaagct cgatccctgtggcgtttggaactcgctcgtaccaaatggtctggcggttttattaattgg taccatccactacgtatcaaacatatcacaacaggtcgttatttgggtatcaatgagaac aacgagttgcttctcatgcgtcgcgaggaagcaacaacagctgcttcgacgttctgtttg cgccaagaaaaagacgatcaaaaagttgttcttgaagacaaagatttggaagttattggt tcggcaatcattaaatacggtgattctaccgttattttgcaacattgtgagacttcgttg tggctcagttacaagagtttcgagacaaagaaaaagggcgtcggtaaagttgaggagaaa caagccattttgcacgaagaaggaaaaatggatgacggtctcgacttttcacgttcacaa gaggaagagtctagaactgctcgcgtcatccggaagtgcaatcatttgttcacgaagttc attaatggcttggaaacgttgcaaggcaatcgtcgtacttcgttgttcttccaaagtgtc aatttgggagagatggtcatgtgtctcgaggatttgattttgtatttctgtcaacctgag gatgatatggaacacgaggagaaacaaaaccgtttaaaagctctccgcaatcgccaagac ttgttccaagaagaaggcgtactaaatctcgttctcgatgccatcgacaaaatcaatctg atcacgtcacagggcttccttgcctctttcctcgcaaacgacgaaagcggccaaagttgg gacatgatttcgatgtatttgtatcaacttctcgccgccatcatcaaaggcaaccacaca aattgcgcccaattcgccaactccaatcgtttgaactggcttttctcccgtttgggcagc caagcatccagcgaaggtagcggcatgttggatgtattgcattgtgtcttgatcgattcg cccgaagctctgaacatgatgcgagatgagcacatcaaagtcattatttcgctgttggag aagcacggacgcgatccaaaagtcttggatgtcttgtgttcactctgcgttggtaacgga gtcgctgtgcgttcatcccagaacaatatcacggactttttgttgcctggaaaaaatttg ctcttgcaaacgcagttggtagatcacgtttcaagcgttcgcccgaacattttcgtggga cgcgtcgaaggatctgccgtttatcacaaatggtatttcgaggtaacaatggatcacatc gagcaaatgactcatatgatgccacatttgcgcattggatgggcaaattcgacgggatac atgccctatccgggcggcggcgagaaatggggcggaaatggcgtcggtgacgacattttt tccttcggatttgatggagtttacttatggaccggcggaagaaagacagctgttgtcgaa acaatccccccagagccatttattcaaaagggagacgtcattggttgtgccttagactta agtgttcccattataacgttcactttcaacggatctcccgttcgtggaagctttacaaat tttaatttagatggcatgttcttccccgtgttgagttgctcctcaaaactcagttgtcgc ttcttgtttggcggagatcacggtcgtttgcgttacaatccgccattgggattctccccg ctttaccaatgtctcatgccgcaccaaaatctcagcttggatccgtgtttctactttgga aatttgagcaaaagtgttctgagtggcccctggctcatcgaagatgataccgctttcgtg ccaaatcccgttgacatcacgccagtaatgctgcccgcattagtggacaacataaaagac aaactcgcggaaaatatccacgaaatgtgggctttgaacaaaatcgaagccggttggagt tggggcgaacgtcgtgacgatcttcacagaattcatccctgtttgacgagtttcgagaaa cttcctgctgcggaaaagcgttacgattgtcaattagcagtgcaaaccttaaaaacgatc attgctttgggttattacatcactttggataaacctccagctcgaatccgcccgataaga ttgccgaacgacatttatatgcaaggaaatggatacaaaccagctccattggacttgtca gcagtcactttaaatccaaaaatggaagaactcgtcgatcaattggctgaaaacacgcat aatttgtgggctaaagagcgaatccaacagggatggacttatggcttggaagaagactcc gaaacgttacgtagtcctcatttagtgccatatagcaaagttgacgaagccatcaagaag gcgaatcgcgatacagcatcagaaactgtaagaactctccttgtctacggttacaatctc gatccgccgactggagaagcgaacgaagcgttgttagcggaagcacttagattgaaatat