KEGG   Cervus canadensis (wapiti): 122420500
Entry
122420500         CDS       T07554                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01521  EGFR tyrosine kinase inhibitor resistance
ccad01522  Endocrine resistance
ccad01524  Platinum drug resistance
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04014  Ras signaling pathway
ccad04015  Rap1 signaling pathway
ccad04022  cGMP-PKG signaling pathway
ccad04024  cAMP signaling pathway
ccad04062  Chemokine signaling pathway
ccad04066  HIF-1 signaling pathway
ccad04068  FoxO signaling pathway
ccad04071  Sphingolipid signaling pathway
ccad04072  Phospholipase D signaling pathway
ccad04140  Autophagy - animal
ccad04150  mTOR signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04152  AMPK signaling pathway
ccad04210  Apoptosis
ccad04211  Longevity regulating pathway
ccad04213  Longevity regulating pathway - multiple species
ccad04218  Cellular senescence
ccad04261  Adrenergic signaling in cardiomyocytes
ccad04370  VEGF signaling pathway
ccad04371  Apelin signaling pathway
ccad04380  Osteoclast differentiation
ccad04510  Focal adhesion
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04611  Platelet activation
ccad04613  Neutrophil extracellular trap formation
ccad04620  Toll-like receptor signaling pathway
ccad04625  C-type lectin receptor signaling pathway
ccad04630  JAK-STAT signaling pathway
ccad04660  T cell receptor signaling pathway
ccad04662  B cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04666  Fc gamma R-mediated phagocytosis
ccad04668  TNF signaling pathway
ccad04722  Neurotrophin signaling pathway
ccad04725  Cholinergic synapse
ccad04728  Dopaminergic synapse
ccad04810  Regulation of actin cytoskeleton
ccad04910  Insulin signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04915  Estrogen signaling pathway
ccad04917  Prolactin signaling pathway
ccad04919  Thyroid hormone signaling pathway
ccad04920  Adipocytokine signaling pathway
ccad04922  Glucagon signaling pathway
ccad04923  Regulation of lipolysis in adipocytes
ccad04926  Relaxin signaling pathway
ccad04929  GnRH secretion
ccad04931  Insulin resistance
ccad04932  Non-alcoholic fatty liver disease
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad04936  Alcoholic liver disease
ccad04973  Carbohydrate digestion and absorption
ccad05010  Alzheimer disease
ccad05017  Spinocerebellar ataxia
ccad05132  Salmonella infection
ccad05135  Yersinia infection
ccad05142  Chagas disease
ccad05145  Toxoplasmosis
ccad05152  Tuberculosis
ccad05160  Hepatitis C
ccad05161  Hepatitis B
ccad05162  Measles
ccad05163  Human cytomegalovirus infection
ccad05164  Influenza A
ccad05165  Human papillomavirus infection
ccad05166  Human T-cell leukemia virus 1 infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05168  Herpes simplex virus 1 infection
ccad05169  Epstein-Barr virus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05200  Pathways in cancer
ccad05205  Proteoglycans in cancer
ccad05207  Chemical carcinogenesis - receptor activation
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05210  Colorectal cancer
ccad05211  Renal cell carcinoma
ccad05212  Pancreatic cancer
ccad05213  Endometrial cancer
ccad05214  Glioma
ccad05215  Prostate cancer
ccad05218  Melanoma
ccad05220  Chronic myeloid leukemia
ccad05221  Acute myeloid leukemia
ccad05222  Small cell lung cancer
ccad05223  Non-small cell lung cancer
ccad05224  Breast cancer
ccad05225  Hepatocellular carcinoma
ccad05226  Gastric cancer
ccad05230  Central carbon metabolism in cancer
ccad05231  Choline metabolism in cancer
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
ccad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122420500 (AKT2)
   04012 ErbB signaling pathway
    122420500 (AKT2)
   04014 Ras signaling pathway
    122420500 (AKT2)
   04015 Rap1 signaling pathway
    122420500 (AKT2)
   04370 VEGF signaling pathway
    122420500 (AKT2)
   04371 Apelin signaling pathway
    122420500 (AKT2)
   04630 JAK-STAT signaling pathway
    122420500 (AKT2)
   04668 TNF signaling pathway
    122420500 (AKT2)
   04066 HIF-1 signaling pathway
    122420500 (AKT2)
   04068 FoxO signaling pathway
    122420500 (AKT2)
   04072 Phospholipase D signaling pathway
    122420500 (AKT2)
   04071 Sphingolipid signaling pathway
    122420500 (AKT2)
   04024 cAMP signaling pathway
    122420500 (AKT2)
   04022 cGMP-PKG signaling pathway
    122420500 (AKT2)
   04151 PI3K-Akt signaling pathway
    122420500 (AKT2)
   04152 AMPK signaling pathway
    122420500 (AKT2)
   04150 mTOR signaling pathway
    122420500 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122420500 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    122420500 (AKT2)
   04218 Cellular senescence
    122420500 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122420500 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    122420500 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122420500 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122420500 (AKT2)
   04613 Neutrophil extracellular trap formation
    122420500 (AKT2)
   04620 Toll-like receptor signaling pathway
    122420500 (AKT2)
   04625 C-type lectin receptor signaling pathway
    122420500 (AKT2)
   04660 T cell receptor signaling pathway
    122420500 (AKT2)
   04662 B cell receptor signaling pathway
    122420500 (AKT2)
   04664 Fc epsilon RI signaling pathway
    122420500 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    122420500 (AKT2)
   04062 Chemokine signaling pathway
    122420500 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122420500 (AKT2)
   04922 Glucagon signaling pathway
    122420500 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    122420500 (AKT2)