gccgcctttagaacataccgcgtggaaaaaacgtacgccgtgacttctggaaagtggtat ttcgagtttgaagttctcactgcaggacctatgagagttggatgggctcgcgctgatgtc agtccaggcacaatgttaggaaatgacgaagcctcgtgggccttcgatggttacaacgaa gaaaaagtgtatggtggatccggcgaaacatttggtaaacaatggggaccaggcgatgtc gtcggtgtttttctcgatttggtcgatcatacaattagcttttcattgaacggagaactt ctcatggatgctcttggaggagaaacatcctttgctgatgtcaccgctgatggcgttgga tttgttcctgcatgtactattggggttggtcaaaaagctcgtttgacttacggtcaaaat gtagattccttgaaattcttcacgacctgcggtttacaagaaggttacgaaccgttctgt gtcaacatgcgtcgtcccgttacgcattggtacacaaaagacttgccaattttcgaaaat acggaagatattcaaggcggcgtcatcgatgtcaatcgtatcccgggaggagctgatacg ccgccatgcttaaaaatttctcacaacactttcgaaacgatggaaaaggcaaattgggag tttttgcgattgtcgttgcctgttacgtgcgacagtcaattcatcacggagcaagaaaag gctcgtcgatgggaagaaattcgtttgcggcaacatcgattgataaatgaggttgaaaat gtcatgacctcgaacatggatcacatcatgaaaagtggttttacgatgaatgacattaaa aatttgcatcgaaactacgacgaagctgaagctgatgaaaatatgggcagaaatggtcca aatcgtcctccgcgaaagggatctgtatcgagaccgagtggatttgatgcgccaacgttg gaagtgaacggaagtggcatgcaacgatccacaagtgctcttgatatggcgagagatacc ggcgaacatgatgacaagcgaaaacgaggaagaagtcccttcaggttgtttggcaagaaa cgcgatcagagcaaagataaggtcaaggcgcaacaggaagatgctcaaagacgtcccatg actcatggcagaaatgtcgttcaagcgcaattaggaacgagaaatcctactgtaagggtt tccaatgctgatttacgatctcaagctccatctccaactgccaaacaaagcatttccgct ccacaaggcaacgttgaatccgctggaaatgaaattttcgatgccgaatgcttaagactt attaatgagtacttctacggtgtcagaatttatccgggtcaagatcccacacacgtctac gttggttgggtaacgactcagtatcacttccacggtcacgaattcaacaaagaaaaggtt cgacgtgcttccgtttgtattgcgggcgattatgagaaccaaattttgcaacaagttgat cgtcaaagttgctacatggtgcgtgccgacgagctttttaacgaagtaacgcaagacgct tctggcaagggagcttctcaaggcatgtttgtcgggtgtttcgtcgatactgctaccggt aaaatccgatttacgtgcgaaggcaaggaaacttctcacgtttggcaaatggaacccgat acgaaactcttccccgcgatttttgtcgaagctacgagtaaagatgtcttgcaagttgaa cttggaagaacgccaacgacacttccgttatcggctgcggtgcttccgacgggcgacaaa cacgtaaatccccaatcgccgcctcgcttgaaggtgcaatgcttgaaaccgcattcgtgg gctcgtgttccgaacactgctcttcaaattcatgccctgaaattgagcgatttgcgtggt tggtcgatgttgtgtgaagatccggtctcgatgttggcactgcatatccctgaagaggat agatgtattgatattttggaacttattgaaatggacaaattattgtcgttccatgcgcat accctgacactttatgctgcgttatgctaccaatctaattatagagctgctcataatttg tgccaacatgtcgatcaaaagcaacttttgtatgccattcaagcggaatacatgagcgga ccactgcgtcaaggattctacgacttgttgattgccctgcatttggaatcgcatgcaact acgatggaggtctgtaagaacgaatttatcatcccattgggtgacgatttgaaagaactt tactcagatccggaaatgtgtcactccctgcgatctcaacgcacagaatctgttcgacct ctgatgaaaatgacagatatcggatctaacaattctgttgttccaaatcctgtgcctgat tctagtgagccgataccggtaatcgatcagctgtattcgcctaaatttccgctggaaatt gtgcgtgcgtacgttatgggagctgtgaaggaagctgtggaaattaatcaaatccataat cgggatcctattggcggatcgaatgaaaatctgttcttgcctctcatcaagctcattgat cgtctcttgctcgttggcgtcctcacagatgaagatatcgagaaacttctcatcatgatc gatcccgaaacttgggatccaacatacgaaaaggaaggcaaggacgaacatcgcaaaggt ttactcacaatgaaaatggctgaaggagcaaaacttcaaatgtgctacttactccatcat ttatgcgatttgcagctccgtcatcgtgttgaaagtatcatcgccttctccttgaacttc gtgggtgacctacaagccgatcagctacgtcgctacatcgaaatcaaacaatctgacttg ccgagtgccgttgctgcgaagaaaactcgtgagttccgttgcccgccacgtgaacaaatg aacgccattctcggttttaagaatttggaagaggatgatcaggaaaattgtacttgcgga ttggatttgcgagcgtatttgaatgacttccatagtgaacttatggcaaaagtgtcgttg aatgccttgcaagagcccgaagttgaggaagttgttacgacagacgataacaaacatggt cccattaagaagttgatgaactttataaataccgtgaaggaattggaagaagatccaaag ccgccagaagagcctgtcacaaaaacgcctgaagagattttccgcaaagttttgatccgc acgatcgtttcgtgggcggaagagacccaaatcgagacaccaaagctcgttcgtgaaatg tttagtcttttggtgcgtcaatacgatacaattggagaactgattcgagcgttgcaaaag acctacgtcatcaatagcaaaacgaaagacgatgttgctatcatgtgggtgggtctttcg cagatccgtgcccttctcccggtacaaatgagtcaagaagaggaagaattgatgcgaaaa cgtctctggaaattggtcaataatcacactttcttccaacatcccgatttaattcgcatt ttgcgtgttcacgagaacgtcatggctgtcatgatgaacactttgggtcgtcgggctcaa gcacagagcgatgcaccggcagttaccgaaggcggcgaagctccagccaaggagaaagac acgtcgcacgaaatggtcgtcgcctgttgtcgtttcttgtgttatttctgtcgcacagga cgtcaaaaccagaaagccatgttcgatcatttcgactttttgctggaaaattcgaatatt ttactatctcgtccaagtttgagaggatccacgcccttggatgtcgcttattctagtttg atggaaaacacggaactggcattggctttgcgtgaacattatttggagaaaattgccgtt tatctctcacgttgcggcttacaaagcaacagtgagttagttgaaaagggatatcccgat cttggttgggatcccgtcgaaggtgaacgttatctcgactttttacgtttctgtgtgtgg gttaatggcgaaagtgtcgaggaaaatgccaatttggtcattcgtttgttgattcggcgt cccgagtgtttgggtccagcgttgcgcggtgaaggcgatggcttgctaaaagctattatc gatgccaacaagatgtcggaacgcattgcggatcgtcgtaagatgcaagatgaagcggaa ggcaccatttcaacgcttggatttaatcatccgttgcccgaaagtgaagacgatgaggat tatatcgacacgggagcagcaattctcaatttctattgtactttggttgatttgttggga cgatgtgcacccgatattgccgtcattgagcaaggcaagaacgaatcgttgcgtgcgcga gctattttgagatctcttgtaccgttggaagacttgcaaggcgtgttgagcttgaagttt gtcatccaaaatcccgctgctggagaagataagccgaaatctgacataccgccgggtttg attccgggacataaacagagtgttgtgttgttcttggaacgtgtctatggcatcgaaacg ccagaactgttctttagactgttggaagatgctttcttgccggatttgagagctgcgaca attttggatagaaccgatggatctgaatccgatatggctctcgcgatgaatcgttacatc ggcaactcaattctcccgttattgatcagtcattcgagattctacaacgaagctgagaac tacgcaagtttgctagatgccagtttgcacaccgtttatcgcctttccaagaaccgcatg ttaaccaaaggacaacgtgagggcgtttctgactttttggttgctctaactgccgctatg