   04920 Adipocytokine signaling pathway
    122420500 (AKT2)
   04929 GnRH secretion
    122420500 (AKT2)
   04915 Estrogen signaling pathway
    122420500 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    122420500 (AKT2)
   04917 Prolactin signaling pathway
    122420500 (AKT2)
   04926 Relaxin signaling pathway
    122420500 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    122420500 (AKT2)
   04919 Thyroid hormone signaling pathway
    122420500 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122420500 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122420500 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    122420500 (AKT2)
   04728 Dopaminergic synapse
    122420500 (AKT2)
   04722 Neurotrophin signaling pathway
    122420500 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122420500 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    122420500 (AKT2)
   04213 Longevity regulating pathway - multiple species
    122420500 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122420500 (AKT2)
   05205 Proteoglycans in cancer
    122420500 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    122420500 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    122420500 (AKT2)
   05230 Central carbon metabolism in cancer
    122420500 (AKT2)
   05231 Choline metabolism in cancer
    122420500 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122420500 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122420500 (AKT2)
   05212 Pancreatic cancer
    122420500 (AKT2)
   05225 Hepatocellular carcinoma
    122420500 (AKT2)
   05226 Gastric cancer
    122420500 (AKT2)
   05214 Glioma
    122420500 (AKT2)
   05221 Acute myeloid leukemia
    122420500 (AKT2)
   05220 Chronic myeloid leukemia
    122420500 (AKT2)
   05218 Melanoma
    122420500 (AKT2)
   05211 Renal cell carcinoma
    122420500 (AKT2)
   05215 Prostate cancer
    122420500 (AKT2)
   05213 Endometrial cancer
    122420500 (AKT2)
   05224 Breast cancer
    122420500 (AKT2)
   05222 Small cell lung cancer
    122420500 (AKT2)
   05223 Non-small cell lung cancer
    122420500 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122420500 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    122420500 (AKT2)
   05161 Hepatitis B
    122420500 (AKT2)
   05160 Hepatitis C
    122420500 (AKT2)
   05164 Influenza A
    122420500 (AKT2)
   05162 Measles
    122420500 (AKT2)
   05168 Herpes simplex virus 1 infection
    122420500 (AKT2)
   05163 Human cytomegalovirus infection
    122420500 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122420500 (AKT2)
   05169 Epstein-Barr virus infection
    122420500 (AKT2)
   05165 Human papillomavirus infection
    122420500 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122420500 (AKT2)
   05135 Yersinia infection
    122420500 (AKT2)
   05152 Tuberculosis
    122420500 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122420500 (AKT2)
   05142 Chagas disease
    122420500 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122420500 (AKT2)
   05017 Spinocerebellar ataxia
    122420500 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122420500 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    122420500 (AKT2)
   05415 Diabetic cardiomyopathy
    122420500 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    122420500 (AKT2)
   04932 Non-alcoholic fatty liver disease
    122420500 (AKT2)
   04931 Insulin resistance
    122420500 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122420500 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122420500 (AKT2)
   01524 Platinum drug resistance
    122420500 (AKT2)
   01522 Endocrine resistance
    122420500 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122420500 (AKT2)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     122420500 (AKT2)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   122420500 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like Pkinase_C PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 122420500
NCBI-ProteinID: XP_043291564
LinkDB
Position
18:23368320..23415094
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPM
DYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITVTPPDRYDSLGSLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccataagcgcggtgaatatatcaag
acctggcggccccggtacttcctgctgaagagcgacggctccttcattggctataaggag
cggcctgaggcccccgaccagaccctgccccccttaaacaacttctctgtcgcagaatgc
cagctgatgaagaccgagagacctcgaccgaataccttcgtcattcgctgtctgcagtgg
accacagtcatcgagaggaccttccatgttgactccccggacgagagggaggagtggatg
cgggccatccagatggttgccaacagcctcaagcagcggggcccgggggaggaccccatg
gactacaagtgcggctcccccagcgactcgtctgcggccgaggagatggaggtggcagtt
agcaaggcgcgggccaaggtgaccatgaatgacttcgactatctcaaactcctgggcaag
ggcacctttggcaaggtcatcctggtgcgggagaaggccaccggccgctactacgccatg
aagatcctgcggaaggaggtgatcatcgccaaggatgaagttgcccacacggtcaccgag
agccgggtcctgcagaacaccaggcacccgttccttaccgcgctgaagtacgccttccag
acacacgaccgcctgtgcttcgtgatggagtatgccaacggtggcgagctgttcttccac
ctgtcgcgggagcgtgtcttcacagaggagcgggcccgcttttacggcgcggagatagtc
tcagccctggagtacctgcactcgcgggacgtggtgtaccgcgacatcaagctggaaaac
ctcatgctggacaaggatggccacatcaagatcaccgacttcggcctgtgcaaggagggc
atcagtgacggggccaccatgaagaccttctgtgggacccctgagtacctggcgcccgag
gtgctggaggacaatgactatggccgggcggtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggatcacgagcgcctcttcgag
ctcatcctcatggaggagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccctaagcagaggctcggcggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagtatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaagcctcaggtcacgtctgaggttgacacaaggtactttgat
gatgagttcaccgcccagtccatcacagtgacgcccccggaccgctatgacagcctgggc
tcgctggagctggaccagcggacgcacttcccccagttctcgtattcggccagcatccga
gagtga

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