caacctgccatgttgctaaaactgctgcgaaaactcacagttgacgtatcaaaactctcg gaatacaccacagtcgctttacgtctcttgacgttgcattacgacagatgtgccaaatat tacggctcaacaagtggtcaaggtgcttacggaacgtcatcggatgaggaaaaacgtctc accatgatgttatttagcaacatttttgactctctgagtaacatggattacgatccggag ttgttcggtaaagcgttgccttgtttgattgccattggatgcgctttgccaccggattac agtttatcgaagacttccgatgatgatttgtatggaaaaccaacgggacaaccggatcaa ccgcaatacaatccgcagccgatcaacacgggaagtgtcaacttgaacaacgacttgaac aatattgtgcagaaattcagcgaacattatcacgatgcatgggcaagcaggaaactcgag tacggatggacttatggcgatagttggactgatacgaataaaacgcatccacgattgaag ccgtataacatgctgaacgactacgaaagagaacgttataaggaaccgattcgcgagagt ttgaaagctttgttggcgatcggatggactgtcgaacatcaagaatcagatttgccttca tcgaatcgcggatcaattagacgtcaatcggcatctcatgattcaccaaataagggtttt caggattcgccattcaattaccatccacatccagtggacatgacgaatcttacgctcagc agagagatgcaaaatatggcggaacgactcgcggaaaatgctcacgatatttgggcgaag aagaagatggaagagttgcaaacgtgtggaggcgccgtgcatccacaacttgtgccgtat gacttgttaacggacaaggagaaacgcaaggacagagaaaggtcacaagagttcttgaaa tatttgcaatatcaaggatacaagttgcataaaccccatcgtggcggagtcgatgaagaa caactcaccggagcagctgctgccgaaactcgtttcgcttacactttactcgaaaaacta attgcttacttggacaaagctacaatcaacatgaagctcttgaaaccttcctcaactttc agtcgtcgcacatcattcaaaaccagctcgcgcgacatcaaattcttctcaaaagtcgtt ttgccgttaattgagaaatatttcaataccaatcgcggttacttcattgctgtagcgact gcgacaaataacgttggagctgcatcgctcaaagagaaggaaatggtcgctgctcttttc tgcaaactcgccagtttactaagaaatcgtttgtcggcgttcggagctgatattcgaatc accgttcgttgcttgcaagtactcgtgaagagcattgatgccaaatccattgtgaaaaat tgcccggaattcattcgtacgtcaatgttgacgttctttaacaacacagccgacgatttg ggacaaacaattcacaatttgcaagaaggacgttacagccatttacgaggaacgcatttg aagacatcaacttcgcttggatatatcaatacggtgatcctgccggtactgacgtcgttg tttgatcatcttgcaacgaacgattatggcagtgatttgcttttggatgagattcaagtc gcttcatacaaaatacttcagtcactttattgcttgggaacggataacactcttcaccaa gaccgtaaattccttaaaactgagttcgaacgtggcaaaccagcacttggatcgtgtctc ggagccttcagttcgacgttcccggttgcctttttggagccacattgcaacaaaaacaat caattctcacttttgaaccgaattgccgatacttcgctcgaagcgcaggaaattatggcg acgatggaaggtgcaatgccaactcttgaagcgattttgcaagaagttgatcaatatgtc gaatctgagaaaaattacatggaagctcaacatgtcattgatgtcattcttcctttactt tgttcttacctgccttattggtgggctcaaggtccggataatgtatcgcctacttcaggc aatcatgttaccatggtgacgtcagattacatgaatcaactgctgaaaaatgttctgaag atgattaaaaagaacattggcaacgaaacagctccttggatgactcgcattgctgcttat acgcaacaaattatcatcaacagctcggaagaattgttgaaagatgttttcttgccactt gcggaacgtgtgaaaaaacgcgttgacacgatgttccacaaagaagagagtttacgagga tttttgaagagctccaacgatgacacatcccaaattgaaggtcaaatccaagaagattgg tcgttgttagtacgtgacatctactcgttctacccgttattgatcaaatatgtcgacttg caacgtaatcactggttgcgcgataatgtcgccgaagcggaggaactttacaactacgtt gccgaaattttcaacgtttggtccaagagtcaatatttccttaaggaagagcaaaatttc atttccgccaatgagatcgataacatggccctcattatgccaactgcctcgcgtcgtcaa accacaatgtccgaagggggtcccgtgcaaggcggcaaagcgaagaagaagaaaaaggac cgcagcaaaaaacgcgacaaagacaaggaaattcaagcatctcttatggttgcttgtctc aaacgtctcctgcctgttggtttaaatctctttgctgggcgagaacaagaactcgttcaa cattgcaaagatcgtttcttaaagaaattaccggaagaggaagtctcggagttcgcacat gcccaaataacagcaccagccaaactagatcccgccgatgaaatgtcctggcaacattat ttgtactccaaactgggcaaaaaagaggaaaatatcgatgaaattttggaaaaatccacg tcgcttgataagaagaaggaaacaatcattcaagataccgtcgaacgggttgtagcaatg gcgaaagttctttacggattgcacatgattgaccatccgcaacaacaaagtaagaatgtc tatcagaaagtcgtttctttccaaagaaaacgtgccgttatcgcctgtttccgtcaaacg tcgttacattcgttgccaagacacaaggcttgtaacatattcgctcgtacttattgtgat ttgtggctagaagaggagaatgttggacaagaaatcatgattgaagatctgacgcaatca tttgaggacgcagaaaagtctaagaaagatgaagaagaaggtgagagcaagccagatccg ttgacgcaattagtaacaacattctgtcgtggtgccatgactgagcgaagcggagcgtta caagaagacccgttgtacatgtcttatgcggaaattgctgccaaatcttgcggcgaagaa gaggaagaagaagaaggcggagacgaggaagaaggaggagcaagtattcatgaacaagaa atggaaaaacagaaacttttgttccatcaagctcgtctcagtaatcgcggtgttgctgaa atggttttgctacacatttccgcctccaagggtgtcccatcagatatggtcatgaaaact ttagagcttggtatcgctattttacgtggcggcaacatcgatatccaaatgggcatgtta aatcacttgaaagagaagaaagacgttggatttttcacatccatcgctggtttgatgaac tcttgcagcgttttggatttggatgcatttgagcgaaacacgaaagctgaaggtttaggc gtcggatctgaaggtgccgcgggtgaaaagaacatgcatgatgctgaattcacttgcgct ctgttccgattcatccaattgacgtgcgaaggtcacaatttggactggcagaattatttg agaacgcaagctggtaacacgacaactgttaatgtcgtcatttgcactgtcgattacttg ttgcgacttcaagagtcaattatggacttttactggcattattcgagcaaggaagtgatt gatcccgcgggaaaagcaaactttttcaaagctattggagtggcaagtcaagttttcaac acacttactgaggttattcaaggtccttgcacacagaatcaacaggctttggcacattcg agattgtgggatgccgttggaggtttcctcttccttttctcccacatgcaagacaaactc tcgaaacacgcgagccagaacgacttgctcaaggaattgctcaacttacaaaaagacatg atcacgatgatgctttcgatgcttgaaggtaacgtcgttaacggcacaattggcaaacag atggttgacacactcgtcgaatcggctgccaatgtcgaattgatcctcaaatacttcgat atgttcttgaaattgaaggatttgacaacttctgcgagtttcttggagattgatgccaac ggcgatggatggatttccgtcaaagatttcaaggaaaaaatggaacaacaaaaatcttac acgcctgacgaaatcgagttcctcctcgcctgttgcgaaacaaatcacgatggaaaagtc gattatatcgcatttacggatcgtttccatgaaccagccaaggaaatcggcttcaatctt gccgttttgctcacaaacttgtccgaacacatgcccaacgagccccgtcttgccaaattc ctcgaaacagctggttcggtattgaactatttcgaatcgttcttgggtcgtatcgagatt atgggttcgtcgaagcgcatcgaacgtgtctacttcgaaattaaggaagacaacatcgag caatgggaaaaaccacaaattaaggagtcgaaacgggcattcttctattcgatcgttact gagggaggtgataaggaaaaattggaagcttttgtcaacttctgcgaagatgcgatcttt gaaatgactcacgcgacagaattgatggcaacggaagacgaaagtggaaatgttaacaga gaatatgcaacaaatacgtacattggcgatgacgatgaagacccgagtgcgaaagatccc gtcaagagaaccattcaaaatgtcaaagaaggtctcaaaacggcttttgtctcgttgagc ccgggcaatattaaacatcaaatcgccgttcttcaaacgaaatctgttcccgaattgatt attggtttcttcaagatgatcttttatgccttttactactccggatatggcgtctcgttg gtaattaaattcttcgtcaacattttgatgtcgctcatgcgtggcccagtcgaagaagaa gcacctccgccaacagatgacttgcttgttcctgcattgccgtcattaccgaaggaagaa ccgccaggtcctgtgcaagcgtttggaatggacatcagcaaagaagacaatggtcaatat aaactcgctccgcatcaatccccggttggatctccaacaagttctgtcgacgaaacgggc gaaagtagtcaagacgagtccggagtcgcattgggagtcgttggtgatgcccaaatgggt gaacaaatggaaatgccaatgactttagtggatctcttgggaggcgaggcagcaaaacgc gcacaacaagaacgcgaagaagcccaaaagttgcaacaagcaacgttggctgctttagat gcggaagccaagaaaggaaaagatgtttcatctgaaccagctgctgttaatcaaatcgat ttctcgagttacacgaagaaagctgtcagtttcttggctcgtaatttctacaatttgaaa tatgtggctttggttctcgctttttgcattaatttcatgctgttgttctacaaagtacga acatttggcgaagcagaagctgaaattgagggttcaggtgatagtttgttcggattgatt tcgggttcaggagctggatcaggcggcggaggtttggatattggtagcggagcaggaagc ggagatggaattacgacaggaggagatgatgatgacgatggtccccaagaagttgtcgaa gtcgacgaggacttcttctacatggaacacgtgatgaaagtcgctgccatccttcacagt atcgtatcgctctgcatgttgatcgcctattaccatctcaaggtgcctcttgccatcttc aaacgtgaaaaagaaatcgctcgtcgtttagaattcgacggtctcttcatcgccgaacaa cctgaagatgacgacatcaagtctcactgggacaaactcgttatttcagcaaaatccttc cccgtgaactactgggacaaatttgtgaagaaaaaagttcgtcaaaagtactgcgaaaca tacgactttgactcgatctccaacttgcttggcatggaaaagaacgcattcgcagcacag gaacaaactgaaggcggcggcggaataattaatttcatcacaaacatcgattggcgctat caagtgtggaaagcaggcgtaactgtgacagataatgctttcctttactccttgtggtac tttacgttctcaattttgggtaatttcaacaactttttcttcgccgcccatttattggat gtcgctgttgcggtagctgccttgcgtacgatcttgcaatccgtaacgcataacggcaaa caactcatgttgactgtgatgctcttgacaatcatcgtgtacatttacaccgtaatcgcc ttcaatttcttccgcaagttttacgtgcaggaggaagacgacgaagtcgaccggaagtgt catgacatgctcacgtgcttcgtgttccacttgtacaagggtgtgcgagctggcggcggt atcggcgacgaaatcggggacccagatggcgacgaatacgaagtttatcgtatcatgttc gatattacgttcttcttcttcgttatcgttatcttgcttgccatcatccaaggtttgatt attgatgccttcggtgagttgcgtgaccagttgcaatcggtgcaagatgacatggagtca aattgcttcatttgcggcatcggcaaggattacttcgataaagtgccgcatggcttcgat acgcatgtccagcaggaacacaatctggccaattacatgttcttccttatgcatctcatc aataagcccgatacggaatacacgggacaggagacatatgtgtggaacatgtaccagcaa cgttgttgggacttcttccccgtcggtgactgcttcaggaagcaatatgaggatgaattg ggtggcggaggcggcagttaa

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